Clinical trials: Desaturation
Apneic Oxygenation
Apneic Oxygenation in the Emergency Department
Apneic oxygenation is a process of delivering continuous oxygen during direct laryngoscopy. Nasal cannulas are used for the purpose of oxygenation; for delivering either low flow or high flow oxygen but haven't been tested in…
- Trial name
- ApOxED (NCT04242537)
- Testing
- High flow nasal cannula oxygen delivery, Low flow nasal cannula oxygen delivery
- Volunteers
- 30 people
- Sponsor
- Aga Khan University Hospital, Pakistan
Hypoxemia, Desaturation of Blood
Alternate Methodology of Pulse Oximeter Validation
This study will determine if the replacement of the measured arterial blood oxygen saturation with expired (end-tidal) oxygen value is an acceptable method to calculate the accuracy of pulse oximeters.
- Trial name
- NCT03628560
- Testing
- RespirAct Step-Wise Normocapnia desaturation sequence, RespirAct Slope Normocapnia desaturation sequence, RespirAct Step-Wise Hypocapnia desaturation sequence
- Where
- United States
- Volunteers
- 2 people, healthy volunteers welcome
- Sponsor
- Duke University
Neonatal Respiratory Failure, Tracheal Intubation Morbidity
Providing Oxygen During Intubation in the NICU Trial
Tracheal intubation in the NICU is frequently complicated by severe oxygen desaturation. Apneic oxygenation, a method of applying free flowing oxygen via nasal cannula to apneic patients undergoing intubation, prevents or delays…
- Trial name
- POINT (NCT05451953)
- Testing
- Apneic Oxygenation, Standard of Care
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Pennsylvania
Delirium, Thoracic Surgery
Cerebral Oxygen Desaturation and Post-Operative Delirium in Thoracic Surgical Patients
This study will assess the incidence and risk factors for post-operative delirium in patients undergoing thoracotomy. Specifically, the study will assess if there is any relationship between an intra-operative decrease in brain…
- Trial name
- NCT03165539
- Testing
- Cerebral oxygen saturation monitoring
- Where
- Canada
- Volunteers
- 200 people
- Sponsor
- University of Manitoba
Shoulder Arthoscopy, Beach Chair Position
Effect of Compression Stockings on Cerebral Desaturation Events in Obese Patients Undergoing Shoulder Arthroscopy in the Beach Chair
The study compares the effect of thigh high compression stockings on cerebral desaturation events in patients undergoing shoulder arthroscopy in the beach chair position with a BMI greater than or equal to 30.
- Conditions
- Shoulder Arthoscopy, Beach Chair Position, Cerebral Desaturation Events, Obese
- Trial name
- NCT03996668
- Testing
- Thigh High Compression Stockings
- Where
- United States
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Loyola University
Covid19, Medical Emergencies
Physical Activity a Vital Sign? 40 Steps to Safety Test for Patients With COVID-19
Exertional desaturation is a feature of COVID-19. The study will measure vital signs of patients discharge by practitioners in primary care, secondary care or by paramedic practitioners.
- Trial name
- NCT04618835
- Testing
- 40-Steps-test
- Where
- United Kingdom
- Volunteers
- 1,000 people
- Sponsor
- Betsi Cadwaladr University Health Board
SpO2 (Peripheral Oxygen Saturation) Measurement Validation
Philps FAST2022 picoSAT Pulse Oximetry Desaturation Study
Validation study to compare the accuracy of non-invasive Philips SpO2 sensors in detecting blood oxygen levels compared to invasive methods requiring a blood draw and lab analysis.
- Trial name
- NCT05683366
- Testing
- No Intervention
- Where
- United States
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Philips Clinical & Medical Affairs Global
Apnea, Postanesthetic, Desaturation of Blood
Transnasal Humidified Rapid-Insufflation Ventilatory Exchange (THRIVE) Could Decrease the Incidence of Oxygen Desaturation During Suspension Laryngoscopy: a Randomized Controlled Trial (Optilaryngo)
Suspension laryngoscopy is realised during apnea. In effect, surgeons are in the mouth of the patient and we can't have access at the aiways.
- Conditions
- Apnea, Postanesthetic, Desaturation of Blood, Apnea, Anesthesia
- Trial name
- optilaryngo (NCT03843580)
- Testing
- optiflow
- Where
- 2 sites in France
- Volunteers
- 80 people
- Sponsor
- University Hospital, Caen
Low Oxygen Saturation
Clinical Performance Evaluation of Pediatric and Neonatal Low Saturation Oximetry Sensors
The general purpose of this study is to evaluate the feasibility, accuracy and performance of the Nellcor/Covidian 600-x and the Masimo rainbow technologypediatric and neonatal oximetry sensors over clinically relevant ranges of…
- Trial name
- NCT00843401
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- Children's National Research Institute
COPD (Chronic Obstructive Pulmonary Disease)
Effect of Rehabilitation on the Respiratory Signal in Patients With COPD and Exercise-Induced Desaturation
The aim is to study the effect of SSOT during a 3-week in-patient pulmonary rehabilitation programme. Further aim is to analyse exercise endurance, distinguishing between those exercising whilst breathing air at 760m "normoxia"…
- Trial name
- NCT07107828
- Testing
- Ambient air, Oxygen, Altitude
- Where
- Kyrgyzstan
- Volunteers
- 52 people
- Sponsor
- Eastern Switzerland University of Applied Sciences
Healthy
Desaturation Validation of INVSENSOR00006
This study is designed to compare the accuracy of a noninvasive measurement of oxygen saturation compared to reference values obtained by a laboratory blood gas analyzer.
- Trial name
- NCT03435211
- Testing
- INVSENSOR00006
- Where
- United States
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Masimo Corporation
Apnea of Prematurity, Desaturation of Blood
Arterial Oxygen Saturation on Ventilatory Stability in Extremely Premature Infants
This is a prospective crossover study to compare the within-subject effect of the two target ranges of arterial oxygen saturation (SpO2), both within the clinically recommended range of 90- 95%.
- Conditions
- Apnea of Prematurity, Desaturation of Blood, Central Apnea, Periodic Breathing
- Trial name
- NCT03695900
- Testing
- Targeting SpO2 at 93-95%, Targeting SpO2 at 90-92%
- Where
- United States
- Volunteers
- 19 people
- Sponsor
- University of Miami
Congenital Disorders, Cerebral Desaturation
International Study of Cerebral Oxygenation and Electrical Activity During Major Neonatal Surgery
The goal of this observational study is to determine the incidence of perioperative cerebral desaturation in neonates undergoing surgery for congenital malformations. The main questions it aims to answer are: 1.
- Conditions
- Congenital Disorders, Cerebral Desaturation, Neonatal Surgery
- Trial name
- NCT05673499
- Testing
- NIRS/EEG monitoring
- Where
- 15 sites in United States, Australia and 5 more
- Volunteers
- 900 people
- Sponsor
- Children's Hospital of Philadelphia
Hypoxia, OSA
MEA DPA Hypoxic Event Reductions
The goal of the study is to compare deoxygenation events during anesthesia induction and mask ventilation when using standard oral pharyngeal airways or the novel distal pharyngeal airway.
- Conditions
- Hypoxia, OSA, Obesity
- Trial name
- NCT07572500
- Testing
- DPA, OPA
- Sponsor
- Stanford University
Surgery
Role of Cerebral Oximetry in Reducing Postoperative End Organ Dysfunction/Failure After Complex Non-Cardiac Surgery
The number of elderly patients requiring general anesthesia for major surgical procedures is increasing dramatically. It is estimated that 20% of these patients will develop major complications after surgery.
- Trial name
- NCT04627506
- Testing
- Bilateral NIRS (Masimo, O3TM Regional Oximetry)
- Where
- Singapore
- Volunteers
- 100 people
- Sponsor
- National University Hospital, Singapore
Intersticial Lung Disease
Can High-Flow Oxygen Therapy Improve Oxygenation During Exercise in ILD Patients?
Objectives: 1.- To compare the level of oxygenation achieved during muscular training with conventional oxygen systems (nasal cannulas) versus nasal High-flow oxygen therapy.
- Trial name
- NCT03287713
- Testing
- oxygen therapy
- Volunteers
- 60 people
- Sponsor
- Fundació Institut de Recerca de l'Hospital de la Santa Creu i Sant Pau
Chronic Obstructive Pulmonary Disease, Oxygen/Therapeutic Use
Correction of Exercise-induced Desaturation by Acute Oxygen Supply and Exercise Responses in COPD
In the literature, the effects of acute oxygen administration on exercise tolerance and related symptoms have often appeared to be contradictory.
- Trial name
- RePox-1 (NCT02055885)
- Where
- 2 sites in France
- Volunteers
- 255 people
- Sponsor
- 5 Santé
Endotracheal Intubation, Obesity
A Comparison of Tracheal Intubation Using the Totaltrack vs the Macintosh Laryngoscope in Obese Patients
Airway management in obese patients has to consider that mask ventilation (DMV) risk is increased and difficult tracheal intubation (DTI) risk may be increased too.
- Conditions
- Endotracheal Intubation, Obesity, Desaturation, Ventilation
- Trial name
- Ovesion (NCT03106974)
- Testing
- orotracheal intubation Macintosh Laryngoscope, orotracheal intubation Totaltrack VLM
- Where
- Spain
- Volunteers
- 1,440 people
- Sponsor
- AnestesiaR
Cerebral Desaturation
Observational Study on the Clinical Impact of Desaturation During Liver Surgery
The purpose of this study is to determine the clinical impact of cerebral and systemic desaturation during liver transplantation and resection on post-operative complications.
- Trial name
- NCT01458262
- Testing
- systemic and cerebral oxymetry
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- Centre hospitalier de l'Université de Montréal (CHUM)
Desaturation, Apnea, Hypoxia
The Effectiveness of Oxygen Reserve Index in Early Detection of Desaturation in Geriatric Patients Scheduled for Oncological Surgery
This prospective observational study aims to evaluate the relationship between the Oxygen Reserve Index (ORI) and tolerable apnea time in geriatric patients undergoing elective oncologic surgery under general anesthesia.
- Conditions
- Desaturation, Apnea, Hypoxia, Oxygen Reserve Index
- Trial name
- NCT07326293
- Where
- Turkey (Türkiye)
- Volunteers
- 44 people
- Sponsor
- Ankara City Hospital Bilkent