Clinical trials: Development, open to volunteers
Autism Spectrum Disorder
Paediatric Autism Communication Therapy (PACT) in Children With Autism Spectrum Disorder
Paediatric Autism Communication Therapy (PACT) is a naturalistic developmental behavioural interventions to reduce autism symptoms.
- Trial name
- DAN-PACT (NCT05673096)
- Testing
- PACT, MAU
- Where
- 6 sites in Denmark
- Volunteers
- 280 people
- Sponsor
- University of Southern Denmark
Socioemotional Development, Cognitive Ability
Early Institutionalization Intervention Impact Project
The purpose of this study is to determine the effects of early intervention (placement into foster care, and a caregiving training) on physical, cognitive, social and brain development and psychiatric symptomatology in children…
- Conditions
- Socioemotional Development, Cognitive Ability, Behavioral and Neural Patterns of Attention, Brain Function
- Trial name
- EI-3 (NCT04165746)
- Testing
- Foster Care, Caregiving Intervention
- Where
- Brazil
- Volunteers
- 220 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Adolescent Idiopathic Scoliosis
Minimally Invasive Surgery vs Standard Posterior Approach in the Treatment of Developmental Idiopathic Scoliosis
This is a randomized trial with 1:1 allocation. The aim of the study is to evaluate clinical and radiographic outcomes in patients with developmental age idiopathic scoliosis treated with mini invasive scoliosis surgery (MIS)…
- Trial name
- NCT05860673
- Testing
- mini invasive scoliosis surgery, posterior spinal fusion technique
- Where
- Italy
- Volunteers
- 126 people
- Sponsor
- Istituto Ortopedico Rizzoli
Neurodevelopmental Disorders (NDD), Preschool Child Development
Efficacy of a Group-based and Digital Parent Sleep Intervention in HK Preschoolers With NDDs
Neurodevelopmental disorders (NDDs) in preschoolers are frequently accompanied by persistent sleep disturbances, such as delayed sleep onset and reduced sleep duration, which exacerbate behavioral problems, impair cognitive…
- Conditions
- Neurodevelopmental Disorders (NDD), Preschool Child Development, Sleep
- Trial name
- NCT07822490
- Testing
- Parent-based Group Face-to-face Intervention, Digital Self-help Intervention
- Where
- Hong Kong
- Volunteers
- 150 people
- Sponsor
- Chinese University of Hong Kong
Sensory Impairments, Cognitive Impairment
Development of an Ensemble Learning-based, Multi-dimensional Sensory Impairment Score to Predict Cognitive Impairment in an Elderly Cohort of Southern Italy
There is now strong scientific literature showing a relationship between sensory loss and cognitive performance and between sensory loss and incident dementia.
- Conditions
- Sensory Impairments, Cognitive Impairment, Artificial Intelligence
- Trial name
- DEMETRA (NCT06783010)
- Volunteers
- 30 people
- Sponsor
- Azienda Sanitaria Locale Bari
Depression, Psychiatric Disorder
Treating Depression on a Day-to-day Basis: Development of a Tool for Physicians Based on a Smartphone Application
Testing and validating an e-health (smartphone application) approach to better understand the determinants of day-to-day symptomatology in depression, medication adherence, and treatment efficacy in the goal of maximizing patient…
- Conditions
- Depression, Psychiatric Disorder, Brain Diseases, Central Nervous System Diseases
- Trial name
- SMART (NCT03678194)
- Testing
- Smartphone Support System
- Where
- France
- Volunteers
- 200 people
- Sponsor
- Centre Hospitalier Charles Perrens, Bordeaux
Autism, Intervention (Training) Condition
Parent-Mediated Social Cognition Intervention for Young Children With Autism Spectrum Disorder
This study evaluates the efficacy of the Companion Mind-Drawing Cooperative Game Program, a parent-mediated, home-based structured play intervention targeting social cognitive development in young children with autism spectrum…
- Conditions
- Autism, Intervention (Training) Condition, Social Cognition, Cognition Improvement
- Trial name
- PMSC-ASD (NCT07708246)
- Testing
- Companion Mind-Drawing Cooperative Game Program
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Children's Hospital of Fudan University
Obesity
Development of a Genetic Score as a Response Modifier for Changes in Weight, Body Composition, and Biochemical Parameters in Obese Adults Undergoing a Low-Energy High-Protein Diet Intervention
The goal of this clinical trial is to evaluate whether a genetic score (Gens-HiPro) acts as a response modifier for weight loss, body composition changes, and biochemical parameters in obese adults undergoing a low-energy…
- Trial name
- Gens-HiPro (NCT07760870)
- Testing
- Low-Energy High-Protein Diet
- Where
- Indonesia
- Volunteers
- 29 people
- Sponsor
- Gadjah Mada University
Neurodevelopment Outcome, Linear Growth
Micronutrient Enhancement for Development and Health in Adolescents - The MEDHA Study
MEDHA is a randomized controlled trial among 10-18 year old girls to examine the use-case of the United Nations International Multiple Micronutrient Antenatal Preparation (UNIMMAP) multiple micronutrient supplement (MMS)…
- Conditions
- Neurodevelopment Outcome, Linear Growth, Micronutrient Status, Bone Mineral Density
- Trial name
- MEDHA (NCT07695883)
- Testing
- Iron (60 mg)- folic acid (400 ug) [IFA], Multiple micronutrient supplement [MMS], Multiple micronutrient supplement Plus [MMS+]
- Where
- Bangladesh
- Volunteers
- 3,000 people, healthy volunteers welcome
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Chronic Pelvic Pain Syndrome, Pelvic Congestive Syndrome
Development of a Patient-reported Outcome Measure for Women With Chronic Pelvic Pain
The purpose of this study is to develop a patient questionnaire that can be utilized to assess the benefit of treatments of chronic pelvic pain in research studies.
- Trial name
- PROM for CPP (NCT06083597)
- Testing
- Qualitative interview
- Where
- United States
- Volunteers
- 55 people, healthy volunteers welcome
- Sponsor
- Weill Medical College of Cornell University
Excessive Crying, Prolonged Pain
Assessment of Prolonged Pain in Infants With Excessive Crying: Contribution of Infrared Thermal Imaging - The NEOTHERM Pilot Study
NEOTHERM is a multicenter, prospective, observational pilot study examining whether infrared thermal imaging (ITI) can contribute to the assessment of prolonged pain in infants with excessive crying.
- Trial name
- NEOTHERM (NCT07693179)
- Where
- 3 sites in France
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- Centre Hospitalier de Saint-Denis
Stuttering, Developmental, Dyslexia
Investigating Individual Differences in Speech Motor Skills in Neurotypical Speakers and Persons With Disordered Speech
This study aims to understand how people use different types of feedback to control their speech. When an individual speaks, the brain relies on several systems at the same time, such as sensory systems that monitor an…
- Conditions
- Stuttering, Developmental, Dyslexia, Healthy Participants
- Trial name
- NCT07459803
- Testing
- Unpredictable auditory feedback perturbation: 2 behavioral sessions, Unpredictable auditory feedback perturbation during tCS: 3 behavioral sessions, Sustained F1 auditory feedback perturbation
- Where
- 2 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Boston University Charles River Campus
Autism Spectrum Disorder
The Effects of Preoperative Intranasal Administration of Dexmedetomidine and Esketamine on Negative Postoperative Behavioral Changes in Children With Autism Spectrum Disorder
The goal of this clinical trial is to learn whether intranasal sedation given before anesthesia can lower negative postoperative behavioral changes in children with autism spectrum disorder who undergo elective surgery.
- Trial name
- NPOBCs (NCT07324057)
- Testing
- Intranasal dexmedetomidine, Intranasal Esketamine, saline control
- Where
- China
- Volunteers
- 234 people
- Sponsor
- Sun Fei
Chronic Obstructive Pulmonary Disease (COPD)
Artificial Intelligence-Based Motion Analysis for Early Detection of COPD
This study aims to develop a non-invasive and contact-free diagnostic system that uses artificial intelligence (AI) to detect Chronic Obstructive Pulmonary Disease (COPD) by analyzing walking patterns.
- Trial name
- NCT07010211
- Testing
- Gait Video Recording and Analysis
- Volunteers
- 56 people, healthy volunteers welcome
- Sponsor
- Burcin Celik
Malignant Tumor, Anxiety
Long-term Follow-up of Anxiety and Depression in Patients With Malignant Tumors
This study was a single-center prospective, real-world observational study with plans to enroll all eligible patients. The basic information, anxiety and depression, treatment and prognosis of these patients were collected.
- Conditions
- Malignant Tumor, Anxiety, Depression
- Trial name
- NCT05596344
- Testing
- Hospital Anxiety and Depression Scale
- Where
- China
- Volunteers
- 200 people
- Sponsor
- Henan Cancer Hospital
Focus on Healthy Infants
Development of Muscle Function in Prepubertal Children As a Response to Growth and Resistance Training
Healthy skeletal muscle development is crucial for a life-long quality of life. Childhood and puberty may be key periods for developing muscle growth and neuromuscular capacities, which are essential for bone-muscle interaction…
- Trial name
- decade-fit (NCT06594900)
- Testing
- resistance training intervention
- Where
- Switzerland
- Volunteers
- 52 people, healthy volunteers welcome
- Sponsor
- Ralf Roth
Breast Cancer
Prospective Ultrasound Data Collection Study for AI-Based Detection of Breast Biopsy Markers
The goal of this observational study is to collect ultrasound imaging data to support the development and refinement of an artificial intelligence (AI)-enhanced ultrasound software designed to detect and localize standard-of-care…
- Trial name
- NCT07427407
- Testing
- Breast Ultrasound Imaging With Investigational AI Software
- Where
- United States
- Volunteers
- 100 people
- Sponsor
- AURA Health Technologies
Pulmonary Nodules, Lung Neoplasms
Deep Learning Time-Series Prediction of Long-Term Growth Patterns of Pulmonary Ground-Glass Nodules Using Serial CT
Pulmonary ground-glass nodules (GGNs) are commonly found on chest CT scans. Some stay stable for years, while others slowly or rapidly turn into lung cancer.
- Conditions
- Pulmonary Nodules, Lung Neoplasms, Adenocarcinoma of Lung
- Trial name
- GGN-Trajectory (NCT07647692)
- Testing
- Serial Thin-Slice Chest CT
- Where
- China
- Volunteers
- 4,750 people
- Sponsor
- Peking University People's Hospital
Pulmonary Hypertension, Insomnia
Self-Help Booklets for Sleep in Adults With Pulmonary Hypertension
The researchers have developed a set of self-help booklets for adults with pulmonary hypertension (PH) who are experiencing sleep problems.
- Conditions
- Pulmonary Hypertension, Insomnia, Sleep Hygiene
- Trial name
- NCT07754981
- Testing
- Sleep Hygiene Self-Help Intervention
- Where
- United Kingdom
- Volunteers
- 60 people
- Sponsor
- University of Sheffield
Healthy Volunteer, Magnetic Resonance Imaging
Study of New Magnetic Resonance Imaging Methods of the Brain
The purpose of this investigation is to develop improved magnetic resonance imaging (MRI) techniques and hardware for studying brain function.
- Conditions
- Healthy Volunteer, Magnetic Resonance Imaging, Healthy, fMRI
- Trial name
- NCT00004577
- Where
- United States
- Volunteers
- 1,100 people, healthy volunteers welcome
- Sponsor
- National Institute of Neurological Disorders and Stroke (NINDS)
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