Clinical trials: Development, open to volunteers
Pressure Ulcers Prevention in Prone Positioning in Intensive Care
Pressure Sore Prevention Strategy for the Prone Position
The aim of this clinical trial is to determine whether 5-layer hydrocellular dressings are effective in preventing the development of pressure sores during prone positioning in the intensive care unit.
- Trial name
- DERM-H-PROTECT (NCT06442657)
- Testing
- Hydrocellular dressing, Hydrocolloids dressing
- Where
- France
- Volunteers
- 180 people
- Sponsor
- University Hospital, Caen
Intimate Partner Violence (IPV)
Familia Imara: A Parenting Program to Reduce Family Violence in Tanzania
This cluster-randomized controlled trial will evaluate the effectiveness, implementation, and scalability of Familia Imara, a group-based, couples-focused, community health worker (CHW)-delivered parenting program, on reducing…
- Trial name
- NCT07574567
- Testing
- Familia Imara
- Where
- Tanzania
- Volunteers
- 6,216 people, healthy volunteers welcome
- Sponsor
- Saini Das
Lung Cancer (Diagnosis)
Prospective Multicenter Cohort Study for the Development and Evaluation of Risk Stratification Tools for Lung Cancers and Their Postoperative Recurrences Using Multimodal Clinical, Radiological, Tissue and Longitudinal Biological Phenotyping Among People at Risk of Lung Cancer
Interventional study with minimal risks and constraints, involving annual assessment of the prevalence and incidence of lung cancer using low-dose contrast-free thoracic CT scans, immunological, inflammatory, metabolic, blood…
- Trial name
- LUCA-pi COHORT (NCT07042867)
- Testing
- biobanking, low dose scan
- Volunteers
- 900 people, healthy volunteers welcome
- Sponsor
- Assistance Publique Hopitaux De Marseille
Cesarean Section; Dehiscence, Uterine Bleeding
Impact of Single- Versus Double-layer Hysterotomy Closure on Cesarean Niche Development: a Randomized Controlled Trial
The objective of this randomized monocentric study is to assess potential variations in the incidence and severity of isthmocele morbidity among women undergoing cesarean section with either single or double-layer closure of the…
- Conditions
- Cesarean Section; Dehiscence, Uterine Bleeding, Uterus; Scar, Uterus Abnormal
- Trial name
- NCT06308172
- Testing
- Hysterotomy closure
- Where
- Italy
- Volunteers
- 150 people
- Sponsor
- Fondazione IRCCS Ca' Granda, Ospedale Maggiore Policlinico
Maternal Depression, Self-Regulation, Emotion
Enhancing Preschool Children's Attention and Behaviour: Parent-Focused Program
This study aims to evaluate the feasibility and efficacy of the Building Regulation in Dual Generations (BRIDGE) program for caregivers with significant mental health concerns and preschool and young children (3-7 years old) with…
- Conditions
- Maternal Depression, Self-Regulation, Emotion, Child Mental Disorder, Child Development
- Trial name
- BRIDGE-McGill (NCT07083037)
- Testing
- Building Regulation in Dual Generations (BRIDGE; DBT + Parenting)
- Where
- 2 sites in Canada
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- McGill University
Inborn Errors of Metabolism
Growth and Development of Children With Inborn Errors of Metabolism in Assiut Governorate
Assessment of growth and development of children with inborn errors of metabolism in Assiut Governorate
- Trial name
- NCT06654765
- Where
- Egypt
- Volunteers
- 201 people
- Sponsor
- Assiut University
Multiple Myeloma
A Study of GC012F in Patients With Relapsed/Refractory Multiple Myeloma
This study is a single-arm, open-lable, phase I/II study to evaluate the efficacy and safety of GC012F in subjects with relapsed/refractory multiple myeloma.
- Trial name
- DURGA-3 (NCT06235229)
- Testing
- GC012F
- Where
- 10 sites in China
- Volunteers
- 110 people
- Sponsor
- Gracell Biotechnologies (Shanghai) Co., Ltd.
Gross Motor Development Delay
Video-based Assessment of Preschool Children's Gross Motor Development
Artificial intelligence (AI) is currently one of the global focal points for industrial development, with its applications in healthcare steadily increasing, such as in disease prediction, image diagnosis, and drug development.
- Trial name
- NCT07054437
- Testing
- Gross Motor Development Screening Tool
- Where
- Taiwan
- Volunteers
- 250 people
- Sponsor
- Chang Gung Memorial Hospital
Colorectal Adenoma
Development and Validation of an Artificial Intelligence-assisted System for Bowel Cleanliness Assessment Based on Withdrawal Distance Weighting
To address the limitations of current AI-based systems that rely on the assumption of a "constant withdrawal speed," this study proposes the integration of the UPD-3 endoscopic positioning system.
- Trial name
- NCT07150130
- Testing
- No Intervention: Observational Cohort
- Where
- China
- Volunteers
- 700 people
- Sponsor
- Fudan University
Depression, Anxiety
Preliminary Testing and Development of a Short Digital Intervention for Patients on Waiting Lists for Psychological Treatment
The goal of this randomized pilot feasibility trial is to assess the feasibility and further develop a single-session digital mental health intervention for patients on waiting lists for psychological treatment.
- Trial name
- NCT07499219
- Testing
- Digital therapy program (short), Digital therapy program (long), Mental health advice
- Where
- Norway
- Volunteers
- 80 people, healthy volunteers welcome
- Sponsor
- University of Oslo
Basal Cell Carcinoma, Locally Advanced Basal Cell Carcinoma
Oral Hedgehog Inhibitors in the Treatment of Basal Cell Carcinoma in the Netherlands: a Prospective Registration Study
Background: Oral hedgehog inhibitors vismodegib and sonidegib have been used for the treatment of locally advanced (laBCC), metastatic basal cell carcinoma (mBCC) and in basal cell nevus syndrome (BCNS) patients.
- Conditions
- Basal Cell Carcinoma, Locally Advanced Basal Cell Carcinoma, Metastatic Basal Cell Carcinoma, Gorlin Syndrome
- Trial name
- NCT05463757
- Testing
- Vismodegib, Sonidegib
- Where
- 8 sites in Netherlands
- Volunteers
- 80 people
- Sponsor
- Maastricht University Medical Center
Head & Neck Cancer
Specialist Nurse-Led Nursing Management for Patients Undergoing Head and Neck Cancer Surgery
The goal of this clinical trial is to evaluate the effectiveness of a multidisciplinary specialist nurse-led perioperative nursing management model for patients undergoing head and neck cancer surgery.
- Trial name
- NCT07622381
- Testing
- Multidisciplinary Specialist Nurse-Led Perioperative Nursing Management, Routine Perioperative Nursing Care
- Where
- China
- Volunteers
- 80 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Crohn Disease (CD)
Qualitative Exploration of Key Symptoms of Stricturing Crohn's Disease: Toward the Development of a Clinical Assessment Score.
The goal of this qualitative study is to identify and better understand the symptoms of stricturing Crohn's disease in order to inform the development of more appropriate clinical evaluation scores.
- Trial name
- SYMCROHNS (NCT07441629)
- Testing
- Semi-structured interview
- Where
- France
- Volunteers
- 15 people
- Sponsor
- University Hospital, Grenoble
Preterm Infant Development, Preterm Infant Health
Neonatal Data and Biobank to Study Factors Influencing Development in Preterm Infants Born at <32 Weeks' Gestation and/or <1500 g Birth Weight
The Neo-Life project aims to establish a prospective neonatal data and biobank to investigate factors influencing the short- and long-term development of very preterm infants.
- Conditions
- Preterm Infant Development, Preterm Infant Health, Prematurity Complications, Premature Birth
- Trial name
- Neo-Life (NCT07490912)
- Where
- Germany
- Volunteers
- 1,300 people
- Sponsor
- University Hospital of Cologne
Factors Associated With a Child's Development of Interaction and Communication Skills and Measures Taken, Reported Stress Level of the Parents of a Newborn and Measures Taken
Pediatric Research in the Outpatient Setting CoHort
Though primary care pediatricians (PCPs) and general practitioners solve 90% of children's health problems without referral to specialized care (about 10% of total health expenditures) there is little data on the common health…
- Trial name
- PROS-CH (NCT07911228)
- Where
- Switzerland
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Inflammatory Bowel Disease (IBD)
Prospective Intestinal Ultrasound Study for Artificial Intelligence Algorithm Development
This observational study will use intestinal ultrasound images to help develop computer programs that may make it easier to assess bowel inflammation.
- Trial name
- PSIUSAD (NCT07814274)
- Testing
- De-identified Intestinal Ultrasound Data Collection
- Where
- Canada
- Volunteers
- 95 people, healthy volunteers welcome
- Sponsor
- University of British Columbia
Amyotrophic Lateral Sclerosis, Home Mechanical Ventilation
Development in Home Mechanical Ventilation for Patient With Amyotrophic Lateral Sclerosis.
The aims of the study are to calculate the positive predictive value (PPV) of the codes for home mechanical noninvasive and invasive ventilation in patients with Amyotrophic lateral sclerosis in Denmark, and to describe the…
- Trial name
- NCT07819890
- Volunteers
- 400 people
- Sponsor
- Copenhagen University Hospital, Rigshospitalet
Stroke, Spatial Neglect
Validation of Web-Based Star Cancellation and Line Bisection Tests in Hemiplegic Stroke
The goal of this observational study is to evaluate the clinical usability and diagnostic performance of newly developed web-based Star Cancellation and Line Bisection tests in assessing visuospatial neglect in hemiplegic stroke…
- Conditions
- Stroke, Spatial Neglect, Spatial Neglect After Stroke
- Trial name
- NCT07538076
- Testing
- Web-Based Star Cancellation Test, Web-Based Line Bisection Test
- Where
- Turkey (Türkiye)
- Volunteers
- 105 people, healthy volunteers welcome
- Sponsor
- Istanbul Medeniyet University
Child Abuse, Parental Burnout
ACT-Based Training for Parental Burnout and Child Well-being
The purpose of the proposed randomized controlled trial is to evaluate the feasibility, acceptability, and potential effectiveness of Acceptance and Commitment Therapy (ACT) in reducing parental burnout and improving children's…
- Trial name
- NCT07047378
- Testing
- ACT Intervention Group, control group
- Where
- 2 sites in Hong Kong
- Volunteers
- 120 people, healthy volunteers welcome
- Sponsor
- Chinese University of Hong Kong
Food Allergy in Children, Legumes Allergy
Improving Diagnosis of Legume Allergy in Children
In France, almost 15% of serious food allergies in children are caused by legumes, especially peanuts. Other legumes like soy, lentils, peas, lupin, chickpeas, beans, and fenugreek can also cause allergic reactions.
- Conditions
- Food Allergy in Children, Legumes Allergy, Molecular Diagnostic
- Trial name
- LACID (NCT06995950)
- Volunteers
- 90 people
- Sponsor
- Central Hospital, Nancy, France
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