Clinical trials: Depressive Symptoms, open to volunteers
Depressive Symptoms
Feasibility and Effects of a Blended Baduanjin Exercise and Green Tea Consumption Program on Depressive Symptoms, Gut Microbiota and Quality of Life in Older Adults
Depression is a common mental health issue in older adults, often manifesting as insomnia, low mood, vague somatic complaints, cognitive decline, and recurrent thoughts of death or suicide.
- Trial name
- NCT07687940
- Testing
- blended Baduanjin and Green Tea consumption program, Non-treatment control
- Where
- Hong Kong
- Volunteers
- 48 people
- Sponsor
- Hong Kong Baptist University
Mild Cognitive Impairment (MCI), Depressive Symptoms
rTMS Combined With Aerobic Exercise for Older Adults With Mild Cognitive Impairment and Comorbid Depression
This study aims to evaluate the effects of repetitive transcranial magnetic stimulation (rTMS) and aerobic exercise on cognitive function and mental health in older adults with mild cognitive impairment (MCI) and comorbid…
- Trial name
- NCT07652775
- Testing
- Repetitive Transcranial Magnetic Stimulation, Aerobic Exercise
- Where
- Taiwan
- Volunteers
- 45 people
- Sponsor
- Cheng-Hsin General Hospital
Depressive Symptoms
Improving Mood for Adolescents Through Teaming With End-Users in Routine Care (The iMATTER Project)
This pilot randomized controlled trial will examine the feasibility, acceptability and preliminary efficacy of an adolescent depression prevention program, Brief Interpersonal Psychotherapy-Adolescent Skills Training (B-IPT-AST)…
- Trial name
- NCT07020572
- Testing
- Brief Interpersonal Psychotherapy - Adolescent Skills Training (B-IPT-AST), Services as usual (SAU)
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Children's Hospital of Philadelphia
Depressive Symptoms, Allostatic Load
Our Voices Matter: Intervention for Depression in Youth
Over 15 million people participated in racial justice protests nationwide during 2020-2021 spotlighting activism as a collective tool against structural racism and discrimination (SRD).
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- OVM (NCT07216326)
- Testing
- Racial Justice Activism Intervention ARM, Adulting 101- Control Arm
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Parturients, Depressive Symptoms
Intranasal Esketamine-dexmedetomidine Combination and Postpartum Depression
Esketamine has rapid-onset antidepressant effects and may reduce postpartum depression in parturients with prenatal depressive symptoms. However, its adverse neuropsychiatric symptoms limits clinical application.
- Conditions
- Parturients, Depressive Symptoms, Esketamine, Dexmedetomidine
- Trial name
- NCT07639099
- Testing
- Esketamine-dexmedetomidine combination
- Where
- China
- Volunteers
- 164 people
- Sponsor
- Peking University First Hospital
Sexual and Gender Minorities, Social Stigma
Examining the Health Effects of NPOWER365 Among Black Same Gender Loving Men
This research study aims to test the effectiveness, reach, and maintenance over time of the NPOWER365 HIV care intervention for Black men who have sex with men (BMSM) living with HIV.
- Conditions
- Sexual and Gender Minorities, Social Stigma, Medication Adherence, Depressive Symptoms
- Trial name
- NCT06315218
- Testing
- NPOWER365 HIV care intervention
- Volunteers
- 350 people
- Sponsor
- Rutgers, The State University of New Jersey
Cancer of Breast, Depressive Symptoms
Cancer Pain Management Using a Web-based Intervention
This study is funded by the HEAL Initiative (https://heal.nih.gov/). Based on Preliminary Studies (PSs), the research team developed and pilot-tested an evidence-based Web App-based information and coaching/support program for…
- Conditions
- Cancer of Breast, Depressive Symptoms, Cancer Pain
- Trial name
- CAI (NCT06085313)
- Testing
- CAI, CAPA
- Where
- United States
- Volunteers
- 300 people
- Sponsor
- University of Texas at Austin
Maternal Mental Health, Early Child Development
Mental Health Support Interventions for Mothers of Infants and Young Children
The goal of this clinical trial is to learn whether a maternal mental health support program can improve maternal mental health and child development when delivered through routine child healthcare services in community health…
- Conditions
- Maternal Mental Health, Early Child Development, Depressive Symptoms, Postpartum
- Trial name
- NCT07627373
- Testing
- Thinking Healthy Extended Program
- Where
- China
- Volunteers
- 440 people
- Sponsor
- Stanford University
Mood Disorders, Anxiety
RXWell to Decrease Post-Operative Opioid Use in Total Knee or Hip Arthroplasty
It is envisioned that multipronged benefits from this pilot work for the UPMC ISD and its members. It is expected the RxWell platform to provide the following benefits: expansion of the use of RxWell to all UPMC ISD members…
- Conditions
- Mood Disorders, Anxiety, Depressive Symptoms, Depression
- Trial name
- RxWell (NCT05658796)
- Testing
- +RxWell, -RxWell
- Where
- 3 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of Pittsburgh
Cancer, Anxiety
My Wellbeing Guide: A Novel Tool for Managing Stress and Improving Quality of Life
The purpose of this study is to examine the implementation and effectiveness of the psychosocial eHealth intervention, My Wellbeing Guide, on the proposed primary outcome, depressive symptoms, in patients diagnosed with cancer…
- Conditions
- Cancer, Anxiety, Depressive Symptoms
- Trial name
- R37 (NCT05369429)
- Testing
- My Wellbeing Guide
- Where
- United States
- Volunteers
- 6,516 people
- Sponsor
- Northwestern University
Anxiety Disorders and Symptoms, Depressive Symptoms
Mobile CBT for Middle Aged and Older Adults
This study aims to assess a mobile app called MAYA for use in middle-aged and older adults with anxiety or mood disorders. The MAYA app is designed to teach coping skills for anxiety and depression that are drawn from cognitive…
- Conditions
- Anxiety Disorders and Symptoms, Depressive Symptoms, Depression
- Trial name
- NCT05754151
- Testing
- MAYA Mobile Application
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- Weill Medical College of Cornell University
Depression, Depressive Symptoms
IMPACT (IMproving Proactive Approaches for Cancer Survivors' Mental Health Treatment)
The purpose of this research study is to evaluate a mobile application (app) for depression treatment called "Moodivate" among cancer survivors.
- Conditions
- Depression, Depressive Symptoms, Cancer
- Trial name
- IMPACT (NCT06582784)
- Testing
- Behavioral Activation Therapy App, Treatment as Usual
- Where
- United States
- Volunteers
- 279 people
- Sponsor
- Medical University of South Carolina
Depressive Symptoms, Caregiver Burden
Caregiver Stress and Sleep Study
The purpose of this research study is to better understand how stress, sleep and activity might impact caregivers' mood and brain health.
- Trial name
- CARES (NCT05219955)
- Testing
- Morning Action Plan Execution, Activity Strategy-based Session with Therapist, Attention-based Session with Therapist
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Artificial Intelligence (AI), Prolonged Grief Symptoms
AI-GF-GNW on Prolonged Grief Reactions
Prolonged Grief Disorder (PGD) is a severe, disabling condition characterized by intense yearning and difficulty accepting the reality of loss, which significantly impairs the academic and psychosocial functioning of bereaved…
- Conditions
- Artificial Intelligence (AI), Prolonged Grief Symptoms, Depression - Major Depressive Disorder, Anxiety
- Trial name
- NCT07589088
- Testing
- AI-Assisted Grief-Focused Guided Narrative Writing, No-Feedback Guided Narrative Writing, Free Writing
- Where
- China
- Volunteers
- 126 people, healthy volunteers welcome
- Sponsor
- Peking University
Treatment Resistant Depression
A Study to Assess the Efficacy, Safety and Tolerability of VLS-01 Buccal Film, Compared to Placebo in Patients With Treatment Resistant Depression (ELUMINA)
This Phase 2 study (protocol number VLS-01-203) will determine the efficacy, safety, and tolerability of short-term treatment with a VLS-01 transmucosal buccal film (VLS-01-BU) in patients with treatment resistant Major…
- Trial name
- NCT06524830
- Testing
- VLS-01-203 BU
- Where
- 48 sites in United States, Australia and 2 more
- Volunteers
- 142 people
- Sponsor
- atai Therapeutics, Inc.
Depressive Symptoms
Depression and Suicide Prevention in Adolescents Attending Special Schools
Depression is a major public health concern. In Dutch adolescents, the prevalence of major depressive disorder is estimated at 3.8%, and one in five adolescents report depressive symptoms.
- Trial name
- STORM (NCT06203899)
- Testing
- Op Volle Kracht, Gatekeeperstraining
- Where
- Netherlands
- Volunteers
- 236 people
- Sponsor
- Ggz Oost Brabant
Depression, Treatment Resistant Depression
Mindfulness Engaged Neurostimulation for Depression (MEND II)
Repetitive Transcranial Magnetic stimulation (rTMS) is an FDA-approved therapy for treatment resistant depression (TRD) that involves brief magnetic stimulation pulses on the dorsolateral prefrontal cortex (DLPFC) brain region.
- Conditions
- Depression, Treatment Resistant Depression, Major Depressive Disorder, Depressive Disorder
- Trial name
- NCT07512284
- Testing
- Medi-TBS
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, San Diego
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Depression, Suicide
Youth Depression and Suicide Research Network
The objective of this study is to build the Texas Youth Depression and Suicide Research Network to support the development of a Network Participant Registry and characterization of systems and interventions to examine statewide…
- Conditions
- Depression, Suicide, Suicidal Ideation, Suicide, Attempted
- Trial name
- YDSRN (NCT04572321)
- Where
- United States
- Volunteers
- 5,000 people
- Sponsor
- University of Texas Southwestern Medical Center
Loneliness, Social Support
Activating Social Resources in Psychotherapy-Seeking Individuals: Effectiveness and Timing of a Social Support Just-in-Time Adaptive Intervention
This study evaluates a Just-In-Time Adaptive Intervention (JITAI) aiming to foster social support processes for adults with elevated depressive symptoms awaiting outpatient psychotherapy.
- Conditions
- Loneliness, Social Support, Depressive Symptoms
- Trial name
- NCT07471529
- Testing
- Social Support Just-in-Time Adaptive Intervention
- Where
- Switzerland
- Volunteers
- 120 people
- Sponsor
- University of Zurich