Clinical trials: Development, open to volunteers
Neurodevelopmental Disorders, Intellectual Disability
Multi-Omics Genetic Investigation Strategies to Enhance the Diagnostic Workflow for Rare Diseases
LEOPARD is a multicenter study aimed at improving the genetic diagnosis of patients with neurodevelopmental disorders (NDDs) of unknown etiology, particularly those with moderate-to-severe intellectual disability.
- Conditions
- Neurodevelopmental Disorders, Intellectual Disability, Autism Spectrum Disorder, Genetic Diseases, Inborn
- Trial name
- LEOPARD (NCT07884227)
- Where
- Italy
- Volunteers
- 200 people
- Sponsor
- Istituto Giannina Gaslini
Autism Spectrum Disorder, Autism Spectrum Disorder (ASD)
Dance, Yoga, And Mindful Movement Training For ASD
The goal of this study is to learn if a dance, yoga, and mindful movement program can improve the lives of adults with autism spectrum disorder (ASD).
- Conditions
- Autism Spectrum Disorder, Autism Spectrum Disorder (ASD), Autism
- Trial name
- NCT07758088
- Testing
- Yoga, dance and Mindful Movement
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- USC Glorya Kaufman School of Dance
Healthy
Hippocampal and Frontoparietal Development and Inference
The goal of this clinical trial is to test if an intervention used to manipulate memory and inference can improve our understanding of how brain development supports these abilities in healthy adolescent and adult volunteers.
- Trial name
- NCT07199907
- Testing
- Associative Inference, Probabilistic Inference
- Where
- United States
- Volunteers
- 142 people, healthy volunteers welcome
- Sponsor
- University of Texas at Austin
Breast Cancer
Sustainable and Efficient Platform Trial of New Therapeutic Development for Early Breast Cancer
Randomized phase II trial targeting early-stage breast cancer (stage II-III) applicable to preoperative chemotherapy (NAC), comparing standard treatment with multiple experimental treatments.
- Trial name
- NCT06535893
- Testing
- TN, TN-1
- Where
- Japan
- Volunteers
- 100 people
- Sponsor
- Nagoya City University
Autism Spectrum Disorder, Psychosis
Neural Basis of Social Cognition Deficits
Difficulties in reciprocal social interaction are hallmark features of several neuropsychiatric disorders, most notably autism spectrum disorder (ASD) and schizophrenia spectrum disorder (SSD).
- Conditions
- Autism Spectrum Disorder, Psychosis, Social Communication
- Trial name
- NCT05185128
- Testing
- PEERS social skills intervention
- Where
- United States
- Volunteers
- 90 people
- Sponsor
- Loma Linda University
Prehospital Emergency Medical Services, Point-of-care Ultrasound
Ultrasound Applications for Emergency Medical Technicians in Taiwan
The goal of this prospective observational study is to develop and assess the core ultrasound applications for emergency medical technicians (EMTs) in Taiwan.
- Trial name
- NCT06950333
- Testing
- POCUS education curriculum
- Volunteers
- 200 people
- Sponsor
- National Taiwan University Hospital
Lung Disease, Pneumothorax
Study of the Disease Process of Lymphangioleiomyomatosis
Pulmonary lymphangioleiomyomatosis (LAM) is a destructive lung disease typically affecting women of childbearing age. Currently, there is no effective therapy for the disease and the prognosis is poor.
- Conditions
- Lung Disease, Pneumothorax, Tuberous Sclerosis, Lymphangioleiomyomatosis
- Trial name
- NCT00001465
- Testing
- Toshibia Aquilion One CT
- Where
- United States
- Volunteers
- 2,000 people
- Sponsor
- National Heart, Lung, and Blood Institute (NHLBI)
Autism Spectrum Disorder
Structured Sensory-Based Occupational Therapy in Children With Autism
This controlled clinical study will investigate the effects of a 12-week structured sensory-based occupational therapy intervention on occupational performance, sensory processing, gross motor development, and eating behaviors in…
- Trial name
- NCT07789704
- Testing
- Structured Sensory-Based Occupational Therapy, Individualized Home Activity Program
- Where
- Turkey (Türkiye)
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- Emre DANSUK
Nursing, Skill Performance
Development and Implementation Haptic VR Simulation
The goal of this experimental study is to increase objectivity in clinical decision-making and skill assessment of nursing students by using haptic-assisted virtual reality simulation, unlike imported products used in nursing…
- Conditions
- Nursing, Skill Performance, Virtual Reality, Simulation-based Training
- Trial name
- VR (NCT07175467)
- Testing
- Haptic-asissted virtual simulation
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- Sakarya University
Working Memory, Inhibitory Control
BID WM Digital Intervention in Aging
The goal of this clinical trial is to learn if engaging with an digital intervention may improve cognitive function. The main questions it aims to answer are: 1.
- Conditions
- Working Memory, Inhibitory Control, Mild Cognitive Impairment (MCI), Aging
- Trial name
- NCT06918704
- Testing
- Coherence, Worder
- Where
- United States
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- University of California, San Francisco
Pectus Excavatum
Field-test and Psychometric Validation of the Pectus Excavatum Evaluation Questionnaire in the Dutch Pectus Excavatum Population
A questionnaire that can measure disease severity from the patients perspective in patients with pectus excavatum already exists in English (Pectus Excavatum Evaluation Questionnaire; PEEQ).
- Trial name
- TRANSLATE (NCT06918392)
- Where
- Netherlands
- Volunteers
- 66 people
- Sponsor
- Erik de Loos
COVID-19 Pneumonia, COVID-19 Pandemic
Corona Virus Disease 2019 Cohort Study
The goal of this observational study is to learn about the influence of Corona Virus Disease 2019 on obstetric outcome and offspring development.
- Conditions
- COVID-19 Pneumonia, COVID-19 Pandemic, COVID-19
- Trial name
- NCT06927622
- Where
- 5 sites in China
- Volunteers
- 1,000 people, healthy volunteers welcome
- Sponsor
- Shandong University
Epileptic Encephalopathy
A First-in-human Study of S230815 in Pediatric Participants With KCNT1-related Developmental and Epileptic Encephalopathy
Study CL1-230815-001 (KANDLE) is a Phase Ib/II, First In Human, multicentre, open-label, multiple ascending dose study to assess the safety, tolerability, pharmacokinetics (PK) and pharmacodynamic (PD) effect of S230815 in…
- Trial name
- KANDLE (NCT07227857)
- Testing
- S230815- Starting dose A, S230815- Dose B, S230815- Dose C
- Where
- 15 sites in United States, France and 3 more
- Volunteers
- 20 people
- Sponsor
- Institut de Recherches Internationales Servier
Alpha and Beta Thalassemia, Sickle Cell Disease
Collection of Human Biospecimens for Basic and Clinical Research Into Globin Variants
Background: Blood disorders like sickle cell disease and malaria affect many people around the world. Researchers want to learn more about blood disorders.
- Conditions
- Alpha and Beta Thalassemia, Sickle Cell Disease, Malaria, Human Physiology
- Trial name
- NCT03937817
- Where
- United States
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Institute of Allergy and Infectious Diseases (NIAID)
Autism Spectrum Disorder
REward SYSTem in Autism Spectrum Disorder and Addictive Disorder
An MRI Study in Subjects with Autism Spectrum Disorder and Subjects with Food Addictive Disorder compared to healthy volunteers.
- Trial name
- RESYSTAA (NCT05391113)
- Testing
- MRI, EEG
- Where
- 3 sites in France
- Volunteers
- 78 people, healthy volunteers welcome
- Sponsor
- University Hospital, Tours
Prenatal Exposure, Postnatal Exposure
Exposure to Organochlorine Pollutants and Impact on Development in the Peripubertal Age in Guadeloupe
In the context of environmental pollution of the French West Indies by chlordecone and questions about health consequences, monitoring at the peripubertal age of children born alive in the TIMOUN cohort is justified in several…
- Trial name
- TIMOUNPUBERTY (NCT06653660)
- Testing
- Clinical examination
- Where
- Guadeloupe
- Volunteers
- 650 people
- Sponsor
- Centre Hospitalier Universitaire de la Guadeloupe
Autism, Autism Disorder
Role of the Gut Vascular Barrier and Microbiota in Autism Spectrum Disorders
Recent research links gut microbiota alterations to Autism Spectrum Disorders (ASD), a neurobiological condition with multifactorial bases.
- Conditions
- Autism, Autism Disorder, Autism Spectrum Disorder (ASD)
- Trial name
- DSA/GVB (NCT07450443)
- Testing
- PostbiotiX Comfort®, Control
- Where
- 2 sites in Italy
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fondazione I.R.C.C.S. Istituto Neurologico Carlo Besta
Neurodevelopmental Disorders, Autism Spectrum Disorder
Characterization of Social Cognition Profiles in Children and Adolescents With Neurodevelopmental Disorders: a Clinical Study Using a Multidimensional Battery
In France, more than one in ten school-aged children suffers from a mental health disorder, and half of these disorders appear before the age of 14. Yet, only half of affected children receive appropriate support.
- Conditions
- Neurodevelopmental Disorders, Autism Spectrum Disorder, Attention Deficit Hyperactivity Disorder, Atypical Neurodevelopmental Disorder
- Trial name
- COGSO (NCT07439276)
- Testing
- Test, Questionnaires
- Where
- France
- Volunteers
- 100 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
fMRI
A Longitudinal Investigation of the Endocrine and Neurobiologic Events Accompanying Puberty
Despite the clear importance of adolescence in the emergence of a number of disease states and processes, there is surprisingly little known about how the endocrine and metabolic events accompanying puberty in humans impact…
- Trial name
- NCT01434368
- Where
- United States
- Volunteers
- 480 people, healthy volunteers welcome
- Sponsor
- National Institute of Mental Health (NIMH)
Developmental Verbal Dyspraxia, Autism Spectrum Disorder
Speech Treatment for Minimally Verbal Children With ASD and CAS
Comorbid Childhood Apraxia of Speech (CAS) may be one factor that limits speech development in some minimally verbal children with autism. CAS is a disorder affecting speech movement planning.
- Trial name
- TxMVASD+CAS (NCT05066178)
- Testing
- CAS Treatment for Minimally Verbal Children with Autism
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- MGH Institute of Health Professions
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