Clinical trials: Dexmedetomidine Analgesia
Postoperative Pain, Cesarean Section Pain
Comparison of Dexmedetomidine + Ketamine for Postoperative Pain in C-Section
This study aims to compare three different doses of dexmedetomidine, when combined with a fixed dose of ketamine, for pain control in women undergoing cesarean section.
- Trial name
- KETODEX-CS (NCT07022821)
- Testing
- Dexmedetomidine, ketamine
- Where
- Pakistan
- Volunteers
- 90 people
- Sponsor
- Fatima Memorial Hospital
Dexmedetomidine, Adjuvant
Dexmedetomidine as an Adjuvant to Bupivacaine in Scalp Block Versus Bupivacaine Alone for Postoperative Pain Management in Patients Undergoing Craniotomy
This study aims to compare dexmedetomidine as an adjuvant to bupivacaine in scalp block versus bupivacaine alone for postoperative pain management in patients undergoing craniotomy.
- Conditions
- Dexmedetomidine, Adjuvant, Bupivacaine, Scalp Block
- Trial name
- NCT06993922
- Testing
- Scalp block, Scalp block + Dexmedetomidine
- Where
- Egypt
- Volunteers
- 50 people
- Sponsor
- Ain Shams University
Arthroscopy, Erector Spinae Plane Block
Dexmedetomidine as Adjuvant in Erector Spinae Plane Block After Shoulder Arthroscopy
The aim of this study is to evaluate the effect of adding dexmedetomidine as an adjuvant to bupivacaine in ultrasound (US) guided erector spinae plane block (ESPB) for managing acute postoperative pain in patients undergoing…
- Conditions
- Arthroscopy, Erector Spinae Plane Block, Analgesia
- Trial name
- NCT05165836
- Testing
- Erector Spinae Plane block without Dexmedetomidine group, Erector Spinae Plane block with Dexmedetomidine group
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Kafrelsheikh University
Obstructive Sleep Apnea, Analgesia
Dexmedetomidine Supplemented Analgesia in Patients at High-risk of Obstructive Sleep Apnea
Obstructive sleep apnea (OSA) is a common sleep disturbance that can cause intermittent hypoxia, hypercapnia, and sleep structure disorders.
- Conditions
- Obstructive Sleep Apnea, Analgesia, Dexmedetomidine, High-flow Nasal Cannula
- Trial name
- NCT04608331
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 152 people
- Sponsor
- Peking University First Hospital
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07525999
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
Post Operative Analgesia
Dexmedetomidine and Bupivacaine Intra-articular for Postoperative Analgesia After Knee Arthroscopic Surgery
The aim of this study to compare the analgesic effects of intraarticular dexmedetomidine added to bupivacaine with those of bupivacaine alone after knee arthroscopy
- Trial name
- DEXMED (NCT06665438)
- Testing
- Bupivacaine 0.25%, Dexmedetomidine
- Where
- 2 sites in Egypt
- Volunteers
- 75 people
- Sponsor
- Al-Azhar University
Post-thoracotomy Pain Syndrome
Effects of Dexmedetomidine Used in Continuous Thoracic Paravertebral Blocks
The purpose of this study is to explore the effectiveness of dexmedetomidine as an adjunctive analgesic, used in ultrasound-guided continuous thoracic paravertebral blocks for Post-thoracotomy Pain Syndrome(PTPS).
- Trial name
- NCT02619513
- Testing
- Dexmedetomidine, Ropivacaine, Mindray M7 series
- Where
- China
- Volunteers
- 60 people
- Sponsor
- Weifeng Tu
Anesthesia
The Effectiveness of the Addition of Dexmedetomidine to Analgesia for Ankle Surgery.
Forefoot surgeries involve a relatively short operation usually completed in 1 - 1½ hours, with patients generally being allowed to go home on the same day.
- Trial name
- NCT02170948
- Testing
- Dexmedetomidine
- Where
- Canada
- Volunteers
- 12 people
- Sponsor
- University Health Network, Toronto
Pain Control
The Effect of Dexmedetomidine in the Management of Pain After Uterine Artery Embolization
The investigators examined the effect of dexmedetomidine in the management of pain after uterine artery embolization.
- Trial name
- NCT01578174
- Testing
- Dexmedetomidine, Normal saline 0.9%
- Where
- South Korea
- Volunteers
- 66 people
- Sponsor
- Severance Hospital
Dexmedetomidine, Bupivacaine
Dexmedetomidine as an Adjuvant to Bupivacaine in Ultrasound-Guided Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy
The aim of this study is to evaluate the effect of adding Dexmedctomidinc as adjuvant to Bubivacaine in Ultrasound-Guided Quadratus Lumborum Block for Postoperative Analgesia in Laparoscopic Cholecystectomy.
- Conditions
- Dexmedetomidine, Bupivacaine, Ultrasound-Guided, Quadratus Lumborum Block
- Trial name
- NCT06825286
- Testing
- Bupivacaine, Bupivacaine and Dexmedetomidinc) group
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University
Head and Neck Cancer, Anesthesia
Effects of Minimal-Flow Sevoflurane and Multimodal Analgesia in Head and Neck Cancer Surgery
This study evaluates the anesthetic-sparing and renal protection effects of minimal-flow sevoflurane anesthesia combined with multimodal analgesia using dexmedetomidine, ketamine, and lidocaine in head and neck cancer patients…
- Conditions
- Head and Neck Cancer, Anesthesia, Renal Protection, Acute Kidney Injury
- Trial name
- NCT06521697
- Testing
- Multimodal analgesia using dexmedetomidine-ketamine-lidocaine mixture, Minimal flow sevoflurane
- Volunteers
- 60 people
- Sponsor
- National Taiwan University Hospital
Intrathecal Dexmedetomidine, Adductor Canal Block
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty
The aim of this work is to evaluate the effect of combined intrathecal dexmedetomidine and adductor canal block for analgesia after total knee arthroplasty (TKA).
- Conditions
- Intrathecal Dexmedetomidine, Adductor Canal Block, Analgesia, Total Knee Arthroplasty
- Trial name
- NCT06837844
- Testing
- Intrathecal Dexmedetomidine, Adductor Canal Block, Intrathecal Dexmedetomidine + Adductor Canal Block
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Kafrelsheikh University
Pain, Anesthesia
Intranasal Dexmedetomidine Sedation and Analgesia During Pediatric Emergency Room Procedures
The study objective is to determine if intranasal dexmedetomidine is a safe and effective sedative drug during small painful procedures in the pediatric emergency room.
- Trial name
- INDEXER (NCT03564093)
- Testing
- Intranasal Drug
- Where
- Finland
- Volunteers
- 112 people
- Sponsor
- University of Oulu
Midline Laparotomy
COMPARISON OF MEAN DURATION OF POST OPERATIVE ANALGESIA FOLLOWING ADDITION OF DEXMEDETOMIDINE TO ROPIVACAINE VERSUS PLAIN ROPIVACAINE ON ULTRASOUND GUIDED RECTUS SHEATH BLOCK
To compare the mean duration of postoperative analgesia following addition of dexmedetomidine to ropivacaine versus plain ropivacaine in ultrasound guided rectus sheath block in patients undergoing midline laparotomies
- Trial name
- NCT07254130
- Testing
- Rectus Sheath Block
- Where
- Pakistan
- Volunteers
- 209 people
- Sponsor
- Quaid-e-Azam Medical College
Postoperative Pain
Intravenous Dexmedetomidin on Postoperative Pain After Hypospadias Repair in Children
This study aimed to evaluate the efficacy of intravenous ketorolac versus dexmedetomidine as analgesia after Hypospadias repair surgery to determine the optimal procedure for pain control and postoperative reduction of analgesic…
- Trial name
- NCT05194904
- Testing
- Dexmedetomidine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Post Operative Pain
Dexamethasone or Dexmedetomidine as Adjunct in Fascia Iliaca Block During Positioning for Sub-arachnoid Block & Post-operative Analgesia After Femur Neck Fracture Surgery: A Randomized Control Trial
Femur fracture is a common injury occurring in the young due to trauma as well as amongst the elderly due to fall. Reduction and fixation of femur fractures pose a challenge to the anesthesiologist.
- Trial name
- NCT05484648
- Testing
- Dexamethasone, Dexmedetomidine
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Aga Khan University Hospital, Pakistan
Postoperative Pain, Total Hip Arthroplasty (THA)
Safety and Efficacy of Dexamethasone Versus Dexmedetomidine as Adjuvants in PENG Block in Hip Surgeries for Postoperative Pain Management
This study evaluates and compares the analgesic efficacy and safety of adding dexamethasone versus dexmedetomidine to bupivacaine in an ultrasound-guided pericapsular nerve group (PENG) block combined with a lateral femoral…
- Trial name
- NCT07847047
- Testing
- Bupivacaine 0.25%, Dexamethasone, Dexmedetomidine
- Volunteers
- 90 people
- Sponsor
- Assiut University
Lung Cancer, Video-assisted Thoracoscopic Surgery
Effects of Dexmedetomidine on Quality of Recovery and Analgesia After Video-assisted Thoracoscopic Surgery
Dexmedetomidine is a selective α2 adrenergic agonist that can be considered analgesics, anxiolytic,and anti-stress effect . This randomized, double-blind placebo-controlled trial of intraoperative dexmedetomidine for improvement…
- Trial name
- NCT02537249
- Testing
- Dexmedetomidine, Normal saline
- Where
- South Korea
- Volunteers
- 111 people
- Sponsor
- Yonsei University
Pain, Post Operative, Pain, Acute
Opioid-free Anesthesia in Thyroidectomies
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective thyroidectomies.
- Conditions
- Pain, Post Operative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT05243940
- Testing
- dexmedetomidine-ketamine-lidocaine (DKL), remifentanil infusion
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Patient-Controlled Analgesia
Effect of Dexmedetomidine for Postoperative Intravenous Patient Controlled Analgesia
The purpose of this study is to explore the effectiveness of dexmedetomidine as an adjunctive analgesic, combined with dezocine and flubiprofen, used in intravenous Patient-Controlled Analgesia (PCA) after open colorectal surgery.
- Trial name
- NCT03014713
- Testing
- Dezocine, Flubiprofen, Dexmedetomidine
- Where
- China
- Volunteers
- 50 people
- Sponsor
- Weifeng Tu