Clinical trials: Dexmedetomidine
Anesthesia, Surgical Procedures, Elective
A Safety and Efficacy Study of Dexmedetomidine in Patients Requiring Sedation During Monitored Anesthesia Care (MAC)
The objective of this study is to evaluate the safety and efficacy of dexmedetomidine as compared to placebo when used for the sedation of subjects requiring monitored anesthesia care (MAC).
- Trial name
- NCT00398827
- Testing
- Dexmedetomidine
- Where
- 27 sites in United States
- Volunteers
- 326 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Sedation
Long-term Clinical Study Evaluating the Safety and Efficacy of Dexmedetomidine in ICU Subjects
Evaluate efficacy and safety of dexmedetomidine long term administration in ICU patients who require more than 24 hours sedation.
- Trial name
- NCT00526760
- Testing
- Dexmedetomidine
- Where
- 10 sites in Japan
- Volunteers
- 80 people
- Sponsor
- Hospira, now a wholly owned subsidiary of Pfizer
Phantom Limb Pain, Neuropathic Pain
Intrathecal Dexmedetomidine and Acute Neuropathic Pain After Lower Limb Amputation
This randomized controlled trial evaluated the effect of adding intrathecal dexmedetomidine (10 µg) to hyperbaric bupivacaine (11 mg) for spinal anesthesia in patients undergoing lower limb amputation.
- Conditions
- Phantom Limb Pain, Neuropathic Pain, Lower Limb Amputation
- Trial name
- DEX-RCT (NCT07565662)
- Testing
- Hyperbaric Bupivacaine plus Saline, Hyperbaric Bupivacaine plus Dexmedetomidine
- Where
- Mexico
- Volunteers
- 30 people
- Sponsor
- Universidad Juárez Autónoma de Tabasco
Time, Dexmedetomidine
Do Increasing Preoperative Timing of Single Dexmedetomidine Dose Have an Effect on Stress Response of Laryngoscopy and Intubation?
This study aims to evaluate the effect of increasing preoperative timing of single dexmedetomidine on the stress response of laryngoscopy and intubation.
- Conditions
- Time, Dexmedetomidine, Stress Response, Laryngoscopy
- Trial name
- NCT07165483
- Testing
- Dexmedetomidine, Saline
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Tanta University
Onset and Duration of Sensory and Motor Block of Femoral Nerve,, Visual Analogue Pain Scores,
Perineural Dexmedetomidine and Femoral Nerve Block
The duration of sensory block after single dose of long acting local anesthetics is not sufficient to avoid the postoperative use of opioids.
- Conditions
- Onset and Duration of Sensory and Motor Block of Femoral Nerve,, Visual Analogue Pain Scores,, Time to First Request of Rescue Analgesics,, Total Morphine Consumption in 24 Hours
- Trial name
- NCT01964040
- Testing
- peri-neural dexmedetomidine as adjuvant to bupivacaine in femoral nerve block
- Where
- Egypt
- Volunteers
- 45 people
- Sponsor
- Cairo University
Benign Prostate Hyperplasia, Bladder Tumor
Effective Dose of Dexmedetomidine for Sedation in Patients Undergoing TURP/TURB Under Spinal Anesthesia With or Without Fentanyl by Age Groups: Randomized Comparative Study
Recently many studies reported that intraoperative dexmedetomidine administration undergoing spinal anesthesia give a satisfactory sedation in elderly patients and cause less respiratory depressions compared other sedatives(e.g.
- Trial name
- NCT01665586
- Testing
- dexmedetomidine
- Where
- South Korea
- Volunteers
- 82 people
- Sponsor
- Yonsei University
Opioid Use, Heart; Surgery, Heart, Functional Disturbance as Result
Opioid-free Anesthesia for Open Cardiac Surgery: A Prospective Randomized Controlled Trial
This study will compare an opioid free anesthetic, using dexmedetomidine, to a traditional opioid based anesthetic, using fentanyl, for patients undergoing cardiac surgery with regards to hemodynamic stability in the first 10…
- Conditions
- Opioid Use, Heart; Surgery, Heart, Functional Disturbance as Result, Anesthesia
- Trial name
- NCT04197570
- Testing
- Opioid Anesthetics, Non Opioid Analgesics
- Where
- United States
- Volunteers
- 9 people
- Sponsor
- Benaroya Research Institute
Lung Diseases, Diagnosis
Dexmedetomidine-ketamine Combination Versus Fentanyl-midazolam During Bronchoscopy
Sedation during flexible bronchoscopy (FB) should maintain an adequate respiratory drive, ensure maximum comfort for the patient, and warrant that the objectives of the procedure are achieved.
- Conditions
- Lung Diseases, Diagnosis, Anesthesia
- Trial name
- NCT06185127
- Testing
- Dexmedetomidine, Ketamine, Midazolam
- Where
- Greece
- Volunteers
- 50 people
- Sponsor
- University of Patras
Continuous Sedation in Initially Sedated Adults in ICU
Dexmedetomidine Versus Propofol for Continuous Sedation in the Intensive Care Unit (ICU)
Patients in the ICU who need help with their breathing are put onto a machine called a ventilator and are also given a medicine, called a sedative, which helps them to sleep and makes them more comfortable.
- Trial name
- Prodex (NCT00479661)
- Testing
- Dexmedetomidine, Propofol
- Where
- 40 sites in Belgium, Finland and 5 more
- Volunteers
- 500 people
- Sponsor
- Orion Corporation, Orion Pharma
Delirium, Cognitive Dysfunction
Cognitive Outcomes After Dexmedetomidine Sedation in Cardiac Surgery Patients
Anesthesia is a drug induced, reversible, comatose state that facilitates surgery and it is widely assumed that cognition returns to baseline after anesthetics have been eliminated.
- Conditions
- Delirium, Cognitive Dysfunction, Cognition Disorder, Neurocognitive Disorders
- Trial name
- CODEX (NCT04289142)
- Testing
- Dexmedetomidine Hydrochloride Group
- Where
- 8 sites in Canada
- Volunteers
- 2,400 people
- Sponsor
- Sunnybrook Health Sciences Centre
Failed Conscious Sedation During Procedure
The Efficacy and the Safety of Dexmedetomidine Sedation on the Pediatric Intensive Unit(PICU) Patients.
To observe the efficacy and safety of dexmedetomidine sedation on the patients admitted to the pediatric intensive care unit after surgery.
- Trial name
- NCT02296073
- Testing
- Midazolam, Dexmedetomidine, Fentanyl
- Volunteers
- 120 people
- Sponsor
- Anhui Provincial Children's Hospital
Procedural Sedation
Dexmedetomidine and Midazolam Nebulization as Sedation During Cesarean Delivery in Pre-eclampsia
Null hypothesis: There is no difference between the effects of nebulization of dexmedetomidine and midazolam as procedural sedation during cesarean delivery under spinal Anesthesia in pre-eclamptic parturients Alternative…
- Trial name
- NCT04873596
- Testing
- Nebulized dexmedetomidine, Nebulized midazolam
- Where
- Egypt
- Volunteers
- 94 people, healthy volunteers welcome
- Sponsor
- Zagazig University
Dexmedetomidine, Midazolam
Intranasal Dexmedetomidine Versus Intranasal Midazolam for MRI In Pediatrics
An increasing number of studies have reported the use of dexmedetomidine in clinical practice. However, few studies have reported on the intranasal use of dexmedetomidine in radiological procedures The aim of this work is to…
- Conditions
- Dexmedetomidine, Midazolam, MRI, Pediatrics
- Trial name
- NCT04652661
- Testing
- Dexmedetomidine, Midazolam
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Tanta University
Delirium, Cognitive Decline
Dexmedetomidine or Clonidine Infusion for Prevention of Delirium After Open Heart Surgery
A parallel-group treatment, five-centre, participant and investigator masked, three-arm study to assess the safety and effectiveness of dexmedetomidine or clonidine infusion compared to placebo for the prevention of delirium and…
- Conditions
- Delirium, Cognitive Decline, Frailty
- Trial name
- ALPHA2PREVENT (NCT05029050)
- Testing
- Dexmedetomidine, Clonidine, Natriumchlorid
- Where
- 5 sites in Norway
- Volunteers
- 900 people
- Sponsor
- Oslo University Hospital
Laparoscopic, Gastrointestinal Surgery
Combination of Nalbuphine and Dexmedetomidine Versus Sufentanil and Dexmedetomidine on Patients
Surgical pain refers to pain that occurs immediately after surgery, including physical pain and visceral pain. Thus, it severely challenges the proper use of analgesics for patients undergoing laparoscope gastrointestinal surgery…
- Trial name
- NCT05445024
- Testing
- nalbuphine group, sufentanil group
- Where
- China
- Volunteers
- 300 people
- Sponsor
- Qianfoshan Hospital
Acupuncture, Dexmedetomidine
Study on the Difference and Cause of Acupuncture Dexmedetomidine Compound Anesthesia Effect
Studies have shown that the use of dexmedetomidine before and during surgery has a good sedative, analgesic and circulatory stabilizing effect.
- Conditions
- Acupuncture, Dexmedetomidine, Anesthesia
- Trial name
- NCT05159674
- Testing
- Dexmedetomidine+electroacupuncture compound anesthesia
- Volunteers
- 22 people
- Sponsor
- Shanghai Yueyang Integrated Medicine Hospital
Postoperative Pain, Opioid Use
Dexmedetomidine and Ketamine in VATS Surgery
Postoperative pain after VATS surgery is significant and associated with moderate to high post operative morphine requirements, which can cause opioid related side effects and delay postoperative recovery.
- Trial name
- NCT03596424
- Testing
- Ketamine Hydrochloride, Dexmedetomidine Hydrochloride, dexmedetomidine Hydrochloride and Ketamine Hydrochloride
- Where
- Canada
- Volunteers
- 40 people
- Sponsor
- Ciusss de L'Est de l'Île de Montréal
Polyuria
Polyuria Associated With Dexmedetomidine in Operating Room
Dexmedetomidine is an a2-adrenergic receptor agonist drug, widely used in intensive care for the sedation of patients on mechanical ventilation, as well as in the operating room during invasive procedures and during general…
- Trial name
- NCT06535386
- Testing
- Dexmedetomidine 0.004 MG/ML
- Volunteers
- 150 people
- Sponsor
- Hospital Privado de Comunidad de Mar del Plata
Pain, Postoperative
Perineural Versus IV Dexmedetomidine as Adjuvant to Quadratus Lamborum Block for Pediatrics Undergoing Pyeloplasty
this prospective parallel group double blinded study will be conducted over 50 pediatric patients ASA (American Association of Anesthesiologists) I and II between the age of 8-13 years old,who will be scheduled for laparoscopic…
- Trial name
- NCT03885804
- Testing
- Quadratus lamborum dexmedetomidine intravenous, Quadratus lamborum dexmedetomidine perineural group(
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Postoperative Pain Intensity
Effect of Opioid-Free Versus Opioid-Based Anesthesia in Discectomy Surgery
This prospective randomized double-blind clinical trial compares opioid-free anesthesia (OFA) versus opioid-based anesthesia (OBA) on postoperative analgesia in patients undergoing elective lumbar discectomy surgeries at Zagazig…
- Trial name
- NCT07787858
- Testing
- Dexmedetomidine and Ketamine-based Opioid-free Anesthesia, Fentanyl-based Opioid Anesthesia
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Zagazig University