Clinical trials: Depressive State
Chemotherapy Effect
Skin Sensitivity Acupuncture and Kinesiotherapy on Breast Cancer Patients Subject to Chemotherapy With Taxans
Objective: to compare different therapies employing acupuncture needles, silicon pellets and kinesiotherapy in breast cancer patients to taxane chemotherapy cycles.
- Trial name
- Acupuncture (NCT03373032)
- Testing
- Stiper, Acupuncture, Exercise
- Where
- Brazil
- Volunteers
- 79 people, healthy volunteers welcome
- Sponsor
- Federal University of São Paulo
Depression
Switching to Duloxetine to Ameliorate SSRI-Induced Sexual Dysfunction
Sexual dysfunction is a common side effect of selective serotonin reuptake inhibitors (SSRIs). The hypotheses of this study are that:1.
- Trial name
- NCT00398632
- Testing
- Duloxetine
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Stanford University
Postpartum Depression
CBT for Postpartum Depression and Infant Emotion Regulation
The primary objective of this study is to determine if online group cognitive behavioral therapy (CBT) for maternal postpartum depression (PPD) added to treatment as usual (TAU) leads to greater improvements in infant emotion…
- Trial name
- NCT05269732
- Testing
- Group Cognitive Behavioural Therapy (CBT)
- Where
- Canada
- Volunteers
- 172 people
- Sponsor
- McMaster University
Anhedonia, Virtual Reality
Mobile Virtual Positive Experiences for Anhedonia
Anhedonia is a symptom dimension that characterizes many individuals suffering from depression, as well as some types of anxiety, psychosis, and substance use.
- Conditions
- Anhedonia, Virtual Reality, Depression, Mood Disorders
- Trial name
- MVR (NCT03715400)
- Testing
- Positive Virtual Reality Training
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- University of California, Los Angeles
Chronic Hepatitis C
Efficacy of Paroxetine in the Prevention of Depressive Syndrome in Patients With Chronic Hepatitis C Treated by PEG-Interferon Alfa Plus Ribavirin
Depression is a common side effect of interferon in the treatment of chronic hepatitis C. The aim of this study is to assess the efficacy and safety of paroxetine, an antidepressant agent, in the prevention of depression induced…
- Trial name
- NCT00196664
- Testing
- Paroxetine
- Where
- France
- Volunteers
- 144 people
- Sponsor
- French National Agency for Research on AIDS and Viral Hepatitis
Anxiety, Anxiety Disorders
Randomized Feasibility Trial of Mind My Mind
In this feasibility RCT of the modular and flexible cognitive and behavioural therapy (Mind My Mind, MMM) compared with treatment as usual, the overall research aim was to explore the trial design and the acceptability of the…
- Conditions
- Anxiety, Anxiety Disorders, Depressive Symptoms, Depressive Disorder
- Trial name
- MindMyMind (NCT03448809)
- Testing
- Mind My Mind, TAU (Treatment as Usual)
- Volunteers
- 150 people
- Sponsor
- Mental Health Centre Copenhagen, Bispebjerg and Frederiksberg Hospital
Burnout, Professional, Stress, Psychological
Improving the Mental Health of Resident Physicians and Fellows Through Transcendental Meditation
This proposal aims to optimize resident physician and fellow wellness and performance at Banner University Medical Center through an evidence-based stress reduction program, Transcendental Meditation (TM).
- Conditions
- Burnout, Professional, Stress, Psychological, Depression, Job Stress
- Trial name
- NCT04586309
- Testing
- Transcendental meditation
- Volunteers
- healthy volunteers welcome
- Sponsor
- University of Arizona
Hypovitaminosis D
Vitamin D, Blood Pressure, Lipids, Infection and Depression
There are numerous indications for a relation between low serum levels of 25(OH)D and blood pressure, lipid levels, frequency of infections and tendency towards depression.
- Trial name
- NCT00960232
- Testing
- Cholecalciferol
- Where
- Norway
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- University of Tromso
Depression
Efficacy of Metformin as an Adjunct to Standard Antidepressant Therapy in Treating Depression Among Obese Patients
To evaluate the efficacy of metformin as an adjunct therapy in improving depressive symptoms and metabolic markers in newly diagnosed obese depressed patients on standard antidepressant therapy.
- Trial name
- NCT06707012
- Testing
- Metformin Hydrochloride
- Where
- 2 sites in Pakistan
- Volunteers
- 140 people
- Sponsor
- Fazaia Ruth Pfau Medical College
Major Depressive Disorder
Psilocybin-assisted CBT for Depression
The primary objectives of this clinical investigation are to (1) determine the acceptability and feasibility of joining psilocybin-assisted therapy with cognitive-behavioral therapy (PA-CBT) for patients with depression, (2)…
- Trial name
- NCT05227612
- Testing
- Psilocybin, Cognitive behavioral therapy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- University of California, Los Angeles
Epilepsy, Major Depressive Disorder (MDD)
Lethargic Depression Study
This is a study of Major Depressive Disorder (MDD) in patients with decreased energy, pleasure and interests.
- Trial name
- NCT00064467
- Testing
- Extended-release bupropion (HCl)
- Where
- 24 sites in United States
- Volunteers
- 268 people
- Sponsor
- GlaxoSmithKline
Major Depression, Alzheimer's Disease
Retinoic Acid Homeostasis in Neuropsychiatric Diseases
It is hypothesized, that local retinoic acid (RA) homeostasis is functionally involved in the pathophysiology of depression. In a cross-sectional (and partly longitudinal) analysis, serum RA status will be assessed in healthy…
- Conditions
- Major Depression, Alzheimer's Disease, Alcoholism, Schizophrenia
- Trial name
- RAHND (NCT02439099)
- Where
- Germany
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Charite University, Berlin, Germany
Posttraumatic Stress Disorder, Depression
Behavioral Activation for PTSD/Depression Treatment in OIF/OEF Veterans
The present study is a randomized, controlled trial that compares Behavioral Activation (BA) to Treatment As Usual (TAU) in PTSD Specialty clinics, as early psychotherapeutic interventions for OIF/OEF veterans with posttraumatic…
- Trial name
- NCT00805532
- Testing
- Behavioral Activation treatment, Treatment as Usual
- Where
- 2 sites in United States
- Volunteers
- 81 people
- Sponsor
- VA Office of Research and Development
Depression, Anxiety
The Effect of Computerized Cognitive Training on Mood and Thinking Style Amongst Patients in Inpatient Settings
The purpose of this randomized controlled trial is to establish feasibility and provide initial estimates of efficacy of two computerized cognitive training procedures (a form of Positive Mental Imagery Training, PMIT, and a form…
- Conditions
- Depression, Anxiety, Anhedonia
- Trial name
- NCT02958228
- Testing
- Positive Mental Imagery Training (PMIT), Cognitive Control Training (CCT), Treatment as Usual
- Where
- 2 sites in Germany
- Volunteers
- 57 people
- Sponsor
- Ruhr University of Bochum
Type 1 Diabetes Mellitus, Depressive Symptoms
Internet-Based Cognitive Behavioral Therapy for Depressive Symptoms in Adolescents With Type 1 Diabetes Mellitus
This study evaluates the use of an established internet-based cognitive behavioral therapy intervention in a group of adolescents with type 1 diabetes and mild to moderate depressive symptoms.
- Trial name
- NCT03655067
- Testing
- CATCH-IT
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Texas Southwestern Medical Center
Epilepsy, Epilepsy, Temporal Lobe
GABA/Glutamate Balance in Temporal Lobe Epilepsy With and Without Major Depression
Objective: To study the relative balance of GABA (A) binding potential and glutamate utilization in subjects with localization-related epilepsy with and without depression, subjects with major depressive disorder alone, and in…
- Conditions
- Epilepsy, Epilepsy, Temporal Lobe, Depression, Depressive Disorder, Major
- Trial name
- NCT00931619
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
Cancer
Internet-delivered Psycho-oncological Support
Cancer patients develop a high psychological burden of the underlying disease. To support patients in outpatient phases psychotherapists are not sufficiently available for establish regularly face-to-face-contact.
- Trial name
- ICBT_MAC (NCT02670200)
- Testing
- cognitive behavior therapy
- Where
- Germany
- Volunteers
- 100 people
- Sponsor
- Neuropsychiatrischen Zentrums Hamburg-Altona
Major Depression, Pain
Effect of Escitalopram vs. Reboxetine on Gastro-intestinal Sensitivity of Patients With Major Depressive Disorder
Patients with major depressive disorder (MDD) commonly have many gastrointestinal complaints. Gastrointestinal pain is classified into 2 categories: visceral and somatic pain.
- Conditions
- Major Depression, Pain, Abdominal Pain
- Trial name
- NCT00209807
- Testing
- escitalopram, Reboxetine, No intervention
- Where
- Spain
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Hospital Universitari Vall d'Hebron Research Institute
Unipolar Depression
Lamotrigine Augmentation in Resistant Depression
This study is intended to evaluate the efficacy and safety of lamotrigine as an antidepressant augmentation agent in a sample of individuals with major depression and a history of both prior non-response and prospective failure…
- Trial name
- NCT00901407
- Testing
- lamotrigine, paroxetine
- Where
- United States
- Volunteers
- 138 people
- Sponsor
- Louisiana State University Health Sciences Center in New Orleans
Late Life Depression
Explore the Neural Mechanism of Mindfulness Training to Reduce Loneliness in Depressed Older Adults
Perceived loneliness causes a global health burden on older adults. Mindfulness training may be a feasible solution. Through our study, we expect that comprehensive and convincing neuroscientific evidence may support the efficacy…
- Trial name
- NCT05620511
- Testing
- Mindfulness based stress reduction
- Where
- Taiwan
- Volunteers
- 180 people
- Sponsor
- Chang Gung Memorial Hospital
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