Clinical trials: Dexamethasone Administration, open to volunteers
Primary Headache
Dexamethasone Plus Metoclopramide Versus Paracetamol/NSAIDs for Primary Headache
Primary headache disorders are among the most common neurological conditions presenting to emergency departments and can significantly impair quality of life and daily functioning.
- Trial name
- DMPH (NCT07605065)
- Testing
- Dexamethasone Plus Metoclopramide, Paracetamol/NSAIDs
- Volunteers
- 94 people
- Sponsor
- Pak Emirates Military Hospital
POEMS Syndrome
KCD (Carfilzomib/Cyclophosphamide/Dexamethasone) Regimen for the Treatment of Newly Diagnosed POEMS Syndrome
This study is a single-center, prospective, open-label clinical study to evaluate the efficacy and safety of KCD(Carfilzomib/Cyclophosphamide/Dexamethasone) regimen in subjects with newly diagnosed POEMS Syndrome.
- Trial name
- NCT07652879
- Testing
- CARFILZOMIB, CYCLOPHOSPHAMIDE, DEXAMETHASONE
- Where
- China
- Volunteers
- 20 people
- Sponsor
- Shanghai Changzheng Hospital
Plasmablastic Lymphoma
Study to Evaluate Combined Treatment of Daratumumab, Bortezomib and Dexamethasone in PBL Patients.
It is an open-label, multicenter, phase II, single arm trial to Evaluate Activity and Safety of Daratumumab in combination with Bortezomib and Dexamethasone in patients about 28 patients with Relapsed or Refractory Plasmablastic…
- Trial name
- FIL_DALYA (NCT04915248)
- Testing
- Daratumumab, Bortezomib, Dexamethasone
- Where
- 18 sites in Italy
- Volunteers
- 28 people
- Sponsor
- Fondazione Italiana Linfomi - ETS
Acute Hypoxemic Respiratory Failure
Interleukin-6 Guided Treatment With Dexamethasone or Tocilizumab in Patients Hospitalized With Acute Respiratory Symptoms - a Feasibility Study
Acute hypoxemic respiratory failure (AHRF) happens when the lungs are unable to absorb enough oxygen. The bloodstream is deprived of oxygen which can eventually lead to more severe conditions like multi-organ failure (MOF) and…
- Trial name
- IDENTIFY (NCT07334379)
- Testing
- Tocilizumab (Actemra®), Dexamethasone
- Where
- Canada
- Volunteers
- 60 people
- Sponsor
- Lorenzo delSorbo
Diabetic Macular Edema (DME)
Efficacy Comparison of DExamethasone Intravitreal Implant Combined With Aflibercept Versus Aflibercept Monotherapy in Treatment-naïve Inflammatory Diabetic Macular Edema Patients
This is a 12-month, prospective, randomized controlled, multi-center, open-label, superiority designed study. Treatment-Naïve DME patient with inflammatory biomarkers, who meet the inclusion and exclusion criteria, will be…
- Trial name
- DECADE (NCT07438119)
- Testing
- Combination Therapy with Aflibercept Intravitreous Injection (2mg) and Dexamethasone Intravitreal Implant, Aflibercept Intravitreous Injection (2mg) Monotherapy
- Volunteers
- 114 people
- Sponsor
- Kun Liu
Knee Osteoarthritis, Gonarthrosis; Primary
Oral vs Intravenous Dexamethasone in Total Knee Arthroplasty
This prospective observational cohort study aims to evaluate the association between perioperative dexamethasone administration and early postoperative recovery following primary total knee arthroplasty.
- Conditions
- Knee Osteoarthritis, Gonarthrosis; Primary, Total Knee Arthroplasty
- Trial name
- TKA (NCT07442812)
- Testing
- Routine perioperative management
- Where
- Turkey (Türkiye)
- Volunteers
- 270 people
- Sponsor
- Haseki Training and Research Hospital
Multiple Myeloma
Prospective Evaluation of the Prognostic Impact of Measurable Residual Disease (MRD) Within a Phase III Study Comparing a Fixed Duration Therapy Versus Continuous Therapy With Daratumumab, Lenalidomide, and Dexamethasone for Relapsed Multiple Myeloma Requiring a First Salvage Treatment.
We propose to conduct an ancillary prospective evaluation of the impact of Dara-Len-Dex discontinuation after 2 years, on the persistence of MRD negativity in patients that were MRD negative at 2 years.
- Trial name
- MRD-CONFIRM (NCT05203003)
- Testing
- Assessment of MRD
- Where
- France
- Volunteers
- 260 people
- Sponsor
- Assistance Publique - Hôpitaux de Paris
Thrombocytopenia
The Study of Different Cycles of High-dose Dexamethasone in the Treatment of ITP
Primary immune thrombocytopenia is an autoimmune disorder characterised by decreased platelet counts and increased bleeding risk.
- Trial name
- NCT06913374
- Testing
- Dexamethasone
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Shandong University
Rib Fractures, Acute Pain
Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures
Traumatic rib fractures cause severe chest wall pain that can impair normal breathing, coughing, and lung function. While systemic opioids are commonly used to treat traumatic pain, their side effects, such as sedation and…
- Conditions
- Rib Fractures, Acute Pain, Thoracic Trauma
- Trial name
- NCT07827157
- Testing
- Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB
- Volunteers
- 100 people
- Sponsor
- Assiut University
Multiple Myeloma, First Relapse
Dara-PD in the Treatment of Patients With First Relapse of Multiple Myeloma
At present, there is no prospective study on the treatment of first-relapsed multiple myeloma with daratumumab plus pomalidomide and dexamethasone (Dara-Pd).
- Trial name
- NCT06252792
- Where
- China
- Volunteers
- 50 people
- Sponsor
- FengYan Jin
Renal Colic
Comparative Efficacy of IV Dexamethasone vs. Nebulized Terbutaline for Renal Colic Pain in the ED
Adult patients (18-55 years of age) with clinical diagnosis of acute renal colic (sudden sharp colic flank pain with or without radiation to genitalia or groin and with or without urinary symptoms) who had pain score of 5 or more…
- Trial name
- NCT06980727
- Testing
- Terbutaline 2.5 mg, Dexamethasone
- Where
- Tunisia
- Volunteers
- 500 people
- Sponsor
- University of Monastir
T-cell Acute Lymphoblastic Leukemia, Lymphoma
Venetoclax, Dexamethasone, Bortezomib, and Daratumumab For The Treatment Of Adolescent And Young Adults With Relapsed Or Refractory T-Cell Acute Lymphoblastic Leukemia And T-cell Acute Lymphoblastic Lymphoma
This is an open-label, single institution, Phase 1 study of Venetoclax, Dexamethasone, Bortezomib, and Daratumumab for adolescent and young adult participants with relapsed or refractory T-ALL or T-LBL
- Trial name
- NCT07513129
- Testing
- Venetoclax, Dexamethasone, Bortezomib
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- M.D. Anderson Cancer Center
Pain Management
Retroclavicular Block in Vascular Surgey
The retroclavicular (coracoid) approach for brachial plexus anesthesia is recognized for its facility and simplicity to perform .
- Trial name
- NCT06406712
- Testing
- retroclavicular block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- New Valley University
Nausea and Vomiting Caused by Chemotherapy
Auricular Point Stimulation Plus Dexamethasone Versus Standard Antiemetic Regimen for Nausea and Vomiting Caused by Gemcitabine Combined With Paclitaxel Protein-bound
This study aims to evaluate whether the preventive and suppressive effects of auricular point stimulation combined with dexamethasone on nausea and vomiting induced by the gemcitabine plus paclitaxel protein-bound regimen are…
- Trial name
- ADGP Ⅱ (NCT07716228)
- Testing
- Auricular point stimulation plus dexamethasone, Standard pharmacologic antiemetic regimen
- Where
- China
- Volunteers
- 74 people
- Sponsor
- Second Affiliated Hospital, Zhejiang University, School of Medicine
Pulpitis
Submucosal Cryotherapy and Anti-inflammatory Drugs for Postoperative Pain Following Root Canal Treatment in Maxillary Molars
Pain after root canal treatment is a common problem, particularly in teeth with symptomatic irreversible pulpitis, a condition involving severe inflammation of the tissue inside the tooth.
- Trial name
- NCT07919938
- Testing
- Articaine Hydrochloride With Epinephrine, Submucosal Cryotherapy, Diclofenac Sodium
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Suez Canal University
Tick-Borne Encephalitis
Dexamethasone in Tick-borne Encephalitis
The purpose of this study is to investigate the efficacy of dexamethasone in patients with tick-borne encephalitis.
- Trial name
- NCT07584525
- Testing
- Dexametasone, Saline (0.9% NaCl)
- Where
- Slovenia
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- University Medical Centre Ljubljana
Carbon Monoxide Poisoning, Carbon Monoxide Intoxication
Carbon Monoxide Hyperbaric Oxygen With Steroid Therapy
Hyperbaric Oxygen Therapy (HBO) is routine treatment of carbon monoxide (CO) poisoning to prevent delayed neurological sequelae. This study looking to see if neurologic outcomes are improved with the addition of dexamethasone.
- Conditions
- Carbon Monoxide Poisoning, Carbon Monoxide Intoxication, Carbon Monoxide Encephalopathy, Carbon Monoxide-induced Parkinsonism
- Trial name
- CODex (NCT06574048)
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 20 people
- Sponsor
- University of Nebraska
Vitreoretinal Surgery, Ocular Inflammation
Dextenza in the Post-op Management of Vitreoretinal Surgeries
This study will assess the control of inflammation at days 1, 7, 14, and 21 days following the vitreoretinal surgical procedure analyzing two randomized study arms: Intracanalicular dexamethasone insert group or topical steroid…
- Conditions
- Vitreoretinal Surgery, Ocular Inflammation, Post-operative Pain, Post-Operative Inflammation
- Trial name
- NCT04371445
- Testing
- Dexamethasone Ophthalmic Insert, Prednisolone Acetate 1% Oph Susp
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The Cleveland Clinic
Acute Respiratory Distress Syndrome (ARDS)
Dexamethasone Treatment for Sepsis-associated Acute Respiratory Distress Syndrome: a Multicenter, Randomised, Double-blinded, Controlled Trial
Acute respiratory distress syndrome (ARDS) is a major cause of acute hypoxemic respiratory failure in critically ill patients and is associated with substantial mortality.
- Trial name
- DEFEND (NCT07576660)
- Testing
- Dexamethasone
- Where
- 2 sites in China
- Volunteers
- 1,704 people
- Sponsor
- Southeast University, China
Major Depression
Added Value of a Neuroendocrine Test Battery in the Response to Repetitive Transcranial Magnetic Stimulation (rTMS) Treatment
The primary objective of the study is to determine the predictive value of the neuroendocrine tests TRH-∆∆TSH (thyreoliberin - thyreostimulin) and DST (dexamethasone suppression test) in the subsequent response to rTMS-TBS…
- Trial name
- Endo-rTMS (NCT05964192)
- Testing
- Repetitive transcranial magnetic stimulation (rTMS)
- Where
- France
- Volunteers
- 50 people
- Sponsor
- Centre Hospitalier Rouffach