Clinical trials: Depressive State
Anxiety, Depression
Neuromodulation Enhanced Cognitive Restructuring: A Proof of Concept Study
Psychological treatments are effective, but take a long time and can be burdensome. Therefore, avenues to optimize behavioral treatments are needed.
- Conditions
- Anxiety, Depression, Personality Disorders, Trauma and Stress-related Disorders
- Trial name
- NCT02573246
- Testing
- Cognitive Restructuring, rTMS
- Where
- United States
- Volunteers
- 148 people
- Sponsor
- Duke University
Major Depressive Disorder
Assessing Symptomatic Clinical Episodes in Depression
Randomized, Double-Blind, Active-Controlled Study of AXS-05 for MDD.
- Trial name
- ASCEND (NCT03595579)
- Testing
- AXS-05, Bupropion
- Where
- 4 sites in United States
- Volunteers
- 97 people
- Sponsor
- Axsome Therapeutics, Inc.
Cigarette Smoking, Smoking Cessation
Goal2Quit + NRT Sampling
The goal of this work is to develop, systematically evaluate, and clinically test an integrated cessation intervention comprised of a depression-specific Behavioral Activation (BA) for cessation mobile app ("Goal2Quit") packaged…
- Conditions
- Cigarette Smoking, Smoking Cessation, Depression
- Trial name
- NCT03837379
- Testing
- Treatment as Usual, Goal2Quit + NRT Sampling
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Medical University of South Carolina
Depression
Pharmaceutical Care Program for Pharmacological Treatment of Depression in Primary Care
The purpose of this study is to evaluate the impact of pharmaceutical services among patients starting a treatment with antidepressants for a diagnosis of depression.
- Trial name
- PRODEFAR (NCT00794196)
- Testing
- Pharmaceutical care program for antidepressant treatment
- Where
- 2 sites in Spain
- Volunteers
- 179 people
- Sponsor
- Fundació Sant Joan de Déu
Depression, Back Pain
ADAPT: Addressing Depression and Pain Together
The primary question addressed by this study is: Using a stepped care approach in primary care, what is the value of the combination of an antidepressant medication (Venlafaxine) and psychotherapy for seniors living with…
- Trial name
- ADAPT (NCT01124188)
- Testing
- Higher-dose venlafaxine, Supportive management, Problem Solving Therapy for Depression and Pain
- Where
- United States
- Volunteers
- 263 people
- Sponsor
- University of Pittsburgh
Major Depressive Disorder
Efficacy and Safety Study of a Combination Product [Drug:BCI-024 (Buspirone) and Drug:BCI-049 (Melatonin)] to Treat Major Depressive Disorder (MDD)
The primary objective of this study are to evaluate the synergistic effect of a combination product, consisting of drug BCI-024 (buspirone) and drug BCI-049 (melatonin), in reducing symptoms of depression in patients with Major…
- Trial name
- NCT00705003
- Testing
- BCI-024: over-encapsulated Buspirone tablet 15 mg QD and BCI-049: over-encapsulated Melatonin tablet 3 mg QD, BCI-024 (Buspirone)
- Where
- 9 sites in United States
- Volunteers
- 142 people
- Sponsor
- Massachusetts General Hospital
Bipolar Depression
Pediatric Bipolar Depression
The purpose of this study is to determine if quetiapine fumarate extended-release (quetiapine XR or SEROQUEL® XR) 150 to 300 mg/day taken by itself is effective and safe in treating children or adolescents aged 10 to 17 with…
- Trial name
- NCT00811473
- Testing
- Quetiapine XR
- Where
- 48 sites in United States, Colombia and 5 more
- Volunteers
- 193 people
- Sponsor
- AstraZeneca
Depression, Physical Activity
tDCS for Increasing Exercise Adherence in Depressed Individuals
The purpose of this study is to examine the efficacy of tDCS (transcranial direct current stimulation) for increasing exercise adherence among low active individuals with elevated depressive symptoms.
- Trial name
- StRIDE (NCT03178903)
- Testing
- tDCS, Aerobic Exercise (AE)
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Butler Hospital
Affect, Bereavement
Neural Mechanisms of Enhancing Emotion Regulation in Bereaved Spouses
This study investigates the underlying mechanisms of a novel emotion regulation intervention among recently bereaved spouses. More specifically, this study examines how thinking about an emotional stimulus in a more adaptive way…
- Conditions
- Affect, Bereavement, Emotions, Depressive Symptoms
- Trial name
- NCT04822194
- Testing
- Cognitive Emotion Regulation Training
- Where
- United States
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Bryan Denny
Bibliotherapy
Guided Self-help for Common Mental Disorders
Common mental disorders (CMDs) like depression and anxiety account for a large proportion of disability worldwide. Access to effective treatments like cognitive-behavioral therapy (CBT) is limited and has not reduced the public…
- Trial name
- DWM (NCT04870099)
- Testing
- Doing What Matters in Times of Stress: An Illustrated Guide
- Where
- United States
- Volunteers
- 141 people, healthy volunteers welcome
- Sponsor
- Indiana University
Major Depressive Disorder
Automatic Self Transcending Meditation Versus Treatment as Usual
Depression is a leading contributor to global burden of disease. Antidepressants do not provide adequate response for many patients.
- Trial name
- NCT02149810
- Testing
- Automatic Self Transcending Meditation
- Where
- Canada
- Volunteers
- 95 people
- Sponsor
- London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's
Sleep Initiation and Maintenance Disorders, Depression
Improving Sleep and Psychological Functioning in People With Depression and Insomnia
This study will evaluate the safety and effectiveness of treatment with both a sleeping pill and antidepressant medication in improving sleep and psychological functioning in people with depression and insomnia.
- Trial name
- NCT00247624
- Testing
- Eszopiclone, Fluoxetine
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Wake Forest University Health Sciences
Bipolar Depression
A Trial of the Fatty Acid Amide Hydrolase Inhibitor Palmitoylethanolamide in Bipolar Depression
The purpose of this study is to o evaluate the antidepressant efficacy of the PEA in Bipolar Depression and the association between antidepressant response with endogenous cannabinoids and cytokine levels
- Trial name
- NCT06229977
- Testing
- Palmitoylethanolamide (PEA), Treatment as Usual (TAU)
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Rodrigo Machado-Vieira, MD, PhD, MSc
Postnatal Depression, Social Isolation
Online Singing Interventions for Postnatal Depression in Times of Social Isolation: a Single Arm Study
Melodies for Mums (M4M) is an intervention developed and tested as part of a collaboration between the Royal College of Music, Imperial College London and University College London from 2015-2017.
- Trial name
- SHAPER-PNDO (NCT04857593)
- Testing
- Melodies for Mums
- Where
- United Kingdom
- Volunteers
- 37 people
- Sponsor
- King's College London
Major Depressive Disorder
A Double-Blind, Placebo-Controlled Study of Aripiprazole Adjunctive to Antidepressant Therapy
The purpose of this study is to determine whether a reduced dose of aripiprazole is effective in treating patients with major depressive disorder
- Trial name
- NCT00683852
- Testing
- Aripiprazole 5mg, Aripiprazole 2mg
- Where
- United States
- Volunteers
- 225 people
- Sponsor
- Massachusetts General Hospital
Depression, Major Depressive Disorder
Hyperthermic Yoga for Depressive Symptoms
Study is a randomized controlled trial to assess the feasibility, acceptability, efficacy, and mechanisms of action of hyperthermic yoga versus a waitlist control for 80 medically healthy adults with mild to moderate depressive…
- Trial name
- NCT02607514
- Testing
- hyperthermic yoga
- Where
- United States
- Volunteers
- 80 people
- Sponsor
- Massachusetts General Hospital
Depressive Symptoms, Depression
Evaluation of a Mobile Therapy for Elevated Depressive Symptoms
The purpose of this research study is to evaluate a mobile application (app) for depression treatment. Participants will be randomly assigned to either receive the mobile app, "Moodivate", or not.
- Trial name
- NCT04463914
- Testing
- Behavioral Activation Therapy app, Behavioral Activation Therapy app + EHR, Treatment as Usual
- Where
- United States
- Volunteers
- 649 people
- Sponsor
- Medical University of South Carolina
Bipolar Disorder, Depression
Acute Psychotherapy for Bipolar II Depression
This proposed study is designed to compare the efficacy of interpersonal and social rhythm therapy (IPSRT) alone to IPSRT plus medication as an acute treatment for bipolar II depression.
- Trial name
- NCT01133821
- Testing
- IPSRT plus quetiapine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Holly Swartz
Mental Health Issue, Anxiety
Clinical Investigation of Wysa
Mental health concerns are a large burden for individuals, healthcare systems, and the economy. Over a million people are referred to UK mental health services each year, but more than half only receive one session of…
- Conditions
- Mental Health Issue, Anxiety, Depressive Symptoms
- Trial name
- NCT05533190
- Testing
- Wysa AI chatbot mental health app
- Where
- 2 sites in United Kingdom
- Volunteers
- 76 people
- Sponsor
- University of Plymouth
Depressive Episodes, Bipolar I Depression
A Clinical Study of an Investigational Drug for the Treatment of Major Depressive Episode Associated With Bipolar I Disorder.
A clinical trial to study the efficacy and safety of an investigational drug in people with major depressive episodes associated with with Bipolar I disorder (bipolar I depression) Participants in the study will either receive…
- Trial name
- NCT05169710
- Testing
- SEP-4199 CR 200 mg, SEP-4199 CR 400 mg
- Where
- 89 sites in United States, Bulgaria and 4 more
- Volunteers
- 83 people
- Sponsor
- Sumitomo Pharma America, Inc.
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