Clinical trials: Depressive State
Depression, Substance Use Disorders
BA Trial for Co-Occurring Depression and Substance Use
A large proportion of people seeking treatment for drug and alcohol issues also have clinically significant depression symptoms.
- Trial name
- NCT03661580
- Testing
- Behavioural Activation, Treatment as Usual
- Where
- United Kingdom
- Volunteers
- 34 people
- Sponsor
- University of Sheffield
Depression/Depressed State
Drug Use Investigation Of Effexor (SECONDARY DATA COLLECTION STUDY; SAFETY AND EFFICACY OF EFFEXOR.UNDER JAPANESE MEDICAL PRACTICE)
SECONDARY DATA COLLECTION STUDY; SAFETY AND EFFICACY OF EFFEXOR.UNDER JAPANESE MEDICAL PRACTICE
- Trial name
- NCT02958527
- Testing
- venlafaxine
- Volunteers
- 1,408 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Major Depressive Disorder
Melatonin Agonist Effects of Tasimelteon Versus Placebo in Patients With Major Depressive Disorder
The purpose of this study is to evaluate the safety and efficacy of an 8-week double-masked treatment of tasimelteon or placebo in male and female subjects with Major Depressive Disorder.
- Trial name
- MAGELLAN (NCT01428661)
- Testing
- tasimelteon
- Where
- 40 sites in United States
- Volunteers
- 507 people
- Sponsor
- Vanda Pharmaceuticals
Treatment, Active Control
Cognitive Training Delivered Remotely to Individuals With Psychosis (ROAM)
Primary study: This study is a single-site, double-blind, randomized, controlled clinical trial to compare an evidence-based structured program of 30-35 hours of on-line cognitive and social cognitive training exercises performed…
- Conditions
- Treatment, Active Control, Schizophrenia, Psychosis
- Trial name
- NCT02782442
- Testing
- Structured Cognitive Training & PRIME, Computer Games Control & PRIME
- Where
- 2 sites in United States
- Volunteers
- 109 people
- Sponsor
- University of Minnesota
Major Depressive Disorder
Real-time Biofeedback With 7-Tesla MRI for Treatment of Depression
Previous research has shown that modulation of a brain region in rodents, the ventral tegmental area (VTA), improves depressive symptoms.
- Trial name
- Biofeedback (NCT04138680)
- Testing
- Active Biofeedback
- Where
- United States
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Icahn School of Medicine at Mount Sinai
Comfort Theory, AI-Assisted Group Music Intervention
Applying Comfort Theory to an AI-Assisted Group Music Intervention: Psychosocial and Physiological Outcomes and Feasibility in Long-Term Care Residents.
The research design adopts a sequential two-phase framework. The study will be conducted in three residential LTC facilities located in Taichung City or Changhua County, with a total planned enrollment of 60 residents.
- Conditions
- Comfort Theory, AI-Assisted Group Music Intervention, Long-Term Care Residents, Loneliness
- Trial name
- NCT07882979
- Testing
- Group music intervention, AI-assisted monitoring system
- Where
- Taiwan
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Yu Chia Chang
Postpartum Depression
Postpartum Wellness
The purpose of this study is to test whether a web-based (eHealth) exercise intervention for new moms at increased risk for postpartum depression increases physical activity and decreases postpartum depression symptoms.
- Trial name
- POW (NCT04414696)
- Testing
- Exercise intervention
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Kaiser Permanente
Depressive Disorder, Major
A Comparison of Sertraline-reboxetine Combination Therapy Versus Sertraline or Reboxetine Monotherapy in the Treatment of Major Depression.
This study was designed to determine if the novel combination of the SSRI, sertraline, and the NRI reboxetine will increase antidepressant efficacy without sacrificing the favorable safety profile of SSRIs.
- Trial name
- NCT00636246
- Testing
- sertraline/[S,S]-reboxetine, sertraline, [S,S]-reboxetine monotherapy
- Where
- 17 sites in Estonia, Russia
- Volunteers
- 510 people
- Sponsor
- Pfizer's Upjohn has merged with Mylan to form Viatris Inc.
Colorectal Cancer Patients and Their Partners
Sexual Dysfunction and the Quality of Sexual Life in Patients With Colorectal Cancer and Their Partners.
In this project the main focus is on assessing sexual functioning and the quality of sexual life after the treatment of colorectal cancer in patients and their partners.
- Trial name
- NCT01234246
- Where
- 4 sites in Netherlands
- Volunteers
- 1,371 people
- Sponsor
- Tilburg University
Depression, Postpartum
A Study to Evaluate the Efficacy and Safety of SAGE-217 in Participants With Severe Postpartum Depression (PPD)
The purpose of this study is to determine if treatment with SAGE-217 reduces depressive symptoms in females with severe postpartum depression (PPD) as compared to placebo.
- Trial name
- NCT04442503
- Testing
- SAGE-217
- Where
- 82 sites in United States, Spain and 1 more
- Volunteers
- 200 people
- Sponsor
- Biogen
Major Depressive Disorder, Depression
Treatment for Adolescents With Depression Study (TADS)
TADS is designed to compare the effectiveness of established treatments for teenagers suffering from major depressive disorder (MDD).
- Trial name
- NCT00006286
- Testing
- Fluoxetine, Psychotherapy
- Where
- 12 sites in United States
- Volunteers
- 432 people
- Sponsor
- National Institute of Mental Health (NIMH)
Diabetes Mellitus, Type 2, Depression
Treatment Adherence Intervention in Patients With Type 2 Diabetes and Comorbid Depression
Patients with diabetes have higher depression rates, impaired QOL and increased mortality rates due to complications and comorbid depression.
- Trial name
- TELE-DD (NCT04097483)
- Testing
- Telephone Intervention Group
- Volunteers
- 428 people
- Sponsor
- Alicia Monreal Bartolomé
Depression
Chatbot-based Mindfulness Programme for Depressive University Students: Pilot Intervention Study
The goal of this study is to evaluate the feasibility, acceptability, safety and preliminary efficacy of a chatbot-based mindfulness-based stress reduction (MBSR) intervention for university students with depressive symptoms.
- Trial name
- NCT06440941
- Testing
- chatbot-based mindfulness-based stress reduction
- Where
- Hong Kong
- Volunteers
- 30 people
- Sponsor
- The Hong Kong Polytechnic University
Metabolic Syndrome, Bipolar Depression
Pioglitazone for the Treatment of Bipolar Disorder and Comorbid Metabolic Syndrome or Insulin Resistance
The study is an open-label 8-week adjunctive trial of pioglitazone for the acute relief of bipolar depression comorbid with metabolic syndrome/insulin resistance.
- Conditions
- Metabolic Syndrome, Bipolar Depression, Insulin Resistance
- Trial name
- NCT00835120
- Testing
- Pioglitazone
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- University Hospitals Cleveland Medical Center
Major Depressive Disorder, Depression
A Positron Emission Topographic (PET) Study on Depression Patient With Electroacupuncture
This is a randomized, assessor-blind, placebo controlled study in major depressive disorder (MDD) patients. Subjects receiving antidepressant drug (FLX) would be assigned to receive either 18 sham / active DCEAS for in 6 weeks.
- Trial name
- NCT01479920
- Testing
- Fluoxetine, DCEAS (Hwato®/ Dongbang®), n-CEA (Strietberger®)
- Where
- 4 sites in China, Hong Kong
- Volunteers
- 36 people
- Sponsor
- The University of Hong Kong
Depression
Pilot Randomized Trial of BA-GSH in VA PC-MHI
Symptoms of depression are highly prevalent among Veterans. However, fewer than 30% of individuals with these symptoms receive any psychotherapy in the Veterans Health Administration (VHA).
- Trial name
- NCT07541482
- Testing
- Behavioral Activation-Guided Self-Help
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- VA Office of Research and Development
Ocular Hypertension, Sleep Disturbance
Ocular Hypertension And Yoga Study
The investigators aim to pilot test the efficacy of a yoga intervention designed specifically for individuals with ocular hypertension.
- Conditions
- Ocular Hypertension, Sleep Disturbance, Stress, Anxiety
- Trial name
- OHAYS (NCT01446588)
- Testing
- Yoga Intervention
- Where
- United States
- Volunteers
- healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Respiratory Depression
Clinical Utility of Capnography in the PACU( Post-anaesthesia Care Unit)
Multi-center observational trial with study device blinded in order to assess in parallel standard monitoring and intervention practices related to management of respiratory compromise in the post-anaesthesia care unit (PACU)
- Trial name
- NCT02707003
- Where
- 2 sites in United States, Canada
- Volunteers
- 250 people
- Sponsor
- Medtronic - MITG
Postpartum Depression, Intimate Partner Violence
Case Management Study for Postpartum Depression and Intimate Partner Violence
The objective of the study was to assess the prevalence, timing, and co-occurrence of positive screens for maternal postpartum depression (PPD) and intimate partner violence (IPV) for women bringing their young infants for…
- Trial name
- NCT00560027
- Testing
- Case Management by Family Support Counselor (not RCT)
- Where
- United States
- Volunteers
- 173 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins University
Type 2 Diabetes, Hyperlipidemia
Using Learning Teams for Reflective Adaptation for Diabetes and Depression
The study will randomize 54 primary care practices to two intervention and a comparison groups. Both interventions will involve an on-site Improvement Facilitator who will assist the practice in forming an Improvement Team, using…
- Conditions
- Type 2 Diabetes, Hyperlipidemia, Hypertension, Depression
- Trial name
- ULTRA-DM/MDD (NCT00414986)
- Testing
- Standard CQI intervention, Chronic Care Improvement (CCI) Intervention, Self-directed practice comparison
- Where
- United States
- Volunteers
- 1,565 people
- Sponsor
- University of Colorado, Denver
The first 1,020 results can be paged through. Add a filter or change the sort order to reach the rest.