Clinical trials: Dermatologic Diseases
Breast Neoplasms
A Study to Evaluate Denosumab in Young Patients With Primary Breast Cancer
This is a prospective, single arm phase IIa trial in which patients with early breast cancer will receive pre-operatively two doses of denosumab 120mg subcutaneously one week apart (maximum 12 days) followed by surgery.
- Trial name
- D-Beyond (NCT01864798)
- Testing
- Denosumab
- Where
- 6 sites in Australia, Belgium
- Volunteers
- 27 people
- Sponsor
- Jules Bordet Institute
Psoriasis
Safety and Efficacy of Topically Applied CTA018 in Plaque Psoriasis
Vitamin D and its analogs are currently widely used for the treatment of psoriasis. The study drug (CTA018) is a novel analog of vitamin D, and this Phase 2 study will investigate the efficacy and safety of CTA018 in the…
- Trial name
- NCT00384098
- Testing
- CTA018 cream
- Where
- 16 sites in United States
- Volunteers
- 140 people
- Sponsor
- OPKO Health, Inc.
Respiratory Tract Infections, Infections
Non-specific Effects of a Modified Measles Vaccination Schedule to Prevent Allergy and Unrelated Infection in Children
The goal of this clinical trial is to evaluate the off-target/non-specific effects of the measles-mumps-rubella (MMR) vaccine in children.
- Conditions
- Respiratory Tract Infections, Infections, Allergy, Eczema
- Trial name
- NEMAU (NCT05758532)
- Testing
- Measles-Mumps-Rubella vaccine (MMR)
- Where
- Switzerland
- Volunteers
- 500 people, healthy volunteers welcome
- Sponsor
- Laure Pittet, MD-PhD
Diabetic Foot Ulcers, Venous Stasis Ulcer
Negative Pressure Wound Therapy Registry
The goal of the Negative Pressure Wound Therapy Registry (NPWTR) for Wounds is to provide real world patient data from electronic health records submitted to meet Stage 2 Meaningful Use in order to understand the effectiveness…
- Conditions
- Diabetic Foot Ulcers, Venous Stasis Ulcer, Pressure Ulcer, Surgical Wound Dehiscence
- Trial name
- NPWTR (NCT02467998)
- Testing
- NPWT
- Where
- United States
- Volunteers
- 50,000 people
- Sponsor
- U.S. Wound Registry
HIV Infections
Endothelial Dysfunction as a Risk Factor in HIV Study
Highly active antiretroviral therapy (HAART) has proven effective in altering the natural history of HIV infection in many patients. However, this therapy may not be sustainable because of the toxicities of the medications.
- Trial name
- NCT00039663
- Testing
- Pravastatin, Gemfibrozil, Rosiglitazone
- Where
- United States
- Volunteers
- 75 people
- Sponsor
- National Institutes of Health Clinical Center (CC)
Pressure Ulcer, Wounds
Wound Powder for Pressure Ulcers at End-of-life
This study will test a special powder for ulcers caused by a variety of conditions such as pressure that sometimes happen when a person is at the end of life.
- Trial name
- RGN107 (NCT02008487)
- Testing
- Wound powder application
- Where
- 3 sites in United States
- Volunteers
- 50 people
- Sponsor
- Medical University of South Carolina
Breast Cancer, Heart Failure
CardioPROTECTion with Dapagliflozin in Breast Cancer Patients Treated with AnthrAcycline - PROTECTAA TRIAL
The purpose of this study is to evaluate the effect of dapagliflozin on the incidence of cancer therapeutics-related cardiac dysfunction in patients with breast cancer receiving anthracycline treatment.
- Trial name
- PROTECTAA (NCT06304857)
- Testing
- Dapagliflozin
- Where
- 3 sites in Poland
- Volunteers
- 188 people
- Sponsor
- 4th Military Clinical Hospital with Polyclinic, Poland
Dermatitis, Atopic
Systemic Therapies for Pediatric Atopic Dermatitis
While many patients with atopic dermatitis (eczema) can be managed with topical creams and treatments for itch, some children have such severe, long-standing disease that they need treatment with oral medications that decrease…
- Trial name
- NCT01447381
- Where
- 3 sites in United States
- Volunteers
- 250 people
- Sponsor
- Rady Children's Hospital, San Diego
Breast Cancer, Iron Chelation
Ketotifen: as a Cardioprotective Agent in Breast Cancer Patients Receiving Anthracycline-containing Chemotherapy
The objective of our study was to evaluate the expected cardioprotective effects of ketotifen due to its activity as an iron-chelating agent previously uncovered by us in the in vitro chemical test which included in the study…
- Trial name
- NCT04435028
- Testing
- Ketotifen 1 MG
- Where
- Egypt
- Volunteers
- 111 people
- Sponsor
- Horus University
External Genital Warts
Efficacy and Tolerability of Topical LFX453 for External Genital Warts
The LFX453X2202 study tested the investigational drug LFX453 against placebo for safety, tolerability, and efficacy in treating genital warts in circumcised men, in parallel with an additional open label arm using imiquimod 5%.
- Trial name
- NCT02482428
- Testing
- Investigational Treatment, Aldara
- Where
- United States
- Volunteers
- 88 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer, Advanced Solid Tumor
An Investigational Study of BG-75202 Alone and in Combination With Other Therapeutic Agents in Adults With Advanced Solid Tumors
The purpose of this study is to evaluate the safety, tolerability, pharmacokinetics (PK), pharmacodynamics, and preliminary antitumor activity of BG-75202 (KAT6A/B inhibitor) alone and in combination with other therapies in…
- Trial name
- NCT07222267
- Testing
- BG-75202, CDK4 Inhibitor, Estrogen Receptor Antagonist
- Where
- 32 sites in United States, Australia and 4 more
- Volunteers
- 86 people
- Sponsor
- BeOne Medicines
Breast Cancer
Trial of RAD001 in Triple Negative Metastatic Breast Cancer
The hypothesis of this clinical research study is to discover if the study drug RAD001 can shrink or slow the growth of Estrogen Receptor/Progesterone Receptor (ER/PR) negative or Human Epidermal growth factor Receptor 2 (Her2…
- Trial name
- NCT00827567
- Testing
- RAD 001
- Where
- United States
- Volunteers
- 6 people
- Sponsor
- Milton S. Hershey Medical Center
Fluid Loss, Symptom Complex, Triple
Saline vs. Lactated Ringers for Emergency Department IV Fluid Resuscitation
Administration of intravascular (IV) fluid is the most common emergency department (ED) procedure. IV fluids are integral to increasing effective blood volume and ensuring organ perfusion in patients with volume depletion and…
- Conditions
- Fluid Loss, Symptom Complex, Triple, Emergencies
- Trial name
- NCT03133767
- Testing
- Lactated Ringer Solution, Normal Saline 0.9% Infusion Solution Bag
- Where
- United States
- Volunteers
- 157 people
- Sponsor
- Nicholas M Mohr
Melanoma (Skin)
Vaccine Therapy in Treating Patients With Metastatic Melanoma
RATIONALE: Vaccines made from a person's white blood cells and melanoma cells may make the body build an immune response and kill tumor cells.
- Trial name
- NCT00003792
- Testing
- MART-1 antigen, filgrastim, flu matrix peptide p58-66
- Where
- United States
- Sponsor
- Baylor Health Care System
ATOPIC DERMATITIS
Evaluation of A-1 Cool Cream Efficacy for Treatment Atopic Dermatitis
Atopic dermatitis (AD) is a chronic inflammatory skin disease, affecting 20% of all babies and children around the world. Diagnosis of atopic dermatitis is clinical and depends on the existence of at least two out of the four…
- Trial name
- NCT01174511
- Testing
- A -1 Cool Cream,Vaselin ointment
- Volunteers
- 30 people
- Sponsor
- Hadassah Medical Organization
Breast Cancer, Image Guided Biopsy
In Vivo Smart Biopsy Device Protocol In Radiology
This study is designed to demonstrate the feasibility of use of the Smart Biopsy Device in real clinical settings.
- Trial name
- NCT03914911
- Testing
- Smart Biopsy Device
- Where
- 2 sites in Israel
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Dune Medical Devices
Breast Cancer
Autotaxin: a Potential Biomarker for Breast Cancer.
The goal of this clinical trial is to test the efficiency of Autotaxin (ATX) as a biomarker for breast cancer patients. The main questions it aims to answer are; is ATX a reliable tumor marker for breast cancer patients in…
- Trial name
- NCT05680311
- Testing
- measurement of serum autotaxin serum level
- Where
- Turkey (Türkiye)
- Volunteers
- 110 people, healthy volunteers welcome
- Sponsor
- Ankara Etlik City Hospital
Cutaneous Leishmaniasis
Thermotherapy + a Short Course of Miltefosine for the Treatment of Uncomplicated Cutaneous Leishmaniasis in the New World¨
The purpose of this trial is to determine the efficacy and safety of a combined therapy using thermotherapy (TT) (one session, 50 degrees Celsius for 30") + miltefosine at a standard dose of 2.5 mg/kg/day for 21 days for the…
- Trial name
- NCT02687971
- Testing
- Miltefosine
- Where
- 2 sites in Colombia, Peru
- Volunteers
- 130 people
- Sponsor
- Drugs for Neglected Diseases
Ulcer, Acral Nevus
Effectiveness of the EmoLED Medical Device in the Healing of Digital Ulcers in Patients With Scleroderma.
The present clinical study aims to compare, in the two groups of patients with acral ulcers, the reparative process of the injured area, the evaluation of the healing time (with "healing" interpreted as the complete…
- Conditions
- Ulcer, Acral Nevus, Scleroderma, Digital Ulcer
- Trial name
- SUITABLE (NCT05181644)
- Testing
- EmoLED treatment, current Standard of Care
- Where
- Italy
- Volunteers
- 36 people
- Sponsor
- Emoled
Breast Cancer
Evaluating the Effects of Genetic Testing on Patients' Stress Levels
This prospective Medical College of Wisconsin Cancer Center study will evaluate stress levels in breast cancer patients undergoing genetic testing.
- Trial name
- NCT02783664
- Testing
- Questionnaires to Evaluate Anxiety Related to Genetic Testing
- Where
- United States
- Volunteers
- 164 people
- Sponsor
- Medical College of Wisconsin
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