Clinical trials: Depressive State
Depression
Inflammation-Induced CNS Glutamate Changes in Depression
Increased inflammation has been implicated in the pathophysiology of a number of neuropsychiatric illnesses including mood disorders, which affect almost 30 million adults in the United States alone.
- Trial name
- NCT03004443
- Testing
- Infliximab
- Where
- United States
- Volunteers
- 22 people
- Sponsor
- Emory University
Physical Violence, Educational Achievement
Good Schools Study
The purpose of this study is to determine whether use of the Good Schools Toolkit is effective in reducing violence against children in primary schools.
- Conditions
- Physical Violence, Educational Achievement, Mental Health, Sexual Violence
- Trial name
- GSS (NCT01678846)
- Testing
- Good School Toolkit
- Where
- Uganda
- Volunteers
- 3,820 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Alcohol Dependence, Bipolar Disorder
Acamprosate vs. Placebo in Bipolar Alcoholics
To conduct a double-blind, randomized, placebo-controlled outpatient clinical trial of acamprosate in individuals with alcohol dependence and bipolar disorder who are also receiving mood stabilizing medication.
- Trial name
- NCT00466661
- Testing
- Acamprosate
- Where
- United States
- Volunteers
- 33 people
- Sponsor
- Medical University of South Carolina
Depression
Treatments for Improving Mood in Depressed Teens-3
Phase 3 is a randomized clinical trial of yoga vs group Cognitive Behavioral Therapy (CBT) for adolescents with depression.
- Trial name
- TeenThrive (NCT03831360)
- Testing
- Yoga, Group CBT
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Brown University
Depressive Disorder, Anhedonia
Study to Treat Major Depressive Disorder With a New Medication
This project is designed to examine the neuronal KCNQ2/3 potassium (K+) channel subtype as a novel treatment target for mood disorders through the administration of the KCNQ-selective channel opener ezogabine (Potiga…
- Trial name
- NCT03043560
- Testing
- Ezogabine
- Where
- 2 sites in United States
- Volunteers
- 45 people
- Sponsor
- James Murrough
Major Depressive Disorder
A Study of ALKS 5461 for the Treatment of Major Depressive Disorder (MDD) - FORWARD-5 Study
This study will evaluate the efficacy and safety of ALKS 5461.
- Trial name
- NCT02218008
- Testing
- ALKS 5461
- Where
- 44 sites in United States, Canada and 2 more
- Volunteers
- 407 people
- Sponsor
- Alkermes, Inc.
Bipolar Disorder, Depression
A Trial of SAMe for Treatment-Resistant Bipolar Depression
S-adenosyl-L-methionine (SAMe) is a dietary supplement with antidepressant properties. SAMe's mechanism of action remains unclear, but it appears to be distinct from that of conventional antidepressants.
- Conditions
- Bipolar Disorder, Depression, Bipolar Depression
- Trial name
- NCT00762268
- Testing
- SAMe
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Mclean Hospital
Leg Cramp, Nocturnal
Effect of Theraworx/[pH]Uel on Night-time Leg Cramps and Spasm Symptoms
The purpose of this study is to determine the effect of Theraworx/[pH]uel on the frequency and severity of night-time cramps and spasms symptoms, including quality of life, depression and sleep quality when compared to a placebo.
- Trial name
- NCT03159260
- Testing
- Theraworx
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- Sport and Spine Rehab Clinical Research Foundation
Parkinson Disease
Kick Out Parkinson's Disease 2
The benefits of exercise for general health and well-being in older adults are well-established. Balance exercises such as tai chi and yoga, along with resistance training, can improve or maintain physical function in older…
- Trial name
- NCT03882879
- Testing
- Karate Classes, Pre-Intervention Study Visit, Bimonthly Online Survey
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Rush University Medical Center
Major Depression
Investigation of Genetic Predictors of the Response to Selective Serotonin Re-uptake Inhibitors (SSRI) Treatment
The antidepressant medications are among the most commonly prescribed pharmacological agents in patients with mood and anxiety disorder.
- Trial name
- NCT03927950
- Testing
- escitalopram, bupropion
- Where
- Estonia
- Volunteers
- 135 people
- Sponsor
- University of Tartu
Depression
Depression Prevention in Older Spousally-bereaved Adults
Using an indicated prevention approach, investigators propose to enroll 150 spousally-bereaved adults aged 60 years and older in the first 12 months after spousal death who are at high risk for major depression disorder because…
- Trial name
- WELL (NCT04016896)
- Testing
- WIdowed Elders' LIfestyle after Loss (WELL), Enhanced Usual Care
- Where
- United States
- Volunteers
- 151 people
- Sponsor
- University of Pittsburgh
Diabetes, Depression
Treatment of Diabetes and Depression in Hispanics and African Americans and Its Effect on A1c and Quality of Life.
This proposed study will test the following hypothesis: Treating depression in Hispanics and African Americans with diabetes will improve their HbA1c and quality of life while on intervention and six months after intervention.
- Trial name
- NCT00624013
- Testing
- sertraline
- Where
- United States
- Volunteers
- 89 people
- Sponsor
- Charles Drew University of Medicine and Science
Depression
Text Messaging and Cognitive Behavioral Therapy for Depression
This study aims to asses whether adding automated text messaging to group cognitive behavioral therapy for depression increases engagement which may lead to improved outcomes.
- Trial name
- HealthySMS (NCT01083628)
- Testing
- Group CBT for Depression with MoodText, Group CBT for Depression
- Where
- United States
- Volunteers
- 85 people
- Sponsor
- University of California, San Francisco
Depression Anxiety and Co-occurring Rural Youth
Implementing and Evaluating an Internet-based Cognitive Behavior Therapy Intervention in School Settings
This research study examines rural youth's experience of an internet based cognitive behavioral therapy intervention, and their experience of symptoms of depression, anxiety and co-occurring disorders.
- Trial name
- NCT04928001
- Testing
- internet based iCBT program, Youth Thrive
- Where
- United States
- Volunteers
- 67 people, healthy volunteers welcome
- Sponsor
- Montana State University
Social Isolation, Depression
Tertulias Social Isolation Women's Groups Study
This study will use a multi-level, community-engaged approach to implement "TERTULIAS" ("conversational gatherings" in Spanish).
- Trial name
- NCT04254198
- Testing
- TERTULIAS structured dialogue peer support groups
- Where
- 2 sites in United States
- Volunteers
- 241 people, healthy volunteers welcome
- Sponsor
- University of New Mexico
Major Depressive Disorder
A Novel Cognitive Remediation Intervention Targeting Poor Decision-making and Depression in Veterans at High Risk for Suicide: A Safe, Telehealth Approach During the COVID-19 Pandemic
Despite large-scale, nationwide efforts to better address suicidal behavior in Veterans at high risk, the development of interventions that target some of the key risk factors associated with suicide remains limited.
- Trial name
- CogRemVet (NCT04952532)
- Testing
- Neuropsychological Educational Approach to Cognitive Remediation (NEAR, termed Cognitive Remediation plus Bridging)
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- VA Office of Research and Development
Depression, Suicidal Ideation
BRITEPath- Phase 2
BRITEPath (BP) aims to support co-located mental health clinicians in the development of a high quality, effective, and personalized safety plan for referred patients who screen positive for depression and/or suicidal ideation.
- Trial name
- NCT04672798
- Testing
- BRITEPath, Treatment As Usual (TAU)
- Where
- 6 sites in United States
- Volunteers
- 101 people
- Sponsor
- University of Pittsburgh
Depression
Emotional and Cognitive Control in Late-Onset Depression
This study may help identify how abnormalities in brain systems that control the ability to ignore irrelevant information may contribute to the development of depression in older adults.
- Trial name
- NCT01728194
- Testing
- Escitalopram, Magnetic Resonance Imaging
- Where
- 2 sites in United States
- Volunteers
- 121 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Hematopoietic/Lymphoid Cancer
Improved Outcome in Allogeneic Hematopoietic Stem Cell Transplant (HSCT) Patients by Reducing Caregiver Distress
PURPOSE: As this is a randomized controlled trial, all subjects receiving stress management psychoeducation will be expected to obtain a new set of coping skills that will allow them to better deal with the stressors of…
- Trial name
- NCT02037568
- Testing
- fPER
- Where
- 2 sites in United States
- Volunteers
- 159 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Bipolar Depression
18F-DOPA PET to Elucidate the Antidepressant Mechanism of Lurasidone in Bipolar Disorder
The goal of this project is to understand what causes bipolar disorder and how medications treat bipolar depression. Particularly, the project focuses on the importance of dopamine signaling in the process.
- Trial name
- NCT03902613
- Testing
- Lurasidone
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- New York State Psychiatric Institute
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