Clinical trials: Developmental Risk
Dementia, Alzheimer Disease
A Study to Evaluate the Efficacy and Safety of Galantamine in Patients With Mild Cognitive Impairment
The purpose of this study is to evaluate the efficacy and safety of galantamine treatment in patients with mild cognitive impairment.
- Trial name
- NCT00236574
- Testing
- Galantamine hydrobromide
- Volunteers
- 974 people
- Sponsor
- Johnson & Johnson Pharmaceutical Research & Development, L.L.C.
Pressure Ulcer (PU), Pressure Injury Prevention
Effect of a Risk-Based Perioperative Pressure Injury Prevention Bundle in Elective Surgery Patients
This study evaluates whether a risk-based perioperative pressure injury prevention bundle reduces the development of pressure injuries in patients undergoing elective surgery lasting 3 hours or longer.
- Conditions
- Pressure Ulcer (PU), Pressure Injury Prevention, Perioperative Care, Braden Scale
- Trial name
- RiPPB (NCT07725068)
- Testing
- Risk-Based Perioperative Pressure Injury Prevention Bundle
- Where
- Turkey (Türkiye)
- Volunteers
- 138 people, healthy volunteers welcome
- Sponsor
- Acibadem University
Obesity, Cardiovascular Disease
Role of Cardiometabolic Risk Factors in Childhood Bone Development
The proposed research brings together complementary expertise to systematically elucidate the longitudinal effects of (1) total and regional body fat and (2) the metabolic impairment that accompanies obesity on bone development…
- Conditions
- Obesity, Cardiovascular Disease, Type 2 Diabetes, Osteoporosis
- Trial name
- NCT02355717
- Testing
- Observational Study
- Where
- United States
- Volunteers
- 400 people, healthy volunteers welcome
- Sponsor
- Augusta University
Cerebral Palsy, Developmental Delay
SmarToyGym: Smart Detection of Atypical Toy-oriented Actions in At-risk Infants
The study aims to develop a SmarToyGym where sensitized, wireless toys are strategically hung and placed within reach of infants to elicit toy-oriented body and arm/hand movements.
- Conditions
- Cerebral Palsy, Developmental Delay, Stroke, Fine Motor Delay
- Trial name
- NCT02813889
- Testing
- SmarToyGym
- Where
- 2 sites in United States
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- University of Pennsylvania
Liver Transplantation
A New Prediction Mode for Predicting the Risk of Pressure Injury in Patients Undergoing Liver Transplantation
Pediatric population is at a high-risk of pressure injury (PI). Patients undergoing liver transplantation are more prone to PIs compared with other types of surgery.
- Trial name
- PMPRPIULT (NCT05588271)
- Testing
- Exposures
- Where
- China
- Volunteers
- 1,200 people, healthy volunteers welcome
- Sponsor
- RenJi Hospital
Osteoporosis, Osteoporotic Fracture of Vertebra
Development and Evaluation of an Exercise Intervention for Prevention of Vertebral Osteoporosis and Deformity in Postmenopausal Women
Osteoporotic fractures of the vertebrae (bones in the back) cause substantial pain and disability. Exercise could help to prevent these fractures by increasing bone strength and improving posture.
- Conditions
- Osteoporosis, Osteoporotic Fracture of Vertebra, Postural, Thoracic Kyphosis
- Trial name
- NCT04660825
- Testing
- A resistance band exercise programme, Control
- Where
- United Kingdom
- Volunteers
- 41 people, healthy volunteers welcome
- Sponsor
- Loughborough University
Cardiac Surgical Procedures, Cardiopulmonary Bypass
Artificial Intelligence for Ulinastatin Responder Outcome & Risk Assessment in CPB
This is a multicenter, retrospective, real-world observational study aimed at developing and validating an artificial intelligence-based tool for identifying ulinastatin treatment responders and risk stratification in cardiac…
- Conditions
- Cardiac Surgical Procedures, Cardiopulmonary Bypass, Systemic Inflammatory Response Syndrome, Multiple Organ Dysfunction Syndrome
- Trial name
- AURORA (NCT07583290)
- Testing
- ulinastatin
- Where
- China
- Volunteers
- 10,000 people
- Sponsor
- Beijing Anzhen Hospital
Colonic Neoplasms, Colorectal Cancer
Molecular and Histological Characteristics of Serrated Lesions of the Colon
Different subtypes of serrated lesions have been recently described. Among them, both sessile serrated polyp/adenoma (SSP/A) and traditional serrated adenoma (TSA) could have malignant potential through the serrated pathway or…
- Conditions
- Colonic Neoplasms, Colorectal Cancer, Sessile Serrated Adenoma, Polyp of Colon
- Trial name
- SERRACOLON (NCT03089268)
- Testing
- Colonoscopy, Polypectomy or biopsy, Molecular analysis
- Where
- Spain
- Volunteers
- 700 people
- Sponsor
- Hospital Universitario La Fe
Bone Marrow Failure, Osteopetrosis
Risk-Adapted Allogeneic Stem Cell Transplantation For Mixed Donor Chimerism In Patients With Non-Malignant Diseases
This study proposes the use of a reduced intensity chemotherapy/radiation therapy regimen followed by stem cell transplantation, as compared to standard ablative chemotherapy regimens associated with stem cell transplantation, in…
- Conditions
- Bone Marrow Failure, Osteopetrosis, Fanconi Anemia, Severe Combined Immunodeficiency
- Trial name
- NCT01019876
- Testing
- Fludarabine, Cyclophosphamide, Busulfan
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Columbia University
Bloody Stool, Necrotizing Enterocolitis
a Clinical Risk Score to Predict Bloody Stool in Neonates
Bloody stool is a main focus in non-neonatal intensive care unit ward, and it is one of the risk factors in neonates with subsequent necrotizing enterocolitis(NEC) and usually lead to longed duration of hospitalization.
- Trial name
- NCT05055817
- Testing
- bloody stool group, non-bloody stool group
- Where
- China
- Sponsor
- Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
Polysomnography, Sleep Apnea Syndromes
Adverse Long-term Consequences of Sleep Disordered Breathing: The Ottawa Hospital (TOH) Sleep Database
The primary purpose of the proposed study is to validate our previously developed predictive model for adults with obstructive sleep apnea using (i) clinical data from multiple large academic centers, (ii) a longer follow-up…
- Conditions
- Polysomnography, Sleep Apnea Syndromes, Risk Factors, Prognosis
- Trial name
- NCT03834792
- Testing
- No intervention but exposure
- Where
- Canada
- Volunteers
- 5,155 people
- Sponsor
- Ottawa Hospital Research Institute
Coronary Artery Disease
CCTA-FFR Registry for Risk Prediction
The investigators sought to investigate the prognostic implication of qualitative and quantitative plaque analysis on coronary CT angiography (CCTA) according to fractional flow reserve (FFR).
- Trial name
- NCT04037163
- Testing
- Fractional flow reserve, Coronary CT angiography
- Volunteers
- 747 people
- Sponsor
- Seoul National University Hospital
Fetomaternal Hemorrhage, Neonatal Anemia
Identification of Early Predictors of Fetomaternal Hemorrhage
Objectives: 1) To determine risk factors for fetomaternal hemorrhage. 2) To identify a cost-effective method to detect fetomaternal hemorrhage prior to significant fetal anemia.
- Trial name
- NCT01232387
- Where
- United States
- Volunteers
- 39 people
- Sponsor
- Icahn School of Medicine at Mount Sinai
Lung Cancer, Nonsmall Cell
Folate One-carbon Malnutrition as the Metabostemness Risk Factor of Malignancy Tumor Development of NSCLC Patients
Non-small cell lung cancer (NSCLC) accounts for more than two-thirds of lung cancer, which is the leading cause of cancer deaths in Taiwan. The overall prognosis of NSCLC is poor with low 5-year survival rates.
- Trial name
- NCT03504098
- Testing
- nutrition consult
- Where
- Taiwan
- Volunteers
- 300 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Venous Thromboembolism
Predicting Bleeding Risk on Anticoagulant Therapy for Venous Thromboembolism
The main objective of the study is to develop or validate a clinical prediction rule for major bleeding in patients on oral anticoagulant therapy who have been safely anticoagulated without bleeding or venous thromboembolism…
- Trial name
- NCT00788736
- Where
- 12 sites in United States, Canada and 1 more
- Volunteers
- 2,537 people
- Sponsor
- Ottawa Hospital Research Institute
Runt
The Effect of Myofascial Release Technique on Sportive Performance, Balance and Injury Risk in Runners
In order to investigate the effect of myofascial release technique on sportive performance, balance and injury risk in runners, 49 athletes will include in the study.
- Trial name
- NCT05392153
- Testing
- Myofascial therapy
- Where
- Turkey (Türkiye)
- Volunteers
- 49 people, healthy volunteers welcome
- Sponsor
- Istanbul Medipol University Hospital
Hyperandrogenism, Metabolic Cardiovascular Syndrome
Phlebotomy and Polycystic Ovary Syndrome
AIMS To study the effects of the decrease in iron tissue depots after scheduled bloodletting on insulin sensitivity, carbohydrate metabolism, classic and non-classic cardiovascular risk factors in patients with functional…
- Trial name
- NCT02460445
- Testing
- Phlebotomy, ethinylestradiol, Cyproterone Acetate
- Where
- Spain
- Volunteers
- 37 people
- Sponsor
- Manuel Luque Ramírez
Cardiovascular Diseases (CVD)
Study Protocol: 10-Year Follow-Up of Patients Screened for Cardiovascular Risk by the "All With Heart" Association - Development of a Morocco-Specific Risk Score
Cardiovascular diseases (CVDs) are the leading cause of death worldwide, and their prevalence is steadily increasing in Morocco.
- Trial name
- NCT07294937
- Where
- 2 sites in Morocco
- Volunteers
- 10,000 people
- Sponsor
- Moroccan Society of Cardiology
HIV Infections, Depression
Intervention Development for Social Stress, Mental Health, and HIV Risk MSM
The proposed study will adapt a cognitive behavioral intervention to support high-risk MSM's adaptive coping with minority stress, alleviate associated depression and anxiety, and reduce HIV risk behavior.
- Conditions
- HIV Infections, Depression, Anxiety
- Trial name
- ESTEEM (NCT02448186)
- Testing
- ESTEEM
- Volunteers
- 63 people, healthy volunteers welcome
- Sponsor
- Yale University
Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia
Alvocidib, Cytarabine, and Mitoxantrone in Treating Patients With Newly Diagnosed Acute Myeloid Leukemia
This phase II trial is studying the side effects and how well giving alvocidib together with cytarabine and mitoxantrone works in treating patients with newly diagnosed acute myeloid leukemia.
- Conditions
- Adult Acute Basophilic Leukemia, Adult Acute Eosinophilic Leukemia, Adult Acute Megakaryoblastic Leukemia (M7), Adult Acute Minimally Differentiated Myeloid Leukemia (M0)
- Trial name
- NCT00407966
- Testing
- alvocidib, cytarabine, mitoxantrone hydrochloride
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- National Cancer Institute (NCI)