Clinical trials: Dermatologic Diseases
Hirsutism
Treatment With Topical Eflornithin After Laser Treatment in Women With Facial Hirsutism
Split-face investigation of the efficacy of applying Eflornithin cream twice daily for six months after a period with six laser treatments for hair removal.
- Trial name
- NCT01817894
- Testing
- Eflornithine cream 11.5 w/w %
- Where
- Denmark
- Volunteers
- 22 people
- Sponsor
- Bispebjerg Hospital
Melanoma
Neoadjuvant Combination Therapy With Ipilimumab and HighDose IFN-α2b for Melanoma
The purpose of this study is to evaluate the safety and potential effectiveness of a new treatment for advanced and recurrent melanoma involving the combination of Ipilimumab and IFN-α2b before surgery and to test for biomarker…
- Trial name
- NCT01608594
- Testing
- administration of ipilimumab10mg/kg, administration of ipilimumab 3mg/kg + HDI
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Diwakar Davar
Breast Cancer, Prostate Cancer
Holistic Acupuncture for Patients With Chemotherapy Induced Nausea
The study explores whether acupuncture as a supplement to conventional antiemetic medicine is superior in reducing the level of chemotherapy induced nausea compared to conventional anitemetic medicine alone.
- Conditions
- Breast Cancer, Prostate Cancer, Lung Cancer, Gynaecologic Cancer
- Trial name
- NCT07201194
- Testing
- Holistic acupuncture and acupressure, Standard medical treatment
- Where
- Denmark
- Volunteers
- 90 people
- Sponsor
- Vejle Hospital
Breast Cancer, Breast Reconstruction
Immediate Autologous Tissue Breast Reconstruction and Radiotherapy Strategy After Breast Cancer Surgery
This is a prospective, open-label, controlled clinical trial aiming to investigate the optimal sequencing strategy between immediate autologous tissue breast reconstruction and radiotherapy in breast cancer patients.
- Conditions
- Breast Cancer, Breast Reconstruction, Radiotherapy
- Trial name
- NCT07798466
- Testing
- Immediate DIEP flap breast reconstruction, Hypofractionated radiotherapy
- Where
- China
- Volunteers
- 128 people
- Sponsor
- Fudan University
Cancer, Breast, Cancer of Colon
Motivational Interviewing to Increase Physical Activity Behaviour in Cancer Patients
Physical activity is not only efficient for primary prevention of several cancer types, but it also plays an important role in cancer survivors.
- Conditions
- Cancer, Breast, Cancer of Colon, Endometrial Cancer
- Trial name
- MIPAClux (NCT03210129)
- Testing
- Motivational interviewing
- Where
- Luxembourg
- Volunteers
- 25 people
- Sponsor
- Luxembourg Institute of Health
Neoplasm, Breast, Heart Failure
Breast Cancer Long-term Outcomes on Cardiac Functioning: a Longitudinal Study
Rationale: In addition to surgery, effective breast cancer (BC) treatment typically requires chemotherapy, radiotherapy, or both.
- Conditions
- Neoplasm, Breast, Heart Failure, Cardiotoxicity, Ventricular Dysfunction
- Trial name
- BLOC-II (NCT05851053)
- Testing
- Echocardiography
- Where
- Netherlands
- Volunteers
- 455 people, healthy volunteers welcome
- Sponsor
- University Medical Center Groningen
Breast Cancer, Chemotherapy
ALND vs ART in Positive Sentinel Node After Neoadjuvant Therapy in Breast Cancer
In the case of primary surgery, in patients with sentinel node involvement, it has already been shown that omitting axillary lymph node dissection (ALND), often combining axillary radiotherapy (RT), does not worsen the prognosis…
- Conditions
- Breast Cancer, Chemotherapy, Sentinel Lymph Node, Axillary Lymph Nodes Dissection
- Trial name
- ADARNAT (NCT04889924)
- Testing
- Axillary Radiotherapy, Lymphadenectomy
- Where
- 61 sites in Australia, Spain
- Volunteers
- 820 people
- Sponsor
- Hospital Universitari de Bellvitge
Breast Cancer
An Enhanced Artificial Intelligence Breast MRI Interpretation System
Interpretation of breast MR images is a very time-consuming process and places a great burden on breast radiologists. This project aims to develop a technical solution that addresses this healthcare challenge by developing a…
- Trial name
- IntelliScan (NCT03829423)
- Testing
- Breast MRI interpretation
- Volunteers
- 1,526 people
- Sponsor
- Jamil Kanfoud
Breast Cancer, Estrogen Receptor-positive Breast Cancer
Biology Guided Therapy for Breast Cancer for ER Positive
There are several approved and guideline-recommended treatments for metastatic, estrogen receptor-positive breast cancer that has progressed on an aromatase inhibitor and a CDK4/6 inhibitor.
- Conditions
- Breast Cancer, Estrogen Receptor-positive Breast Cancer, HER2-negative Breast Cancer
- Trial name
- SPOCK (NCT04965688)
- Testing
- Biopsy-Guided Therapy Selection
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Inova Health Care Services
HER2-positive Breast Cancer, Early Breast Cancer (EBC)
SHR-A1811 Versus Trastuzumab Plus Pertuzumab in ctDNA-Positive HER2-Positive Early Breast Cancer After Pathologic Complete Response
This investigator-initiated, single-center, randomized, open-label, phase II trial will evaluate the efficacy and safety of intensified adjuvant SHR-A1811 compared with trastuzumab plus pertuzumab in women with initially stage…
- Trial name
- NCT07856303
- Testing
- SHR-A1811, Trastuzumab, Pertuzumab
- Where
- China
- Volunteers
- 358 people
- Sponsor
- Fudan University
Breast Cancer, Gastric Cancer
NK Cell Infusions With Trastuzumab for Patients With HER2+ Breast and Gastric Cancer
This study will determine the safety and efficacy of expanded activated autologous NK cells administered after Trastuzumab in patients with HER2-positive breast or gastric cancer.
- Trial name
- NCT02030561
- Testing
- Trastuzumab + NK cells
- Where
- 2 sites in Singapore
- Volunteers
- 29 people
- Sponsor
- National University Hospital, Singapore
Interdigital Tinea Pedis
Clinical Equivalence of Two Generic Butenafine Hydrochloride 1% Creams as Compared to Lotrimin Ultra Cream in Patients With Interdigital Tinea Pedis
To demonstrate comparable safety and efficacy of Taro Pharmaceuticals, Inc butenafine hydrochloride cream 1% test product and Lotrimin Ultra cream (reference listed drug) in the treatment of interdigital tinea pedis, and to show…
- Trial name
- BNF-0909 (NCT01119742)
- Testing
- Butenafine Hydrochloride 1%, Butenafine Hydrochloride 1% B, Vehicle A
- Volunteers
- 428 people
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Systemic Sclerosis, Raynaud Disease
Phase III Randomized, Double-Blind, Placebo-Controlled Study of Oral Iloprost for Raynaud's Phenomenon Secondary to Systemic Sclerosis
OBJECTIVES: I. Evaluate the safety and efficacy of oral iloprost, a prostacyclin analog, in patients with Raynaud's phenomenon secondary to systemic sclerosis.
- Trial name
- NCT00004786
- Testing
- iloprost
- Volunteers
- 200 people
- Sponsor
- National Center for Research Resources (NCRR)
Metastatic Uveal Melanoma, Metastatic Cutaneous Melanoma
Hepatic Arterial Infusion of Autologous Tumor Infiltrating Lymphocytes in Patients With Melanoma and Liver Metastases
The purpose of this study is to evaluate the feasibility, safety and tolerability of treatment with autologous tumor infiltrating lymphocytes (TIL) administered via hepatic arterial infusion in patients with liver metastases…
- Trial name
- HAITILS (NCT04812470)
- Testing
- Autologous Tumor Infiltrating Lymphocytes, Melphalan, Interleukin-2
- Where
- Sweden
- Volunteers
- 8 people
- Sponsor
- Vastra Gotaland Region
Triple Negative Breast Cancer, Neoadjuvant Immunotherapy
Observational Study on the Sensitivity of Neoadjuvant Immunotherapy in Early Triple-Negative Breast Cancer
Studies have reported that tumors with the same immunogenic mutations may induce T cell receptor (TCR) domains with similar antigen recognition functions.
- Conditions
- Triple Negative Breast Cancer, Neoadjuvant Immunotherapy, Sensitivity
- Trial name
- NCT06448169
- Testing
- PD-1 inhibitor
- Volunteers
- 200 people
- Sponsor
- Shandong University
Behcet Syndrome
Assessment of Disease Activity in Behcet by Complete Blood Count
To determine platelet to lymphocyte ratio (PLR), lymphocytes to monocytes ratio (LMR), mean platelet volume (MPV) and neutrophile lymphocyte ratio (NLR), levels in Behçet's disease (BD) To investigate their correlation with…
- Trial name
- NCT03747354
- Testing
- blood samples
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Breast Neoplasms
Pilot Study of Bisphosphonates for Breast Cancer
The goal of this study is to mechanistically define the potential anticancer activities of the osteoporosis bisphosphonate (BP) drug alendronate, and extend the analysis to learn novel information about the impact of BP on gamma…
- Trial name
- NCT02781805
- Testing
- Alendronate
- Where
- United States
- Volunteers
- 6 people, healthy volunteers welcome
- Sponsor
- University of Wisconsin, Madison
Melasma
Comparison of Intralesional Tranexamic Acid and Platelets Rich Plasma in the Treatment of Melasma
ABSTRACT Objective: To study the efficacy while comparing Intralesional tranexamic acid Vs Platelets rich plasma (PRP) in treatment of Melasma. Study design: Randomized-controlled trial (RCT).
- Trial name
- NCT05884151
- Testing
- Tranexamic acid, Platelets rich plasma
- Where
- 3 sites in Pakistan
- Volunteers
- 60 people
- Sponsor
- Combined Military Hospital Abbottabad
Breast Cancer
IMPACT Trial: Intervention to iMProve AdherenCe Equitably
To determine the efficacy of a multicomponent adherence intervention among participants with early-stage breast cancer on endocrine therapy and at least one oral cardiovascular disease (CVD) medication on adherence to endocrine…
- Trial name
- NCT05496829
- Testing
- Multicomponent Adherence Intervention, Usual Care
- Where
- United States
- Volunteers
- 350 people
- Sponsor
- Columbia University
Epidermolysis Bullosa
Phase I Study of Isotretinoin in Patients With Recessive Dystrophic Epidermolysis Bullosa
OBJECTIVES: I. Determine the safety of isotretinoin in patients with recessive dystrophic epidermolysis bullosa.
- Trial name
- NCT00014729
- Testing
- isotretinoin
- Volunteers
- 20 people
- Sponsor
- University of North Carolina
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