Clinical trials: Dermatologic Diseases
Dermatitis, Atopic
An Efficacy and Safety Study of Tacrolimus Ointment in Pediatric Participants With Atopic Dermatitis
The purpose of this study is to evaluate the safety and efficacy of tacrolimus ointment in treating the signs and symptoms of moderate (medium level of seriousness) to severe (very serious, life threatening) atopic dermatitis (an…
- Trial name
- NCT01782729
- Testing
- Tacrolimus
- Where
- Vietnam
- Volunteers
- 30 people
- Sponsor
- Janssen-Cilag Ltd.,Thailand
Metastatic Melanoma
Long-term Data Collection for Subjects in MDX-010 Studies
The objective of this study is to collect disease status and overall survival information for all Subjects in MDX-010 studies.
- Trial name
- MDX010-28 (NCT00928031)
- Where
- 11 sites in United States
- Volunteers
- 160 people
- Sponsor
- Bristol-Myers Squibb
Melanoma
Nuclear and Near-Infrared (NIR) Imaging in Melanoma
Objectives: 1. To determine the feasibility of using microdose amounts of near-infrared (NIR) fluorescent contrast agent to image tumor-draining and contralateral lymphatics in melanoma patients prior to standard-of-care sentinel…
- Trial name
- NCT01295931
- Testing
- Indocyanine Green (IC-Green), Imaging
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- M.D. Anderson Cancer Center
Osteoporosis, Breast Cancer
Bone Health Management for Women Diagnosed With Breast Cancer
The purpose of this study is to test the feasibility of the study protocol. The study protocol was designed to evaluate questions - "Do educational materials improve dual x-ray absorptiometry (DXA) screening rates for women…
- Trial name
- NCT02484131
- Testing
- Educational materials/mail, Educational materials/participant choice
- Where
- Canada
- Volunteers
- 54 people
- Sponsor
- University of British Columbia
Breast Neoplasms, Recurrence
Prevention of Breast Cancer Recurrence Through Weight Control, Diet, and Physical Activity Intervention
The main purpose of our study is to assess the effect of a lifestyle intervention combining weight control, diet and physical activity on the risk of recurrences among breast cancer patients with non-metastatic tumours in terms…
- Trial name
- PREDICOP (NCT02035631)
- Testing
- Diet, Physical activity, Minimal diet intervention
- Where
- 5 sites in Spain
- Volunteers
- 2,000 people
- Sponsor
- Institut Català d'Oncologia
Melanoma
Combined Treatment of Sorafenib and Pegylated Interferon α2b in Stage IV Metastatic Melanoma
To evaluate the efficacy and safety of a combined treatment with Sorafenib (Nexavar®) and pegylated interferon-α-2b (PegIntron®) in patients with malignant melanoma in stage IV.
- Trial name
- SoraPeg (NCT00623402)
- Testing
- Sorafenib, pegylated interferon α-2b
- Where
- 10 sites in Germany
- Volunteers
- 55 people
- Sponsor
- University Hospital Schleswig-Holstein
Breast Cancer
Bioequivalency Study of Anastrozole 1 mg Under Fasted Conditions
The objective of this study was to prove the bioequivalence of Anastrozole Tablet under fasted conditions.
- Trial name
- NCT01155102
- Testing
- Anastrozole
- Where
- United States
- Volunteers
- 31 people, healthy volunteers welcome
- Sponsor
- Roxane Laboratories
Diabetes Foot Care
Therapeutic Effect of Electroacupuncture at Zusanli (ST-36) on Diabetic Foot Wounds
The goal of this clinical trial is to learn if electroacupuncture at the Zusanli (ST-36) can assist in the treatment of diabetic foot ulcers.
- Trial name
- EA for DFU (NCT07482137)
- Testing
- Electroacupuncture at Zusanli (ST-36)
- Where
- China
- Volunteers
- 76 people
- Sponsor
- Zhongda Hospital
Acute Biphenotypic Leukemia, Acute Leukemia
Depletion of CD45RA Positive Naive T Cells for the Prevention of Graft Versus Host Disease in Older Patients Undergoing Allogeneic Hematopoietic Cell Transplantation for Acute Leukemia or Myelodysplastic Syndrome
This phase II trial tests how well removing CD45RA positive naive T cells works to prevent graft versus host disease in older patients undergoing standard of care allogeneic hematopoietic stem cell transplantation for the…
- Conditions
- Acute Biphenotypic Leukemia, Acute Leukemia, Acute Leukemia of Ambiguous Lineage, Acute Lymphoblastic Leukemia
- Trial name
- NCT07819396
- Testing
- Allogeneic CD34+-enriched and CD45RA-depleted PBSCs, Biospecimen Collection, Bone Marrow Aspiration
- Where
- United States
- Volunteers
- 52 people
- Sponsor
- Fred Hutchinson Cancer Center
Atopic Dermatitis
Indigo Naturalis in Treating Atopic Dermatitis Topically
Atopic dermatitis (AD) is a chronic inflammatory skin disorder that most commonly occurs in children. The aims of this project are: 1. To evaluate the efficacy of indigo naturalis ointment in treating AD topically; 2.
- Trial name
- NCT02669888
- Testing
- Indigo naturalis ointment
- Where
- 3 sites in Taiwan
- Volunteers
- 48 people
- Sponsor
- Chang Gung Memorial Hospital
Rosacea
To Evaluate the Therapeutic Equivalence and Safety of Azelaic Acid 15% Topical Gel
A Multi-Center, Double-Blind, Randomized, Placebo Controlled, Parallel-Group Study
- Trial name
- NCT03094403
- Testing
- Azelaic Acid 15% topical gel, Finacea® (azelaic acid) Gel, 15%
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Sun Pharmaceutical Industries, Inc.
Post-inflammatory Hyperpigmentation
Tolerance of Cyto-selective Difluoroethane-based Cryotherapy in the Treatment of Post-inflamamatory Hyperpigmentation (PIH).
CS5_2 study aims to evaluate the tolerance of 4 different conditions of cryotherapy treatments applied on dorsal post-inflammatory hyperpigmentation (PIH) spots.
- Trial name
- NCT05495503
- Testing
- Prototype (814A-v1), Prototype (814B-v1), Prototype (814C-v1)
- Where
- South Africa
- Volunteers
- 12 people
- Sponsor
- Cryonove Pharma
Cancer Survivor, Central Obesity
Exercise Intervention in Targeting Adiposity and Inflammation With Movement to Improve Prognosis in Breast Cancer
This randomized phase II trial studies how well exercise intervention works in targeting adiposity and inflammation with movement to improve prognosis in stage I-III breast cancer survivors.
- Conditions
- Cancer Survivor, Central Obesity, Estrogen Receptor Positive, Postmenopausal
- Trial name
- NCT03091842
- Testing
- Exercise Intervention, Informational Intervention, Laboratory Biomarker Analysis
- Where
- United States
- Sponsor
- University of Southern California
LGCMN, Large and Giant Congenital Melanocytic Nevi
Mirdametinib to Reduce the Size of Large/Giant Congenital Melanocytic Nevi in Children, Adolescents and Young Adults
Background: Large and giant congenital melanocytic nevi (LGCMN) are dark birthmarks (moles). They can grow to 8 inches or more across.
- Conditions
- LGCMN, Large and Giant Congenital Melanocytic Nevi, NF1, Solid Tumor
- Trial name
- NCT07891286
- Testing
- Mirdametinib
- Where
- United States
- Volunteers
- 15 people
- Sponsor
- National Cancer Institute (NCI)
Cutaneous Leishmaniasis
Frequency of Parasite Infection in Hyraxes and Sandflies During Outbreak of Leishmania Tropica Epidemic in The West Bank
The objective of the project is to study the pathogenesis of Leishmania tropica infection in a focus of infection, to learn about relationship of infection in humans with ecological factors such as infection in hyraxes reservoir…
- Trial name
- NCT00737386
- Where
- Israel
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Advanced Cancer, Metastatic Melanoma
A Study of LY3214996 Administered Alone or in Combination With Other Agents in Participants With Advanced/Metastatic Cancer
The purpose of this study is to determine the safety of an extracellular signal regulated kinase (ERK1/2) inhibitor LY3214996 administered alone or in combination with other agents in participants with advanced cancer.
- Conditions
- Advanced Cancer, Metastatic Melanoma, Metastatic Non-small Cell Lung Cancer, Colorectal Cancer
- Trial name
- NCT02857270
- Testing
- LY3214996, Midazolam, Abemaciclib
- Where
- 13 sites in United States, Australia and 2 more
- Volunteers
- 210 people
- Sponsor
- Eli Lilly and Company
Melanoma Stage III, Melanoma
Adjuvant Treatment Determined By Pathological Response To Neoadjvuant Nivolumab
Subjects with resectable melanoma will receive neoadjuvant nivolumab followed by surgical resection. Post-operatively, subjects will receive open-label treatment with up to 1 year of adjuvant nivolumab or ipilimumab plus…
- Trial name
- NCT04013854
- Testing
- nivolumab, Ipilimumab
- Where
- 3 sites in United States
- Volunteers
- 67 people
- Sponsor
- Abramson Cancer Center at Penn Medicine
Herpes Simplex, HIV Infections
The Safety and Effectiveness of Valacyclovir HCl in the Treatment of Herpes Simplex or Varicella/Zoster Infections in HIV-1 Infected Children
To obtain tolerance, safety, and pharmacokinetic data for oral valacyclovir hydrochloride ( 256U87 ) in HIV-1 infected children with herpes simplex virus infections ( cold sores ) and/or varicella / zoster virus infections …
- Conditions
- Herpes Simplex, HIV Infections, Chickenpox
- Trial name
- NCT00001054
- Testing
- Valacyclovir hydrochloride
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Skin Condition
Efficacy Testing of Hibiscus Sabdariffa Extract and Collagen Products
To assess Hibiscus sabdariffa extract and collagen products on skin condition improvement
- Trial name
- NCT05988554
- Testing
- Hibiscus sabdariffa extract and collagen products
- Where
- Taiwan
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- TCI Co., Ltd.
Breast Cancer
Evaluating the Dose Timing (Morning vs Evening) of Endocrine Therapy and Its Effects on Tolerability and Compliance
Endocrine therapy is an established treatment for hormone receptor-positive breast cancer, but can cause significant side effects with deterioration in quality of life.
- Trial name
- NCT04864405
- Testing
- Morning administration of endocrine therapy, Evening administration of endocrine therapy
- Where
- 2 sites in Canada
- Volunteers
- 245 people
- Sponsor
- Ottawa Hospital Research Institute
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