Clinical trials: Depressive State
Posttraumatic Stress Disorders, Multiple Sclerosis
The Efficacy of EMDR in Patients With PTSD in Multiple Sclerosis
Multiple Sclerosis (MS) can be associated to many psychological symptoms. One of the most relevant is the experience of distress related to the disease, that can lead to the development of Post Traumatic Stress Disorder (PTSD).
- Trial name
- NCT01743664
- Testing
- EMDR, Relaxation
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- San Luigi Gonzaga Hospital
Depressive Disorder, Major
Major Depressive Disorder In The Elderly
This is a placebo-controlled study evaluating the effectiveness of medication in elderly subjects with Major Depressive Disorder (MDD).
- Trial name
- NCT00093288
- Testing
- bupropion XL
- Where
- 16 sites in Australia, Belgium and 4 more
- Volunteers
- 364 people
- Sponsor
- GlaxoSmithKline
Dental Pain, Pulpitis
Evaluation of Pulpal and Salivary Neuropeptides in Dental Pain
This observational cross-sectional study is designed to evaluate pulpal and salivary levels of Substance P (SP) and Calcitonin Gene-Related Peptide (CGRP) in individuals with and without dental pain.
- Conditions
- Dental Pain, Pulpitis, Pulpal Inflammation, Psychological Stress
- Trial name
- PAIN-SPCGRP (NCT07330024)
- Where
- Turkey (Türkiye)
- Volunteers
- 72 people
- Sponsor
- Kahramanmaras Sutcu Imam University
Major Depressive Disorder
Ketamine Anesthesia for Improvement of Depression in ECT
The purpose of this prospective randomized clinical trial is to determine if patients receiving ketamine as a part of general anesthesia during electroconvulsive therapy (ECT) rather than standard of care will have improvement in…
- Trial name
- KAID (NCT02752724)
- Testing
- Ketamine, Methohexital
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- VA Puget Sound Health Care System
Wellness, Quality of Life
Assessing the Effectiveness of Digital Wellness Modules on Perceived Quality of Life
The study will examine the role of digital wellness modules (brief mindfulness and light to moderate physical exercise) delivered through a smartphone wellness application and their short-term effects on health behavior…
- Conditions
- Wellness, Quality of Life, Anxiety, Depression
- Trial name
- NCT05810259
- Testing
- Caravan Wellness app
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Yale University
Depressive Disorder, Major
Ropinirole Controlled Release (CR) as an Adjunctive Agent in the Treatment of Major Depression
This is an 8 week study for patients who are currently taking antidepressant medication but not fully responding. Ropinirole CR would be taken in conjunction with current antidepressant medication.
- Trial name
- NCT00285727
- Testing
- Ropinirole CR
- Where
- 2 sites in United States
- Volunteers
- 60 people
- Sponsor
- Stanford University
Depression
MoodHelper: Internet Cognitive Behavioral Therapy (CBT) for Depression
Evidence-based treatments (EBTs) for mental health conditions are often not available to persons needing them in the community. Our aim is to test a novel Internet intervention that has the promise of eventually improving the…
- Trial name
- NCT01379027
- Testing
- Pure self-help Internet CBT for depression, Guided self-help Internet CBT, Stepped-Care Internet CBT condition
- Where
- United States
- Volunteers
- 1,816 people
- Sponsor
- Kaiser Permanente
Low Back Pain, Exercise Program
Short-term Effects of Exercise Program Versus Electropuncture in Patients With Chronic Non-specific Low Back Pain: A Randomized Clinical Trial.
This study evaluate the effectiveness that exists when performing a treatment based on a table of exercises for strengthening the lumbar muscles versus a treatment based on electropuncture in patients with chronic low back pain.
- Conditions
- Low Back Pain, Exercise Program, Electroacupuncture
- Trial name
- NCT03794869
- Testing
- Percutaneous electrostimulation treatment (EPS), Exercise program
- Where
- Spain
- Volunteers
- 68 people
- Sponsor
- Universidad de Almeria
Critical Illness, Depressive Symptoms
Subanesthetic Ketamine Infusions for Depressive Symptoms in Intensive Care Unit Patients
Depressive symptoms are common among patients admitted to the intensive care unit (ICU) and may adversely affect recovery, participation in care, treatment adherence, quality of life, and outcomes after critical illness.
- Trial name
- KID-ICU (NCT07639359)
- Testing
- Ketamine (0.5 mg/kg), Normal Saline (0.9% NaCl)
- Where
- 2 sites in United States, Argentina
- Volunteers
- 50 people
- Sponsor
- Hospital Italiano de Buenos Aires
Suicidal Ideation/Behavior, Depression
Randomized, Placebo-controlled Multicenter Trial of Lithium Plus Treatment as Usual (TAU) for Acute Suicidal Ideation and Behavior in Patients With Suicidal Major Depressive Episode
The primary hypothesis of this confirmatory study is that lithium therapy will acutely decrease suicidal ideation and/or suicidal behaviour in inpatients with a major depressive episode (MDE, unipolar and bipolar disorder…
- Trial name
- NCT02039479
- Testing
- Lithium Carbonate
- Where
- 5 sites in Germany
- Volunteers
- 254 people
- Sponsor
- Technische Universität Dresden
Depression
CALM Phase 2b Pilot
Managing Cancer And Living Meaningfully (CALM) is a brief psychotherapy designed to alleviate distress in advanced cancer. In an earlier intervention-only pilot trial, CALM was associated with reductions in depressive symptoms…
- Trial name
- CALM (NCT02353546)
- Testing
- CALM
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- University Health Network, Toronto
Mental Disorder, Depressive Symptoms
Module-Based Psychological (MBP) for Community Youths
This waitlist, randomised controlled trial (RCT) aims to examine the effectiveness of the Module-Based Psychological (MBP) intervention in reducing mental distress for youths aged 12-30 years in Hong Kong.
- Conditions
- Mental Disorder, Depressive Symptoms, Anxiety Symptoms
- Trial name
- MBP_RCT (NCT06005961)
- Testing
- Module-Based Psychological (MBP) Intervention
- Where
- Hong Kong
- Volunteers
- 400 people
- Sponsor
- The University of Hong Kong
Major Depressive Disorder
Behavioral Activation for Major Depression With and Without Mindfulness
The objective of the study is to compare, in individuals who meet the diagnostic criteria for major depression, the effects of Behavioral Activation (BA) strictly behavioral with a BA protocol that includes mindfulness practices.
- Trial name
- NCT04768361
- Testing
- Behavioral Activation without Mindfulness, Behavioral Activation with Mindfulness
- Where
- Spain
- Volunteers
- 150 people
- Sponsor
- Hospital Miguel Servet
Anxiety Depression, HIV/AIDS
Acupuncture Therapy VS Chiropractor Group Therapy to Reduce Anxiety and Depression.
This study aims to determine and compare acupuncture therapy and chiropractor group therapy to reduce anxiety and depression among HIV/AIDS patients at Being Alive, Los Angeles.
- Trial name
- NCT05936905
- Testing
- Acupuncture, Chiropractic
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Yo San University of Traditional Chinese Medicine
Depression
Enhancing the Therapeutic Efficacy of Sleep Deprivation by Modafinil
The study aims to investigate whether the administration of the stimulant modafinil during a 40 hour sleep deprivation period in depressed patients can intensify the antidepressant effect of the sleep deprivation as assessed by a…
- Trial name
- NCT00670813
- Testing
- Modafinil (Vigil)
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Technical University of Munich
Anxiety, Depression - Major Depressive Disorder
Profiling Vulnerability and Resilience for Mental Illness Following Viral Infections: Translating Epidemiology to Deep-phenotyping.
The study protocol was submitted to ERA-NET NEURON for funding on 28/06/2023. Description of the Israeli responsibilities was extracted from the full submitted research protocol. The protocol includes two studies (CHS1 and CHS2).
- Conditions
- Anxiety, Depression - Major Depressive Disorder, Bipolar, Schizophenia Disorder
- Trial name
- Viral-MI (NCT07453420)
- Where
- Israel
- Volunteers
- 100,000 people, healthy volunteers welcome
- Sponsor
- Shalvata Mental Health Center
Postpartum Depression, Psychoeducation
Psychoeducatıon Interventıon Postpartum Depressıon Breastfeedıng
This study was planned to evaluate the effects of psychoeducation intervention for postpartum care on postpartum depression and breastfeeding.
- Conditions
- Postpartum Depression, Psychoeducation, Breastfeeding, Postpartum Care
- Trial name
- NCT06779903
- Testing
- the psychoeducation intervention program booklet, routine care
- Where
- Turkey (Türkiye)
- Volunteers
- 102 people, healthy volunteers welcome
- Sponsor
- Eskisehir Osmangazi University
Bipolar, Depression
Adjunctive Lisdexamfetamine (LDX) in Bipolar Depression
The specific aim of this study is to evaluate the efficacy and tolerability of lisdexamfetamine in the adjunctive treatment of bipolar disorder.
- Trial name
- NCT01131559
- Testing
- Lisdexamfetamine
- Where
- United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Lindner Center of HOPE
Depression During Pregnancy, Postpartum Depression (PPD)
Treatment With Repetitive Transcranial Magnetic Stimulation in Peripartal Depression
The goal of this clinical trial is to learn whether repetitive transcranial magnetic stimulation (rTMS) can reduce depressive symptoms in women who are pregnant or up to 12 months after childbirth and have peripartum depression.
- Conditions
- Depression During Pregnancy, Postpartum Depression (PPD), Peripartum Depression
- Trial name
- PPD and rTMS (NCT07774559)
- Testing
- Repetitive transcranial magnetic stimulation
- Where
- 2 sites in Switzerland
- Volunteers
- 60 people
- Sponsor
- Psychiatric University Hospital, Zurich
Depression
The Bonny Method of Guided Imagery and Music (GIM) in the Treatment of Depression
The purpose of this research is to study the effectiveness of the Bonny Method of Guided Imagery and Music (GIM) as a treatment approach for depression.
- Trial name
- NCT03917979
- Testing
- Individual GIM, Waitlist Control
- Where
- 2 sites in United States
- Volunteers
- 30 people
- Sponsor
- Aalborg University
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