Clinical trials: Development, open to volunteers
Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate
LY4268989 in Adults With Moderately to Severely Active Ulcerative Colitis
The main purpose of this study is to evaluate the safety and effectiveness of LY4268989 when compared to placebo in adult participants with moderately to severely active ulcerative colitis (UC).
- Conditions
- Ulcerative Colitis (UC), Ulcerative Colitis, Active Moderate, Ulcerative Colitis, Active Severe
- Trial name
- EMERALD-3 (NCT07415044)
- Testing
- LY4268989
- Where
- 258 sites in United States, Argentina and 26 more
- Volunteers
- 1,431 people
- Sponsor
- Eli Lilly and Company
Quadriplegia/Tetraplegia
Development and Validation of a New Questionnaire for Caregivers to Assess Hip Pain in Quadriplegic Pediatric Patients: Non-Ambulatory Hip Pain Questionnaire
The goal of this clinical trial is twofold: 1. to develop a questionnaire for care givers to assess hip pain in quadriplegic pediatric patients who are not able to communicate it independently 2.
- Trial name
- NAHPq (NCT06798233)
- Testing
- Non-Ambulatory Hip Pain questionnaire
- Where
- 2 sites in Italy
- Volunteers
- 100 people
- Sponsor
- Azienda USL Reggio Emilia - IRCCS
Developmental and Epileptic Encephalopathy
A Study to Investigate LP352 in Children and Adults With Developmental and Epileptic Encephalopathy (DEE)
This (DEEp OLE Study) is a multicentre, open-label study to investigate the long-term safety, efficacy, tolerability, and pharmacokinetics (PK) of LP352 in the treatment of seizures in children and adults with DEE who completed…
- Trial name
- NCT06908226
- Testing
- LP352
- Where
- 88 sites in United States, Australia and 15 more
- Volunteers
- 324 people
- Sponsor
- Longboard Pharmaceuticals
ADHD or ADHD Traits
Development and Evaluation of a Digital Game Intervention Targeting Children Vulnerable to ADHD
The goal of this clinical trial is to learn whether a self-administered digital game can improve attention, memory, and planning and reduce ADHD-like symptoms in children aged 6-12 in Hong Kong who have subclinical or vulnerable…
- Trial name
- NCT07900048
- Testing
- Digital Game Intervention, Tetris
- Volunteers
- 100 people
- Sponsor
- The Hong Kong Polytechnic University
Unilateral Cerebral Palsy
Wereables for Upper Limb Functionality in Hemiparesis
The project is configured as a national interventional study that aims to determine the effectiveness of an intervention strategy using wearable technology, tailored to improve function (WeFun-wearable), on the spontaneous use of…
- Trial name
- WeFun (NCT06872736)
- Testing
- WeFun-wearable activated, WeFun-wearable desactivated
- Where
- Spain
- Volunteers
- 40 people
- Sponsor
- Universidade da Coruña
Metastatic Breast Cancer, Lobular Breast Carcinoma
Improving Survival for Metastatic Lobular Breast Cancer (PLUMB Registry)
This is a prospective observational registry for patients with invasive lobular carcinoma (ILC) of the breast. After the first 1cohort is enrolled, the collected data will be utilized to develop an ILC specific response…
- Trial name
- NCT05964504
- Testing
- Blood Specimen
- Where
- 4 sites in United States
- Volunteers
- 150 people
- Sponsor
- University of California, San Francisco
Depression
Teen Brain Online II: Understanding How Social Media Affects the Teen Brain
There has been much interest in the potential role of social media (SM) use in driving a current mental health crisis among teens, with a dire need for evidence that goes beyond self-report.
- Trial name
- TBO-II (NCT06817993)
- Testing
- Rejection and Acceptance Feedback
- Where
- United States
- Volunteers
- 60 people
- Sponsor
- University of Pittsburgh
Amelogenesis Imperfecta
Oral Health Related Quality of Life of Children With Amelogenesis Imperfecta
This project aims to evaluate the impact of anterior veneer treatment on oral health-related quality of life in children with amelogenesis imperfecta (AI).
- Trial name
- NCT07250906
- Testing
- Veneers
- Where
- Turkey (Türkiye)
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Istanbul University
Advanced Cancer, Pain
Integrated Smartphone Technology to Alleviate Malignant Pain (I-STAMP) Testing
The purpose of the study is to evaluate if the smartphone app, I-STAMP (Integrated Smartphone Technology to Alleviate Malignant Pain), helps participants with cancer pain manage symptoms and keep track of medications.
- Trial name
- NCT06117709
- Testing
- I-STAMP
- Where
- United States
- Volunteers
- 73 people
- Sponsor
- Dana-Farber Cancer Institute
Myeloproliferative Neoplasm
Replacing Bone Marrow Diagnostics With Peripheral Blood Analysis in MPN Patients
The PERIBLOOD-MPN study aims to develop and validate a minimally invasive peripheral blood test using single-cell RNA sequencing to accurately diagnose and classify myeloproliferative neoplasms, potentially reducing the need for…
- Trial name
- NCT07648433
- Testing
- PERIBLOOD-MPN
- Volunteers
- 500 people
- Sponsor
- Weizmann Institute of Science
Insomnia
Parent-Mediated Telehealth Intervention for Insomnia in Young Autistic Children
This study will evaluate the efficacy of a structured parent-mediated behavioral intervention called Sleep Parent Treatment (SPT) for insomnia in autistic children ages 3 to 7 years 11 months, compared to another behavioral…
- Trial name
- NCT07435740
- Testing
- Sleep Parent Training (SPT), Sleep Parent Education (SPE)
- Where
- 3 sites in United States
- Volunteers
- 130 people
- Sponsor
- The Cleveland Clinic
Disorder of Sex Development, 46,XY
Search for Structural Variants in Patients With DSD and Inconclusive Molecular Diagnosis
The goal of this clinical trial is to identify structural variants by Optical Genome Mapping (OGM) in the described participant population.
- Trial name
- GENEXPLOR (NCT05867979)
- Testing
- Identify structural variants by Optical Genome Mapping of DNA extracted from blood leukocytes
- Where
- France
- Volunteers
- 20 people
- Sponsor
- University Hospital, Montpellier
Breastfeeding, Smartphone
Breastfeeding Failure: Influence of Smartphone Use and Distraction Factors
The benefits of breastfeeding no longer need to be proven. Many studies have shown its positives effects on both infants and mothers. Exclusive breastfeeding is thus recommended within the first six months of life.
- Trial name
- BRIEFCALL (NCT05916079)
- Where
- France
- Volunteers
- 300 people
- Sponsor
- Centre Hospitalier Universitaire, Amiens
Preventative Health, Well-Being, Psychological
Reducing School Dropout and Enhancing Pupils' Sense of Belonging and Participation Through Co-created Music-based Activities
RESONATE is a cluster-randomised crossover trial focusing on reducing school dropout rates and fostering belonging through co-created music-based activites, by combining music therapy (MT), psychology, and social sciences.
- Conditions
- Preventative Health, Well-Being, Psychological, Salutogenesis, Mastery
- Trial name
- RESONATE (NCT07632391)
- Testing
- Group music activity, co-created by pupils and music therapists, 1x/week over 1 school semester, Usual school schedule over 1 school semester
- Where
- 16 sites in Norway
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- NORCE Norwegian Research Centre AS
Osteogenesis Imperfecta, Osteoporosis
REMS25: Study on the Use of REMS Technology in Diseases Commonly Associated With Reduced Bone Mineral Density (BMD)
This study evaluates bone mineral density (BMD) in pediatric patients aged 5-18 years with conditions negatively affecting bone health, using REMS (Radiofrequency Echographic Multi Spectrometry), a non-invasive and radiation-free…
- Conditions
- Osteogenesis Imperfecta, Osteoporosis, Hypogonadisms, Neoplasia
- Trial name
- NCT07412782
- Testing
- REMS
- Where
- Italy
- Volunteers
- 100 people
- Sponsor
- Meyer Children's Hospital IRCCS
Psoriasis
An AI-Based Erythema Measurement System for Psoriasis Lesions
Psoriasis is a common chronic inflammatory skin disease. Disease severity is commonly assessed using the Psoriasis Area and Severity Index (PASI), in which erythema is graded subjectively on a 0-4 scale.
- Trial name
- NCT07494396
- Testing
- No additional drugs(control Group)
- Where
- Thailand
- Volunteers
- 50 people
- Sponsor
- Khon Kaen University
Autism Disorder, Autism Spectrum Disorder (ASD
Effectiveness of Interactive Techniques on Oral Hygiene Skills in a Group of Autistic Egyptian Children
The present study will be performed to evaluate the effectiveness of peer modeling and audiovisual peer modeling video on toothbrushing skills in comparison to the visual pedagogical method at home.
- Conditions
- Autism Disorder, Autism Spectrum Disorder (ASD, Autism, Plaque Reduction
- Trial name
- Autism ASD (NCT07859696)
- Testing
- Peer model, Pre-recorded video of peer modeling, Pedagogical method
- Volunteers
- 90 people
- Sponsor
- Faculty of Dental Medicine for Girls
Asthma, Allergic Disease
Screening and Management of Adults With Asthma and Allergic Diseases
The aim of this study is to develop and validate a digital screening tool and digital management system for asthma and allergic diseases among Chinese adults and to evaluate the effectiveness of integrated non-pharmacological…
- Trial name
- NCT07523724
- Testing
- Allergen Avoidance Intervention - group 1, Exercise Intervention - group 1, Dietary Intervention - group 1
- Volunteers
- 9,666 people
- Sponsor
- Beijing Hospital
Emergency Department, Revisit
Development, Validation, and Clinical Trial of a Prediction Tool for High-Risk Emergency Department Revisits
Emergency department (ED) visits have grown tremendously in Taiwan over the past few years, reaching approximately 7 million visits in 2019.
- Trial name
- NCT07909096
- Testing
- ED-HIKRS, Usual Care
- Volunteers
- 4,010 people
- Sponsor
- National Taiwan University Hospital
Sleep Duration, Child Obesity
Effect of Sleep Extension on Body Weight and Learning in Children (More2Sleep)
More2Sleep is a randomized, controlled, parallel trial with two groups (sleep extension vs control) including 142 school-aged children (6-12 years) who have a BMI above average, defined as age- and sex-specific BMI Z-score above…
- Conditions
- Sleep Duration, Child Obesity, Child Development, Child Behavior
- Trial name
- More2Sleep (NCT06341179)
- Testing
- Sleep extension
- Where
- 3 sites in Denmark
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Copenhagen
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