Clinical trials: Depressive State
Anxiety, Depression
Adjusting to Chronic Conditions Using Education Support and Skills
Medically ill patients with Congestive Heart Failure (CHF) and Chronic Obstructive Pulmonary Disease (COPD) are at increased risk for developing symptoms of anxiety and depression and are among the least frequent users of mental…
- Trial name
- ACCESS (NCT00727155)
- Testing
- Adjusting to Chronic Conditions Using Education Support and Skills
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- US Department of Veterans Affairs
Depression
Efficacy and Safety of Low Amplitude Electroconvulsive Therapy
The purpose of this study is to demonstrate the clinical feasibility of low amplitude electroconvulsive therapy (ECT) to reduce, and possibly eliminate the side effects of ECT by lowering the strength of the ECT stimulus from the…
- Trial name
- NCT02351843
- Testing
- MECTA Spectrum 5000Q
- Where
- United States
- Volunteers
- 1 people
- Sponsor
- Duke University
Depression, Major Depressive Disorder
Stress Generation and Recurrent Depression: The Role of Differential Treatment Response
Depression affects over one million people in Canada, resulting in $14.4 billion per year in costs to Canadian society. In order to prevent this often lifelong disorder, it is critically important to identify risk factors for the…
- Trial name
- NCT00745017
- Testing
- Cognitive Behavioral Therapy, Interpersonal Therapy, Antidepressant medication
- Where
- Canada
- Volunteers
- 72 people
- Sponsor
- Centre for Addiction and Mental Health
Major Depressive Disorder
Efficacy, Safety and Tolerability of Agomelatine Sublingual Tablets in the Treatment of Major Depressive Disorder
The study will assess efficacy, safety and tolerability of 0.5 mg/day and 1 mg/day of sublingual (under the tongue) formulation of agomelatine in patients with Major Depressive Disorder.
- Trial name
- NCT01110889
- Testing
- Agomelatine (AGO178C)
- Where
- 48 sites in United States, Puerto Rico
- Volunteers
- 582 people
- Sponsor
- Novartis Pharmaceuticals
Covid19, Depression
Depression and Anxiety in Long Term Coronavirus Disease COVID-19
Background : Depression and Anxiety are linked to COVID (Coronavirus Disease)-19 long-term impact through several mechanisms. The possible way is the alteration of neurotransmitter regulation from the interaction of severe acute…
- Conditions
- Covid19, Depression, Anxiety
- Trial name
- DALT-COV (NCT04893668)
- Testing
- Depression, Anxiety
- Where
- Indonesia
- Volunteers
- 165 people, healthy volunteers welcome
- Sponsor
- Hasanuddin University
Depression
Effect of Minocycline on Inflammation in Depressed Patients
The study aims to evaluate or to assess: An improvement in the peripheral inflammatory levels in depressed patients after 8 weeks of treatment with Minocycline in addition to their current antidepressant treatment; Any…
- Trial name
- NCT06207760
- Testing
- Minocycline
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- IRCCS Centro San Giovanni di Dio Fatebenefratelli
Major Depressive Disorder
Patient Management of Depression Through Technology: a Study of Digitally Enabled Engagement
The current randomized controlled trial is a pilot study that will assess the effectiveness and feasibility of a mobile phone application intervention.
- Trial name
- NCT03242213
- Testing
- Mobile App
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Wake Forest University Health Sciences
COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis)
Psilocybin Therapy for Psychological Distress in Palliative Patients
The goal of this clinical trial is to evaluate whether psilocybin therapy can effectively treat depression and psychological distress in adult patients with COPD, ALS, MS, or APD who have at least 6 months life expectancy.
- Conditions
- COPD (Chronic Obstructive Pulmonary Disease), ALS (Amyotrophic Lateral Sclerosis), MS (Multiple Sclerosis), Major Depressive Disorder (MDD)
- Trial name
- PsyPal (NCT06782724)
- Testing
- Psilocybin therapy
- Where
- 4 sites in Czechia, Denmark and 2 more
- Volunteers
- 108 people
- Sponsor
- University Medical Center Groningen
Depression
Effect of a Single Nights' Wake Followed by Bright Light Therapy for Severe Depression
A randomized controlled trial comparing wake therapy (single night) followed by bright light therapy to treatment as usual.
- Trial name
- NCT02503124
- Testing
- Single night's wake therapy, Bright light, Treatment as usual - inpatient care
- Where
- Sweden
- Volunteers
- 32 people
- Sponsor
- Sahlgrenska University Hospital
Breastfeeding, Postpartum Depression (PPD)
Telehealth-Supported Breastfeeding Counseling in Primiparous Mothers
Breastfeeding is critical for infant and maternal health; however, many first-time mothers experience difficulties that may lead to early discontinuation of breastfeeding.
- Conditions
- Breastfeeding, Postpartum Depression (PPD), Breastfeeding Self-Efficacy
- Trial name
- TELE-BF (NCT07396415)
- Testing
- Telehealth-Supported Breastfeeding Counseling, Routine Postpartum Care
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Marmara University
Depression
Lithium and Standard Therapy in Resistant Depression
The principal clinical question is whether lithium is effective in reducing the risk of suicidal behaviour in subjects with treatment-resistant depression and suicide risk.
- Trial name
- LAST (NCT00927550)
- Testing
- lithium, usual care
- Where
- Italy
- Volunteers
- 230 people
- Sponsor
- Universita di Verona
Severe Major Depression Disorder
Neurochemical, Metabonomics and Neuroimaging Characterization of TCM Diagnostic Subtypes of Major Depression Disorder
There is heterogeneity in patients with depression. Many scholars propose that individualization of antidepressant achieves better outcomes.
- Trial name
- NMNTDM (NCT02346682)
- Testing
- venlafaxine
- Where
- China
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Zhejiang Provincial Tongde Hospital
Breast Cancer
Psychosocial Adjustment of Patients and Their Partners Following Breast Cancer Diagnosis
The purpose of this study is to describe psychosocial adjustment in patients with breast cancer and their cohabiting partners/spouses throughout the cancer trajectory, to study mutual influences of the partner on the patient and…
- Trial name
- NCT01392066
- Testing
- questionnaire
- Where
- Denmark
- Volunteers
- 1,584 people
- Sponsor
- University of Southern Denmark
Pregnancy and Medically Assisted Reproduction
Antenatal Stress and Infants In MAR
The goal of this observational longitudinal study is to examine the association between prenatal psychological and biological stress and neonatal health outcomes in couples who conceived through medically assisted reproduction.
- Trial name
- SARA (NCT07408453)
- Testing
- Diagnostic procedures
- Where
- Italy
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- IRCCS Eugenio Medea
Cardiovascular Diseases, Coronary Artery Disease
Virtual Reality Therapy in Cardiology
This study evaluates the effectiveness of virtual reality (VR) therapy in the treatment of depression and anxiety symptoms in patients undergoing second stage of cardiac rehabilitation.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Depressive Symptoms, Mood Disorders
- Trial name
- NCT04313777
- Testing
- Cardiac rehabilitation, Virtual therapeutic support, Schultz Autogenic Training
- Where
- 2 sites in Poland
- Volunteers
- 77 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Major Depressive Disorder
NBI-1065845-MDD3025: Study to Assess the Efficacy and Safety of NBI-1065845 as an Adjunctive Treatment in Participants With Major Depressive Disorder (MDD)
The study will evaluate the efficacy of NBI-1065845 compared with placebo as an adjunctive treatment in participants with MDD on improving symptoms of depression.
- Trial name
- NCT06911112
- Testing
- NBI-1065845
- Where
- 39 sites in United States, Bulgaria and 3 more
- Volunteers
- 200 people
- Sponsor
- Neurocrine Biosciences
Inflammatory Bowel Diseases, Mental Health Issue
IBDminds - Mapping the Influence of aNxiety and DepreSsion on IBD
People with Inflammatory bowel disease (IBD) can get challenging symptoms. Things like diarrhoea, tummy pain and being tired all the time are common. People often get IBD in their teens or twenties.
- Trial name
- IBDminds (NCT07175454)
- Testing
- Questionnaire
- Where
- United Kingdom
- Volunteers
- 450 people
- Sponsor
- The Royal Wolverhampton Hospitals NHS Trust
Postpartum Depression
Mobile Phone Based Peer Support to Prevent Postpartum Depression Among Adolescent Mothers
This pilot study will evaluate the feasibility and acceptability of a mobile phone based peer support intervention among adolescent mothers.
- Trial name
- NCT02818075
- Testing
- Mobile Phone Based Peer Support, Usual Care
- Where
- Canada
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Toronto
Depression
Benefits of Switching Antidepressants Following Early Nonresponse
Introduction and Purpose: Most of the guidelines for the treatment of major depression recommend the use of antidepressants for 4 to 8 weeks.
- Trial name
- NCT00519012
- Testing
- Sertraline to Paroxetine, Paroxetine to Sertraline
- Where
- Japan
- Volunteers
- 200 people
- Sponsor
- Oizumi Hospital
Anxiety Disorders, Depressive Disorder, Major
Auricular Acupuncture vs. Progressive Muscle Relaxation in Patients With Anxiety Disorders or Major Depressive Disorder.
The purpose of this study is to determine whether auricular acupuncture (AA) according to the NADA protocol and progressive muscle relaxation (PMR) differ in their effectiveness of treating people with anxiety disorders or major…
- Trial name
- NCT02340351
- Testing
- Auricular acupuncture, Progressive muscle relaxation
- Volunteers
- 136 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
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