Clinical trials: Dermal Filler
Facial Lipoatrophy (FLA)
Evaluation of HA Dermal Fillers in the Treatment of Pathological Facial Lipoatrophy
Facial lipoatrophy (FLA) refers to the loss of adipose tissue and is manifested by flattening or indentation of convex contours of the face.
- Trial name
- HAtrophy (NCT05776836)
- Testing
- Dermal filler
- Where
- 3 sites in France
- Volunteers
- 30 people
- Sponsor
- Symatese
Facial Wrinkles
Global Management of Facial Rejuvenation With a New Range of Hyaluronic Acid Dermal Fillers
The aim of this study is to assess performance and tolerance as well as investigator and subject satisfaction linked to the global management of facial rejuvenation with a new range of hyaluronic acid dermal fillers.
- Trial name
- FRESH (NCT01151436)
- Testing
- hyaluronic acid dermal fillers
- Where
- 5 sites in France, Germany
- Volunteers
- 77 people
- Sponsor
- Galderma R&D
Midface Volume Deficit
Safety and Effectiveness of Mosaic for the Treatment of Midface Volume Deficit
The goal of this clinical trial is to study whether the Mosaic Injectable Dermal Implant is a safe and effective treatment for age-related midface volume deficit in adults who are at least 22 years of age.
- Trial name
- PRIME (NCT07710443)
- Testing
- Injectable dermal implant
- Where
- 5 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Helios Aesthetics Inc.
Metatarsalgia
Volume Restoration of Plantar Pad With a Hyaluronic Acid Dermal Filler in Metatarsalgia
Aim of this study is to evaluate the decrease of plantar pain of forefeet due to restoration of plantar pad tissue density and of cushioning function with an hyaluronic acid dermal filler as mechanical-supplementation in subjects…
- Trial name
- ELFE (NCT02369380)
- Testing
- Hyaluronic acid
- Where
- France
- Volunteers
- 15 people
- Sponsor
- Galderma R&D
Lip Augmentation
New Dermal Filler for Lip Augmentation
To demonstrate non-inferiority of Kysse versus a control in lip fullness augmentation
- Trial name
- NCT03320824
- Testing
- New Dermal Filler, Device: FDA Approved Dermal Filler
- Where
- 14 sites in United States
- Volunteers
- 273 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Chin Augmentation and Correction
New Dermal Filler for Chin Correction and Augmentation
Randomized, evaluator-blinded, no treatment controlled multicenter study to evaluate safety and effectiveness of GP0109 for augmentation and correction or retrusion in the chin region in Canada
- Trial name
- NCT04631263
- Testing
- Hyaluronic Acid
- Where
- 9 sites in Canada
- Volunteers
- 140 people, healthy volunteers welcome
- Sponsor
- Galderma R&D
Infraorbital Hollows
TEOSYAL RHA® 1 for the Correction of Moderate to Severe Tissue Volume Deficiency in the Infraorbital Region in Chinese Adults
This is a prospective, multi-center, randomized, no-treatment controlled, evaluator-blinded clinical investigation to identify whether TEOSYAL RHA® 1 is superior to no treatment for the correction of moderate to severe tissue…
- Trial name
- NCT06749587
- Testing
- TEOSYAL RHA® 1
- Where
- China
- Volunteers
- 260 people, healthy volunteers welcome
- Sponsor
- Teoxane SA
Lateral Canthal Lines (LCL), Perioral Rhytids
A Non-Interventional PMCF Study Evaluating Croma Revitalis for the Correction of Fine Lines
This study will serve to collect and analyze additional data on the use of the device croma revitalis for treatment of fine lines on the face including LCL and PR in the routine practice and as "real-world" performance.
- Trial name
- RICHER (NCT07492277)
- Where
- Austria
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Croma-Pharma GmbH
Skin Aging, Skin Wrinkling
Efficacy and Performance Evaluation of mIntense L+AS 25 mg/ml Hyaluronic Acid for the Correction of Moderate to Deep Wrinkles and Folds
The investigation is a single-centre, interventional, prospective, non-randomized, open-label, uncontrolled, single-arm, un-blinded investigation for evaluation of the safety and performance of the product mIntense L+AS in the…
- Trial name
- M-INT-LS (NCT06451822)
- Testing
- mIntense L+AS
- Where
- Bulgaria
- Volunteers
- 42 people, healthy volunteers welcome
- Sponsor
- Mesoestetic Pharma Group S.L.
Perioral Lines
A Study to Assess Adverse Events and Effectiveness of Intradermally Injected JUVÉDERM® VOLITE™ Gel Filler in Adult Participants in China With Fine Lines Around the Mouth
Facial fine lines and wrinkles are caused by skin thinning, loss of moisture, and loss of elasticity due to factors such as age, ultraviolet (UV) radiation, and environmental exposures.
- Trial name
- NCT05454033
- Testing
- JUVÉDERM® VOLITE™, Control
- Where
- 11 sites in China
- Volunteers
- 198 people
- Sponsor
- AbbVie
Facial Wrinkles at the Nasolabial Folds
A Study to Compare the Safety and Effectiveness of a Non-FDA Approved Device Dermal Gel Extra (DGE) and an FDA Approved Device for the Correction of Nasolabial Folds (NLFs)
The purpose of this research study is to evaluate the safety and effectiveness of injection with DGE Injectable Gel (hyaluronic acid with lidocaine manufactured by Genzyme Biosurgery) as compared to injection with Restylane (a…
- Trial name
- NCT00444626
- Testing
- Dermal Gel Extra (DGE), Restylane, EMLA Cream
- Where
- 6 sites in United States
- Volunteers
- 140 people
- Sponsor
- Genzyme, a Sanofi Company
Nasolabial Folds
Dermal Evaluation of Facetem™ S in Nasolabial Folds Esthetics Improvement: DEFINE Study
This is a multicenter, prospective, non-randomized, uncontrolled post-market clinical follow-up (PMCF) study designed to evaluate the performance and safety of Facetem S dermal filler for the correction of moderate-to-severe…
- Trial name
- DEFINE (NCT07855224)
- Testing
- Facetem S
- Where
- 5 sites in France, Spain
- Volunteers
- 100 people
- Sponsor
- CGBio Inc.
Nasolabial Folds, Wrinkles
Real-Life Evaluation of the HA Dermal Filler ESTYME® LIFT
The objective of this post-market interventional study is to confirm, under real-life conditions, the safety and performance of a hyaluronic acid-based dermal filler intended for the aesthetic correction of nasolabial folds.
- Trial name
- NCT07385053
- Testing
- Injection of the Hyaluronic Acid-Based Dermal Filler ESTYME® LIFT (Now Marketed as ESTYME® FORM).
- Where
- 3 sites in France
- Volunteers
- 96 people, healthy volunteers welcome
- Sponsor
- Symatese
Nasolabial Folds
Radiesse® Injectable Dermal Filler for the Treatment of Nasolabial Folds in Persons of Color
Post marketing study to assess the likelihood of hypertropic scarring, keloid formation and hyper- or hypopigmentation in patients with Fitzpatrick Skin Types IV, V, and VI receiving nasolabial fold treatment with Radiesse®…
- Trial name
- NCT01012388
- Testing
- Radiesse® Injectable Dermal Filler
- Where
- 5 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Merz North America, Inc.
Skin Folds, Wrinkle
Clinical Investigation to Assess Safety and Performance of Dermal Filler of Hyaluronic Acid
The objective of this clinical investigation is to assess the safety and performance of dermal filler of hyaluronic acid to provide firmness and counteract sagging for the correction of deep wrinkles and imperfections in the…
- Trial name
- NCT05450380
- Testing
- LIFT001
- Where
- 2 sites in Spain
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Mesoestetic Pharma Group S.L.
Lip; Anomaly
THIODERM ELATE for Volume Augmentation in Lips
A pivotal, randomized, subject- and evaluator-blinded, controlled, non-inferiority, multicenter, parallel group comparison study to evaluate effectiveness and safety of THIODERM ELATE for lip augmentation in order to correct lip…
- Trial name
- TIVOLI (NCT06133153)
- Testing
- THIODERM ELATE, Juvéderm Ultra 3
- Where
- Austria
- Sponsor
- Croma-Pharma GmbH
Aging, Skin Wrinkling
Safety and Effectiveness of STYLAGE® L for Correction of Moderate and Severe Nasolabial Folds in Chinese Adults
This is a safety and efficacy study of STYLAGE® Lin Chinese adults with Nasolabial Folds.
- Trial name
- NCT04861766
- Testing
- STYLAGE® L, Active Comparator
- Where
- 8 sites in China
- Volunteers
- 390 people, healthy volunteers welcome
- Sponsor
- Laboratoires Vivacy
Healthy Male and Female Subjects
Histological Analysis of CelluJuve® Injections in the Brachium
Single-center, exploratory study assessing the safety and histological presentation of CelluJuve® injected into the brachium of healthy volunteers
- Trial name
- NCT06930209
- Testing
- CelluJuve®
- Where
- Canada
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Spiderwort Biotechnologies Inc.
Wrinkles
Safety Study of Cosmetic Tissue Augmentation in People of Color
Elevess is intended for all skin types. However, further study of all soft tissue fillers is needed in people of color because of the increasing use of cosmetic dermal filler products.
- Trial name
- NCT01147172
- Testing
- Elevess
- Where
- 9 sites in United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Anika Therapeutics, Inc.
Wrinkle, Nasolabial Fold
RHA® 4 NLF Cannula
This is a randomized, controlled, single-blinded, within-subject (split-face), multicenter, prospective study to investigate whether RHA®4 injected in NLFs with a cannula is non-inferior to RHA®4 injected in NLFs with a sharp…
- Conditions
- Wrinkle, Nasolabial Fold, Aging
- Trial name
- NCT04754646
- Testing
- Split-face injection of RHA® 4 with a cannula into a single NLF., Split-face injection of RHA® 4 with a needle (TSK 27G x ½") into the contralateral NLF.
- Where
- 4 sites in United States
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Teoxane SA