Clinical trials: Dexmedetomidine Analgesia
Scoliosis Correction, Postoperative Analgesia
Mini-dose Esketamine-dexmedetomidine Supplemented Analgesia and Long-term Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe postoperative acute pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT05718544
- Testing
- Esketamine, Dexmedetomidine, Sufentanil
- Where
- China
- Volunteers
- 199 people
- Sponsor
- Peking University First Hospital
Postoperative Pain After Laparoscopic Sleeve Gastrectomy
Intraperitoneal Versus Intravenous Dexmedetomidine for Post-operative Analgesia Following Laparoscopic Sleeve Gastrectomy Surgery
One of most common bariatric surgery is laparoscopic sleeve gastrectomy. Pain after laparoscopic surgery may be due to stretching of the intra-abdominal cavity, peritoneal inflammation, and diaphragmatic irritation caused by…
- Trial name
- NCT04370392
- Testing
- intraperitoneal local anaesthetic instillation
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Tanta University
Dexmedetomidine, Transurethral Resection of Prostate
Intrathecal Versus Intravenous Dexmedetomidine in Prostate Transurethral Resection
This study was conducted to compare the effects of intrathecal versus intravenous dexmedetomidine administration in patients undergoing Transurethral resection of the prostate under spinal anesthesia.
- Conditions
- Dexmedetomidine, Transurethral Resection of Prostate, Analgesia
- Trial name
- NCT05525819
- Testing
- Control group, Intrathecal group, Intravenous group
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Tanta University
Elderly, Surgery
Impact of Dexmedetomidine on Sleep Quality
Sleep disturbances frequently occur in elderly patients after major surgery; and their occurrence are associated with worse outcomes including increased incidence of delirium.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03117790
- Testing
- Dexmedetomidine
- Where
- China
- Volunteers
- 118 people
- Sponsor
- Peking University First Hospital
Analgesia, Postoperative
Erector Spinae Plane Block with Dexmedetomidine and Bupivacain Versus Dexamethasone and Bupivacain for Postoperative Analgesia in Patients Undergoing Abdominal Surgeries
To compare the analgesic effect of dexmedetomidine combined with bupivacaine versus dexamethasone combined with bupivacaine for ultrasound-guided ESPB for postoperative pain control in patients scheduled for abdominal surgeries
- Trial name
- NCT06658418
- Testing
- Erector Spinae Plane Block
- Volunteers
- 90 people
- Sponsor
- Loay Gamal
Pediatric Adenotonsillectomy, Post Operative Analgesia
Dexmedetomidine in Pediatric Tonsillectomy
The hypothesis of this study is that the administration of an intra-operative dose of dexmedetomidine will result in adequate analgesia without respiratory depression thereby resulting in an early discharge from the post…
- Trial name
- NCT01057381
- Testing
- Dexmedetomidine 0.75 mcg/kg, Morphine 50 mcg/kg, Morphine 100 mcg/kg
- Where
- United States
- Volunteers
- 109 people, healthy volunteers welcome
- Sponsor
- Baylor College of Medicine
Anesthesia
Comparison Between Adjuvants Added to Bupivacaine in Adductor Canal Block
Adult patients undergoing anterior cruciate ligament repair under Spinal Anaesthesia will be randomly assigned into one of the following groups (The Four study groups will receive the standard treatment in the form of spinal…
- Trial name
- NCT04892420
- Testing
- Dexamethasone, Dexmedetomidine, Magnesium sulfate
- Where
- Egypt
- Volunteers
- 120 people
- Sponsor
- Ain Shams University
Sore Throat, Dexmedetomidine Analgesia
Effect of Preoprative Nebulized Dexmedetomidine Compared to Nebulized Lidocaine in Attenuating Sore Throat Following Tonsillectomy In Childern.
The aim of the study is to compare the effect of nebulized Dexmedetomidine compared to nebulized Lidocaine on postoperative sore throat in childern undergoing Tonsillectomy.
- Conditions
- Sore Throat, Dexmedetomidine Analgesia, Tonsillectomy
- Trial name
- NCT07780760
- Testing
- Group D (dexmedetomidine group), Group L (Lidocaine group)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Pain, Postoperative, Pain, Acute
Opioid-free Anesthesia With a Mixture of Dexmedetomidine-lidocaine-ketamine
The aim of this study will be to investigate the effect of an opioid-free anesthesia regimen with a mixture of dexmedetomidine-lidocaine-ketamine in the same syringe versus fentanyl analgesia in elective laparoscopic…
- Conditions
- Pain, Postoperative, Pain, Acute, Pain, Chronic, Pain, Neuropathic
- Trial name
- NCT04858711
- Testing
- ketamine-lidocaine-dexmedetomidine, fentanyl
- Where
- Greece
- Volunteers
- 60 people
- Sponsor
- Aretaieion University Hospital
Analgesia
Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy
Opioid sparing analgesia: Continuous intraoperative infusion of dexmedetomidine versus lidocaine for laparoscopic cholecystectomy, a randomized double-blind clinical trial.
- Trial name
- NCT05788393
- Testing
- Dexmedetomidine Injection [Precedex], Lidocaine IV
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Post Operative Pain
Dexmedetomidine Ropivacaine Versus Plain Ropivacaine in Bilateral Pectoralis Nerve Block
Background: Multimodal analgesia for control of postoperative pain in cardiac surgical patients helps in early recovery and ambulation.
- Trial name
- NCT05897307
- Testing
- Ropivacaine
- Where
- Saudi Arabia
- Volunteers
- 90 people
- Sponsor
- Fayoum University Hospital
Surgery
Analgesic Efficacy of Intravenous Dexmedetomidine for Supraclavicular Plexus Block
The goal of the study is to compare the duration of analgesia in patients undergoing forearm or hand surgery with a supraclavicular brachial plexus block, who receive either iv dexmedetomidine or placebo.
- Trial name
- TwoDex (NCT05389852)
- Testing
- Dexmedetomidine
- Where
- Switzerland
- Volunteers
- 100 people
- Sponsor
- Hôpital du Valais
Primary Total Hip Arthroplasty
Opioid Free Anesthesia in Total Hip Arthroplasty
Total hip arthroplasty (THA) is one of the most common orthopedic surgical procedure and is associated with severe pain in the immediate postoperative period, thus limiting early recovery.
- Trial name
- OFATHA (NCT05072704)
- Testing
- Sufentanil, Dexmedetomidine
- Where
- France
- Volunteers
- 80 people
- Sponsor
- CMC Ambroise Paré
Interstitial Cystitis
Usefulness of Dexmedetomidine on Post-operative Pain Management in Patients With Interstitial Cystitis
The purpose of this study is to assess the effects of dexmedetomidine while patients undergo treatment for Interstitial Cystitis (IC).
- Trial name
- NCT01195116
- Testing
- Dexmedetomidine, Normal Saline
- Where
- United States
- Volunteers
- 41 people
- Sponsor
- University of Rochester
Pregnancy Related
Effectiveness of Clonidine, Dexmedetomidine, and Fentanyl Adjuncts for Labor Epidural Analgesia
The purpose of this randomized controlled trial is to compare the effectiveness of epidural clonidine, dexmedetomidine, or fentanyl adjuncts for labor analgesia.
- Trial name
- NCT05487196
- Testing
- Clonidine, Dexmedetomidine, Fentanyl
- Where
- United States
- Volunteers
- 88 people, healthy volunteers welcome
- Sponsor
- Grace Lim, MD, MS
Epilepsy, Radiofrequency Ablation
Brain Regions and Functional Neuronal Network Characteristics of Dexmedetomidine Analgesia
Background: Dexmedetomidine (Dex) is a highly selective 2-adrenergic receptor agonist with significant analgesia affection. This study is planned to explore the brain regions and functional neuronal network involved in promoting…
- Conditions
- Epilepsy, Radiofrequency Ablation, Intracranial Surgery
- Trial name
- NCT05500703
- Testing
- Dexmedetomidine Injectable Solution, Sodium Chloride 0.9% Inj
- Where
- China
- Volunteers
- 28 people
- Sponsor
- China International Neuroscience Institution
Regional Anaesthesia
Ultrasound-Guided Infraclvicular Block Using Dexmedetomidine Versus Nalbuphine as Adjuvants to Bupivacaine in Upper Limb Orthopedic Surgery
this study is designed to evaluate and compare the efficacy of dexmedetomidine and nalbuphine as adjuvants to 0.5% bupivacaine in ultrasound-guided infraclavicular brachial plexus block for patients undergoing elective upper limb…
- Trial name
- NCT07279727
- Testing
- Nalbuphine, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 66 people
- Sponsor
- Assiut University
Nephrectomy
Dexmedetomidine Versus Fentanyl as Adjuvants to Erector Spinae Plane Block for Postoperative Analgesia Following Simple Nephrectomy: A Randomized Clinical Trial
The aim of this clinical trial is to compare the time to first analgesic request between dexmedetomidine and fentanyl as adjuvants in erector spinae plane block in patients undergoing simple nephrectomy .
- Trial name
- DEX/Fentanyl (NCT06799442)
- Testing
- Erector Spinae Plane Block, Dexmedetomidine, fentanyl
- Where
- Egypt
- Volunteers
- 46 people
- Sponsor
- Assiut University
Pain, Hypospadias
Dexmedetomidine Infusion and Surgical Pleth Index In Pediatrics
This non-invasive dimensionless score index -SPI-reflects the Patients' sympathetic response to surgical stimulation. Its effectiveness in detecting the balance between nociceptor activation and analgesia was not only reported…
- Trial name
- NCT05727969
- Testing
- Dexmedetomidine, Lactated Ringer, Hypospadias
- Where
- Egypt
- Volunteers
- 90 people, healthy volunteers welcome
- Sponsor
- Fayoum University Hospital
Rib Fractures, Acute Pain
Comparison of Dexmedetomidine Versus Dexamethasone as Adjuvants to Bupivacaine in Ultrasound-Guided Erector Spinae Plane Block for Acute Pain Management in Patients With Traumatic Rib Fractures
Traumatic rib fractures cause severe chest wall pain that can impair normal breathing, coughing, and lung function. While systemic opioids are commonly used to treat traumatic pain, their side effects, such as sedation and…
- Conditions
- Rib Fractures, Acute Pain, Thoracic Trauma
- Trial name
- NCT07827157
- Testing
- Dexmedetomidine with Bupivacaine in ESPB, Dexamethasone with Bupivacaine in ESPB
- Volunteers
- 100 people
- Sponsor
- Assiut University