Clinical trials: Depressive State
Major Depressive Disorder
Positioning of Esketamine Treatment in the Real-world Management of Depression
The goal of this naturalistic, open label, single arm intervention study is to investigate the effects of Esketamine in treating depression.The main aims to answer are: to investigate whether Esketamine is effective when added to…
- Trial name
- PoET (NCT06103760)
- Testing
- Esketamine Nasal Spray [Spravato]
- Where
- Australia
- Volunteers
- 162 people
- Sponsor
- Royal North Shore Hospital
Anxiety Depression, Breast Cancer Female
Online Mindfulness for Women Treated for Breast Cancer and Men Treated for Prostate Cancer
AIM: The aim of the present study is to investigate if Internet-delivered Mindfulness-Based Cognitive Therapy (I-MBCT) can reduce symptoms of depression and anxiety among women treated for breast cancer and men treated for…
- Conditions
- Anxiety Depression, Breast Cancer Female, Prostate Cancer
- Trial name
- NCT03100981
- Testing
- Internet-delivered Mindfulness-Based Cognitive Therapy, Waitlist control
- Where
- Denmark
- Volunteers
- 150 people
- Sponsor
- University of Aarhus
Postpartum Depression, Preterm Infant
The Impact of a Newborn Behavioral Intervention on the Mental Health of Mothers With Late Pre-Term Infants
Preterm birth is a serious public health issue, affecting 10% of all births in the US alone. Three quarters of these infants are born between 34 0/7 and 36 6⁄7 weeks' gestation or late-preterm (LP).
- Conditions
- Postpartum Depression, Preterm Infant, Infant Development
- Trial name
- BabyAMOR (NCT03836430)
- Testing
- Newborn Behavioral Observation-Family Wellness (NBO-FW)
- Where
- United States
- Volunteers
- 208 people
- Sponsor
- Brigham and Women's Hospital
Unrecognized Condition
The Impact of Tai Chi Combined With Music Therapy Intervention on Depression and Anxiety Among College Students
This study aims to investigate the effects of Tai Chi combined with music therapy on alleviating depression and anxiety among college students.
- Trial name
- NCT06464328
- Testing
- Tai Chi Combined with Music Therapy Intervention, Music intervention only, Tai Chi intervention only
- Where
- Malaysia
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Wu Jiarun
Insomnia, Depression
Reducing Suicidal Ideation Through Insomnia Treatment
Epidemiologic reports have linked insomnia to suicidal ideation and suicide death. However, no studies have determined whether treating insomnia decreases the risk of suicidality.
- Conditions
- Insomnia, Depression, Suicidal Ideation
- Trial name
- REST-IT (NCT01689909)
- Testing
- Zolpidem-CR
- Where
- 4 sites in United States
- Volunteers
- 103 people
- Sponsor
- Augusta University
Depression, Postpartum, Anxiety
eMBC for Perinatal Depression and Anxiety
Depression and anxiety that occur around the time of pregnancy can adversely impact a person's health and well-being, and their child's health and development.
- Trial name
- eMBC (NCT04836585)
- Testing
- eMBC Intervention
- Where
- Canada
- Volunteers
- 42 people
- Sponsor
- Women's College Hospital
Major Depressive Disorder
A Longitudinal Observational Cohort Study of NSI-189, With Out-Patients With Major Depressive Disorder
All subjects completing the randomized treatment period in Protocol NS2014-1 will discontinue study drug and be asked to provide consent to be followed in this 6-month study, at their final safety visit.
- Trial name
- NCT02724735
- Testing
- NSI-189
- Where
- 12 sites in United States
- Volunteers
- 220 people
- Sponsor
- Neuralstem Inc.
Substance Use Disorders, Depression
Study of a Transdiagnostic, Emotion-focused Group Intervention for Young Adults With Substance Use Disorders
The overall aim of this pilot study is to conduct a preliminary trial to evaluate the acceptability and feasibility of adding a transdiagnostic, emotion-focused group intervention (the Unified Protocol, UP) to treatment as usual…
- Conditions
- Substance Use Disorders, Depression, Anxiety, Emotional Disorder
- Trial name
- ARMS UP (NCT03315208)
- Testing
- Unified Protocol (UP), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Massachusetts General Hospital
Depressive Symptoms, Aging
Twelve Weeks of Resistance Training is Equally As Effective At Improving Cardiovascular Risk Factors in Older Women with and Without Depression: a Non-randomized Cross-over Trial
Background: the purporse was to evaluate and compare the effects of 12 weeks of resistance training (RT) on cardiovascular disease (CVD) risk factors in older women with and without depressive disorders Methods: We included 79…
- Conditions
- Depressive Symptoms, Aging, Resistance Training, Cardiovascular Risk Factor
- Trial name
- NCT06591325
- Testing
- exercise, Control
- Where
- Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Universidade Estadual de Londrina
Suicide Ideation, Depression
Family Therapy as Hospital Aftercare for Adolescent Suicide Attempters
Few empirically-based treatment models exist for adolescent suicide attempters post psychiatric hospitalization, despite the fact that managed care has limited the role of hospitalization to stabilization, rather than remission.
- Conditions
- Suicide Ideation, Depression, Family Conflict
- Trial name
- NCT01195740
- Testing
- Attachment Based Family Therapy, Enhanced Usual Care
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- Children's Hospital of Philadelphia
Treatment Resistant Depression
KET-RO Plus RO DBT for Treatment Resistant Depression
This pilot study will assess the safety and feasibility of intravenous (IV) ketamine combined with RO DBT in young adults with Treatment-Resistant Depression (TRD).
- Trial name
- KET-RO (NCT06138691)
- Testing
- Ketamine Infusion plus RO DBT
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Washington University School of Medicine
Vaginal Discharge, Sexually Transmitted Diseases
Point-of-care Tests for Vaginal Discharge in Nepal
The goal of this clinical trial is to examine if and how the implementation of point-of care-tests (POCT) for sexually transmitted infections in the management of abnormal vaginal discharge reduces the overtreatment with…
- Trial name
- POCT-BRA (NCT05977491)
- Testing
- Health care practitioner is informed of POCT results for CT and NG, Health care practitioner is informed about POCT result for TV and BV, addressing psycholsocial problems
- Where
- Nepal
- Volunteers
- 1,500 people, healthy volunteers welcome
- Sponsor
- Norwegian University of Science and Technology
Depressive Symptoms
TreadWill, an Automated Intervention for Depressive Symptoms
TreadWill is a fully automated digital intervention that provides a multi-modal treatment for depressive symptoms. It includes: 1. Slides and interactive text-based conversations based on Cognitive Behavioral Therapy (CBT); 2.
- Trial name
- NCT04703491
- Testing
- Interactive and full-featured intervention, Feature-limited CCBT, Waitlist control
- Where
- India
- Volunteers
- 500 people
- Sponsor
- Indian Institute of Technology Kanpur
Elderly
Strength Training in Nonagenarians
The Health Enhancing Strength Training in Nonagenarians (STRONG) is a randomised control trial to assess the effectiveness of an aerobic and strength training program for improving functional capacity and quality of life in…
- Trial name
- STRONG (NCT00848978)
- Testing
- 8-week aerobic and strength training program
- Where
- Spain
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Hospital General Universitario Gregorio Marañon
Late Life Depression
TBS,TMS, Suicidal Ideation, Magnetic Resonance Imaging, Dorsolateral Prefrontal Cortex, Ventrolateral Prefrontal Cortex
Transcranial magnetic stimulation (TMS) is a noninvasive brain stimulation technique, its approved therapeutic indication is high-frequency stimulation to the left dorsolateral prefrontal cortex (DLPFC) for treatment resistant.
- Trial name
- NCT05010915
- Testing
- Transcranial magnetic stimulation
- Where
- Taiwan
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Chang Gung Memorial Hospital
Depression
Physiologic Monitoring of Antidepressant Treatment Response
Study Objectives: to identify neurophysiologic effects of venlafaxine treatment in normal controls using quantitative EEG (QEEG) cordance to examine the effects of venlafaxine on different rating scales measuring mood and anxiety…
- Trial name
- Ven Nls I (NCT00759317)
- Testing
- venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 37 people, healthy volunteers welcome
- Sponsor
- University of California, Los Angeles
Long Covid, Depression
Development of an Accessible Cognitive Behavioral Therapy Digital Therapeutic for Individuals With Long COVID
This study will evaluate Toivoa-004 as an experimental digital therapeutic for persons with Long COVID suffering from anxiety or depression.
- Conditions
- Long Covid, Depression, Anxiety
- Trial name
- NCT07714889
- Testing
- Rauha® Digital Therapeutic Platform (Toivoa-004)
- Sponsor
- Toivoa Inc
Maternal Depression
Developing and Testing Motherly App: a Smartphone Application to Promote Mothers' Mental Health
The investigators plan to develop and test Motherly, a smartphone app to promote maternal mental health and child development. The Motherly app is visually appealing aimed at engaging the user with a minimalistic layout.
- Trial name
- NCT03955718
- Testing
- Motherly App, Educational App (Active Control)
- Where
- Brazil
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Sao Paulo
Dementia
Mindfulness Research Program: Designed to Enhance Wellbeing in People Living With Dementia and Their Spouses
People with dementia forget things and have trouble concentrating. In addition, they and their caregivers can become depressed. This project will show whether Mindfulness-Based Cognitive Therapy (MBCT) can lessen depression…
- Trial name
- MBCT_AD (NCT01774448)
- Testing
- Mindfulness-Based Cognitive Therapy
- Volunteers
- 36 people
- Sponsor
- Lakehead University
Newborn Infant, Bonding
The Effect of Lullaby During Bath Time on Mother-Infant Bonding, Postpartum Depression, and Parental Self-Efficacy in Infants
This randomized, single-blind controlled trial aims to evaluate the effects of maternal lullaby singing during infant bathing on mother-infant bonding, postpartum depressive symptoms, and perceived parenting self-efficacy in…
- Conditions
- Newborn Infant, Bonding, Self Efficacy, Postpartum Depression (PPD)
- Trial name
- NCT07370025
- Testing
- Maternal Lullaby Singing
- Where
- Turkey (Türkiye)
- Volunteers
- 98 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
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