Clinical trials: Depressive Symptoms, open to volunteers
Depressive Symptoms, Allostatic Load
Rise & Thrive: Community-Engagement Intervention for Stress and Depression in Youth.
American youth and young adults face persistent and chronic stressors, which have contributed to a mental health crisis in the United States.
- Conditions
- Depressive Symptoms, Allostatic Load, Metabolic Syndrome
- Trial name
- R&T (NCT07554326)
- Testing
- Rise Together: Community Engagement Intervention, Adulting 101: Life Skills
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
PTSD, Suicidal Thoughts and Behaviors
Cannabis, Neuroinflammation, and Suicidal Ideation: A Supplemental Brain Imaging Study
This study will be the first to use brain imaging to explore how cannabis affects the brain and inflammation in U.S. military veterans with PTSD.
- Conditions
- PTSD, Suicidal Thoughts and Behaviors, PTSD Symptoms, Depressive Symptoms
- Trial name
- CNS (NCT07222306)
- Testing
- 1-(2-[+F]fluoroethyl)-L-tryptophan
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Wayne State University
Subclinical Depressive Symptoms
Preventing Depression of Chinese American Adolescents by RRE
The goal of this clinical trial is to test if a culturally sensitive mobile health application (Relax, Reflect, Empower-RRE) is feasible and effective in promoting psychological wellbeing and reducing depressive symptoms among…
- Trial name
- NCT05921201
- Testing
- Relax, Reflect, and Empower mobile application
- Where
- United States
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Northeastern University
Depressive Symptoms, Anxiety Disorders and Symptoms
Family Spirit Strengths
This project addresses the disproportionate morbidity and mortality associated with mental and behavioral health problems in American Indian and Alaska Native communities.
- Conditions
- Depressive Symptoms, Anxiety Disorders and Symptoms, Substance Use, Mental Health Issue
- Trial name
- FSS (NCT05836090)
- Testing
- Family Spirit Strengths (FSS), Family Spirit Nurture
- Where
- 3 sites in United States
- Volunteers
- 188 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Anxiety Symptoms, Post-traumatic Stress Symptoms
Improving Student Mental Health Through a Universal Trauma-Informed Intervention
The goal of this trial is to identify the most effective ways for schools to deliver RAP Club, a universal school-based mental health intervention.
- Conditions
- Anxiety Symptoms, Post-traumatic Stress Symptoms, Depressive Symptoms, Behavioral Problems
- Trial name
- PPP (NCT07842432)
- Testing
- RAP Club Delivered by a School Clinician, RAP Club Delivered by a Teacher, Standard Supervision
- Where
- 3 sites in United States
- Volunteers
- 960 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Depression, Unipolar
FMRI-neurofeedback in Depression
Previous studies with fMRI-neurofeedback in depression have demonstrated a good safety profile and considerable symptom reduction.
- Trial name
- NCT05640089
- Testing
- fMRI-based neurofeedback
- Where
- 3 sites in Netherlands
- Volunteers
- 120 people
- Sponsor
- Maastricht University Medical Center
Major Depressive Disorder With Excessive Daytime Sleepiness Symptoms
Clinical Assessment of Response in the Treatment of Depression With Daytime Sleepiness Using Solriamfetol
CLARITY (Clinical Assessment of Response in the Treatment of Depression with Daytime Sleepiness Using Solriamfetol) is a Phase 3, double-blind, placebo-controlled, multicenter randomized withdrawal trial in patients with major…
- Trial name
- CLARITY (NCT07484217)
- Testing
- Solriamfetol 150 MG
- Where
- 40 sites in United States
- Volunteers
- 508 people
- Sponsor
- Axsome Therapeutics, Inc.
Depressive; Disorder, Major, Single Episode, Major, With Psychotic Symptoms, Depressive; Disorder, Major, Single Episode, Major (Without Psychotic Symptoms)
Deep Phenotyping for Clinical Inferring Response in Treatment Resistant Depression
DECIDE- Deep phenotyping for clinical inferring response in treatment resistant depression -Study Building upon the "Biobanking" initiative at the Max Planck Institute of Psychiatry, the present project aims to identify…
- Conditions
- Depressive; Disorder, Major, Single Episode, Major, With Psychotic Symptoms, Depressive; Disorder, Major, Single Episode, Major (Without Psychotic Symptoms), Depressive Disorder, Major, Recurrent, With Psychotic Symptoms, Depressive Disorder, Major, Recurrent, Without Psychotic Symptoms
- Trial name
- DECIDE (NCT06396312)
- Where
- Germany
- Volunteers
- 130 people
- Sponsor
- Max-Planck-Institute of Psychiatry
Depression Symptoms, Depression - Major Depressive Disorder
Evaluating a Personalised Online Program With Human Support for Women With Depression and Its Impact on Mental Health and Biological Changes
This study aims to evaluate the efficacy of a specially developed internet-based Cognitive Behavioural Therapy (CBT) programme with human interaction-referred to as the 3D programme-tailored specifically for women experiencing…
- Conditions
- Depression Symptoms, Depression - Major Depressive Disorder, Depressive Disorder
- Trial name
- 3D01 (NCT07060690)
- Testing
- iCBT with human interaction, Psychoeducational videos
- Where
- 2 sites in Spain
- Volunteers
- 120 people
- Sponsor
- Francesc Colom, PsyD, PhD
Depression / Major Depressive Disorder, Mental Health (Depression)
Stress Management and Meditative Movements for Asian Americans With Depression and Physical Symptoms
Many Asian Americans with depression also struggle with physical symptoms-such as pain, fatigue, or other forms of bodily discomfort-that occur at the same time.
- Trial name
- NCT07610928
- Testing
- Stress Management and Resiliency Training with Qigong/Tai Chi, Healthy Living Program
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- Massachusetts General Hospital
Suicide, Depressive Disorder, Treatment-Resistant
Investigation of the Antidepressant Effects of (2R,6R)-HNK, an Enhancer of Synaptic Glutamate Release, in Treatment-Resistant Depression
Background: Major depressive disorder (MDD) is a serious mental illness that can put people at risk of self-harm and death. Many drugs are used to treat MDD, but it can take a long time for them to be effective.
- Conditions
- Suicide, Depressive Disorder, Treatment-Resistant, Ketamine, Molecular Mechanisms of Pharmacological Action
- Trial name
- NCT06511908
- Testing
- (2R,6R)-hydroxynorketamine (0.25 to 2.0 mg/kg)
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- National Institute of Mental Health (NIMH)
Depression - Major Depressive Disorder, Generalized Anxiety Disorder
Ultra-brief Psychological Treatments for Emotional Symptoms and Disorders
The main objective of this randomized clinical trial is to study if various modalities of brief (eight sessions) and ultra-brief (four sessions) transdiagnostic cognitive-behavioral treatment work for decrease emotional symptoms…
- Conditions
- Depression - Major Depressive Disorder, Generalized Anxiety Disorder, Generalized Anxiety, Anxiety
- Trial name
- UltraPsyBrief (NCT06909669)
- Testing
- Group ultra-brief transdiagnostic cognitive-behavioral therapy, Group brief transdiagnostic cognitive-behavioral therapy, Individual ultra-brief transdiagnostic cognitive-behavioral therapy
- Where
- 2 sites in Spain
- Volunteers
- 184 people
- Sponsor
- Universidad de Córdoba
Behavioral Symptoms, Suicide
Natural History of Depression, Bipolar Disorder and Suicide Risk
Mood disorders, such as depression and bipolar disorder, are difficult to treat. One reason is that there are no objective ways to measure how these disorders affect the body and respond to different treatments.
- Conditions
- Behavioral Symptoms, Suicide, Self-Injurious Behavior, Sensory System Agents
- Trial name
- NCT06462196
- Where
- United States
- Volunteers
- 500 people
- Sponsor
- National Institute of Mental Health (NIMH)
Irritable Bowel Syndrome (IBS), Functional Dyspepsia
Interactive Effects of Early-Life Stress, Diet, and Metabolism on Gastrointestinal Dysfunction With Neuropsychiatric Symptoms
The goal of this observational case-control study is to learn how stressful experiences, dietary habits, and blood nutrient levels are associated with gastrointestinal symptoms and symptoms of depression and anxiety in adults…
- Conditions
- Irritable Bowel Syndrome (IBS), Functional Dyspepsia, Inflammatory Bowel Disease (IBD), Gastroparesis
- Trial name
- NCT07852819
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Shandong University
Depressive Symptoms, Emotional Depression
Parenting-STAIR Modular for Military Fathers and OCONUS Families
The goal of this clinical trial is to learn if a family-based treatment called Parenting-STAIR-Modular (PSTAIR-M) can help military parents recover from trauma, strengthen emotion regulation skills, and improve parent-child…
- Conditions
- Depressive Symptoms, Emotional Depression, Depression, Parent Child Relationship
- Trial name
- NCT07843654
- Testing
- Parenting-STAIR Modular (PSTAIR-M), Treatment as Usual (TAU)
- Where
- 6 sites in United States, South Korea
- Volunteers
- 243 people
- Sponsor
- New York University
Depression, Depressive Disorder
The Oh Happy Day Class - Digital Connections (OHDC-DC): A Pilot Study
The goal of this clinical trial is to see if a mobile phone app can deliver depression treatment to African Americans who are depressed.
- Conditions
- Depression, Depressive Disorder, Depressive Symptoms
- Trial name
- OHDC-DC (NCT06206226)
- Testing
- OHDC-DC
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- University of Wisconsin, Madison
Depressive Symptoms, Cognitive Symptom
JAK Signaling in Depression and Cognition in Male Football Players
This study is being done to learn more about the role of inflammation in depressive and cognitive symptoms in patients with depression who have played at least 11 years of organized tackle football.
- Trial name
- JAK DC in Play (NCT07608796)
- Testing
- Baricitinib
- Where
- 3 sites in United States
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Emory University
Anxiety Symptoms, Screen Time
Effects of Digital Detox on Mental Health in Young Adults
The goal of this clinical trial is to learn whether a short, self-guided program for cutting down smartphone screen time can reduce symptoms of depression in young adults.
- Conditions
- Anxiety Symptoms, Screen Time, Depressive Symptoms
- Trial name
- NCT07827703
- Testing
- App-based smartphone screen time restriction program
- Where
- Norway
- Volunteers
- 200 people
- Sponsor
- University of Bergen
Borderline Personality Disorder, Borderline Personality Pathology
ADEPT Psilocybin-Assisted Therapy With DBT for Borderline Personality Disorder
ADEPT is an open-label proof-of-concept study evaluating the safety and tolerability of psilocybin-assisted therapy in conjunction with Dialectical Behavior Therapy for participants with borderline personality disorder.
- Conditions
- Borderline Personality Disorder, Borderline Personality Pathology, Depressive Symptoms, Emotion Dysregulation
- Trial name
- ADEPT (NCT07833761)
- Testing
- Psilocybin, Psilocybin-Assisted Therapy With Dialectical Behavior Therapy
- Where
- 2 sites in United States
- Volunteers
- 18 people
- Sponsor
- University of Minnesota
Depressive Symptoms, Hiv
A Remotely Delivered Tai Chi/Qigong Intervention for Older People Living With HIV
The goal of this randomized clinical trial is to learn if tai chi/qigong decreases depressive symptoms among older people living with HIV compared to a health education class.
- Trial name
- NCT06586619
- Testing
- Tai chi/qigong intervention group, Health Education group
- Where
- United States
- Volunteers
- 326 people
- Sponsor
- Florida International University