Clinical trials: Dexmedetomidine
Anesthesia, Local
Combined Intravenous Dexamethasone and Dexmedetomidine as Adjuncts to Popliteal and Saphenous Nerve Blocks in Patients Undergoing Orthopaedic Surgery of the Foot and Ankle
The investigators will investigate the beneficial and harmful effects of combining dexamethasone (12 mg) and dexmedetomidine (1mcg/kg) as adjuncts to popliteal and saphenous nerve blocks in patients undergoing surgery of their…
- Trial name
- ADJUNCT2 (NCT04818749)
- Testing
- Saline, Dexamethasone 12 mg, Dexamethasone 12 mg + dexmedetomidine 1 mcg/kg
- Where
- 2 sites in Denmark
- Volunteers
- 120 people
- Sponsor
- Zealand University Hospital
Patients Undergoing Rigid Bronchoscopy
A Comparative Study Between Combination of Propofol and Dexmedetomidine Versus Propofol Alone in Anesthesia for Rigid Bronchoscopy by Using the Patient State Index Monitor
Standard ASA fasting guidelines will be followed. IV 20 gauge cannula will be inserted and dedicated to the infusion drugs. Standard ASA monitors will be attached, and baseline heart rate (HR), mean arterial blood pressure (MAP)…
- Trial name
- NCT07409935
- Testing
- Propofol saline, Propofol Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- Cairo University
Upper Extremity Injury
Infraclavicular Brachial Plexus Block With Bupivacaine Alone or With Both Dexmedetomidine and Dexamethasone
Upper-extremity regional anesthetic techniques, using brachial plexus blockade, have been shown to reduce adverse effects related to opioid administration, improve patient satisfaction, and provide significantly improved…
- Trial name
- NCT06356415
- Testing
- Bupivacaine injection, Bupivacaine+ Dexamethasone+ Dexmedetomidine
- Volunteers
- 40 people
- Sponsor
- Suez Canal University
Coughing Response, Thyroid Surgery
Effects of Dexmedetomidine on Cough Response and Postoperative Recovery Quality in Patients Undergoing Thyroid Surgery With General Anesthesia
Coughing is a common adverse reaction of thyroid surgery,which could result in postoperative bleeding.Postoperative bleeding is a serious and potentially life-threatening complication，which could result in acute upper airway…
- Conditions
- Coughing Response, Thyroid Surgery, General Anesthesia
- Trial name
- NCT02613806
- Testing
- Dexmeditomidine, normal saline
- Where
- China
- Volunteers
- 118 people
- Sponsor
- First Affiliated Hospital of Chongqing Medical University
Emergence Deliruim; Cerebral Palsy
Consequence of Dexmedetomidine on Emergence Deliruim After Sevoflurane Anesthesia in Children With Cerebral Palsy
The purpose of this study is to determine whether dexmedetomidine is effective in the treatment of emergence deliruim after sevoflurane anesthesia in children with cerebral palsy.
- Trial name
- NCT02244515
- Testing
- dexmedetomidine
- Volunteers
- 80 people
- Sponsor
- Jin Ni
Remimazolam, Dexmedetomidine
Application of Remimazolam, Dexmedetomidine, and Esketamine in Pediatric Preoperative Sedation
By comparing the application effects of three drugs in pediatric preoperative sedation, this study explores the optimal medication regimen, aiming to provide safer, more effective, and more personalized medication options for…
- Conditions
- Remimazolam, Dexmedetomidine, Esketamine
- Trial name
- NCT07050212
- Testing
- remimazolam group, dexmedetomidine group, esketamine group
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Maternal and Child Health Hospital of Hubei Province
Adults, Major Noncardiac Surgery
Dexmedetomidine-Esketamine Combination and Sleep Disturbances After Major Noncardiac Surgery
Sleep disturbances are common early after major surgery, and are associated with delayed recovery. A previous study showed that dexmedetomidine-esketamine combination as a supplement to patient-controlled intravenous analgesia…
- Conditions
- Adults, Major Noncardiac Surgery, Dexmedetomidine, Esketamine
- Trial name
- NCT06859892
- Testing
- Dexmedetomidine-esketamine combination
- Where
- China
- Volunteers
- 476 people
- Sponsor
- Peking University First Hospital
Postoperative Nausea and Vomiting, Post Operative Pain
Effect of Dexmedetomidine on Prevention of Postoperative Nausea and Vomiting in Children
this study will aim to evaluate the effects of dexmedetomidine, dexamethasone and Ondansetron on the prevention of postoperative nausea and vomiting in children undergoing dental rehabilitation surgery.
- Conditions
- Postoperative Nausea and Vomiting, Post Operative Pain, Emergence Delirium
- Trial name
- NCT05124067
- Testing
- Dexamethasone, Ondansetron, Dexmedetomidine
- Where
- Saudi Arabia
- Volunteers
- 4 people, healthy volunteers welcome
- Sponsor
- Tanta University
Cleft Lip
Dexmedetomidine as Adjuvant for Bupivacaine in Ultrasound Guided Infraorbital Nerve Block for Cleft Lip Repair
To assess the efficacy of dexamethasone versus dexmedetomidine as adjuncts to bupivacaine for infra-orbital nerve block in infants undergoing cleft lip surgery.
- Trial name
- NCT03480607
- Testing
- Dexmedetomidine group, Dexamethasone group
- Where
- Egypt
- Volunteers
- 44 people
- Sponsor
- Mansoura University
Pain, Postoperative, Cancer of Larynx
Efficacy of Adding Dexmedetomidine in Ultrasound-guided Intermediate Cervical Plexus Block for Thyroidectomy Surgery
The cervical plexus block (CPB) is one such block used to provide effective anesthesia and analgesia for surgery in the head and neck region.
- Trial name
- NCT05814744
- Testing
- dexmedetomidine, bupivacaine 0.25%, Thyroidectomy Surgery
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- National Cancer Institute, Egypt
Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries
Dexmedetomidine Versus Nitroglycerin on Surgical Field Quality and Drug Cost in Functional Endoscopic Sinus Surgeries
Sinus surgery is one of the most prevalent ear, nose, and throat (ENT) surgeries, which is mainly carried out nowadays through functional endoscopic sinus surgery (FESS) and leads to significant improvement in the clinical…
- Conditions
- Intraoperative Bleeding, Functional Endoscopic Sinus Surgeries, Hypotension
- Trial name
- NCT07585201
- Testing
- controlled hypotension using dexmedetomidine, controlled hypotension hypotension using nitroglycerin
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Zagazig University
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Pre-Eclampsia
Peri-operative Dexmedetomidine Infusion in Pre-eclamptic Patients
The purpose of this study is to investigate the effects of dexmedetomidine infusion on the stress response to intubation, postoperative analgesia, and renal functions (urinary output [UOP], creatinine and glomerular filtration…
- Trial name
- NCT03391609
- Testing
- Dexmedetomidine infusion
- Where
- Egypt
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Assiut University
Delirium
Dexmedetomidine to Lessen Intensive Care Unit (ICU) Agitation
The primary aim of the DahLIA trial is to determine, in patients with ICU-associated delirium and agitation who are otherwise pathophysiologically stable (as defined), the number of ventilator-free hours in the incident ICU…
- Trial name
- DahLIA (NCT01151865)
- Testing
- Dexmedetomidine
- Where
- 7 sites in Australia
- Volunteers
- 96 people
- Sponsor
- Austin Health
Breast Cancer
Observation of the Effect of Preoperative Use of Dexmedetomidine Hydrochloride Nasal Spray on Optimizing Awake Sedation During Breast-Conserving Surgery for Breast Cancer and Postoperative Awake Status
This clinical trial aims to evaluate the efficacy and safety of Dexmedetomidine Hydrochloride Nasal Spray for conscious sedation and anxiety relief during breast-conserving surgery.
- Trial name
- NCT07350928
- Testing
- Induction of anesthesia with dexmedetomidine nasal spray prior to surgery
- Where
- China
- Volunteers
- 394 people
- Sponsor
- Tianjin Medical University Cancer Institute and Hospital
Preoperative Anxiety, Preoperative Sedation
Determination of ED50 and ED95 With Clinical Efficacy of Intranasal Dexmedetomidine Combined With Esketamine for Preoperative Sedation in Pediatric General Anesthesia
For pediatric patients undergoing general anesthesia, poor anesthesia induction compliance often has adverse effects on individual behavior in the early postoperative period.
- Conditions
- Preoperative Anxiety, Preoperative Sedation, Children, Dexmedetomidine
- Trial name
- NCT06853431
- Testing
- dexmedetomidine, Esketamine
- Where
- 2 sites in China
- Volunteers
- 80 people
- Sponsor
- Second Affiliated Hospital of Wenzhou Medical University
Chills
Comparison Of Dexmedetomidine & Ketamine For Control Of Shivering In Vaginal Hysterectomy Under Spinal Anesthesia
comparison of Dexmedetomidine And Ketamine For Control Of Shivering In Vaginal Hysterectomy Proceeded Under Spinal Anesthesia.
- Trial name
- NCT05481281
- Testing
- Dexmedetomidine, Ketamine
- Volunteers
- 104 people, healthy volunteers welcome
- Sponsor
- Hamdard University
Auditory Brainstem Response
Intranasal Dexmedetomidine for Sedated Hearing Testing
Auditory brainstem response testing is necessary in children who are not able to be tested by classical audiogram, because of their age or an associated retarded psycho-motor development or behavioral and cognitive troubles.
- Trial name
- NCT03530371
- Testing
- Dexmedetomidine Hydrochloride
- Where
- France
- Volunteers
- 60 people
- Sponsor
- Fondation Lenval
Withdrawal; Therapeutic Substance
Protocolized Initiation of Clonidine to Prevent Dexmedetomidine Withdrawal
The purpose of this study is to determine if the protocolized use of clonidine will reduce dexmedetomidine withdrawal symptoms, reduce PICU length of stay, and reduce costs related to sedation during hospital admission.
- Trial name
- NCT05575219
- Testing
- Clonidine (without protocolized initiation), Clonidine (protocolized initiation)
- Where
- United States
- Volunteers
- 128 people
- Sponsor
- The University of Texas Health Science Center, Houston
Anesthesia Recovery Period, Postoperative Complications
The Anesthesia Effects of Dexmedetomidine Combined With Desflurane or Propofol in Lobectomy
In one-lung ventilation surgery, compared with dexmedetomidine combined with propofol, dexmedetomidine combined with desflurane may be beneficial to accelerate patients' recovery and reduce postoperative pulmonary complications…
- Trial name
- NCT06207344
- Testing
- Dexmedetomidine and propofol, Dexmedetomidine and desflurane
- Where
- 2 sites in China
- Volunteers
- 120 people
- Sponsor
- The Second Affiliated Hospital of Chongqing Medical University