Clinical trials: Development
Follicle Development, Ovarian Follicle
A Study to Evaluate Ovarian Follicular Activity and Hormone Levels for DR-102 Compared to Two 28-Day Oral Contraceptives
This study is being conducted to evaluate the impact of a 28-day oral contraceptive compared to two 28-day oral contraceptive regimens containing different synthetic progestins on ovarian follicular activity and hormone levels in…
- Conditions
- Follicle Development, Ovarian Follicle, Follicle Count, Follicle Size
- Trial name
- NCT01291004
- Testing
- Desogestrel/ethinyl estradiol and ethinyl estradiol, 28-day drospirenone oral contraceptive, 28-day levonorgestrel oral contraceptive
- Where
- 2 sites in United States
- Volunteers
- 206 people, healthy volunteers welcome
- Sponsor
- Teva Branded Pharmaceutical Products R&D, Inc.
Osteopetrosis
Gene-Modified Stem Cell Therapy for Children With Autosomal Recessive Osteopetrosis (ARO)
This is a non-randomized, one-arm, open label, single-center, phase I/II, prospective study, to assess safety, feasibility and efficacy of FT024 in 8 children (Age: ≥ 28 days and ≤ 2 years old, Body weight: ≥ 4 kg) affected by…
- Trial name
- ARO (NCT07665021)
- Testing
- FT024
- Where
- Italy
- Volunteers
- 8 people
- Sponsor
- Fondazione Telethon
Labral Tear, Glenoid
Return to Play Checklist
This study will try to develop and determine objective and validated criteria for our athletes to safely return to sports after labral repair.
- Trial name
- NCT04278716
- Testing
- Safe return to play checklist
- Where
- United States
- Volunteers
- 1,000 people
- Sponsor
- Rothman Institute Orthopaedics
Rheumatoid Arthritis, Lung Diseases
Investigate the Development and Progression of Lung Disease in Rheumatoid Arthritis Over Time
The purpose of this study is to investigate the link between the lungs and rheumatoid arthritis (RA). Additionally, to understand why RA patients get lung disease, how to treat, and prevent the disease.
- Trial name
- RA-LD (NCT03616158)
- Where
- United States
- Volunteers
- 340 people
- Sponsor
- National Jewish Health
Aging
Epigenetics in the Aging Process
This study will examine the role of epigenetics (heritable changes in gene function that occur without a change in DNA sequence) in the aging process.
- Trial name
- NCT00242255
- Where
- 4 sites in United States
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
Infant Development
Assessment of the "Appui Parental": A Program of Early Support to Parenthood
In so-called at risk families, the child-parent attachment relationship is more difficult to set up and this can be a barrier to social and emotional development of young children.
- Trial name
- NCT02895126
- Testing
- "Appui Parental" program, Regular parental support
- Where
- France
- Volunteers
- 88 people
- Sponsor
- University Hospital, Montpellier
Autism Spectrum Disorder, Complication of Prematurity
Correlation of CXCR4 Expression in Premature Infants With a Diagnosis of Autism at 24 Months
Preterm children are at increased risk for autism spectrum disorders, with an estimated rate of 10%. In the US, about 1 in 8 pregnancies ends with a premature birth.
- Trial name
- ASD-CXCR4 (NCT01686685)
- Where
- Israel
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Hadassah Medical Organization
Anorexia Nervosa
Helping HAND: Healing Anorexia Nervosa Digitally
The proposed project will develop and pilot a coached mobile app, including a social networking component, for individuals with anorexia nervosa to use in the post-acute period
- Trial name
- NCT05499676
- Testing
- SilverCloud Health Mobile Intervention, Social Networking Intervention: Facebook
- Where
- 3 sites in United States
- Volunteers
- 90 people
- Sponsor
- Washington University School of Medicine
Autism Spectrum Disorder, Intellectual Disability
TMS for the Investigation of Brain Plasticity in Autism Spectrum Disorders
The main purpose is to study brain plasticity (the changes that occur in the brain through experience) in individuals with autism spectrum disorder (ASD).
- Trial name
- NCT02836405
- Testing
- Transcranial Magnetic Stimulation
- Where
- 2 sites in United States
- Volunteers
- 164 people, healthy volunteers welcome
- Sponsor
- Boston Children's Hospital
Type 1 Diabetes, Adolescent Development
Emoticare: Serious Game for the Adaptation to the Disease of Adolescents With Type 1 Diabetes Mellitus.
The intervention program targets adolescents with chronic Type 1 Diabetes Mellitus. Given the critical developmental stage and life transitions, necessitating robust personal resources, psychological support becomes imperative.
- Trial name
- NCT06331429
- Testing
- EmoTiCare
- Where
- Spain
- Volunteers
- 200 people
- Sponsor
- University of Valencia
Infant Development
Measurements of Anemia and Physiologic Tissue Response to Blood Transfusions in VLBW Infants Using Quantitative NIRS
The study quantified functional measures of red blood cell mass and oxygen in neonatal tissues using a non-invasive optical technique: near infrared optical spectroscopy .
- Trial name
- NCT00544375
- Testing
- Optical measurement
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- University of California, Irvine
Suicide
Development of a Recovery Oriented Treatment for Post-Acute Suicidal Episode (PASE) Veterans
Mental health care for Veterans with suicidal symptoms is of paramount import to the VA. Unfortunately, VA suicide reports show suicide rates increasing, suggesting a need for enhancing current VA suicide mental health care…
- Trial name
- NCT04731519
- Testing
- Continuous Identity Cognitive Therapy (CI-CT), General Health Education
- Where
- United States
- Volunteers
- 57 people
- Sponsor
- VA Office of Research and Development
Vascular Anomaly, Osler Rendu Disease
Pregnancy in Women With Rare Multisystemic Vascular Diseases: COGRare5 Study
There are no prospective studies of pregnancies for the diseases studied here in (Heredity Hemorrhagic Telangiectasia, Marfan syndrome or related, primary lower limb lymphedema, superficial arteriovenous malformations, and…
- Conditions
- Vascular Anomaly, Osler Rendu Disease, Marfan Syndrome or Related, Lymphedema Primary
- Trial name
- COGRare5 (NCT04194619)
- Testing
- Questionnaire
- Where
- 37 sites in France
- Volunteers
- 400 people
- Sponsor
- Hospices Civils de Lyon
Autism Spectrum Disorder, Self-Regulation, Emotion
Treatment to Promote Self-regulation in Children With Autism Spectrum Disorder
This study will evaluate the feasibility of repetitive Transcranial Magnetic Stimulation (rTMS) in Autism Spectrum Disorder (ASD) with self-regulation impairment.
- Trial name
- NCT05235919
- Testing
- repetitive transcranial magnetic stimulation (rTMS)
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- Holland Bloorview Kids Rehabilitation Hospital
Myeloma, Plasma-Cell, Myeloma-Multiple
Study of T Cells Targeting B-Cell Maturation Antigen for Previously Treated Multiple Myeloma
Background: T cells are white blood cells that fight several cancers. One cancer therapy involves removing a persons' T cells, changing them in a lab, and then returning them to the person.
- Trial name
- NCT02215967
- Testing
- Cyclophosphamide, Fludarabine, Anti-B-cell maturation antigen (BCMA) chimeric antigen receptor (CAR) T cells
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- National Cancer Institute (NCI)
Dementia
Development and Effectiveness of a User-centered Mobile Application for Informal Caregivers of People Living With Dementia: Randomized Controlled Trial
The research shows that the mobile application developed for informal caregivers of people living with dementia affects caregivers' care burden, quality of life; It was planned as a mixed-type, randomized controlled study to…
- Trial name
- NCT06179667
- Testing
- Mobile Application
- Where
- Turkey (Türkiye)
- Volunteers
- 75 people, healthy volunteers welcome
- Sponsor
- Gulhane Training and Research Hospital
Mental Health Issue
UNIPDES- An Internet-Based Transdiagnostic Intervention for College Students' Psychological Symptoms
This study is a randomised clinical trial. This study evaluates the effect of an internet-based intervention developed based on a transdiagnostic cognitive behavioural approach on psychological symptoms of university students.
- Trial name
- UNIPDES (NCT06245200)
- Testing
- UNIPDES - Internet Based Intervention - GUIDED, UNIPDES - Internet Based Intervention - UNGUIDED
- Volunteers
- 330 people, healthy volunteers welcome
- Sponsor
- Anadolu University
Open-Heart Surgery
Development of Delirium in Patients Undergoing Open-Heart Surgery
Malnutrition is a prevalent issue among patients undergoing cardiac surgery. This can lead to delirium risk factors, including postoperative functional and cognitive impairment.
- Trial name
- NCT06195592
- Where
- Turkey (Türkiye)
- Volunteers
- 100 people
- Sponsor
- Kubra Gunes
Autism Spectrum Disorder, Autism
Allogenic Cord Blood Transfusion in Patients With Autism
Autism is one of those disorders in Autism spectrum disorders (ASD), which characterized by social interaction abnormalities, impaired verbal and non-verbal communication, and repetitive, obsessive behavior, while the therapeutic…
- Trial name
- NCT03786744
- Testing
- ASD CB-MNC injection., Standard therapy.
- Where
- Russia
- Volunteers
- 20 people
- Sponsor
- State-Financed Health Facility "Samara Regional Medical Center Dinasty"
Comorbid Insomnia and Sleep Apnea, Insomnia
Wearable Voice-Guided BBTi for Comorbid Insomnia and Sleep Apnea (COMISA)
This study investigates the efficacy of a wearable voice-guided Brief Behavioral Therapy for Insomnia (BBTi) combined with a smart eye-mask device for individuals with Comorbid Insomnia and Sleep Apnea (COMISA).
- Conditions
- Comorbid Insomnia and Sleep Apnea, Insomnia, Obstructive Sleep Apnea
- Trial name
- BBTi-COMISA (NCT07521319)
- Testing
- Brief Behavioral Therapy for Insomnia (BBTi), Smart Eye-Mask with Voice-Guided Modules
- Where
- Taiwan
- Volunteers
- 361 people
- Sponsor
- National Sun Yat-sen University