Clinical trials: Dermatologic Diseases
Breast Cancer
Neoadjuvant Inetetamab and Pyrotinib and Nab-paclitaxel for HER2+Breast Cancer
Explore the efficacy and safety of the combination of inetetamab, pyrotinib and nab-paclitaxel in the neoadjuvant treatment of HER2 positive early or locally advanced breast cancer
- Trial name
- NCT05444998
- Testing
- Inetetamab, pyrotinib, nab-paclitaxel
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Xijing Hospital
Psoriasis
Study of Secukinumab With 2 mL Pre-filled Syringes
The aim of the study was to demonstrate efficacy, safety and tolerability of 2 mL pre-filled syringe of 300 mg secukinumab in treatment of moderate to severe plaque psoriasis.
- Trial name
- ALLURE (NCT02748863)
- Testing
- Secukinumab 2 mL form, Secukinumab 1 mL form
- Where
- 52 sites in United States, Belgium and 9 more
- Volunteers
- 214 people
- Sponsor
- Novartis Pharmaceuticals
Breast Cancer
Radiologic Evaluation and Breast Density (READ)
The purpose of this study is to determine whether cessation of hormone replacement therapy for one or two months before a screening mammogram will improve its performance by decreasing breast density.
- Trial name
- NCT00117663
- Testing
- temporary discontinuation of hormone therapy for 1 month, temporary discontinuation of hormone therapy for 2 months
- Where
- United States
- Volunteers
- 1,704 people, healthy volunteers welcome
- Sponsor
- Kaiser Permanente
Scleroderma, Systemic
Thalidomide for Decreasing Collagen Biosynthesis in People With Progressive Systemic Sclerosis
Progressive systemic sclerosis (SSc) is an immune-based disease that causes abnormal connective tissue growth of the skin and internal organs. At this point, there are no effective therapies for treating SSc.
- Trial name
- NCT00418132
- Testing
- Thalidomide
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- NYU Langone Health
Wound Infection, Abscess
Oritavancin Versus IV Vancomycin for the Treatment of Patients With Acute Bacterial Skin and Skin Structure Infection
The purpose of this Phase 3 trial is to evaluate the efficacy, safety, and tolerability of oritavancin in ABSSSIs, including those caused by MRSA and to evaluate the potential economic benefit of oritavancin administered as a…
- Conditions
- Wound Infection, Abscess, Systemic Inflammation, Cellulitis
- Trial name
- SOLO II (NCT01252732)
- Testing
- Single-Dose IV Oritavancin Diphosphate, IV Vancomycin
- Where
- United States
- Volunteers
- 1,019 people
- Sponsor
- Melinta Therapeutics, Inc.
Breast Cancer, Hormone Receptor Positive Tumor
Study in Women With Advanced Breast Cancer Receiving Palbociclib With AI or Fulvestrant
The purpose of this study is to evaluate the efficacy and quality of life in women with advanced breast cancer (locally advance inoperable or metastatic adenocarcinoma of the breast), HR+ / HER2-, who are treated with an…
- Conditions
- Breast Cancer, Hormone Receptor Positive Tumor, Human Epidermal Growth Factor 2 Negative Carcinoma of Breast
- Trial name
- INGE-B (NCT02894398)
- Testing
- Palbociclib, Letrozole, Anastrozole
- Where
- 70 sites in Germany
- Volunteers
- 388 people
- Sponsor
- iOMEDICO AG
Female, With
New Treatment in Melasma
This randomized controlled trial aims to compare different therapeutic approaches for the treatment of melasma. Participants will be randomly allocated into three treatment groups receiving modified Kligman formula…
- Conditions
- Female, With, Facial, Melasma
- Trial name
- NCT07887399
- Testing
- Tranexamic Acid - topical, Microneedling with Topical Tranexamic acid, Modified Kligman's Formula
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Sohag University
Breast Cancer
TRIal evalUating the Menstrual and Ovarian Function of Young Breast Cancer Patients Treated With a cycloPHosphamide-free Regimen
Recently, there has been a rising trend of delaying childbearing and hence more women are diagnosed with breast cancer before completing their families.
- Trial name
- TRIUMPH (NCT02053597)
- Testing
- Doxorubicin, paclitaxel
- Where
- 4 sites in Belgium
- Sponsor
- Jules Bordet Institute
Breast Cancer
Paricalcitol and Chemotherapy in Treating Women With Metastatic Breast Cancer
RATIONALE: Drugs used in chemotherapy, such as paclitaxel albumin-stabilized nanoparticle formulation, docetaxel,, paclitaxel, and ixabepilone work in different ways to stop the growth of tumor cells, either by killing the cells…
- Trial name
- NCT00637897
- Testing
- docetaxel, ixabepilone, paclitaxel
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Wake Forest University Health Sciences
Cancer
Irradiated Donor Lymphocyte Infusion in Treating Patients With Relapsed or Refractory Hematologic Cancer or Solid Tumor
RATIONALE: When irradiated lymphocytes from a donor are infused into the patient they may help the patient's immune system kill cancer cells.
- Trial name
- NCT00161187
- Testing
- therapeutic allogeneic lymphocytes
- Where
- United States
- Volunteers
- 37 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Breast Cancer
Widening Aims and Giving Patients a Voice for Expanded Structures in Breast Cancer Care Jointly Developed by Patients and Physicians
The aim of this BZKF project is to record the current care structure for breast cancer patients in order to use this as a basis for developing possible future models for improvement.
- Trial name
- WAVES (NCT06416293)
- Testing
- Questionnaire patients, Questionnaire physicians
- Where
- Germany
- Volunteers
- 2,000 people, healthy volunteers welcome
- Sponsor
- University Hospital Augsburg
Recurrent Melanoma, Stage IV Skin Melanoma
Bevacizumab With or Without Interferon Alfa in Treating Patients With Metastatic Malignant Melanoma
This randomized phase II trial is studying giving bevacizumab together with interferon alpha to see how well it works compared to giving bevacizumab alone in treating patients with metastatic malignant melanoma.
- Trial name
- NCT00026221
- Testing
- Recombinant Interferon Alfa, Bevacizumab
- Where
- 2 sites in United States
- Volunteers
- 57 people
- Sponsor
- National Cancer Institute (NCI)
Cancer Survivor, Stage I Breast Cancer AJCC v7
Ginseng in Decreasing Cancer-Related Fatigue After Treatment in Cancer Survivors
This randomized pilot trial studies how well North American ginseng extract AFX-2 (ginseng) works in decreasing cancer-related fatigue after treatment in cancer survivors.
- Conditions
- Cancer Survivor, Stage I Breast Cancer AJCC v7, Stage I Colon Cancer AJCC v6 and v7, Stage IA Breast Cancer AJCC v7
- Trial name
- NCT03407716
- Testing
- American Ginseng, Laboratory Biomarker Analysis, Questionnaire Administration
- Where
- United States
- Volunteers
- 2 people
- Sponsor
- Mayo Clinic
Rheumatoid Arthritis, Ankylosing Spondylitis
Impact of Air Pollution on the Course of Inflammatory Rheumatism
The objective of this study is to see if there is a link between air pollution and inflammatory rheumatism (rheumatoid arthritis and ankylosing spondylitis) To do this, the investigators are going to follow a cohort of about…
- Conditions
- Rheumatoid Arthritis, Ankylosing Spondylitis, Psoriatic Arthritis
- Trial name
- NCT05862584
- Testing
- Questionnaires
- Where
- France
- Volunteers
- 86 people
- Sponsor
- Centre Hospitalier Universitaire de Nice
Oral Lichen Planus, Mucous Membrane Pemphigoid
Dexamethasone Solution and Dexamethasone in Mucolox™
Topical steroid therapy is considered the first line of treatment for Oral Inflammatory Ulcerative Diseases with current treatment regimens requiring multiple application or rinses daily.
- Conditions
- Oral Lichen Planus, Mucous Membrane Pemphigoid, Pemphigus Vulgaris, Chronic Graft-versus-host-disease
- Trial name
- NCT04540133
- Testing
- dexamethasone 0.5mg/5ml solution, dexamethasone 0.5mg/5ml solution in Mucolox™
- Where
- United States
- Volunteers
- 29 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Atopic Dermatitis, Allergy
Bathing Babies and Allergy
Atopic dermatitis (AD) is a chronic allergic skin disease with onset in early childhood and increasing prevalence in Westernized countries. Current well newborn guidelines for washing babies with soap were adopted by U.S.
- Trial name
- BBA (NCT03050658)
- Where
- United States
- Volunteers
- 28 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetic Foot Ulcer, Diabetic Foot Ulcer (DFU)
Study to Assess Remote Imaging System to Monitor Diabetic Foot Ulcers
The goal of this observational pilot study is to evaluate whether a new remote monitoring platform (TASHA) can support accurate and reliable assessment of diabetic foot ulcers in adult patients receiving care in a UK NHS clinic.
- Trial name
- NCT07013448
- Testing
- Foot scan
- Where
- United Kingdom
- Volunteers
- 40 people
- Sponsor
- Medical Intelligence Group
Diabetes, Diabetic Foot
Assessing the Efficacy of Anti-staphylococcal Phages in the Management of Infected Foot Ulcers in Diabetes
Work Package 1: Observational cohort pilot safety study Work Package 2: Randomised, double-blind, placebo controlled pilot study Work Package 3: Observer-blind pilot RCT
- Conditions
- Diabetes, Diabetic Foot, Diabetic Foot Infection
- Trial name
- PDFI (NCT04289948)
- Testing
- Phage
- Where
- United Kingdom
- Sponsor
- University Hospitals of Derby and Burton NHS Foundation Trust
Fear of Cancer Recurrence
The Effect of Metacognition-based, Manualized Intervention on Fear of Cancer Recurrence
The primary aim of this study is to assess the effect of ConquerFear, a metacognition-based manualized intervention on fear of cancer recurrence, using the randomized controlled trial approach, among Chinese patients newly…
- Trial name
- NCT04568226
- Testing
- ConquerFear Intervention, Active control: Basic Cancer Care
- Where
- 6 sites in Hong Kong
- Volunteers
- 177 people
- Sponsor
- The University of Hong Kong
Metastatic Breast Cancer, Brain Metastases
Lapatinib and Temozolomide for the Treatment of Progressive Brain Disease in HER-2 Positive Breast Cancer
Objectives: Primary - Determine the maximum tolerated dose (MTD) and evaluate the dose limiting toxicities (DLT) of combining lapatinib and temozolomideSecondary - Obtain preliminary information on the clinical anti-tumor…
- Conditions
- Metastatic Breast Cancer, Brain Metastases, HER2 Positive
- Trial name
- LAPTEM (NCT00614978)
- Testing
- lapatinib and temozolomide
- Where
- Belgium
- Volunteers
- 18 people
- Sponsor
- Jules Bordet Institute
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