Clinical trials: Developing Countries
HIV, HIV Infections
Evaluation of Conditional Cash Transfers to Increase Retention in PMTCT Services in Akwa Ibom State, Nigeria
A randomized controlled trial will be conducted to assess the effectiveness of conditional cash transfers (CCTs) at increasing retention in prevention of mother-to-child transmission (PMTCT) services specifically, in relation to…
- Conditions
- HIV, HIV Infections, Pregnancy, Infant, Newborn, Diseases
- Trial name
- NCT02447159
- Testing
- Conditional Cash Transfers
- Where
- 3 sites in Nigeria
- Volunteers
- 554 people
- Sponsor
- University of California, San Francisco
Postpartum Hemorrhage
Misoprostol for the Treatment of Postpartum Hemorrhage
The purpose of this study is to test whether misoprostol is as effective as oxytocin for treating primary postpartum hemorrhage (PPH) with uterine atony as the suspected cause in two circumstances: 1) where women have received…
- Trial name
- NCT00116350
- Testing
- Misoprostol, Oxytocin
- Where
- 6 sites in Burkina Faso, Ecuador and 3 more
- Volunteers
- 1,786 people
- Sponsor
- Gynuity Health Projects
Pneumonia, Bronchiolitis
Diagnosing Pneumonia Under Low-resource Conditions
Pneumonia is the commonest cause of death in children worldwide, killing 1.5 million children under the age of 5 years, every year. This is more than the number of children dying from AIDS, malaria and tuberculosis combined.
- Conditions
- Pneumonia, Bronchiolitis, Asthma
- Trial name
- NCT01997047
- Where
- Canada
- Volunteers
- 502 people
- Sponsor
- University of British Columbia
Hypothermia
Evaluation of Use of Plastic Bags to Prevent Neonatal Hypothermia-Part III
The overall hypothesis is that plastic bags used in combination with WHO thermoregulation care will reduce the incidence of hypothermia in preterm/low birth weight and full term infants when compared to routine WHO…
- Trial name
- NCT01604434
- Testing
- Incubator-torso bag, Incubator-no plastic bag
- Where
- Zambia
- Sponsor
- University of Alabama at Birmingham
Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology
Adapting Mental Health Interventions for War-Affected Youth Through Employment Programs
The research will first examine data obtained from YRI participants to investigate effects of the group sessions on psychosocial functioning outcomes in youth aged 15 - 24.
- Conditions
- Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology, Social Problems/Psychology, Violence, Non-accidental
- Trial name
- NCT02561949
- Testing
- YRI, Income generating activity program
- Where
- Sierra Leone
- Volunteers
- 80 people
- Sponsor
- Boston College
Healthy Participants, Non-anemic Children
Ferrous Fumarate and Ferric Pyrophosphate as Food Fortificants in Developing Countries
Iron fortification of foods is usually considered the most cost-effective approach to prevent iron deficiency. However, iron is the most difficult mineral to add to foods.
- Conditions
- Healthy Participants, Non-anemic Children, Helicobacter Pylori Infection
- Trial name
- NCT00867867
- Testing
- Ferrous fumarate, Ferric pyrophosphate
- Volunteers
- 235 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Depressive Disorders, Anxiety Disorders
Evaluating the Benefits and Affordability of a Program to Improve the Care of Common Mental Disorders in Primary Care
Depressive and anxiety disorders (termed as 'Common Mental Disorders') affect as many as one in four persons attending primary care; most patients do not receive effective treatments.
- Conditions
- Depressive Disorders, Anxiety Disorders, Depression
- Trial name
- MANAS (NCT00446407)
- Testing
- Collaborative Stepped Care Intervention, Enhanced Usual Care
- Where
- India
- Volunteers
- 2,796 people
- Sponsor
- London School of Hygiene and Tropical Medicine
Postpartum Hemorrhage
Misoprostol for Preventing Postpartum Hemorrhage
This hospital-based, multicenter, randomized, placebo-controlled trial will assess the effects of misoprostol as part of active management of the third stage of labor on postpartum blood loss, complications, and side effects.
- Trial name
- NCT00124540
- Testing
- misoprostol
- Where
- 5 sites in Nigeria, South Africa and 1 more
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- Gynuity Health Projects
Home Mechanical Ventilation, Prolonged Mechanical Ventilation
Patient Characteristics, Feasibility, and Outcomes of a Home Mechanical Ventilation Program in a Developing Country
This study aims to describe the patient characteristics, feasibility, and outcomes of an home mechanical ventilation (HMV) program at a university hospital in Thailand.
- Trial name
- NCT02927613
- Where
- Thailand
- Volunteers
- 12 people
- Sponsor
- Thammasat University
Pancreatic Cancer
Pancreaticoduodenectomy: Outcomes of a Complex Surgical Procedure From a Developing Country
ABSTRACT BACKGROUND Pancreaticoduodenectomy (PD) plays an integral part in the management of pancreatic, periampullary and duodenal cancers along with few other pathologies of this region.
- Trial name
- NCT04395898
- Testing
- pancreaticoduodenectomy
- Where
- Pakistan
- Volunteers
- 161 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology
Trial of the Youth Readiness Intervention
The research will first examine data obtained from YRI participants to investigate effects of the group sessions on psychosocial and functioning outcomes in youth.
- Conditions
- Anxiety Disorder/Anxiety State, Depressive Disorder/Psychology, Social Problems/Psychology, Stress, Psychological
- Trial name
- YRI (NCT01684488)
- Testing
- YRI, EducAid educational programming
- Where
- Sierra Leone
- Volunteers
- 443 people
- Sponsor
- Boston College
Hand Washing Behavior, Hand Cleansing Behavior
Waterless Hand Cleansing With Chlorhexidine During the Perinatal Period
Background (brief): 1. Burden: Neonatal death still unacceptably high in low income countries. The common causes of neonatal death are pneumonia, sepsis and omphalitis.
- Conditions
- Hand Washing Behavior, Hand Cleansing Behavior, Chlorhexidine, Neonatal Period
- Trial name
- NCT01955317
- Testing
- Hand cleansing with chlorhexidine, Mother and neonatal health counselling
- Where
- Bangladesh
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- International Centre for Diarrhoeal Disease Research, Bangladesh
Pregnancy
Antenatal Vitamin D3 Supplementation in Bangladesh: Randomized Controlled Trial
This study is a randomized placebo-controlled trial of oral weekly vitamin D3 (cholecalciferol) supplementation during the third trimester of pregnancy among women in Dhaka, Bangladesh.
- Trial name
- AViDD-2 (NCT01126528)
- Testing
- Vitamin D3
- Where
- Bangladesh
- Volunteers
- 160 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Cyanotic Congenital Heart Disease
Predicting Factors for Mortality in Congenital Heart Disease Patients After Shunt Procedure in Developing Country.
Blalock Taussig (BT) is a palliative procedure that preserves blood circulation to the lungs and alleviates cyanosis in patients with congenital heart diseases and reduced pulmonary blood flow.
- Trial name
- NCT05800691
- Where
- Indonesia
- Volunteers
- 197 people
- Sponsor
- Universitas Sumatera Utara
Depressive Symptoms, Anxiety
Pilot Feasibility Trial of the Family Strengthening Intervention in Rwanda (FSI-R)
The research will examine the following Specific Aims: Specific Aim 1: To adapt a U.S.-developed family-focused and strengths-based prevention program to the context of HIV/AIDS-affected families in Rwanda (the…
- Conditions
- Depressive Symptoms, Anxiety, Parenting
- Trial name
- NCT01509573
- Testing
- Family Strengthening Intervention in Rwanda (FSI-R)
- Where
- Rwanda
- Volunteers
- 82 people
- Sponsor
- Harvard School of Public Health (HSPH)
HIV Infections, Pregnancy
Maternal/Infant Peripartum NVP, Versus Infant Only Peripartum NVP, or Maternal LPV/r in Addition to Standard ZDV Prophylaxis for the Prevention of Perinatal (PMTCT) HIV in Thailand
The purpose of this study is to compare the efficacy of two doses of nevirapine (NVP) given only to the infants or lopinavir/ritonavir (LPV/r) from 28 weeks gestation with single dose (SD) NVP given to the mothers plus two doses…
- Trial name
- PHPT-5 (NCT00409591)
- Testing
- Maternal and infant nevirapine, Maternal lopinavir+ritonavir, zidovudine
- Where
- 43 sites in Thailand
- Volunteers
- 435 people
- Sponsor
- Institut de Recherche pour le Developpement
Surgical Site Infection
Benefit of a Single Preoperative Dose of Antibiotics for the Prevention of Surgical Site Infections
In a rural hospital in Tanzania the rate of surgical site infections (SSI) was 21.6%. Inappropriate choice of antibiotics and of administration time were determined as sole risk factors in this setting.
- Trial name
- SSI2 (NCT00801099)
- Testing
- Amoxicillin/Clavulanic Acid
- Where
- Switzerland
- Volunteers
- 276 people
- Sponsor
- Swiss Tropical & Public Health Institute
Tuberculosis
Training Inmate Peer Educators in Detecting Tuberculosis in a Developing Country Prison: A Cluster Randomized Trial
Introduction: Finding and successfully treating all tuberculosis (TB) patients is the cornerstone of the Global Strategy to Stop TB. However, many patients in resource-limited countries remain undiagnosed.
- Trial name
- NCT02744521
- Testing
- Symptom-based screening intervention
- Volunteers
- healthy volunteers welcome
- Sponsor
- Maastricht University
Common Bile Duct Calculi
The Cost Effectiveness of Endoscopic Ultrasound ( EUS ) Based Strategy in Diagnosis of Common Bile Duct Stones
Multiple reports in the literature showed the efficacy of EUS comparable to ERCP in the diagnosis of common bile duct ( CBD ) stone.
- Trial name
- NCT02349568
- Testing
- High risk group, Intermediate risk group
- Where
- Thailand
- Volunteers
- 141 people
- Sponsor
- Prince of Songkla University
HIV Infections
Perinatal Antiretroviral Intensification for PMTCT of HIV in Late Comers
The purpose is to evaluate the efficacy of maternal and infant perinatal antiretroviral prophylaxis intensification for the prevention of mother-to-child intrapartum transmission of HIV-1 in women receiving less than 8 weeks of…
- Trial name
- PHPT-5 (NCT01511237)
- Testing
- Nevirapine, zidovudine, lamivudine
- Where
- 36 sites in Thailand
- Volunteers
- 379 people
- Sponsor
- Institut de Recherche pour le Developpement