Clinical trials: Development, open to volunteers
Epilepsy, Intracranial Tumors
Magnetoencephalography in Children
This study is a single-center observational clinical study, which evaluates the diagnostic value of magnetoencephalography (MEG) in the diagnosis of neurodevelopmental diseases in children, such as the localization of epileptic…
- Conditions
- Epilepsy, Intracranial Tumors, Cerebrovascular Disease, Autism
- Trial name
- NCT06668519
- Testing
- Magnetoencephalography
- Where
- China
- Volunteers
- 1,500 people
- Sponsor
- Children's Hospital of Fudan University
Mental Health Services, Mobile Technologies
A Mobile Text Approach to Measurement and Feedback for Wraparound Care Coordination
This SBIR Phase II proposal will fully develop and test the acceptability, feasibility, and efficacy of a novel measurement and feedback system, SMART-Wrap, tailored to Wraparound service model (WSM) for youth with serious…
- Conditions
- Mental Health Services, Mobile Technologies, Technology Development
- Trial name
- SMARTwrap (NCT07300930)
- Testing
- SMARTwrap
- Where
- United States
- Volunteers
- 216 people
- Sponsor
- 3-C Institute for Social Development
Fluorosis, Dental, Fluorosis
Design of a Multicomponent Intervention to Reduce the Risk of Exposure Fluorine
Introduction Systemic exposure to fluoride is a significant challenge for global public health; this is because although fluoride prevents dental caries, prolonged exposure to high concentrations can cause adverse effects on…
- Trial name
- NCT07359937
- Testing
- multicomponent intervention, Conventional intervention
- Where
- Colombia
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Universidad Antonio Nariño
Coronary Artery Disease, Elderly (Aged >70)
Development and Validation of a cCTA and Biomarker Based Risk Model for Coronary Revascularization in Elderly Patients With Coronary Artery Disease
This study is a prospective multi-center observational cohort involving elderly patients (≥70 years old) with multi-vessel coronary disease identified by coronary computed tomography angiography (cCTA) and scheduled for invasive…
- Trial name
- NCT07311954
- Testing
- No Intervention: Observational Cohort
- Volunteers
- 800 people
- Sponsor
- China National Center for Cardiovascular Diseases
Intraventricular Hemorrhage Neonatal, Post-hemorrhagic Hydrocephalus
Advanced MRI in IVH
55,000 babies are born prematurely in the UK annually. Bleeding in the fluid spaces of the brain (ventricles) is common after prematurity; in England around 450 babies suffer from severe bleeds every year.
- Trial name
- NCT07412886
- Testing
- Advanced MRI
- Where
- 2 sites in United Kingdom
- Volunteers
- 30 people
- Sponsor
- Great Ormond Street Hospital for Children NHS Foundation Trust
7q11.23 Microduplication Syndrome (7DUP), Autism Spectrum Disorder (ASD)
Characterization of the Natural History of Microduplication Syndrome 7q11.23
7q11.23 duplication syndrome (7q duplication syndrome/7DUP) is caused by a microduplication of the 7q11.23 chromosomal region, encompassing 26-28 genes, including the GTF2I gene.
- Conditions
- 7q11.23 Microduplication Syndrome (7DUP), Autism Spectrum Disorder (ASD), Neurodevelopmental Disorders (NDD)
- Trial name
- HINADU7 (NCT07469566)
- Testing
- clinical assessment, Parental questionnaires, Cognitive assessment
- Where
- 2 sites in France
- Volunteers
- 15 people
- Sponsor
- Hospices Civils de Lyon
Prostate Cancer (Adenocarcinoma)
Dyadic Co-learning Intervention for Patients With Prostate Cancer and Their Spouses
This study aims to help patients with prostate cancer and their spouses cope better with the challenges of cancer by learning and supporting each other together.
- Trial name
- NCT07196488
- Testing
- Dyadic Co-learning Intervention
- Where
- 2 sites in Taiwan
- Volunteers
- 60 people
- Sponsor
- National Taipei University of Nursing and Health Sciences
Advanced Solid Tumor
A Study of YL242 in Subjects With Advanced Solid Tumors
This is a multicenter, open-label study to evaluate the safety and tolerability of YL242 monotherapy and combination in participants with advanced solid malignant tumors.
- Trial name
- NCT07197827
- Testing
- YL242, YL242; Pembrolizumab, YL242; 5-FU; LV
- Where
- 15 sites in United States, Australia and 1 more
- Volunteers
- 424 people
- Sponsor
- MediLink Therapeutics (Suzhou) Co., Ltd.
Dental Plaque, Gingivitis
A Study Investigating Gingival Crevicular Fluid Biomarkers Following Use of a Commercially Available Toothpaste Containing Stannous Fluoride
The aim of this study is to evaluate the feasibility, sensitivity, and interpretability of gingival crevicular fluid (GCF) cytokine biomarkers as early indicators of tissue recovery following use of commercial dentifrice compared…
- Trial name
- NCT07842042
- Testing
- Test Toothpaste, Regular Fluoride Toothpaste
- Where
- United Kingdom
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- HALEON
Medical Adhesive Related Skin Injury, Central Venous Catheter
Medical Adhesive and Barrier Products for Preventing MARSI in Central Venous Catheter Dressings
The goal of this clinical trial is to compare three different dressing securement strategies used for central venous catheters (CVCs) to determine which is more effective in preventing medical adhesive-related skin injury (MARSI)…
- Trial name
- NCT07697430
- Testing
- Acrylic Adhesive Tape, Silicone Adhesive Tape, Skin Barrier Film + Acrylic Adhesive Tape
- Where
- Turkey (Türkiye)
- Volunteers
- 162 people
- Sponsor
- Azize Özdaş Gündoğan
Cancer
Evidence Development in Cancer Treatment - Real World: PREDiCTrw
This pilot clinical trial aims to assess the real world quality of life and survival of patients treated with therapy that has preliminary evidence of efficacy but uncertainty of the magnitude of clinical benefit or cost…
- Trial name
- NCT06242912
- Testing
- QOL - quality of life, Radiographic or laboratory evaluation
- Where
- Canada
- Volunteers
- 100 people
- Sponsor
- British Columbia Cancer Agency
Liver Cancer, Adult
Development of 3D Multi-Parametric Ultrasound (MPUS) as a Decision Support Tool for Patients
This clinical trial studies how well 3-dimensional multi-parametric ultrasound (3D MPUS) imaging works as a decision-support tool for patients with liver tumors undergoing therapy.
- Trial name
- 3DMPUS (NCT05705219)
- Testing
- 3D-MPUS
- Where
- 3 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of California, San Diego
Autism, Suicide Prevention
Crisis Interventions for Pediatric Providers - Autism Version
The goal of this clinical trial is to examine the initial feasibility, acceptability, and effectiveness of Crisis Interventions for Pediatric Providers - Autism version (CIPP-A) for providers serving autistic youth in outpatient…
- Trial name
- NCT07508436
- Testing
- Safety Planning Intervention, Crisis Interventions for Pediatric Providers - Autism version (CIPP-A)
- Where
- United States
- Volunteers
- 70 people, healthy volunteers welcome
- Sponsor
- Children's Hospital Los Angeles
ADHD, Autism Spectrum Disorder
AWARE: Management of ADHD in Autism Spectrum Disorder
This study is a pragmatic clinical trial examining the comparative effectiveness of two stimulant medications (methylphenidate and amphetamine) in the treatment of ADHD in children and adolescents with autism.
- Trial name
- NCT05916339
- Testing
- Randomization to either Amphetamine (AMP) class of stimulant medication or Methylphenidate (MPH) class of stimulant medication, Randomization to either Alpha 2 agonist class of medication or alternate class of stimulant.
- Where
- 13 sites in United States, Canada
- Volunteers
- 500 people
- Sponsor
- Daniel Coury
Kidney Disease, Chronic, End Stage Renal Disease
Development and Test of a Communication Skills Training for Transplant Providers - Aims 2 & 3
The goal of this clinical trial is to understand the communication occurring between Black and Caucasian patients and their transplant providers during transplant evaluation consultations and assess relationships between these…
- Conditions
- Kidney Disease, Chronic, End Stage Renal Disease, Kidney Replacement
- Trial name
- EPPComm (NCT06182475)
- Testing
- EPPComm Provider Training
- Where
- 2 sites in United States
- Volunteers
- 70 people
- Sponsor
- Temple University
Disruptive Behavior, Developmental Disability
Behavioral Parent Training to Address Early Childhood Disruptive Behavior Using the DOCS Parenting Programs
DOCS Parenting offers group-delivered behavioral parent training interventions for caregivers of children ages 0-12 years.
- Conditions
- Disruptive Behavior, Developmental Disability, Developmental Delay (Disorder), Behavior Problem of Childhood
- Trial name
- DOCS parenting (NCT07505381)
- Testing
- DOCS Parenting: Early Years, DOCS Parenting: School Years
- Where
- United States
- Volunteers
- 800 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Periodontal Diseases, Periodontitis
Development of A Self-Assessment Tool for Personalized Preventive Periodontal Care Among the Saudi Population Using Semi-Supervised Learning
This observational study will collect labeled data to assess the accuracy of an online periodontal self-assessment tool in adults.
- Conditions
- Periodontal Diseases, Periodontitis, Gingivitis
- Trial name
- NCT07410351
- Testing
- Online periodontal self-assessment questionnaire and clinical periodontal examination (reference standard)
- Where
- Saudi Arabia
- Volunteers
- 393 people, healthy volunteers welcome
- Sponsor
- Universiti Sains Malaysia
Obesity
Development of a Genetic Score as a Response Modifier for Changes in Weight, Body Composition, and Biochemical Parameters in Obese Adults Undergoing a Low-Energy High-Protein Diet Intervention
The goal of this clinical trial is to evaluate whether a genetic score (Gens-HiPro) acts as a response modifier for weight loss, body composition changes, and biochemical parameters in obese adults undergoing a low-energy…
- Trial name
- Gens-HiPro (NCT07760870)
- Testing
- Low-Energy High-Protein Diet
- Where
- Indonesia
- Volunteers
- 29 people
- Sponsor
- Gadjah Mada University
Hyperandrogenism
Combined Use of Machine Learning and Metabolomics to Improve the Diagnosis and Management of Hyperandrogenism
Hyperandrogenism is a common reason for consultation, the causes of which can range from common conditions (PCOS) to rarer conditions with major genetic implications (NC21OHD).
- Trial name
- HYPERMETABO (NCT07253454)
- Testing
- data collection
- Volunteers
- 800 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Rheumatoid Arthritis (RA), Lung Neoplasms
The Impact of Rheumatoid Arthritis Treatments on the Modulation of Extracellular Vesicles and Other Biomarkers Involved in the Development of Lung Cancer
Patients with rheumatoid arthritis (RA) have an increased risk of lung cancer, potentially influenced by targeted therapies such as JAK inhibitors and biologics.
- Trial name
- RAPTOR (NCT07913256)
- Volunteers
- 136 people
- Sponsor
- University Hospital, Limoges
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