Clinical trials: Depressive Symptoms, open to volunteers
Major Depression
Single Day of Ultra-accelerated TMS With a Single Dose of NRX-101
In this pilot study, investigators aim to combine D-cycloserine, lurasidone, and single-day repeated intermittent Theta Burst Stimulation (iTBS) to preliminarily assess clinical improvement in an open-label cohort and monitor for…
- Trial name
- SPARC-LI (NCT07785102)
- Testing
- TMS, NRX-101
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Mclean Hospital
Treatment Resistant Depression, Elderly Depression (≥65y.o.)
Randomized Controlled Trial Testing the Efficacy of Transcranial Magnetic Stimulation by Accelerated & High-dose Theta-burst, Functional Imaging Guided, in the Treatment of Depression in Elderly Subjects With Cognitive Impairment
This trial aims at testing a new intensive, personalized functional targeting, transcranial magnetic stimulation technique for elderly patients (aged ≥ 65 years) suffering from a current treatment resistant depressive episode to…
- Trial name
- OLDEP-TBS (NCT07188753)
- Testing
- transcranial magnetic stimulation by accelerated & high-dose theta-burst, functional imaging guided, i
- Volunteers
- 186 people
- Sponsor
- Rennes University Hospital
Depression Symptoms, Anxiety Symptoms
Developing a Booster Session for Problem Management Plus in the Bahamas: A Pilot Randomized Controlled Trial
Therapists at the Grand Bahama Resilience Center (GBRC) will be trained to deliver Problem Management Plus (PM+), a WHO intervention.
- Trial name
- NCT07208851
- Testing
- Problem Management Plus booster session
- Where
- The Bahamas
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- The New School
Heart Diseases, Type2 Diabetes
Psychosocial, Environmental, and Chronic Disease Trends in Puerto Rico
The overall goal is to identify trends and longitudinal associations in psychosocial, food-related, and cardiometabolic risk factors that can guide public health priorities and future research needs aimed at reducing…
- Conditions
- Heart Diseases, Type2 Diabetes, Hypertension, Obesity
- Trial name
- PROSPECT (NCT03794531)
- Where
- Puerto Rico
- Volunteers
- 2,500 people, healthy volunteers welcome
- Sponsor
- Harvard School of Public Health (HSPH)
Depressive Symptoms, Mild Traumatic Brain Injury
rTMS for Military TBI-related Depression
The purpose of this study is to investigate the efficacy, safety, and tolerability of two dorsolateral prefrontal cortex (DLPFC) repetitive transcranial magnetic stimulation (rTMS) protocols to alleviate symptoms of depression in…
- Conditions
- Depressive Symptoms, Mild Traumatic Brain Injury, Concussion
- Trial name
- ADEPT (NCT05426967)
- Testing
- Repetitive Transcranial Magnetic Stimulation (rTMS)
- Where
- 3 sites in United States
- Volunteers
- 198 people
- Sponsor
- Henry M. Jackson Foundation for the Advancement of Military Medicine
Severe Depression, Moderate Depression
Nebulized Ketamine for the Treatment of Major Depressive Disorder
This is a double-blind active placebo controlled clinical trial for individuals with moderate to severe depression. The purpose of this study is to assess if nebulized ketamine can reduce depressive symptoms.
- Conditions
- Severe Depression, Moderate Depression, Ketamine, Midazolam
- Trial name
- NCT06752759
- Testing
- nebulized ketamine, nebulized midazolam
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- Theresa Jacob, PhD, MPH
Depression - Major Depressive Disorder
Discontination of Antidepressants in Remitted Depression
Overprescribing and long-term use of antidepressants (ADs) are common and may increase the risk of adverse effects and withdrawal symptoms when discontinuation is attempted.
- Trial name
- DISCARD (NCT07393919)
- Testing
- Hyperbolic tapering, Linear tapering
- Volunteers
- 150 people
- Sponsor
- Universita di Verona
Burn, Chronic Pain Following Thermal Burn Injury
VR-PMR for Post-Burn Symptoms
The goal of this clinical trial is to learn whether progressive muscle relaxation (PMR), delivered either alone or enhanced with virtual reality (VR), can help treat chronic symptom, such as pain, itch, anxiety, sleep…
- Conditions
- Burn, Chronic Pain Following Thermal Burn Injury, Non-Pharmacological Interventions, Virtual Reality
- Trial name
- VIBE (NCT07317271)
- Testing
- Virtual Reality-Enhanced Progressive Muscle Relaxation, Standard Progressive Muscle Relaxation
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- Johns Hopkins University
Major Depressive Disorder, Opioid Use Disorder
Cortical rTMS as a Treatment for Depression
Depression is a leading cause of disability worldwide with a 19% lifetime prevalence in the United States. Dysfunctional reward processing is one of the core features of depression.
- Conditions
- Major Depressive Disorder, Opioid Use Disorder, Suicidality
- Trial name
- NCT05487911
- Testing
- Repetitive Transcranial Magnetic Stimulation
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- Baylor College of Medicine
Depressive Disorder
Psilocybe Cubensis Mushrooms With or Without Fluoxetine for Refractory Depression
This Phase 2a pilot, exploratory, randomized, double-blind, placebo-controlled, parallel-group trial will estimate whether concurrent fluoxetine alters the antidepressant effect, acute psychedelic experience, or safety of a…
- Trial name
- COGUNILA (NCT06898606)
- Testing
- Psilocybin and Psilocyn, Psychotherapy-assisted session, Fluoxetine
- Where
- Brazil
- Volunteers
- 24 people, healthy volunteers welcome
- Sponsor
- Federal University of Latin American Integration
Depression
A Study of the Efficacy of Fecal Microbiota Transplantation(FMT) in the Treatment of Depression
Patients with depression were enrolled and randomly divided into two groups, namely FMT combined with antidepressant group and Antidepressant alone group.The former received FMT capsules and antidepressants, and the latter…
- Trial name
- NCT05850572
- Testing
- Fecal microbiota transplantation(FMT)
- Volunteers
- 100 people
- Sponsor
- First Affiliated Hospital Xi'an Jiaotong University
Major Depressive Disorder, Major Depressive Disorder, Recurrent
Accelerated Intermittent Theta-Burst Stimulation Ameliorate Major Depressive Disorder by Regulating CAMKII Pathway
Major depressive disorder(MDD) is a complex and heterogeneous mental disorder. Repeated transcranial magnetic stimulation (rTMS), as a non-invasive neuroregulatory technique, has shown a promising function in the treatment of…
- Trial name
- NCT05913960
- Testing
- accelerated intermittent theta burst stimulation, high frequency stimulation
- Where
- China
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital of Zhejiang University
Depression, Depressive Disorder
Metformin as Adjunct Therapy in Depression-obesity Comorbidity: Clinical and Genetic Evaluation
The patients with depression and obesity will receive add-on metformin with antidepressant therapy, which may result in greater improvement in depressive symptoms and BMI reduction compared to antidepressant monotherapy.
- Conditions
- Depression, Depressive Disorder, Overweight or Obesity, Depressive Symptoms
- Trial name
- NCT07654179
- Testing
- Metformin, Antidepressant Therapy
- Where
- 2 sites in Pakistan
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Riphah International University
Major Depressive Disorder
Positioning of Esketamine Treatment in the Real-world Management of Depression
The goal of this naturalistic, open label, single arm intervention study is to investigate the effects of Esketamine in treating depression.The main aims to answer are: to investigate whether Esketamine is effective when added to…
- Trial name
- PoET (NCT06103760)
- Testing
- Esketamine Nasal Spray [Spravato]
- Where
- Australia
- Volunteers
- 162 people
- Sponsor
- Royal North Shore Hospital
Anorexia Nervosa
Metreleptin in Anorexia Nervosa
The treatment of anorexia nervosa often proves to be difficult. There are no drugs that work specifically for the treatment of anorexia nervosa.
- Trial name
- METRAN (NCT06305182)
- Testing
- Metreleptin, Sodium chloride
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Gabriella Milos
Alcohol Drinking Related Problems, Alcohol Use Disorders
Co-occurence of Mental Illness and Problematic Alcohol Use: an Internet-based Cognitive Behavior Therapy Intervention
The goal of this clinical trial is to learn if internet-based cognitive behavior therapy (ICBT ) works to treat co-occurent of problematic alcohol use and mental illness including mild to moderate symptoms of either depression…
- Conditions
- Alcohol Drinking Related Problems, Alcohol Use Disorders, Depressive Disorders, Mental Illness
- Trial name
- CoMiT (NCT06789250)
- Testing
- Internet-based cognitive behavior therapy
- Where
- 2 sites in Sweden
- Volunteers
- 240 people
- Sponsor
- Linkoeping University
Depression
rTMS Response Trajectories in Depression
Notwithstanding the cumulative evidence on the safety and efficacy of transcranial magnetic stimulation in depression care, the non-response rate to transcranial magnetic stimulation (TMS) amongst treatment-resistant depression…
- Trial name
- NCT03348761
- Testing
- rTMS group
- Where
- Hong Kong
- Volunteers
- 70 people
- Sponsor
- Chinese University of Hong Kong
Parkinson Disease, Idiopathic, Freezing of Gait
Vortioxetine for Depressive Symptoms and Freezing of Gait in Parkinson Disease
The present study involves patients with Parkinson Disease (PD) suffering from freezing of gait (FOG) and depressive symptoms. The main aim of the study is evaluating the efficacy of vortioxetine in reducing moderate/severe FOG…
- Conditions
- Parkinson Disease, Idiopathic, Freezing of Gait, Depression Not Otherwise Specified
- Trial name
- NCT06805266
- Testing
- Vortioxetine (tablet)
- Volunteers
- 40 people
- Sponsor
- Marianna Amboni
Postpartum Depression
The ROSE Scale-up Study: Informing a Decision About ROSE as Universal PPD Prevention
The Reach Out, Stand Strong, Essentials for New Mothers (ROSE) program is an evidence-based intervention that prevents half of cases of postpartum depression and was one of two interventions recommended by the US Preventive…
- Trial name
- ROSES-II (NCT05700760)
- Testing
- ROSE (Reach Out, Stay Strong, Essentials for mothers of newborns), Enhanced Care as Usual (CAU)
- Where
- United States
- Volunteers
- 2,320 people, healthy volunteers welcome
- Sponsor
- Michigan State University
Depression - Major Depressive Disorder
Dual Neuromodulation for Depression: Boosting TMS With tES
Major depressive disorder (MDD) is a common and disabling condition. Transcranial magnetic stimulation (TMS) is an established non-invasive neuromodulation treatment for depression, but clinical response varies considerably…
- Trial name
- DUAL MOD (NCT07879924)
- Testing
- Transcranial Magnetic Stimulation, Transcranial Alternating Current Stimulation
- Where
- 2 sites in United Kingdom
- Volunteers
- 60 people
- Sponsor
- Mersey Care NHS Trust