Clinical trials: Depressive State
Depressive Symptoms, Psychological Distress
Internet-based Intervention for Enhancing the Psychological Well-being of Elderly Caregivers
This study will examine whether an Internet-based Acceptance and Commitment Therapy (ACT) intervention is effective, firstly, on reducing depressive symptoms, and, secondly, on improving well-being of elderly family caregivers.
- Conditions
- Depressive Symptoms, Psychological Distress, Quality of Life
- Trial name
- CareACT (NCT03391596)
- Testing
- Internet-based ACT intervention, Standardized rehabilitation, Support by voluntary caregiver associations
- Where
- Finland
- Volunteers
- 151 people, healthy volunteers welcome
- Sponsor
- The Gerocenter Foundation for Research and Development
Shift Work Type Circadian Rhythm Sleep Disorder
The Effectiveness of Using Low-level Light Therapy to Treat Sleep and Psychological Symptoms Among Shift-work Nurses
The purpose of this study is to explore the treatment of Low Level Light Therapy(LLLT) mitigate possible insomnia and psychological symptoms, when nurses have taken shifts.The investigators hope that the goal of this…
- Trial name
- t-PBM (NCT05146596)
- Testing
- use low level light therapy,The Dr.Tai's energy cap
- Where
- Taiwan
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Chronic Kidney Disease(CKD), Depression
Pharmacogenomics of Mood Disorder in Chronic Kidney Disease Patients
By using genetic information we could predict the prevalence of mood disorder and response to treatment.
- Trial name
- CKD (NCT06675396)
- Testing
- Antidepressants
- Volunteers
- 300 people
- Sponsor
- Wonju Severance Christian Hospital
Folate Deficiency, Vitamin B 12 Deficiency
Effectiveness of Fortification With Folic Acid and Vitamin B12 Among Teenage Girls
Folic acid and vitamin B12 play an interdependent role in key cellular processes, namely deoxyribonucleic acid synthesis, cell division, red blood cell formation, and nervous system myelination.
- Conditions
- Folate Deficiency, Vitamin B 12 Deficiency, Anemia, Megaloblastic, Cognitive Development
- Trial name
- NCT06100146
- Testing
- Folic acid and vitamin B12 fortified flour, Unfortified cereal flour
- Where
- 2 sites in Ethiopia
- Volunteers
- 472 people, healthy volunteers welcome
- Sponsor
- University Ghent
Bipolar Disorder, Depressive Disorder
Acute Effectiveness of Additional Drugs to the Standard Treatment of Depression
This study will compare the effectiveness of relatively new antidepressants which have different mechanisms of action. Buproprion (Wellbutrin) works on dopamine and the dopaminergic pathway.
- Trial name
- NCT00001483
- Testing
- buproprion (Wellbutrin), sertraline (Zoloft), venlafaxine (Effexor)
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institute of Mental Health (NIMH)
Parent Child Abuse, Domestic Violence
Parenting for Lifelong Health - Thailand
Pilot design: The feasibility pilot of PLH for Young Children in Thailand has a single-site, pre-post design with no control group, with the aims of assessing programme implementation, cultural and contextual relevance, and study…
- Conditions
- Parent Child Abuse, Domestic Violence, Child Behavior Problem, Child Neglect
- Trial name
- NCT03539341
- Testing
- PLH-Thailand parenting programme, Control (care as usual)
- Where
- 4 sites in Thailand
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Oxford
Depression, Anxiety
The Mental Health Experiences of Sexual and Gender Minorities Living With Cancer and Their Care Partners
The purpose of this study is to examine relationships between contextual stressors and stress moderators, depression symptom experience, resilience, frailty, and quality of life among older sexual gender minorities cancer…
- Conditions
- Depression, Anxiety, Caregiver Burden, Stress
- Trial name
- SGMC (NCT05866705)
- Where
- United States
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- University of Alabama at Birmingham
Heart Rate Variability
Impact of Community-Based Biofeedback Program on Drug Use and Mental Health Among People Experiencing Homelessness
The purpose of this randomized controlled trial was to compare the effectiveness of an HRV-BF intervention versus a health promotion active control intervention focused on improving mental health symptoms among people…
- Trial name
- HRV-BF (NCT05897580)
- Testing
- Heart Rate Variability - Biofeedback (HRV-BF), Health Promotion (HP)
- Where
- 3 sites in United States
- Volunteers
- 40 people
- Sponsor
- University of California, Irvine
Depression, Dysthymic Disorder
Duloxetine Treatment in Elderly With Dysthymia
Dysthymic disorder (DD) denotes chronic depression with fewer symptoms than major depressive disorder (MDD), and it affects ~ 2-4 % of adults with a similar prevalence in the elderly.
- Trial name
- NCT01852383
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- New York State Psychiatric Institute
Depression, Postpartum, Maternal Behavior
The Effect of Baby Massage on Postpartum Depression and Maternal Attachment
This study was conducted to determine the effect of baby massage on postpartum depression and maternal attachment in the postpartum period.
- Conditions
- Depression, Postpartum, Maternal Behavior, Attachment
- Trial name
- NCT05813782
- Testing
- Baby Massage
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Tokat Gaziosmanpasa University
Refractory Depression, Anxiety Disorders
Focused Ultrasound and Exosomes to Treat Depression, Anxiety, and Dementias
This study is designed to evaluate the safety and efficacy of exosome deployment with concurrent transcranial ultrasound in patients with refractory, treatment resistant depression, anxiety, and neurodegenerative dementia.
- Conditions
- Refractory Depression, Anxiety Disorders, Neurodegenerative Diseases
- Trial name
- NCT04202770
- Testing
- Exosomes
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- Neurological Associates of West Los Angeles
Health Care Utilization
Modifying Treatment Expectations in Depression: the Role of Social Learning
Research has shown that treatment expectations play a major role in the course of mental disorders and that positive expectations have a beneficial impact on treatment outcomes.
- Trial name
- NCT05245370
- Testing
- Control video, Rationale video, Clinician testimonial
- Where
- Germany
- Volunteers
- 171 people, healthy volunteers welcome
- Sponsor
- Philipps University Marburg
Anxiety, Depression
Stress Levels and Mental Well-Being Among Students During e-Learning
Introducing restrictions on human contact has been effective in preventing the uncontrolled spread of COVID-19, however, it appears to have negatively impacted mental health.
- Trial name
- NCT04926441
- Testing
- Stress Levels and Mental Well-Being assessment
- Where
- 8 sites in Lithuania, Poland and 1 more
- Volunteers
- 4,870 people, healthy volunteers welcome
- Sponsor
- The Opole University of Technology
Depression
Telehealth Depression Treatments for Older Adults
This study aims to find an effective and sustainable approach to reducing disparities in accessing mental health services for an underserved and growing population group of low-income, racially diverse, homebound older adults.
- Trial name
- NCT02600754
- Testing
- IT-PST, IT-SCM
- Where
- United States
- Volunteers
- 277 people
- Sponsor
- University of Texas at Austin
Major Depressive Disorder
Investigating the Effectiveness of Telepsychiatry for Treating Major Depression in a Chinese American Nursing Home
The current use of telepsychiatry, or psychiatric care using videoconferencing, is very limited. The present study investigates the use of this method with a depressed Chinese American population in a nursing home.
- Trial name
- NCT00505518
- Testing
- Psychotropic medication (at discretion of psychiatrist), Collaborative psychiatric and primary medical care
- Where
- 2 sites in United States
- Volunteers
- 9 people
- Sponsor
- Massachusetts General Hospital
Depression, Suicidal Ideation
A Double-Blind Study of Buprenorphine Treatment of Acute Suicidality
The acutely suicidal patient presents a complex and dangerous clinical dilemma. Many suicidal patients receive antidepressant medications, but the onset of action of these medications is at least three weeks, and despite their…
- Conditions
- Depression, Suicidal Ideation, Suicidal Action
- Trial name
- NCT00863291
- Testing
- buprenorphine
- Where
- Israel
- Volunteers
- 40 people
- Sponsor
- Abarbanel Mental Health Center
Baby Massage, Postpartum Depression
The Effect of Baby Massage Training Given to Pregnant Women on Maternal Attachment and Postpartum Depression
The research to be conducted within the scope of the project will be randomized controlled, and the population of the research will be primiparous pregnant women reached through social media.
- Trial name
- NCT06136520
- Testing
- Baby massage
- Where
- Turkey (Türkiye)
- Volunteers
- 54 people, healthy volunteers welcome
- Sponsor
- Istanbul University - Cerrahpasa
Treatment Resistant Depression
An Open-Label Study to Evaluate the Safety, Tolerability and Pharmacodynamics of BPL-003 in Patients With Treatment Resistant Depression
An open-label, multi-centre, Phase 2a study to evaluate the safety, tolerability, and pharmacodynamics of one and two doses of intranasal BPL-003 combined with psychological support, in patients with treatment resistant…
- Trial name
- NCT05660642
- Testing
- BPL-003
- Where
- 3 sites in United Kingdom
- Volunteers
- 72 people
- Sponsor
- Beckley Psytech Limited
Bipolar Depression
Adjunctive Bright Light Therapy in Patients With Bipolar Depression and Eveningness
This is a randomized placebo-controlled trial to examine the efficacy of six-week bright light therapy as adjunctive treatment for patient with bipolar depression and eveningness.
- Trial name
- NCT05357313
- Testing
- Bright light therapy, Inactive negative ion generator
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Depression
Antiglucocorticoid Augmentation of antiDepressants in Depression
Depression is one of the most common mental health problems, with at least one in six adults suffering from this at some time in their life. It can become long-lasting and frequently recurs.
- Trial name
- ADD (NCT01375920)
- Testing
- Metyrapone
- Where
- 11 sites in United Kingdom
- Volunteers
- 190 people, healthy volunteers welcome
- Sponsor
- Jane Barnes
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