Clinical trials: Dexamethasone Administration
Glioma, Dapagliflozin (Forxiga)
Dapagliflozin Versus Dexamethasone Role in Pre-operative Management of Non- Diabetic Brain Tumor Patients
The aim of the study is to compare between the role of dapagliflozin versus dexamethasone in pre-operative management of non-diabetic glioma patients on levetiracetam as anti-seizure drug.
- Conditions
- Glioma, Dapagliflozin (Forxiga), Dexamethasone
- Trial name
- NCT06750458
- Testing
- DexamethasoneGroup III (n=25) (Dexamethasone group)
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Non-infectious Anterior Uveitis
Evaluation of DEXTENZA in the Management of Pain and Inflammation in Patients With Anterior Uveitis Compared to Standard of Care Topical Corticosteroids
This a prospective study review of the clinical efficacy of DEXTENZA for the treatment of anterior uveitis compared to the standard of care topical corticosteroid treatment
- Trial name
- DiverT (NCT04426734)
- Testing
- Dextenza Dexamethasone Implant, Topical Prednisolone Acetate 1%
- Volunteers
- 30 people
- Sponsor
- New England Retina Associates
Multiple Myeloma
Observational Study on the Combination of Selinexor With Bortezomib and Dexamethasone for the Treatment of MM Patients
This is an observational study aiming at collecting efficacy and safety data on the use of SVd outside clinical trials, for the treatment of adult patients with MM who have received 1-3 prior line of therapy.
- Trial name
- NCT06933277
- Where
- Italy
- Volunteers
- 159 people
- Sponsor
- Gruppo Italiano Malattie EMatologiche dell'Adulto
Multiple Myeloma
Carfilzomib, Pomalidomide, and Dexamethasone in Treating Patients With Relapsed or Refractory Multiple Myeloma
The study will investigate the effects of adding carfilzomib to the combination of pomalidomide and dexamethasone in sequential dose escalation cohorts in patients with relapsed or refractory multiple myeloma.
- Trial name
- NCT01665794
- Testing
- Pomalidomide, Carfilzomib, dexamethasone
- Where
- 5 sites in United States, Canada
- Volunteers
- 25 people
- Sponsor
- University of Chicago
Cataract
Levo-Dexa vs. Tobra+Dexa for Prevention and Treatment of Inflammation and Prevention of Infection in Cataract Surgery
The purpose of this study is to demonstrate the non-inferiority of the study treatment (combined levofloxacin + dexamethasone eye drops) followed by dexamethasone eye drops alone vs.
- Trial name
- LEADER7 (NCT03739528)
- Testing
- Levofloxacin + dexamethasone followed by dexamethasone, Tobramycin + Dexamethasone
- Where
- 57 sites in Italy
- Volunteers
- 808 people
- Sponsor
- NTC srl
Liver Cirrhosis
Treatment of Sodium Retention in Liver Cirrhosis With Dexamethasone
Accumulation of salt and water in patients with liver disease (so called liver cirrhosis) is possibly related to the increased effect of steroid hormones on salt reabsorption in the kidney.
- Trial name
- NCT01311167
- Testing
- Dexamethasone
- Where
- 3 sites in Switzerland
- Volunteers
- 2 people
- Sponsor
- Insel Gruppe AG, University Hospital Bern
Primary Amyloidosis
A Trial of Treatment With Lenalidomide-Melphalan-Dexamethasone in Patients With Primary (AL) Amyloidosis
The treatment with oral melphalan and prednisone has been recommended as standard treatment of AL amyloidosis but the results are rather disappointing.
- Trial name
- LEOMEX (NCT00883623)
- Testing
- Lenalidomide
- Where
- Germany
- Volunteers
- 50 people
- Sponsor
- Heidelberg University
Multiple Myeloma
MC210808 Venetoclax in Combination With Lenalidomide and Dexamethasone (Ven-Rd), Daratumumab and Dexamethasone (Ven-Dd), or Daratumumab-Lenalidomide-Dexamethasone (Ven-DRd) for the Treatment of Multiple Myeloma
This phase I trial tests the safety, side effects, and best dose of venetoclax in combination with lenalidomide and dexamethasone, daratumumab and dexamethasone, or daratumumab, lenalidomide, and dexamethasone in treating…
- Trial name
- NCT06042725
- Testing
- Biospecimen Collection, Bone Marrow Aspiration, Bone Marrow Biopsy
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Mayo Clinic
Multiple Myeloma
Bendamustine, Lenalidomide (Revlimid®) and Dexamethasone (BRd) as 2nd-line Therapy for Patients With Relapsed or Refractory Multiple Myeloma
Almost all patients with multiple myeloma who survive initial treatment will eventually relapse and require further therapy. Background: Treatment with lenalidomide and dexamethasone has proven efficacy in two large randomized…
- Trial name
- BRd (NCT01701076)
- Testing
- Bendamustine
- Where
- Switzerland
- Volunteers
- 50 people
- Sponsor
- Cantonal Hospital of St. Gallen
ITP - Immune Thrombocytopenia
High-dose Dexamethasone Plus Hetrombopag vs High-dose Dexamethasone Alone as Frontline Treatment for Newly Diagnosed Adult Primary Immune Thrombocytopenia: A Prospective, Multicenter, Randomized Trial
The project was undertaking by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of Hetrombopag plus high-dose dexamethasone for the treatment of adults with newly-diagnosed primary immune…
- Trial name
- NCT05943691
- Testing
- hetrombopag 5mg po qd, High-dose Dexamethasone
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Shandong University
Otitis Media in Patients With Tympanostomy Tubes
Bioequivalence of Two Ciprofloxacin 0.3%/Dexamethasone 0.1% Sterile Otic Suspensions in Otitis Media in Children With Tympanostomy Tubes
The objective of this study is to compare the relative efficacy and safety of the test formulation of ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension (Par) to the already-marketed formulation CIPRODEX®…
- Trial name
- NCT01994642
- Testing
- Ciprofloxacin 0.3%/dexamethasone 0.1% sterile otic suspension, CIPRODEX® (ciprofloxacin 0.3%/dexamethasone 0.1%)
- Where
- 23 sites in United States
- Volunteers
- 203 people
- Sponsor
- Par Pharmaceutical, Inc.
Quality of Life, Pelvic Organ Prolapse
Does Dexamethasone Administration Improve Recovery In Patients Undergoing Minimally Invasive Sacrocolpopexy?
The primary aim is to evaluate whether standard administration of Dexamethasone at the time of general anesthesia induction at the time of minimally invasive sacrocolpopexy (MISC) would result in improved quality of recovery…
- Conditions
- Quality of Life, Pelvic Organ Prolapse, Prolapses, Vaginal Vault
- Trial name
- NCT03094442
- Testing
- Dexamethasone, Normal saline
- Where
- United States
- Sponsor
- The Cleveland Clinic
Multiple Myeloma
Early Patient Access Treatment Use Protocol CA204-220
The objective of this expanded access program is to provide treatment with elotuzumab in combination with lenalidomide and dexamethasone for patients with relapsed or refractory multiple myeloma at Japanese sites where licensed…
- Trial name
- NCT02856438
- Testing
- Elotuzumab, Lenalidomide, Dexamethasone
- Where
- 4 sites in Japan
- Sponsor
- Bristol-Myers Squibb
Primary Headache
Dexamethasone Plus Metoclopramide Versus Paracetamol/NSAIDs for Primary Headache
Primary headache disorders are among the most common neurological conditions presenting to emergency departments and can significantly impair quality of life and daily functioning.
- Trial name
- DMPH (NCT07605065)
- Testing
- Dexamethasone Plus Metoclopramide, Paracetamol/NSAIDs
- Volunteers
- 94 people
- Sponsor
- Pak Emirates Military Hospital
Macular Edema Caused by Retinal Vein Occlusion
Dexamethasone-implant for the Treatment of RVO
To evaluate the efficacy and safety of a dexamethasone-implant alone or in combination with bevacizumab. 64 eyes are prospectively investigated.
- Trial name
- NCT01767545
- Testing
- Dexamethasone implant, Bevacizumab
- Where
- Germany
- Volunteers
- 64 people
- Sponsor
- Ludwig-Maximilians - University of Munich
Migraine
Oral Dexamethasone for Treatment of Migraine
The aim of this project is to determine if a single dose of oral dexamethasone at the time of discharge from the emergency department (ED) [after successful treatment] prevents rebound headache.
- Trial name
- NCT00216736
- Testing
- Dexamethasone
- Where
- Australia
- Volunteers
- 63 people
- Sponsor
- The Joseph Epstein Centre for Emergency Medicine Research
Neoplasm Metastasis
Dexamethasone for Palliation - Brain Metastases
Brain metastases occur when cancer cells from the initial tumour site (for example, lung or breast) spread to the brain. This develops in approximately 10% - 30% of adults with cancer.
- Trial name
- NCT00188864
- Testing
- dexamethasone
- Where
- Canada
- Volunteers
- 50 people
- Sponsor
- University Health Network, Toronto
Croup
Community Care for Croup (RCT)
This randomized clinical trial was to compare the effectiveness of prednisone 2mg/kg/day for 3 days vs. dexamethasone 0.6mg/kg for 1 day for treatment of children with mild or moderate croup.
- Trial name
- NCT01042145
- Testing
- Prednisone, Dexamethasone
- Where
- United States
- Volunteers
- 87 people
- Sponsor
- Washington University School of Medicine
Vitreoretinal Surgery, Ocular Inflammation
Dextenza in the Post-op Management of Vitreoretinal Surgeries
This study will assess the control of inflammation at days 1, 7, 14, and 21 days following the vitreoretinal surgical procedure analyzing two randomized study arms: Intracanalicular dexamethasone insert group or topical steroid…
- Conditions
- Vitreoretinal Surgery, Ocular Inflammation, Post-operative Pain, Post-Operative Inflammation
- Trial name
- NCT04371445
- Testing
- Dexamethasone Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Multiple Myeloma
Higher Frequency Zoledronic Acid in the Treatment of Multiple Myeloma
The purpose of this study is to determine whether lower than conventional doses of dexamethasone and thalidomide; and a higher dosing frequency of zoledronic acid are effective in the treatment of newly-diagnosed multiple myeloma.
- Trial name
- dtZ (NCT00263484)
- Testing
- dexamethasone, thalidomide, zoledronic acid
- Where
- 10 sites in India, Singapore and 1 more
- Volunteers
- 56 people
- Sponsor
- Gleneagles Hospital