Clinical trials: Depressive State
Depression
Evaluation of the H1-Coil TMS- Double Blind Placebo Controlled Study in Adolescent Patients Suffering From Major Depression
This study is a randomized double blind placebo controlled EEG monitored study of deep rTMS treatment to treat adolescent depression.
- Trial name
- NCT03541707
- Testing
- Deep TMS Brainsway's H coil
- Where
- Israel
- Volunteers
- 52 people
- Sponsor
- Shalvata Mental Health Center
Depression Disorders, HIV (Human Immunodeficiency Virus)
Improving the Treatment of Depression Among Youth With HIV
Depression is a common psychiatric condition among Youth with HIV (YWH), with prevalence as high as 25% in the United States. The treatment of depression is essential for improving both psychiatric and medical outcomes for YWH…
- Trial name
- NCT07211087
- Testing
- COMBEX, COMB
- Volunteers
- 130 people
- Sponsor
- Rhode Island Hospital
Alcohol Relapse Prevention, Alcoholism
Quetiapine vs. Placebo in Alcohol Relapse Prevention - a Pilot Study
Due to Quetiapine's particulars and the promising receptor profile, we want to examine the efficacy concerning relapse prevention of alcoholics suffering from persisting craving and/or affective symptoms (persisting sleep…
- Conditions
- Alcohol Relapse Prevention, Alcoholism, Alcohol Drinking, Alcohol Consumption
- Trial name
- NCT00561587
- Testing
- Seroquel®
- Where
- Germany
- Volunteers
- 40 people
- Sponsor
- Institut fuer anwendungsorientierte Forschung und klinische Studien GmbH
Depression
The Effects of JNJ-39393406 on Psychometric Performance and Residual Depressive
To evaluate the effects of the nicotinic allosteric modulator JNJ-39393406 on psychometric performance and residual depressive symptoms in patients who have been diagnosed with unipolar and bipolar depression but currently DO NOT…
- Trial name
- JNJ-DEP (NCT02677207)
- Testing
- JNJ-39393406
- Where
- 4 sites in Moldova, Romania
- Volunteers
- 80 people
- Sponsor
- Tangent Data
Pregnancy, Depression
An Intervention Study to Increase Physical Activity and Maternal Well-being During Pregnancy
To refine, implement and evaluate a motivationally-tailored exercise intervention for increasing physical activity and mental health during pregnancy and the postpartum.
- Trial name
- NCT00419211
- Testing
- Exercise
- Where
- Canada
- Volunteers
- 76 people, healthy volunteers welcome
- Sponsor
- McGill University
Depression Mild, Depression Moderate
Long-term Effects ReSet Your Mind - Mechanisms
See: ClinicalTrials.gov ID: NCT05402150 Relevant for this Paper: This investigation aims to evaluate the stability of the effectiveness of different two-week online interventions in a four months follow-up regarding reward…
- Trial name
- NCT06072209
- Testing
- Behavioral Activation, Mindfulness and Gratitude, Combination of Behavioral Activation and Mindfulness and Gratitude
- Where
- Germany
- Volunteers
- 224 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Emotional Disorders
The Unified Protocol for Transdiagnostic Treatment of Emotional Disorders in Older Adults: a Feasibility Study
Psychological treatment is less likely to be offered in an older population. In order to adapt treatment effectively for this population, more research is necessary.
- Trial name
- UPS (NCT06777693)
- Testing
- Unified Protocol
- Where
- Norway
- Volunteers
- 24 people
- Sponsor
- NKS Olaviken Gerontopsychiatric Hospital
Bipolar Disorder, Depression
Relapse Prevention for Bipolar Type-II Disorder
This 62-week study will compare the safety and effectiveness of fluoxetine (Prozac®), lithium, the combination of these two medications, and placebo in treating and preventing recurrent depressive episodes in people with bipolar…
- Trial name
- NCT00044616
- Testing
- Fluoxetine, Lithium
- Where
- United States
- Volunteers
- 180 people
- Sponsor
- University of Pennsylvania
Depression
The Use Of L-Methylfolate As A Treatment For Depression
This is an open-label study assessing the efficacy of l-methylfolate as monotherapy in patients with mild to moderate major depressive disorder (MDD).
- Trial name
- NCT02133898
- Testing
- L-methylfolate
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- University of Florida
PTSD (Childbirth-Related), Severe Maternal Morbidity
Debriefing Consult for Psychiatric Symptoms After Severe Maternal Morbidity
The primary objective of this study is to determine if a maternal fetal medicine (MFM) debriefing consult six to eight weeks postpartum reduces self-reported post-traumatic stress, depression, and anxiety symptoms following a…
- Conditions
- PTSD (Childbirth-Related), Severe Maternal Morbidity, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07684521
- Testing
- Virtual maternal fetal medicine debriefing consult
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Cedars-Sinai Medical Center
Depressive Symptoms, Anxiety
The Impact of PM+For Moms Intervention on Improving Mother's Mental Health in Zambia (PM+FM)
CMHD are particularly prevalent among women, posing a major threat to their own and their children's wellbeing. Despite the high prevalence of CMHD and the existence of effective treatments, interventions supporting women living…
- Conditions
- Depressive Symptoms, Anxiety, Trauma, Psychological
- Trial name
- PM+FM (NCT05627206)
- Testing
- Problem Management + For Moms
- Where
- Zambia
- Volunteers
- 270 people
- Sponsor
- Swiss Tropical & Public Health Institute
Depression
Transcranial Magnetic Stimulation in Major Depression With EEG and Near Infrared Spectroscopy (NIRS) Monitoring
This a 12- week study (1-4 week screening, 6 weeks treatment, 2 weeks follow-up) outpatient open label clinical trial. Twenty-five subjects diagnosed with depression with a Montgomery Asberg Depression Rating Scale (MADRAS) score…
- Trial name
- NCT01192685
- Testing
- Transcranial Magnetic Stimulation (TMS), near infrared spectroscopy (NIRS)
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Boston University
Dementia, Depression
3D Team Care for Cognitively Vulnerable Older Adults
This study addresses how to achieve better outcomes for cognitively vulnerable community-dwelling older adults and their families.
- Conditions
- Dementia, Depression, Delirium
- Trial name
- NCT02945085
- Testing
- Home Based Care Team, Telephone Based Care Team
- Where
- United States
- Volunteers
- 506 people
- Sponsor
- UConn Health
Irritable Bowel Syndrome With Subthreshold Depression
Lactobacillus-containing Cultured Milk Drink Alleviates Depression Score Among Adults With Irritable Bowel Syndrome
Irritable bowel syndrome (IBS) is frequently associated with any form of psychiatric comorbidities including subthreshold or subclinical depression.
- Trial name
- NCT05266443
- Testing
- Lactobacillus containing cultured milk drink
- Where
- Malaysia
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- National University of Malaysia
Bipolar Disorder, Bipolar Depression
Maintenance Ketamine Infusions for Treatment-Resistant Bipolar Depression
Growing evidence has supported rapid and robust antidepressant effects with subanesthetic doses of intravenous (IV) ketamine for treatment resistant depression (TRD).
- Conditions
- Bipolar Disorder, Bipolar Depression, Bipolar I Disorder, Bipolar II Disorder
- Trial name
- KET-BD-Sustain (NCT05339074)
- Testing
- Ketamine Hydrochloride
- Where
- 3 sites in Canada
- Volunteers
- 41 people
- Sponsor
- Joshua Rosenblat
Perinatal Depression
Telehealth Group Intervention for Perinatal Depressive Symptoms
The goal of the project is to evaluate for the first time, the effectiveness of using a telehealth approach to reducing perinatal depressive symptoms in diverse groups of childbearing women; urban and rural-dwelling, and from…
- Trial name
- TePOP (NCT03932760)
- Testing
- UPLIFT Program, Attention Control Group
- Where
- United States
- Volunteers
- 99 people, healthy volunteers welcome
- Sponsor
- University of Utah
Sleep Initiation and Maintenance Disorders, Depression
Night in Japan Home Sleep Monitoring Study
The investigators hypothesized that depression is associated with home sleep EEG, subjective sleepiness and insomnia symptoms. To test this, the investigators plan to perform sleep examination with single channel EEG, in…
- Trial name
- NinJaSleep (NCT03276585)
- Where
- Japan
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- Shiga University
Major Depressive Disorder
Open-label Long Term (52 Weeks) Safety and Tolerability of Agomelatine Sublingual Tablets in Major Depressive Disorder (MDD)
The study will assess safety and tolerability of 0.5 mg/day and 1 mg/day of sublingual (under the tongue) formulation of agomelatine (AGO178) in patients with Major Depressive Disorder over a 52-week open-label phase.
- Trial name
- NCT01156415
- Testing
- AGO178
- Where
- 98 sites in United States, Puerto Rico
- Volunteers
- 837 people
- Sponsor
- Novartis Pharmaceuticals
Anxiety Depression
Influence of Oral Probiotics on Anxiety and Depression in Adolescents After Non-cardiac and Non-gastrointestinal Surgeries: A Prospective, Double-blind, Placebo-controlled Study
This study intends to conduct a prospective, double-blind, randomized, controlled trial. Adolescents aged 12-17 years old and American Society of Anesthesiologists (ASA) physical status I and II are selected as subjects.
- Trial name
- NCT07640490
- Testing
- C Group, P Group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henan Provincial People's Hospital
Depressive Disorder, Major
Dialogue to Empower Traditional and Faith Healers to Deliver mhGAP-IG Adapted Psychosocial Interventions in Kenya
The project aimed to create a dialogue between the informal sector (traditional and faith healers) and the formal sector (trained health care workers) in order to increase synergy and communication between the two systems, by…
- Trial name
- Dialogue (NCT03165513)
- Testing
- mhGAP-IG
- Volunteers
- 4,081 people, healthy volunteers welcome
- Sponsor
- Africa Institute of Mental and Brain Health (AFRIMEB)
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