Clinical trials: Depressive State
Anxiety Depression, Alcohol Abuse
CBD Oil for Reducing Emotional Impact of COVID-19
Our purpose is to conduct a 4-arm placebo-controlled clinical trial to investigate the relative clinical efficacy of 300 mg. of pure hemp-derived CBD isolate, 300 mg. of full spectrum CBD oil, 300 mg.
- Conditions
- Anxiety Depression, Alcohol Abuse, Substance Abuse, Anger
- Trial name
- CBDOIL (NCT04603781)
- Testing
- CBD Isolate, Full Spectrum CBD Oil, Broad-Spectrum CBD Oil
- Where
- United States
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Obesity, Depressive Symptoms
The MIND-GUT Digital Pilot Intervention Study
This 12-week pilot study aims to evaluate the feasibility and effectiveness of a dietary intervention targeting diet, obesity, mental health, and the gut microbiome in promoting weight loss and enhancing mental health among obese…
- Conditions
- Obesity, Depressive Symptoms, Anxiety, Stress
- Trial name
- MINDGUT (NCT06374407)
- Testing
- Dietary intervention based on the MIND diet
- Where
- Sweden
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- University of Skövde
Treatment Resistant Major Depressive Disorder
DBS of the Lateral Habenula in Treatment-Resistant Depression
This research study will investigate the safety, tolerability, and benefit of bilateral deep brain stimulation (DBS) to the lateral habenula in subjects with treatment-resistant major depression (TRD) secondary to either…
- Trial name
- NCT01798407
- Testing
- Activa Tremor Control Sys (DBS Implant), Randomized, staggered withdrawal phase
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Wayne Goodman MD
Chronic Pain, Depression
Propofol-Enhanced Assessment of Ketamine for Chronic Pain and Depression
The goal of this clinical trial is to compare ketamine to a placebo when given as a single infusion during IV sedation in adults with chronic pain and depression.
- Trial name
- PEAK (NCT06317636)
- Testing
- Ketamine, Normal saline
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Stanford University
Depression During Pregnancy
Virtual Reality-enhanced Psychotherapy for Perinatal Depression
Perinatal depression is a growing public health crisis in the United States, affecting one in five individuals during pregnancy or postpartum.
- Trial name
- NCT07279311
- Testing
- Virtual reality behavioral activation
- Where
- United States
- Volunteers
- 44 people
- Sponsor
- Stanford University
Alcohol-Related Disorders, Depressive Disorder
Psilocybin in Alcohol Use Disorder With Comorbid Depression
Up to 40% of people with alcohol use disorder (AUD) experience depression. Depression is a risk factor for early relapse of AUD after withdrawal in a controlled environment.
- Conditions
- Alcohol-Related Disorders, Depressive Disorder, Addiction
- Trial name
- PAD (NCT06235411)
- Testing
- Psilocybin therapy, Inactive Psilocybin therapy, Electroencephalogram
- Where
- France
- Volunteers
- 30 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Depression
Using Computer Tasks to Predict Response to Antidepressants
In England over 800,000 patients each year are either newly diagnosed with depression or present with a new episode of depression in primary care.
- Trial name
- NCT02800577
- Testing
- General Practitioner Emotional Test Battery (GP-ETB)
- Where
- 10 sites in United Kingdom
- Volunteers
- 80 people
- Sponsor
- P1vital Products Limited
Major Depressive Disorder
Feasibility of Resistance Exercise to Treat Major Depression Via Cerebrovascular Mechanisms
This project is a single-arm pilot trial to investigate the feasibility, acceptability, and plausible efficacy of a 16-week resistance exercise training (RET) program for treatment of major depressive disorder.
- Trial name
- NCT05695365
- Testing
- Resistance Exercise Training
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Iowa State University
Major Depression
Assessment of Hedonic and Motivational States in Major Depression ( MOODDIS)
Major depression is a frequent psychiatric disorder with an estimated lifetime prevalence of 16-17% in the general population. Although its pathophysiology is not completely understood, a large body of literature pleads for a…
- Trial name
- MOODDIS (NCT03060967)
- Testing
- Computer-based tasks
- Where
- France
- Volunteers
- healthy volunteers welcome
- Sponsor
- Institut National de la Santé Et de la Recherche Médicale, France
Depression - Major Depressive Disorder, Bipolar Disorder (BD)
Flumazenil for Benzodiazepine Reversal in Electroconvulsive Therapy
The goal of this study is to investigate whether administering flumazenil to reverse the effects of benzodiazepines and/or zopiclone during electroconvulsive therapy (ECT) can help reduce cognitive side effects without…
- Conditions
- Depression - Major Depressive Disorder, Bipolar Disorder (BD), Functional Magnetic Resonance Imaging (fMRI), Cognition
- Trial name
- FLEET (NCT07619092)
- Testing
- Flumazenil, Electroconvulsive therapy (ECT)
- Where
- Denmark
- Volunteers
- 145 people
- Sponsor
- Anders Jørgensen
Unipolar Depression
Evaluation of Metacognitive Training for Depression (D-MCT) in Outpatient Care
Aim of the current study is to investigate the acceptance and efficacy of Metacognitive Training for Depression (D-MCT) compared to cognitive remediation in outpatients with major depressive disorders in a randomized, controlled…
- Trial name
- NCT03268434
- Testing
- D-MCT, Cognitive remediation
- Where
- Germany
- Volunteers
- 86 people
- Sponsor
- Universitätsklinikum Hamburg-Eppendorf
Perinatal Mental Health, Reproductive Behavior
Women's Reproductive Choices and Mental Health During Pregnancy and After Birth in Wartime Ukraine
The goal of this observational study is to learn how war affects reproductive decisions and perinatal mental health in Ukrainian women.
- Conditions
- Perinatal Mental Health, Reproductive Behavior, Women, Cohort Studies
- Trial name
- NCT07551934
- Testing
- Psychological Assessment, Routine Clinical Data Collection
- Where
- Ukraine
- Volunteers
- 328 people, healthy volunteers welcome
- Sponsor
- Taras Shevchenko National University of Kyiv
Cardiovascular Diseases, Coronary Artery Disease
Supporting Methods in Cardiovascular Diseases Rehabilitation
The study evaluates how various therapeutic approaches perform in addressing depression, anxiety symptoms, and stress levels among patients in the second stage of cardiac rehabilitation.
- Conditions
- Cardiovascular Diseases, Coronary Artery Disease, Mood Disorders, Depressive Symptoms
- Trial name
- NCT06241534
- Testing
- Cardiac rehabilitation, Relaxation-therapeutic recordings, Virtual reality therapy
- Where
- Poland
- Volunteers
- 45 people
- Sponsor
- Wroclaw University of Health and Sport Sciences
Depression
COMMIT Depression Trial Nepal
Community health workers (CHWs) have successfully used Motivational Interviewing (MI) to improve treatment adherence (i.e. taking medications and attending clinic appointments) for patients with depression in the US and globally.
- Trial name
- NCT04510909
- Testing
- COMMIT mHealth application
- Where
- Nepal
- Volunteers
- 86 people
- Sponsor
- Possible
Bipolar I Depression
Armodafinil Treatment as Adjunctive Therapy in Adults With Major Depression Associated With Bipolar I Disorder
The primary objective of the study is to determine if armodafinil treatment, at a dosage of 150 mg/day, is more effective than placebo treatment as adjunctive therapy for adults who are experiencing a major depressive episode…
- Trial name
- NCT00481195
- Testing
- Armodafinil
- Where
- 55 sites in United States, Bulgaria and 2 more
- Volunteers
- 257 people
- Sponsor
- Cephalon
Chronic Disease, Obesity
Virtual Lifestyle Medicine Comparative Effectiveness Research
This study evaluates the effectiveness of two online Lifestyle Medicine programs. Participants will be randomized by residence, urban vs. rural, into one of two Lifestyle Medicine programs.
- Conditions
- Chronic Disease, Obesity, Sleep Disorder, Depression
- Trial name
- NCT03731481
- Testing
- Lifestyle Medicine
- Where
- United States
- Volunteers
- 46 people
- Sponsor
- Ohio University
Epilepsy
Telephone-Based Support Programs for People With Epilepsy
This is a two-arm randomized controlled trial to compare telephone-based depression self-management (UPLIFT) to telephone-based support groups (BOOST).
- Trial name
- NCT05082181
- Testing
- UPLIFT (Using Practice and Learning to Increase Favorable Thoughts), BOOST (Bringing Out Our Strength Together)
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- NYU Langone Health
Hereditary AngioEdema, Anxiety
Hereditary AngioEdema, Neurobiology and Psychopathology
Since 1963 Hereditary AngioEdema (HAE) is considered an autosomal dominant disorder (Donaldson and Evans), characterized by a quantitative and/or qualitative deficit of C1 esterase inhibitor (C1-INH), which affects approximately…
- Conditions
- Hereditary AngioEdema, Anxiety, Depression
- Trial name
- HAENP (NCT02159430)
- Testing
- Clinical and psychopathological assessment of HAE patients
- Where
- Italy
- Volunteers
- 35 people
- Sponsor
- University Hospital, Catania
Depression
IN2SHAPE: A Study of Physical Activity and Depressive Symptoms in Adolescence
The purpose of this study is to determine whether physical activity prevents development of depressive symptoms in adolescents.
- Trial name
- IN2SHAPE (NCT00738634)
- Testing
- Self-motivated physical activity, Nutrition, Physical activity researcher contact
- Where
- Australia
- Volunteers
- 26 people
- Sponsor
- Australian National University
Chronic Depression
Cognitive Behavioural Analysis System of Psychotherapy (CBASp) Versus Escitalopram in Chronic Depression
60 patients with chronic major depressive disorder according to DSM-IV will be included into the study. Patients will be randomized to receive an open treatment either with CBASP, a psychotherapy for chronic depression, or…
- Trial name
- NCT00837564
- Testing
- CBASP psychotherapy, Escitalopram
- Where
- 2 sites in Germany
- Volunteers
- 60 people
- Sponsor
- University Hospital Freiburg
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