Clinical trials: Dexamethasone Administration
Diabetic Retinopathy
Prospective Trial of Dexamethasone implAnt for Treatment Naïve diabeTic Macular Edema
The purpose of the investigator's study is to evaluate the efficacy and safety profile of the pro re nata (PRN) regimen to 12 months by using intravitreal dexamethasone implant in eyes with treatment-naive diabetic macular edema…
- Trial name
- DANTE (NCT04448496)
- Testing
- Dexamethasone implant
- Where
- 7 sites in South Korea
- Volunteers
- 49 people
- Sponsor
- Yeungnam University College of Medicine
Diabetic Macular Edema (DME)
Efficacy Comparison of DExamethasone Intravitreal Implant Combined With Aflibercept Versus Aflibercept Monotherapy in Treatment-naïve Inflammatory Diabetic Macular Edema Patients
This is a 12-month, prospective, randomized controlled, multi-center, open-label, superiority designed study. Treatment-Naïve DME patient with inflammatory biomarkers, who meet the inclusion and exclusion criteria, will be…
- Trial name
- DECADE (NCT07438119)
- Testing
- Combination Therapy with Aflibercept Intravitreous Injection (2mg) and Dexamethasone Intravitreal Implant, Aflibercept Intravitreous Injection (2mg) Monotherapy
- Volunteers
- 114 people
- Sponsor
- Kun Liu
Headache, Occipital Nerve Block
Steroids in Occipital Nerve Block for Treatment of Headache
Currently there is limited evidence of benefit for the addition of steroids to occipital nerve blocks for treatment of headache, and not all steroids have been explored.
- Trial name
- NCT05732532
- Testing
- Bupivacaine, Lidocaine, Dexamethasone
- Where
- United States
- Volunteers
- 120 people
- Sponsor
- Mayo Clinic
Diffuse Large B-Cell Lymphoma (DLBCL)
DA-EDOCH14-R in Poor-prognosis Diffuse Large B-cell Lymphoma
Poor prognosis dufuse large B-cell lymphoma (DLBCL) represents 50% of all DLBCL with overall cure rates ranging from 50-60% with modern dose-dense immunochemotherapy regimens such as R-CHOP14.
- Trial name
- NCT01066429
- Testing
- Dexamethasone and dose-dense immunochemoterapy
- Where
- Spain
- Volunteers
- 30 people
- Sponsor
- Hospital Universitario Principe de Asturias
Pain Management
Dexmedetomidine in Postoperative Analgesia
There is a high incidence reaching up to 45%; of severe intraoperative and postoperative pain associated with arthroscopic shoulder surgery, which is often significant enough to interfere with initial recovery and…
- Trial name
- Any (NCT05705128)
- Testing
- Dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- New Valley University
Immune Thrombocytopenia
Caffeic Acid Combining High-dose Dexamethasone in Management of ITP
The project was undertaking by Qilu Hospital of Shandong University in China. In order to report the efficacy and safety of caffeic acid tablets combining with high-dose dexamethasone for the treatment of adults with…
- Trial name
- NCT02556814
- Testing
- Caffeic acid tablets, Dexamethasone
- Where
- China
- Volunteers
- 214 people
- Sponsor
- Shandong University
Multiple Myeloma
Study to Evaluate Two Lenalidomide Dose Regimens With Low Dose Dexamethasone for the Treatment Relapsed Multiple Myeloma
This is a research study to evaluate two different Lenalidomide doses (15 mg vs. 25 mg) in combination with low dose dexamethasone in patients with relapsed multiple myeloma.
- Trial name
- NCT01380106
- Testing
- Lenalidomide 15mg, Lenalidomide 25mg
- Where
- 7 sites in United States
- Volunteers
- 33 people
- Sponsor
- Boston VA Research Institute, Inc.
Postoperative Pain
Comparative Efficacy Of 4 mg VS. 8 mg Submucosal Dexamethasone In Postoperative Pain Management After Dental Implant Surgery: A Randomized Double-Blind Controlled Clinical Trial
This study aims to compare the effectiveness of 4mg and 8mg dexamethasone administered submucosally in reducing postoperative pain after dental implant surgery.
- Trial name
- NCT07413055
- Testing
- Dexamethasone 4 Mg/mL Injectable Solution, Dexamethasone 8Mg Solution for Injection
- Where
- Oman
- Volunteers
- 138 people
- Sponsor
- Oman Ministry of Health
Asthma
Dexamethasone Tolerability in the Treatment of Acute Asthma in Children
The purpose of this study is to assess whether smaller volumes of oral dexamethasone result in better tolerability, specifically less vomiting, in pediatric patients during an acute asthma exacerbation.
- Trial name
- NCT00973687
- Testing
- Ora Sweet, Dexamethasone
- Where
- Canada
- Volunteers
- 430 people
- Sponsor
- IWK Health Centre
Multiple Myeloma in Relapse, Refractory Multiple Myeloma
TJ202, Lenalidomide and Dexamethasone vs. Lenalidomide and Dexamethasone in Subjects With Relapsed or Refractory Multiple Myeloma
A phase 3, randomized, open-label, parallel-controlled, multi-center study comparing TJ202, Lenalidomide and Dexamethasone vs. Lenalidomide and Dexamethasone in subjects with relapsed or refractory multiple myeloma who received…
- Trial name
- NCT03952091
- Testing
- TJ202, Lenalidomide and Dexamethasone, Lenalidomide and Dexamethasone
- Where
- 41 sites in China, Taiwan
- Volunteers
- 289 people
- Sponsor
- TJ Biopharma Co., Ltd.
Spinal Stenosis Lumbar, Low Back Pain
Relief of Lumbar Spinal Stenosis Symptoms
The aim of this study was to compare the efficacy of caudal epidural steroid injection and caudal epidural pulsed radiofrequency stimulation in the relief of symptoms of lumbar spinal stenosis.
- Trial name
- NCT06393959
- Testing
- Caudal epidural pulsed radiofrequency, Caudal epidural steroid enjection
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 50 people
- Sponsor
- Diskapi Teaching and Research Hospital
Adrenal Insufficiency
Bioavailability of Infacort When Administered Onto Food Compared to Direct Oral Administration
This is a single centre, open-label, randomised, single dose, three-period, crossover study to evaluate the bioavailability of Infacort® administered as 'sprinkles' with soft food and yoghurt compared with direct administration…
- Trial name
- NCT03178214
- Testing
- Infacort
- Where
- United Kingdom
- Volunteers
- 19 people, healthy volunteers welcome
- Sponsor
- Neurocrine UK Limited
Laminectomy, Postperative Pain Management
Dexamethasone as ESPB Adjuvant in Lumbar Laminectomy
Laminectomy is a routine procedure for patients with lumbar spinal stenosis, offering significant benefits such as reduced low back pain, alleviation of radiculopathy, and improved motor strength 1 23.
- Conditions
- Laminectomy, Postperative Pain Management, Prostaglandin E2, Lumbal Disc Herniation
- Trial name
- NCT07429708
- Testing
- Bilateral ESPB: Ropivacaine 0.375% + Dexamethasone 5mg, Bilateral ESPB: Ropivacaine 0.375%
- Where
- Indonesia
- Volunteers
- 36 people
- Sponsor
- Udayana University
Multiple Myeloma
Assessment of Molecular Remission by ASO-qPCR After Bortezomib-dexamethasone (Vel/Dex) Followed by ASCT
The primary objective of this study is to determine the rate of molecular remissions (MolR) assessed by ASO-RQ-PCR technique after induction treatment with bortezomib and dexamethasone (Vel/Dex) prior to high-dose therapy with…
- Trial name
- NCT00861250
- Testing
- bortezomib + dexamethasone
- Where
- Finland
- Volunteers
- 47 people
- Sponsor
- Tampere University Hospital
Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement
Intra-Articular PRP Versus Dexamethasone for TMJ Internal Derangement
This study looked at whether an injection into the jaw joint (temporomandibular joint, or TMJ) can help people who have pain, clicking, and difficulty opening their mouth due to a slipped joint disc.
- Conditions
- Temporomandibular Joint Disorders, Temporomandibular Joint Internal Derangement, Temporomandibular Joint Dysfunction Syndrome
- Trial name
- NCT07691684
- Testing
- Platelet-Rich Plasma (PRP), Dexamethasone with Local Anaesthetic
- Where
- Iraq
- Volunteers
- 30 people
- Sponsor
- University Of Anbar
Pelvic Organ Prolapse, PONV
Effects of Preoperative Dexamethasone Study on QOL After Vaginal Reconstructive Surgery for POP
The investigators hypothesize that preoperative administration of 8 mg IV dexamethasone will benefit patients' perceived quality of recovery after surgery.
- Trial name
- NCT02073734
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 63 people
- Sponsor
- TriHealth Inc.
Pterygium of Both Eyes
Dextenza for Post-operative Treatment of Pterygium
DEXTENZA for the Treatment of Post-Surgical Pain and Inflammation Compared to Standard of Care Topical Cortico-steroid Treatment in Patients who Undergo Bilateral Pterygium Surgery
- Trial name
- PERSIST (NCT04351737)
- Testing
- Intracanalicular Dexamethasone, (0.4 mg) Insert, Prednisolone Acetate
- Where
- United States
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Brandon Eye Associates, PA
Lichen Planus
Dexamethasone Solution for the Treatment of Oral Lichen Planus
The objective of this single center, 4-week, open label randomized, phase II study is to evaluate and characterize the tolerability and clinical effectiveness of dexamethasone 0.5mg/5ml solution in a mucoadhesive vehicle…
- Trial name
- NCT02850601
- Testing
- Dexamethasone
- Where
- United States
- Volunteers
- 24 people
- Sponsor
- Brigham and Women's Hospital
Multiple Myeloma in Relapse
Carfilzomib + Elotuzumab + Dexamethasone for Relapsed Multiple Myeloma After 1-3 Prior Treatment Lines
The main aim of this study is to assess the ORR with a new drug combination, carfilzomib (CAR) + elotuzumab (ELO) + dexamethasone (CAR-ELO-Dex).
- Trial name
- KEd (NCT03155100)
- Testing
- Carfilzomib for Inj 60 milligram (MG), Elotuzumab 400 MG, Dexamethasone
- Where
- 8 sites in Finland, Sweden
- Volunteers
- 15 people
- Sponsor
- Raija Silvennoinen
Immune Thrombocytopenic Purpura
Initial Treatment of Patients With Immune Thrombocytopenic Purpura
This study will compare treatment with 3 courses of high-dose dexamethasone versus treatment with prednisone, for patients recently diagnosed with immune thrombocytopenic purpura (ITP).
- Trial name
- ITP^2 (NCT00991939)
- Testing
- Dexamethasone USP Micronized, Prednisone
- Where
- 18 sites in United States
- Volunteers
- 8 people
- Sponsor
- Carelon Research