Clinical trials: Development, open to volunteers
Heart Failure, Older Adults (65 Years and Older)
Development and Evaluation of a Disease-oriented Scenario Game to Promote ACP Among Older Adults and Family Caregivers
Current advance care planning (ACP) tabletop games mostly focus on exploring "personal values." While a few explore care preferences through "hypothetical scenarios," they are not disease-oriented, which can create discrepancies…
- Conditions
- Heart Failure, Older Adults (65 Years and Older), Family Caregivers, Life Support Treatment
- Trial name
- NCT07883369
- Testing
- tabletop game, ACP Exercise Book
- Where
- Taiwan
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Taipei Veterans General Hospital, Taiwan
Neurodevelopmental Outcomes, ADHD - Attention Deficit Disorder With Hyperactivity
Where Wild Things Grow: Nature- and Activity-based Group Interventions for Neurodivergent Children and Youth
The goal of this action research project is to develop and implement nature- and activity-based group interventions across health care, school and leisure settings in Southern Norway.
- Conditions
- Neurodevelopmental Outcomes, ADHD - Attention Deficit Disorder With Hyperactivity, Autism, Tourette Syndrome
- Trial name
- NCT07203469
- Testing
- Universal approach, Selective approach, Outdoor therapy
- Where
- 2 sites in Norway
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Sorlandet Hospital HF
Mental Health, Psychological Wellbeing
This Study Tests the Development and Efficacy of a Kindness Focused Intervention on University Students in Islamabad. It Aims to See the Impact of This Intervention on the Psychosocial Well-being of These Emerging Adults.
The primary purpose of this study is to evaluate the development and efficacy of an evidence-based kindness intervention. By focusing on university students in Islamabad, this research aims to determine whether a positive…
- Conditions
- Mental Health, Psychological Wellbeing, Social Wellbeing, Psychosocial Well-being
- Trial name
- KFT (NCT07911189)
- Testing
- therapy
- Where
- Pakistan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National University of Modern Languages
Sleep, Foster Care
A Sleep Intervention for Preschoolers in Foster Care
Healthy sleep is critical for optimal health and development, but there are no public health interventions to support sleep for children in foster care.
- Trial name
- NCT06549491
- Testing
- Nurturing Sleep
- Volunteers
- 72 people, healthy volunteers welcome
- Sponsor
- Bradley Hospital
Type 2 Diabetes, Gestational Diabetes Mellitus
The Next Generation Longitudinal Birth Cohort Diabetes Study
The overall aim of this project is to understand the independent roles of maternal factors, intrauterine exposures, genetic factors, and postnatal environment on the development of obesity and youth-onset type 2 diabetes (T2D) in…
- Trial name
- NextGen (NCT04621396)
- Testing
- Observational screening study
- Where
- Canada
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- University of Manitoba
Colorectal Cancer
Development of a New Simplified Tool to Predict LNPCPs Histology and Assess the Risk of Submucosal Invasive Cancer. The Colorectal Regular-Irregular Score
Colorectal cancer (CRC) is the third most common malignancy worldwide and the second leading cause of cancer related death. It can be prevented by endoscopic detection and complete resection of colorectal polyps.
- Trial name
- CRIS (NCT07584486)
- Testing
- Learning tool (CRIS/JNET), Learning tool (JNET/CRIS)
- Where
- Belgium
- Volunteers
- 764 people
- Sponsor
- University Hospital, Ghent
Rare Diseases, Thoracic Aortic Aneurysm (TAA)
Fibroblasts and Thoracic Aortic Aneurysms: in Vitro Characterization in With Marfan Syndrome and Genetic Aortic Diseases
The aim of the present study is to characterise the phenotype of fibroblasts and to classify different mechanisms involved in the onset and progression of TAAD in syndromic and non-syndromic subjects in order to evaluate…
- Conditions
- Rare Diseases, Thoracic Aortic Aneurysm (TAA), Marfan Syndrome
- Trial name
- FIBRA (NCT06786754)
- Where
- Italy
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- IRCCS Policlinico S. Donato
Craniofacial Abnormalities
FACE.S-4-KIDS : A Deep Phenotyping Database of Craniofacial Anomalies During Development With 4 Pilot Projects
FACE.S-4-KIDS is an ambitious database project addressing the scientific question of the variable expression of craniofacial disorders in humans, to reach a sound clinical management (diagnosis, prognosis), and the establishment…
- Trial name
- FACES-4-KIDS (NCT07422454)
- Where
- France
- Volunteers
- 3,100 people
- Sponsor
- Imagine Institute
Body Temperature Changes, Heat Stress
Ambient Temperature and Thermoregulation During Exercise in Children and Youth
Little is known about how children and youth regulate body temperature during exercise across different environmental temperatures compared with young adults, including whether differences in whole-body heat exchange contribute…
- Conditions
- Body Temperature Changes, Heat Stress, Child Development, Heat
- Trial name
- NCT07781605
- Testing
- Exercise at 22°C, Exercise at 26°C, Exercise at 31°C
- Where
- Canada
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of Ottawa
Periodontal Diseases, Periodontitis
Development, Validation, and Assessment of the Diagnostic Accuracy of a Questionnaire for Periodontitis Screening
The present study aims at validating the Italian version of one of the most widely used epidemiological questionnaires for periodontitis screening: the CDC/AAP questionnaire [hereafter referred to as the CDC/AAP_ITA…
- Trial name
- Q_ITA (NCT07461753)
- Volunteers
- 495 people, healthy volunteers welcome
- Sponsor
- Azienda Unità Sanitaria Locale (A.U.S.L.) Ferrara, Italy
Embryo Culture, Embryo Culture Media
Evaluation of an Undisturbed Embryo Culture System for Embryo Development in IVF/ICSI Cycles
This is a prospective, multicenter, randomized controlled clinical trial designed to evaluate whether a fully undisturbed closed embryo culture system can improve the developmental potential of embryos cultured in vitro and…
- Conditions
- Embryo Culture, Embryo Culture Media, Embryo Quality
- Trial name
- Embryos UECS (NCT07522281)
- Testing
- Gems FEM fertilization medium + Geri incubator+Gems one-step medium, Vitrolife fertilization medium+benchtop incubator + Vitrolife sequential culture media
- Volunteers
- 478 people, healthy volunteers welcome
- Sponsor
- Sun Yat-sen University
Molar Incisor Hypomineralisation, Dental Caries
Selective Versus Non-selective Caries Excavation in MIH Affected Teeth.
The aim of this study is to compare the clinical and radiographic outcomes of selective versus nonselective caries removal in MIH affected teeth with deep carious lesions using enhanced clinical protocols.
- Trial name
- NCT07142629
- Testing
- Selective caries removal, Non-Selective caries removal
- Where
- Jordan
- Volunteers
- 60 people
- Sponsor
- King Abdullah University Hospital
Autism, Sleep Disturbances in Children
Differences in Rest, Emotion, and Arousal Modulation in Youth
The goal of this study is to examine the relationship between sensory responsivity, bedtime arousal levels, sleep disturbances, and daytime emotion dysregulation for autistic children (ages 6-10).
- Conditions
- Autism, Sleep Disturbances in Children, Sleep
- Trial name
- DREAMY-Autism (NCT07476937)
- Testing
- Power Down bedtime manipulation
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Family Resilience, Parent-Infant Bonding
Development and Evaluation of an Intelligent Parent-Infant Connection-Based Intervention to Strengthen Family Resilience in Preterm Infant Care
This study aims to develop, optimize, and evaluate the effectiveness of a family resilience intervention centered on intelligent parent-infant connection for parents of preterm infants.
- Conditions
- Family Resilience, Parent-Infant Bonding, Parents of Premature Infants, Intelligent Intervention
- Trial name
- NCT07373002
- Testing
- Intelligent Intervention to enhance Parent-Infant Connection and Family Resilience, Routine Care
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Defense Medical Center, Taiwan
Core Muscle Weakness, Postural Control Deficit
"CORE Training for Musculoskeletal Health: A Study on Adaptive Exercise Protocols"
This study aims to evaluate the effects of an adaptive core training protocol that integrates core stability, core strength, and high-intensity core power exercises on muscle activation, hypertrophy, balance, and quality of life.
- Conditions
- Core Muscle Weakness, Postural Control Deficit, Trunk Stability Impairment, Functional Performance Limitation
- Trial name
- RCT-EMG-US-QoL (NCT07025395)
- Testing
- - Core Training Protocol, Control Group Core Routine
- Where
- Greece
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Ioannis Tsartsapakis
Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease
Biomarker Panel for PCOS-Associated Liver Steatosis in Adolescent Girls (COMPASS-pedPCOS)
This single-center, prospective, observational, cross-sectional mechanistic pilot study will evaluate whether polycystic ovary syndrome (PCOS) contributes to hepatic steatosis in adolescent girls independently of adiposity.
- Conditions
- Polycystic Ovary Syndrome (PCOS), Metabolic Dysfunction-Associated Steatotic Liver Disease, Pediatric Obesity, Hyperandrogenism
- Trial name
- COMPASSpedPCOS (NCT07731373)
- Testing
- Extended Serum Biomarker and Hormonal Panel, Liver Elastography with Controlled Attenuation Parameter, Targeted Genotyping of PNPLA3 rs738409 and HSD17B13 rs72613567
- Where
- Turkey (Türkiye)
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Kayseri City Hospital
Post-traumatic Brain Injury Depression, Veteran Health
Development of Low-Intensity Focused Ultrasound for Post Traumatic Brain Injury Depression
The goal of this clinical trial is to learn about evaluate the safety, tolerability, and feasibility of MRI-guided LIFU targeting the sgACC in Veterans with post-traumatic brain injury depression.
- Trial name
- NCT07828483
- Testing
- Active Low-Intensity Focused Ultrasound (LIFU)
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Stanford University
Endometrial Cancer
Development of a Non-invasive IVD for Endometrial Cancer Screening on High-risk Populations
CYTOMARK, a non-invasive in vitro diagnostic (IVD) test measuring a defined panel of protein biomarkers in cervical fluid, can accurately detect endometrial cancer in both symptomatic and asymptomatic women at high risk for the…
- Trial name
- NCT07148154
- Testing
- Cytology
- Where
- 2 sites in Spain
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- MiMARK Diagnostics, S.L.
Autism Spectrum Disorder
Integrated Platform for Measuring and Reducing Symptoms of Autism Spectrum Disorder
This study will consist of a randomized, double-blind, sham-controlled clinical trial at SUNY Upstate Medical University and Mt.
- Trial name
- IPMR ASD (NCT06006637)
- Testing
- Cognilum TM: Light Treatment Condition
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- State University of New York - Upstate Medical University
Intraventricular Hemorrhage Neonatal, Post-hemorrhagic Hydrocephalus
Advanced MRI in IVH
55,000 babies are born prematurely in the UK annually. Bleeding in the fluid spaces of the brain (ventricles) is common after prematurity; in England around 450 babies suffer from severe bleeds every year.
- Trial name
- NCT07412886
- Testing
- Advanced MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
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