Clinical trials: Development, open to volunteers
Smith-Magenis Syndrome, Autism Spectrum Disorder
Smith Magenis Syndrome and Autism Spectrum Disorders
Autism Spectrum Disorders (ASD) are a neurodevelopmental disorder. Their prevalence is estimated at around 0.4% of the general population worldwide.
- Trial name
- SMS/TSA (NCT05116904)
- Testing
- Assessment
- Where
- 2 sites in France
- Volunteers
- 40 people
- Sponsor
- Hospices Civils de Lyon
Children, Only, Vestibular Disorder
Vestibular and Postural Function in Children Suspected of Balance Disorders
The goal of this prospective cohort study is to investigate the vestibular function in children suspected of balance disorders, and to follow up on their balance progressions after rehabilitation.
- Conditions
- Children, Only, Vestibular Disorder, Vestibular Function Disorder, Development Delay
- Trial name
- VASIC (NCT06229704)
- Testing
- video Head Impulse Test, Cervical Vestibular Evoked Myogenic Potential, Ocular Vestibular Evoked Myogenic Potential
- Where
- Denmark
- Volunteers
- 30 people
- Sponsor
- Gødstrup Hospital
Antibiotic, Allergic Diseases
Probiotic Intervention on the Development of Allergic Diseases in Infants Exposed to Antibiotics Early in Life
Early antibiotic exposure is an important environmental factor that disrupts the establishment of the infant gut microbiota and leads to microbial dysbiosis.
- Conditions
- Antibiotic, Allergic Diseases, Infants, Probiotic
- Trial name
- NCT07532421
- Testing
- Probiotic mixture
- Where
- China
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Peking University Third Hospital
Anticoagulants; Circulating, Hemorrhagic Disorder
MEdication Counselling Models for Outpatient oRal antIcoaguLation
The goal of this clinical trial is to investigate whether telepharmacy-led counselling can improve medication adherence, knowledge, and hospitalisation/mortality compared with pharmacist-led counselling in adult outpatients…
- Trial name
- MEMORIAL (NCT06290440)
- Testing
- Telepharmacy-led counselling, Pharmacist-led counselling
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Gia Dinh People Hospital
Autism, Autism Spectrum Disorder
The Supplementation Therapy in Autism and Response to Treatment Study
In addition to the "core" symptoms of ASD (i.e., impaired communication, impaired reciprocal social interaction and restricted, repetitive and stereotyped patterns of behaviors or interests), it is estimated that up to 70% of…
- Conditions
- Autism, Autism Spectrum Disorder, Autism Spectrum Disorder High-Functioning, Asperger Syndrome
- Trial name
- START (NCT06187090)
- Testing
- Oral Ultramicronized-Palmitoylethanolamide (um-PEA; 600 mg per day) in tablet form
- Where
- Italy
- Volunteers
- 20 people
- Sponsor
- University of Udine
Ovarian Cancer
Spanish Decision Tool for Ovarian Cancer Maintenance Therapy
To develop a shared decision-making (SDM) tool to help Spanish-speaking patients make decisions about their maintenance therapy
- Trial name
- NCT06036810
- Testing
- Shared Medical Decision Tool, Engaging Patients in Decision Making, Literacy Spanish Language
- Where
- United States
- Volunteers
- 70 people
- Sponsor
- M.D. Anderson Cancer Center
Multiple Myeloma
A Study to Learn About the Effects of the Combination of Elranatamab, Daratumumab and Lenalidomide Compared With Daratumumab, Bortezomib, Lenalidomide, and Dexamethasone in Patients With Newly Diagnosed Multiple Myeloma Who Are Not Candidates for Transplant
Elranatamab is a bispecific antibody: binding of elranatamab to CD3-expressing T-cells and BCMA-expressing multiple myeloma cells causes targeted T-cell-mediated cytotoxicity.
- Trial name
- MagnetisMM-6 (NCT05623020)
- Testing
- Elranatamab, Daratumumab, Lenalidomide
- Where
- 180 sites in United States, Argentina and 23 more
- Volunteers
- 1,060 people
- Sponsor
- Pfizer
Multiple Sclerosis
Evaluation of the Clinical Contribution of Quantitative MRI in Neuro-imaging
This study aims to develop the use of a quantitative MRI (qMRI) approach in neuroimaging for MS patients. To achieve this task the main goals of this study will be: to standardize and optimize qMRI protocols (acquisition time…
- Trial name
- NormaBRAIN (NCT07245589)
- Testing
- 3T MRI, 7T MRI, Clinical examination of MS patients
- Where
- France
- Volunteers
- 272 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Autism Spectrum Disorder
Assessing the Impact of Probiotic Supplementation in Children Diagnosed With Autism Spectrum Disorder: the PROBI-O-TISM Study
Children with autism spectrum disorder (ASD) present with stereotyped behaviors and often with comorbidities including gastrointestinal symptoms and sleep disturbances.
- Trial name
- (PROBI-O-TISM) (NCT06906068)
- Testing
- Three strains of Lactobacillus: L. acidophilus CL1285®, L. casei LBC80R® and L. rhamnosus CLR2®
- Where
- Canada
- Volunteers
- 108 people
- Sponsor
- Valérie Marcil
Autism Spectrum Disorder
Play Therapy With Gamified Biofeedback in Children With Autism Spectrum Disorder
This clinical trial tests whether combining regular play therapy with gamified biofeedback helps children with autism spectrum disorder better regulate their emotions and improve social skills, compared to play therapy alone.
- Trial name
- NCT07322640
- Testing
- Gamified Biofeedback, Play Therapy, Deactivated Biofeedback
- Where
- Brazil
- Volunteers
- 68 people
- Sponsor
- Luiz Alexandre Viana Magno
Alpha-1-antitrypsin Deficiency, Emphysema
Development of a Prediction Score for the Occurrence of Death or Lung Transplantation in Patients With Emphysema Secondary to Alpha-1-anti-tripsin Deficiency
Emphysema linked to alpha-1-antitrypsin deficiency (DAAT): towards a better prediction of risks Emphysema caused by alpha-1-antitrypsin deficiency (DAAT) is a rare genetic disorder that can lead to serious complications, such as…
- Conditions
- Alpha-1-antitrypsin Deficiency, Emphysema, Artificial Intelligence (AI), Predictive Learning Models
- Trial name
- FLARE (NCT07715617)
- Where
- 4 sites in France
- Volunteers
- 230 people
- Sponsor
- University Hospital, Bordeaux
Child Development
Effectiveness of a Baby App for Enhancing Infant Mental Well-being (RCT)
This RCT aims to design and develop a developmental guidance program delivered by a smartphone app "Happy Baby HK" and evaluate its effectiveness for enhancing the mental well-being of recently born infants in Hong Kong.
- Trial name
- NCT06163560
- Testing
- Smartphone app "Happy Baby HK", Family Health Service parenting booklet
- Where
- Hong Kong
- Volunteers
- 586 people, healthy volunteers welcome
- Sponsor
- The University of Hong Kong
Spinal Cord Injury, ALS (Amyotrophic Lateral Sclerosis)
Clinical Outcome Assessment for AT & BCI
Many individuals with severe motor impairments rely on Assistive Technologies (ATs) or Brain-Computer Interfaces (BCIs) to interact with digital devices such as their computers.
- Trial name
- NCT07407725
- Testing
- Eye Tracker, Mouth Operated Joystick, Non-invasive electroencephalogram (EEG) Headset
- Where
- United States
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Shirley Ryan AbilityLab
Arthroplasty Replacement, Knee, Arthroplasty, Replacement, Hip
Development and Measurement of the Effects of a Digital Education Solution for Patients Undergoing Total Hip or Knee Arthroplasty
This study aims to evaluate the effectiveness of a digital patient education solution, CHUVeduc@home, in improving preoperative preparation for patients undergoing total hip or knee arthroplasty.
- Trial name
- CHUVeduc@home (NCT07345299)
- Testing
- Digital Preoperative Education with CHUVeduc@home, Standard Care Pathway
- Where
- Switzerland
- Volunteers
- 160 people
- Sponsor
- Haute Ecole de Santé Vaud
Breast Feeding, Exclusive, Enteral Feeding
Tactile/kinesthetic Stimulus Program
The study will be carried out as a prospective randomized controlled clinical study to determine the effect of tactile/kinesthetic stimulus program on preterm infants on transition time to full sucking, sucking success and…
- Conditions
- Breast Feeding, Exclusive, Enteral Feeding, Hospital Stay
- Trial name
- NCT05486663
- Testing
- Tactile/kinesthetic Group
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Gonca Karatas Baran
TBI, TBI Traumatic Brain Injury
fREMS for Mortality Prediction in TBI
This prospective observational study aims to develop and internally validate a new clinical score, the FOUR-Rapid Emergency Medicine Score (fREMS), for predicting in-hospital mortality in patients with traumatic brain injury…
- Trial name
- fREMS (NCT07816016)
- Where
- Iraq
- Volunteers
- 2,000 people
- Sponsor
- Al-Nahrain University
Down Syndrome
How Simplified Language Affects Comprehension and Learning in Young Children With Down Syndrome
The long-term study goal is to experimentally evaluate the components (and likely active ingredients) of early language interventions for young children with Down syndrome (DS).
- Trial name
- NCT06951516
- Testing
- Linguistic simplification
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Michigan State University
Pediatric Obstructive Sleep Apnea
Development of a Wearable Point of Care Monitoring Device for Pediatric Obstructive Sleep Apnea
Background: Obstructive sleep apnea (OSA) occurs when the blockage of the airway causes a person to stop breathing involuntarily for 10 seconds or more throughout the night during sleep.
- Trial name
- NCT05052216
- Where
- United States
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Fall, Fall Accident
Developing Post-falls Management Principles in Care Homes
Falls are common among older people living in care homes and can cause serious injuries. After a fall, older people require post-falls management.
- Trial name
- NCT07818200
- Where
- United Kingdom
- Volunteers
- 138 people
- Sponsor
- Nottingham University Hospitals NHS Trust
Autism Spectrum Disorder, Developmental Disabilities
A Self-Instructional Online Program for Early Childhood and Elementary Teachers Supporting Autistic Children and Children With Developmental Delays
The goal of this clinical trial is to evaluate the preliminary effectiveness and acceptability of a self-instructional, web-based teacher training program designed to support the development of autistic children and children with…
- Conditions
- Autism Spectrum Disorder, Developmental Disabilities, Developmental Delay, Teacher Training
- Trial name
- SEED (NCT07524192)
- Testing
- SEED Online Self-Instructional Program, Comparison Educational Materials (Kit for Kids)
- Where
- South Korea
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Boin Choi
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