Clinical trials: Depth of Anaesthesia
Airway Complication of Anesthesia, Respiratory Complications of Care
Comparison of Deep Versus Awake Tracheal Extubation in Adults
Prospective, randomized, single-blinded controlled study to compare the airway and respiratory complications of deep and awake tracheal extubations in adults.
- Trial name
- CDATE (NCT05361850)
- Testing
- Extubation
- Where
- United States
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- United States Navy
Neuromuscular Blockade
Depth of Neuromuscular Blockade and the Perioperative Conditions in Laparoscopic Surgery in Pediatric Population
This randomized study prospectively evaluates our experience with administration of cisatracurium and rocuronium antagonized by sugammadex and evaluates the effects of various depths of neuromuscular blockage on providing optimal…
- Trial name
- PedLapBlock (NCT02546843)
- Testing
- Rocuronium, Cisatracurium, Nonspecific Neuromuscular Blockade reversal
- Where
- Czechia
- Volunteers
- 66 people
- Sponsor
- Brno University Hospital
Pain Management After Surgery, Regional Anaesthesia
We Have Two Groups. Both Groups Received a Deep Serratus Anterior Plane Block. One Group Had a Catheter for Continuous Infusion, While the Other Received IV Analgesics Postoperatively. Analgesic Effects Between the Two Groups Were Compared
The aim of this observational study is to compare the analgesic efficacy of continuous infusion via peripheral catheter versus single-shot serratus anterior plane block in women aged 18 to 80 undergoing breast-conserving surgery.
- Trial name
- DSAPB (NCT07053397)
- Testing
- Serratus Anterior Plane Block (SAPB) group, DSAPB
- Where
- Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Istanbul Medeniyet University
Parkinson's Disease (PD)
A General Anesthesia Regimen for DBS Surgery in Patients With PD
Patients who meet the enrollment criteria and voluntarily join this study will be admitted to the operating room on the day of surgery, and will receive endotracheal intubation under general anesthesia.
- Trial name
- GADBS (NCT06658132)
- Testing
- 0.5~1ug/kg/min remifentanil combined with 0.2~0.5mg/kg/h esketamine for the physiological testing phase of DBS surgery.
- Where
- China
- Volunteers
- 20 people
- Sponsor
- RenJi Hospital
Retinoblastoma
Cardio-respiratory Events During Ophthalmic Artery Chemotherapy for Retinoblastoma Under a Deep Anesthesia
Background: Serious adverse cardio-respiratory events (SCRE) occur during super selective ophthalmic artery chemotherapy for retinoblastoma in children.
- Trial name
- NCT02764398
- Volunteers
- 32 people
- Sponsor
- Fondation Ophtalmologique Adolphe de Rothschild
Opioid Use
Impact of Bilateral Deep Parasternal Intercostal Plane Block on Intraoperative Opioid Consumption in Open Heart Surgery
This study aims to assess the impact of bilateral deep parasternal intercostal plane block on intraoperative opioid consumption in open heart surgery
- Trial name
- NCT05103787
- Testing
- deep parasternal intercostal plane block, control
- Where
- 2 sites in Indonesia
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Universitas Indonesia
Anesthesia Depth Monitoring, Analgesia Assessment
Target-Controlled Infusion (TCI) Effectiveness in Hysteroscopy
This prospective, randomized, observational study aims to evaluate the perioperative anesthetic efficacy of different Target-Controlled Infusion (TCI) models-specifically Minto, Schnider, and Eleveld pharmacokinetic models-in…
- Conditions
- Anesthesia Depth Monitoring, Analgesia Assessment, Perioperative Safety and Recovery, Target Controlled İnfusion
- Trial name
- NCT07023263
- Testing
- Schnider+ Mİnto, Eleveld
- Where
- Turkey (Türkiye)
- Volunteers
- 90 people
- Sponsor
- Gazi University
Neuromuscular Block
Can Adequacy of Anesthesia Depth and Quality of Recovery be Influenced by the Level of Neuromuscular Blockade?
The investigators hypothesize that an anesthetic protocol maintaining deep neuromuscular block throughout the entire surgical procedure followed by sugammadex reversal, would suppress EMG activity and result in improved…
- Trial name
- NCT02484651
- Testing
- Sugammadex, Rocuronium
- Where
- Portugal
- Volunteers
- 70 people
- Sponsor
- Centro Hospitalar do Porto
Intensive Care Unit Syndrome
Different Volatile Anaesthetics and the Depth of Long Term ICU Sedation
The MIRUS system (TIM, Andernach, Germany) as well as the AnaConDa uses a reflector to conserve volatile anaesthetics (VA). Both systems can be paired with ICU ventilators, but MIRUS features an automated control of end-tidal VA…
- Trial name
- NCT03860129
- Testing
- Isoflurane, Sevoflurane, Desflurane
- Volunteers
- 30 people
- Sponsor
- Ruhr University of Bochum
Pain
Evaluate the Depth and Duration of Anesthesia
The purpose of the study is to determine the depth (mm) of anesthesia provided by the Synera topical patch (using sensory depth and pain depth evaluations), and to determine the duration (minutes) of anesthesia provided by the…
- Trial name
- NCT00891163
- Testing
- Synera™ Topical Patch (70 mg lidocaine/70 mg tetracaine)
- Where
- United States
- Volunteers
- 25 people, healthy volunteers welcome
- Sponsor
- ZARS Pharma Inc.
Cesarean Section
Comparison of Surgical Conditions in Cesarean Section Under General Anesthesia With Deep Neuromuscular Blockade Versus Succinylcholine
Cesarean delivery under general anesthesia is one of few only surgical procedures, where the most important factor of safety is the speed of the surgery, as a newborn adaptation strongly depends on a time between induction to the…
- Trial name
- NCT01941628
- Testing
- Rocuronium, Succinylcholine
- Where
- Czechia
- Volunteers
- 91 people
- Sponsor
- Charles University, Czech Republic
Heart Disease
Assessment of Cardiac Function and Anesthesia Depth in Patients Undergoing Cardiac Surgery
The SHAPE study is a prospective, randomized study evaluating changes in cardiac function in adult patients undergoing cardiac surgery with cardiopulmonary bypass.
- Trial name
- SHAPE (NCT07770269)
- Testing
- BIS-guided anesthesia: BIS 45-55, BIS-guided anesthesia: BIS 30-35
- Where
- Greece
- Volunteers
- 70 people
- Sponsor
- AHEPA University Hospital
General Anesthesia-Induced Altered Consciousness
Brain Activity and Changes in Consciousness During General Anesthesia
This study aims to investigate how general anesthetics alter brain activity and consciousness across different age groups. The study will evaluate four anesthetic agents with different mechanisms of action: propofol, remimazolam…
- Trial name
- NCT07836205
- Testing
- Propofol (Group P), Remimazolam group, Esketamine group
- Where
- China
- Volunteers
- 320 people, healthy volunteers welcome
- Sponsor
- Beijing Chao Yang Hospital
Deep Brain Stimulation
EC50 of Anesthetics During Microelectric Recording
The investigators determine the half maximum effective concentration (EC50) of the Cet value of propofol in target-controlled infusion (TCI) when co-administered with dexmedetomidine for the maintenance of general anesthesia…
- Trial name
- NCT03213912
- Where
- Taiwan
- Volunteers
- 23 people
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Rhinoplasty, Depth of Anesthesia
Processed EEG Monitoring During Controlled Hypotension in Patients Undergoing Rhinoplasty
This prospective observational study evaluates intraoperative processed electroencephalography parameters in adult patients undergoing elective rhinoplasty under total intravenous anesthesia with controlled hypotension.
- Conditions
- Rhinoplasty, Depth of Anesthesia, Surgical Bleeding, Postoperative Recovery
- Trial name
- NCT07671781
- Where
- Turkey (Türkiye)
- Volunteers
- 64 people
- Sponsor
- Gazi University
Neuromuscular Block, Esophageal Cancer
Deep Neuromuscular Relaxation in Patients for Thoraco-laparoscopic Esophagectomy
Rationale: Endoscopic (thoraco-laparoscopic) esophageal surgery is a high risk procedure where the use of deep neuromuscular block (NMB) may increase field visibility and anaesthesia conditions.
- Conditions
- Neuromuscular Block, Esophageal Cancer, Surgery
- Trial name
- DEPTH (NCT02320734)
- Testing
- Rocuronium
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Academisch Medisch Centrum - Universiteit van Amsterdam (AMC-UvA)
Sore Throat
Effect of Intraoperative Muscle Relaxation Depth on Postoperative Sore Throat and Hoarseness After General Anesthesia
Investigators assess and compare postoperative sore throat and hoarseness in the group maintaining moderate relaxation and deep relaxation during operation.
- Trial name
- NCT03391700
- Testing
- Rocuronium(deep), Rocuronium(moderate)
- Where
- South Korea
- Volunteers
- 206 people
- Sponsor
- SMG-SNU Boramae Medical Center
Anesthesia, General
Calculated and Graphically Produced Depth of Anesthesia
There are studies that suggest that unsatisfying levels of anesthesia can cause peri- and postoperative complications in the patient undergoing surgery.
- Trial name
- NCT03807271
- Testing
- Calculated and graphically produced depth of anesthesia (Smart Pilot® View)
- Where
- Norway
- Volunteers
- 114 people
- Sponsor
- Norwegian University of Science and Technology
Double-lumen Tube, One-lung Ventilation (OLV)
The Role of Existing Formulas in the Double-lumen Tube in Thoracic Surgery Anesthesia
In most clinical scenarios, left DLT is preferred for one-lung ventilation because of its anatomical ease of placement; these tubes allow separate ventilation of both lungs.
- Conditions
- Double-lumen Tube, One-lung Ventilation (OLV), Thoracic Anesthesia
- Trial name
- NCT07191002
- Testing
- placement depth of the double lumen tube
- Where
- Turkey (Türkiye)
- Volunteers
- 30 people
- Sponsor
- Ankara Ataturk Sanatorium Training and Research Hospital
Anesthesia, Anesthesia Awareness
Pediatric Validation of CONOX Monitor During Surgery
Pediatric Validation of CONOX Monitoring device (qCON and qNOX indices) for anesthesia depth during surgery
- Conditions
- Anesthesia, Anesthesia Awareness, Nociceptive Pain, Pediatric ALL
- Trial name
- NCT04826146
- Testing
- Validation of qCON versus BIS
- Where
- 2 sites in Spain
- Volunteers
- 65 people, healthy volunteers welcome
- Sponsor
- Patricio Gonzalez Pizarro