Clinical trials: Dermatologic Conditions
Surgical Site Infections
PHMB-based Antiseptic Use in Full-thickness Surgical Wounds
To study the effect of applying a PHMB-based antiseptic solution to tie-over dressings in full-thickness surgical wounds in dermatologic surgery in order to minimise the development of surgical site infections.
- Trial name
- NCT02253069
- Testing
- Applying Prontosan antiseptic solution to tie-over dressings
- Where
- Sweden
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Region Skane
Procedural Anxiety, Procedural Pain
VR-PAT for Pain and Anxiety Management During Pediatric Dermatologic Laser Procedures
This study will assess the feasibility and efficacy of our Virtual Reality Pain Alleviation Therapy (VR-PAT) for pain management during pediatric and young adult outpatient laser procedures and evaluate the impact of VR use on…
- Trial name
- NCT05645224
- Testing
- VR-PAT
- Where
- United States
- Volunteers
- 65 people
- Sponsor
- Nationwide Children's Hospital
Type 2 Diabetes Mellitus
Examination of Dermatologic Effects From Subcutaneous Injections of ISIS 113715
10 healthy volunteers will be enrolled to each receive two subcutaneous injections of ISIS 113715 in the abdomen on Study Day 1. Each subject will receive their two injections within a 5-minute period.
- Trial name
- NCT00365781
- Testing
- ISIS 113715
- Where
- United States
- Volunteers
- 10 people, healthy volunteers welcome
- Sponsor
- Ionis Pharmaceuticals, Inc.
Inflammatory Disease, Immune System Disorder
Cross-condition Validation of the Steroid PRO
Testing a questionnaire about treatment with steroids for skin, lung or gastric conditions
- Conditions
- Inflammatory Disease, Immune System Disorder, Gastrointestinal Diseases, Dermatologic Disease
- Trial name
- NCT06314451
- Testing
- Cognitive Interview
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of the West of England
Suture, Dermatologic Surgery
Aesthetic Outcome of Running Cuticular Suture Distance (2mm vs 5mm)
It is standard teaching that the top layer of sutures should be placed 3-5mm from the wound edge. However, there is lack of data regarding the most optimal placement of sutures from the wound edge for the best cosmetic outcome.
- Conditions
- Suture, Dermatologic Surgery, Scar, Cosmetic Outcome
- Trial name
- NCT04870008
- Testing
- Suture
- Where
- United States
- Volunteers
- 50 people
- Sponsor
- University of California, Davis
Pain, Anxiety
Music and Local Anesthesia During Dermatologic Procedures
The goal of the study is to determine the effect of classical music on participants pain and anxiety associated with lidocaine administration during routine standard of care dermatologic procedures.
- Trial name
- NCT04317170
- Testing
- Music
- Where
- United States
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Washington University School of Medicine
Psoriasis
A 36-Week Extension to Protocol ISA04-03
The purpose of this study is to determine the safety and efficacy of voclosporin in patients with plaque psoriasis.
- Trial name
- SPIRIT (NCT00258713)
- Testing
- voclosporin
- Where
- 29 sites in Canada
- Volunteers
- 309 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Alopecia Areata (AA)
A Study to Evaluate the Safety, Pharmacokinetics and Efficacy of IMG-007 in Adult Alopecia Areata Participants
The primary objective of the study is to evaluate the safety of IMG-007 in adults with Alopecia Areata.
- Trial name
- NCT06060977
- Testing
- IMG-007
- Where
- 17 sites in United States, Canada
- Volunteers
- 29 people
- Sponsor
- Inmagene LLC
Psoriasis
Randomized, Placebo and Ciclosporin Controlled Study of ISA247 in Plaque Psoriasis Patients
The purpose of this study is to determine the safety and efficacy of voclosporin in patients with plaque psoriasis.
- Trial name
- ESSENCE (NCT00408187)
- Testing
- voclosporin, Ciclosporin
- Where
- 49 sites in Canada, Germany and 1 more
- Volunteers
- 642 people
- Sponsor
- Aurinia Pharmaceuticals Inc.
Shwachman Syndrome, Fanconi's Anemia
Phase II Pilot Study of Granulocyte Colony-Stimulating Factor for Inherited Bone Marrow Failure Syndromes
OBJECTIVES: I. Assess the efficacy of recombinant human granulocyte colony-stimulating factor (G-CSF) in raising the absolute neutrophil count, platelet count, and hemoglobin level in patients with inherited bone marrow failure…
- Conditions
- Shwachman Syndrome, Fanconi's Anemia, Dyskeratosis Congenita, Thrombocytopenia
- Trial name
- NCT00004787
- Testing
- filgrastim
- Volunteers
- 20 people
- Sponsor
- National Center for Research Resources (NCRR)
Actinic Keratosis, Keratosis, Actinic
Study to Evaluate Safety and Tolerability of BF-200 ALA (Ameluz®) for Photodynamic Therapy in the Treatment of the Expanded Field of Actinic Keratosis on Face and Scalp
The aim of the study is to evaluate the safety and tolerability of PDT for treatment of mild to severe actinic keratosis on the face and scalp in the expanded treatment field using 3 tubes of BF-200 ALA 10% gel (Ameluz®) in…
- Conditions
- Actinic Keratosis, Keratosis, Actinic, Keratosis
- Trial name
- NCT05060237
- Testing
- BF-200 ALA and red light LED lamp
- Where
- 9 sites in United States
- Volunteers
- 112 people
- Sponsor
- Biofrontera Bioscience GmbH
Skin Ulcers, Sickle Cell Anemia
Phase II Randomized Trial:Arginine Butyrate Plus Standard Local Therapy in Patients With Refractory Sickle Cell Ulcers
OBJECTIVES: I. Compare the efficacy of local care alone vs local care plus arginine butyrate in terms of healing rate in patients with refractory sickle cell ulcers. II.
- Trial name
- NCT00004412
- Testing
- Arginine Butyrate, Standard local care dressing
- Where
- 4 sites in United States
- Volunteers
- 23 people
- Sponsor
- Susan P. Perrine
Psoriasis
Study of Topical Calcitriol or Oral Calcitriol in Patients With Psoriasis
OBJECTIVES: I. Evaluate the long term safety and efficacy of orally administered calcitriol in patients with at least 5% of their body covered with psoriasis. II.
- Trial name
- NCT00004468
- Testing
- calcitriol
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Ichthyosis
Phase III Study of Monolaurin Cream Therapy for Patients With Congenital Ichthyosis
OBJECTIVES: I. Compare the safety and efficacy of monolaurin cream versus a placebo vehicle cream in suppressing the signs of nonbullous congenital ichthyosiform erythroderma. II.
- Trial name
- NCT00004690
- Testing
- monolaurin cream
- Volunteers
- 90 people
- Sponsor
- Cellegy Pharmaceuticals
Pain, Phlebotomy
Synera Venipuncture Pain
Synera, which is a heated topical patch containing both lidocaine and tetracaine, is intended to reduce the pain associated with venipuncture and superficial dermatologic procedures by numbing the skin.
- Conditions
- Pain, Phlebotomy, Palliative Care
- Trial name
- NCT01744197
- Testing
- Synera (lidocaine 70mg/tetracaine 70mg)
- Where
- United States
- Volunteers
- 61 people
- Sponsor
- US Oncology Research
Body Image, Psychological Distress
Testing a Body-functionality Intervention for Body Image in Individuals With Skin Conditions
'Expand Your Horizons', a self-help writing intervention that seeks to train individuals to focus on what their body can do (functionality) rather than what it looks like (appearance), has produced promising results in improving…
- Conditions
- Body Image, Psychological Distress, Dermatologic Disease, Quality of Life
- Trial name
- NCT04445974
- Testing
- Expand your horizons: More than my skin, Creative writing activities
- Where
- United Kingdom
- Volunteers
- 454 people
- Sponsor
- University of Sheffield
Hyperhidrosis
Study of Botulinum Toxin in Patients With Primary Hyperhidrosis
OBJECTIVES: I. Determine the optimal dose of botulinum toxin necessary to decrease sweating in patients with primary hyperhidrosis.
- Trial name
- NCT00004480
- Testing
- botulinum toxin type A
- Where
- United States
- Sponsor
- Icahn School of Medicine at Mount Sinai
Cancer, Dermatologic Conditions
Quality of Life (QoL) Assessment in Cancer Patients and Survivors With Dermatologic Conditions Using Dermatologic QoL Instruments
The purpose of this study is to see how skin conditions that are related to different kinds of cancer or cancer treatments affect a patient's overall well-being. Skin conditions are common in cancer patients and survivors.
- Trial name
- NCT02296450
- Testing
- Quality of Life (QoL) Assessment
- Where
- 4 sites in United States
- Volunteers
- 839 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Sleep Disorder
Sleep Disturbances in Dermatology Patients
This study is to investigate sleep disorders in patients with dermatologic diseases by taking into consideration dermatologic (itch, pain) and non- dermatologic (medication, depression) factors.
- Trial name
- NCT03903263
- Testing
- survey on sleep disorders
- Where
- Switzerland
- Volunteers
- 624 people
- Sponsor
- University Hospital, Basel, Switzerland
Psoriasis
Study of Topical Calcitriol in Children With Psoriasis
OBJECTIVES: I. Determine the therapeutic efficacy and safety of topical calcitriol in children with psoriasis.
- Trial name
- NCT00006275
- Testing
- calcitriol
- Volunteers
- 20 people
- Sponsor
- National Center for Research Resources (NCRR)