Clinical trials: Depressive State
Treatment Resistant Depressive Disorder
A Study to Evaluate the Safety and Efficacy of Intranasal Esketamine in Treatment-resistant Depression
The purpose of this study is to assess the efficacy and dose response of intranasal esketamine (Panel A: 28 mg, 56 mg, and 84 mg and Panel B: 14 mg and 56 mg) compared with placebo in improving depressive symptoms in participants…
- Trial name
- SYNAPSE (NCT01998958)
- Testing
- Esketamine 14 mg, Esketamine 28 mg, Esketamine 56 mg
- Where
- 25 sites in United States, Belgium and 1 more
- Volunteers
- 108 people
- Sponsor
- Janssen Research & Development, LLC
Antidepressant Induced Sexual Dysfunction
Study of Maca Root for the Treatment of Antidepressant-Induced Sexual Dysfunction in Females
The purpose of this study is to find out whether Maca Root is effective for treating sexual dysfunction in females that is caused by antidepressant drugs.
- Trial name
- NCT00568126
- Testing
- Maca Root
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Cardiovascular Risk Factor, Stress
Stress-reduction Wellness Program for Midlife Black Women (B-SWELL)
This research study examines the unique cultural and gender-based factors that influence how midlife Black women experience stress and incorporate healthy lifestyle behaviors into daily life.
- Conditions
- Cardiovascular Risk Factor, Stress, Self Efficacy, Depressive Symptoms
- Trial name
- B-SWELL (NCT04404478)
- Testing
- B-SWELL: Midlife Black Women's Stress Reduction Wellness Program, WE: Wellness program for Midlife Black Women
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- University of Cincinnati
Postpartum Depression
Evaluate SAGE-547 in Female Participants With Severe Postpartum Depression
This is an open-label proof-of-concept study designed to evaluate the safety, tolerability, pharmacokinetics (PK), and efficacy of SAGE-547 Injection in adult female participants diagnosed with severe postpartum depression (PPD).
- Trial name
- NCT02285504
- Testing
- SAGE-547
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- Supernus Pharmaceuticals, Inc.
Depression in Adolescence
Evaluation of MoodRing on Improving the Quality of Depression Management in Adolescents
The MoodRing intervention is a mobile application for adolescents, parents, and an accompanying web-based clinician portal which enables adolescents to monitor their mood through the use of passively collected smartphone data.
- Trial name
- TECH-E (NCT05376358)
- Testing
- MoodRing App, Usual Care
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Ana Radovic
Opioid Toxicity, Pupillary Miosis
Pupillary Unrest as an Indicator of Central Opioid Effect in Subjects 40-60 Years of Age
This study will establish the relationship between magnitude of opioid exposure and a pupillary measure referred to as PUAL (pupillary unrest in ambient light), in subjects aged 40-60.
- Conditions
- Opioid Toxicity, Pupillary Miosis, Respiratory Depression
- Trial name
- NCT05391555
- Testing
- Remifentanil Hydrochloride, Pupillometry measurement
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Cognitive Side Effects of Cancer Therapy, Depression
Typhoid Vaccine in Testing Response to Immune Stress in Patients With Stage I-IIIA Breast Cancer
This randomized clinical trial uses an inactive typhoid vaccine to briefly stimulate an immune response in patients with stage I-IIIA breast cancer who received primary cancer treatment and studies whether patients' fitness…
- Conditions
- Cognitive Side Effects of Cancer Therapy, Depression, Recurrent Breast Carcinoma, Stage IA Breast Cancer
- Trial name
- IMPACT (NCT02415387)
- Testing
- typhoid vaccine
- Where
- United States
- Volunteers
- 172 people
- Sponsor
- Ohio State University Comprehensive Cancer Center
Bipolar Disorder, Bipolar Depression
Vitamin D Supplementation for Bipolar Depression
The purpose of this study is to whether vitamin d supplementation in those with low levels may reduce depression symptoms in people experiencing bipolar depression.
- Trial name
- NCT01884844
- Testing
- Vitamin D3, Cholecalciferol
- Where
- 2 sites in United States
- Volunteers
- 33 people
- Sponsor
- University of Massachusetts, Worcester
Dementia, Mild, Depression
Decision Making Tool for Firearm Storage
This is a one-arm pilot study testing the feasibility and acceptability of a decision aid about safe firearm storage.
- Trial name
- NCT06382194
- Testing
- Decision aid
- Where
- United States
- Volunteers
- 5 people
- Sponsor
- University of Washington
Postpartum Depression
Postpartum Wellness
The purpose of this study is to test whether a web-based (eHealth) exercise intervention for new moms at increased risk for postpartum depression increases physical activity and decreases postpartum depression symptoms.
- Trial name
- POW (NCT04414696)
- Testing
- Exercise intervention
- Where
- United States
- Volunteers
- 99 people
- Sponsor
- Kaiser Permanente
Military Personnel, Family Members
Telephone Support During Overseas Deployment for Military Spouses
Deployment impacts both service member and family, and the cost can be high. Spouses' reactions to deployment may include emotional distress, loneliness, anticipatory fear or grief, somatic complaints, and depression.
- Conditions
- Military Personnel, Family Members, Resilience, Psychological, Deployment
- Trial name
- NCT01828983
- Testing
- Telephone support groups, Education webinars
- Where
- United States
- Volunteers
- 161 people, healthy volunteers welcome
- Sponsor
- Memphis VA Medical Center
Affective Disorders
Ziprasidone vs. Sertraline/Haloperidol in Psychotic Depression
The purpose of this study is to compare ziprasidone (Geodon) monotherapy for the treatment of psychotic major depression (PMD)with an antidepressant/antipsychotic combined therapy.
- Trial name
- NCT00340379
- Testing
- Ziprasidone, Sertraline, Haloperidol
- Where
- 3 sites in United States, Egypt and 1 more
- Volunteers
- 72 people
- Sponsor
- Duke University
Major Depressive Disorder
Combination Deplin® and Antidepressant Therapy for a Major Depressive Episode (MDE)- a Retrospective Analysis
This is a retrospective chart review study to determine if Deplin® 7.5mg-15mg combined with an antidepressant is better than an antidepressant alone in adults with major depression.
- Trial name
- NCT01001559
- Testing
- L-methylfolate, Selective serotonin reuptake inhibitor (SSRI), Serotonin and norepinephrine reuptake inhibitor (SNRI)
- Where
- United States
- Volunteers
- 242 people
- Sponsor
- Pamlab, Inc.
Unipolar Depression, Bipolar Depression
Ketamine as an Augmentation Strategy for Electroconvulsive Therapy (ECT) in Depression
The study aims to compare outcomes of Electroconvulsive Therapy (ECT) using ketamine versus methohexital anesthesia in depressed patients.
- Trial name
- NCT01881763
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 31 people
- Sponsor
- Northwell Health
Major Depressive Disorder
A 6-Month Open-Label Extension Study to the B2061014 Study to Evaluate the Safety, Tolerability and Efficacy of DVS SR in the Treatment of Children and Adolescents With MDD
This is a 6-month, open-label, flexible-dose study evaluating desvenlafaxine succinate sustained release (DVS SR) in the treatment of child and adolescent outpatients with major depressive disorder (MDD).
- Trial name
- NCT01371721
- Testing
- DVS SR
- Where
- 35 sites in United States, Mexico
- Volunteers
- 269 people
- Sponsor
- Pfizer
Breast Cancer Female, Depressive Symptoms
The Role of Emotional Processing in Improving the Quality of Life of Breast Cancer Patients
The purpose of this study is to examine two mechanistic changes: emotion processing (awareness, expression and acceptance) and cholinergic anti-inflammatory processes (HRV and cytokine expression) through which an Art Therapy…
- Conditions
- Breast Cancer Female, Depressive Symptoms, Fatigue, Pain
- Trial name
- REPAT (NCT03377816)
- Testing
- Art Therapy
- Where
- Israel
- Volunteers
- 318 people
- Sponsor
- University of Haifa
Bipolar Disorder, Depression
Acute Psychotherapy for Bipolar II Depression
This proposed study is designed to compare the efficacy of interpersonal and social rhythm therapy (IPSRT) alone to IPSRT plus medication as an acute treatment for bipolar II depression.
- Trial name
- NCT01133821
- Testing
- IPSRT plus quetiapine
- Where
- United States
- Volunteers
- 92 people
- Sponsor
- Holly Swartz
HIV/AIDS, Clinical Depression
Zaleplon in HIV Patients With Depression
In HIV positive patients with sleep onset insomnia and receiving pharmacologic treatment for comorbid depression, the proposed study aims to evaluate the impact of zaleplon on sleep measures determined by insomnia severity index…
- Trial name
- NCT03489304
- Testing
- Zaleplon
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Pennsylvania
Major Depressive Disorder
Creatine Treatment for Female Adolescents With Depression Who Are Non-Responders to Fluoxetine or Escitalopram
The purpose of this study is to see if creatine, which is a naturally occurring chemical in the body, is effective for treating Major Depressive Disorder (MDD) in female teenagers.
- Trial name
- NCT00851006
- Testing
- Creatine Monohydrate
- Where
- United States
- Volunteers
- 13 people, healthy volunteers welcome
- Sponsor
- University of Utah
Depression
Open Treatment of Minocycline in Geriatric Depression
This research study will examine whether elderly depressed patients whose depressive symptoms do not respond satisfactorily to therapy with a mood stabilizer or antidepressant alone gain any benefit from taking minocycline alone…
- Trial name
- NCT01659320
- Testing
- Minocycline
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Weill Medical College of Cornell University
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