Clinical trials: Dexmedetomidine Analgesia, active
Cancer, Palliative Care, Patient Care
Dexmedetomidine for Refractory Pain in Palliative Cancer Patients
The goal of this study is to find out whether the medication dexmedetomidine can be a safe and effective additional treatment for cancer patients whose pain is not well controlled by standard pain medicines (such as opioids).
- Conditions
- Cancer, Palliative Care, Patient Care, Pain Management, Dexmedetomidine Analgesia
- Trial name
- DEX-PAL (NCT07885475)
- Where
- 4 sites in Norway
- Volunteers
- 30 people
- Sponsor
- St. Olavs Hospital
Dexmedetomidine Analgesia, Knee Surgery
Intravenous Regional Analgesia of Dexmedetomidine
Dexmedetomidine is a highly selective α₂-adrenergic receptor agonist that exerts its effects by inhibiting the release of norepinephrine at presynaptic nerve terminals, leading to reduced sympathetic activity; This mechanism…
- Trial name
- Dexmedetomidin (NCT07131579)
- Testing
- Normal Saline, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Mansoura University
Pain, Acute Post-Operative, Dexmedetomidine
Esmolol Versus Dexmedetomidine for Opioid-sparing in Laparoscopic Gynecological Surgery
The aim of this study is to investigate and compare the effects of a continuous infusion of low-dose esmolol and dexmedetomidine versus placebo on intraoperative and postoperative opioid consumption and analgesic efficacy in…
- Conditions
- Pain, Acute Post-Operative, Dexmedetomidine, Analgesia, Esmolol
- Trial name
- NCT07846722
- Testing
- Esmolol hydrochloride, Dexmedetomidine, Normal (0.9%) saline
- Where
- Greece
- Volunteers
- 90 people
- Sponsor
- Vasiliki Samartzi
Dexmedetomidine, Ketamine
Safety and Efficacy of Esketamine - Dexmedetomidine Combination Versus Dexmedetomidine Monotherapy for Hyperactive Delirium in ICU Patients on Non-Invasive Respiratory Support (SEED-NIRS Trial): Study Protocol of a Randomized Controlled Trial
This investigator-initiated, randomized, controlled, single-blind, superiority trial aims to assess the efficacy and safety of esketamine combined with dexmedetomidine for the management of agitation or delirium in intensive care…
- Conditions
- Dexmedetomidine, Ketamine, Analgesia, Respiratory Therapy
- Trial name
- SEED-NIRS (NCT07377981)
- Testing
- Esketamine combined with dexmedetomidine, Dexmedetomidine
- Where
- China
- Volunteers
- 356 people
- Sponsor
- The First Affiliated Hospital with Nanjing Medical University
Sore Throat, Dexmedetomidine Analgesia
Effect of Preoprative Nebulized Dexmedetomidine Compared to Nebulized Lidocaine in Attenuating Sore Throat Following Tonsillectomy In Childern.
The aim of the study is to compare the effect of nebulized Dexmedetomidine compared to nebulized Lidocaine on postoperative sore throat in childern undergoing Tonsillectomy.
- Conditions
- Sore Throat, Dexmedetomidine Analgesia, Tonsillectomy
- Trial name
- NCT07780760
- Testing
- Group D (dexmedetomidine group), Group L (Lidocaine group)
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Fayoum University Hospital
Elderly, Surgery
Dexmedetomidine Supplemented Analgesia and Long-term Survival After Cancer Surgery
A majority of the elderly patients undergo surgery for malignant tumors. For these patients, postoperative tumor recurrence and metastasis are main factors that worsen long-term outcomes.
- Conditions
- Elderly, Surgery, Analgesia, Dexmedetomidine
- Trial name
- NCT03012971
- Testing
- Dexmedetomidine supplemented morphine analgesia, Morphine analgesia
- Where
- 12 sites in China
- Volunteers
- 1,500 people
- Sponsor
- Peking University First Hospital
Analgesia Assessment, Above Knee Amputation
The Analgesic Efficacy of Dexmedetomidine Versus Fentanyl as an Adjuvant to Bupivacaine in Ultrasound Guided Peripheral Nerve Blocks as a Solo Anesthetic Technique in High Risk Patients Undergoing Unilateral Above Knee Amputation .
The aim of this study is to compare the analgesic efficacy and safety of dexmedetomidine versus fentanyl as adjuvants to bupivacaine in ultrasound-guided combined supra-inguinal fascia iliaca and proximal sciatic nerve blocks…
- Conditions
- Analgesia Assessment, Above Knee Amputation, Fentanyl vs Dexmedetomidine
- Trial name
- NCT07640516
- Testing
- Dexmedetomidine, Fentanyl (as Citrate)
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Kasr El Aini Hospital
Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids
Adding Dexmedetomidine or Clonidine to Spinal Anesthesia for Cesarean Delivery
This study will examine whether addition of dexmedetomidine or clonidine (two alpha-2 adrenergic agonists) will improve the comfort of patients during spinal anesthesia for cesarean delivery.
- Conditions
- Cesarean Delivery, Cesarean Delivery; Neuraxial Opioids, Spinal Anesthesia for Cesarean Section, Dexmedetomidine
- Trial name
- NCT07567495
- Testing
- Clonidine, Dexmedetomidine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Columbia University
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Chronic Postsurgical Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07525999
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
Spinal Surgery, Pain Intensity
Dexmedetomidine-esketamine Combination and Moderate-to-severe Pain After Spinal Surgery
Spinal surgery is generally followed by severe postoperative pain, and poor pain control may cause adverse outcomes such as cardiovascular events, neurocognitive disorders, and chronic postsurgical pain (CPSP).
- Conditions
- Spinal Surgery, Pain Intensity, Dexmedetomidine, Esketamine
- Trial name
- NCT07523321
- Testing
- Combined dexmedetomidine-esketamine administration
- Where
- China
- Volunteers
- 274 people
- Sponsor
- Peking University First Hospital
Scoliosis Correction, Esketamine
Different Dose Esketamine and Dexmedetomidine Combination for Supplemental Analgesia After Scoliosis Correction Surgery
Scoliosis correction surgery is associated with severe pain. Patients after scoliosis correction surgery usually require high dose opioids and long duration analgesia, which may increase side effects and drug tolerance.
- Conditions
- Scoliosis Correction, Esketamine, Dexmedetomidine, Postoperative Analgesia
- Trial name
- NCT06062550
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital
Postoperative Analgesia, Morphine and Dexmedetomidine
Compare Morphine and Dexmedetomidine as Adjuvants to Bupivacaine in Ultrasound-guided ACB for Postoperative Analgesia After Knee Surgeries
This study aims to compare morphine and dexmedetomidine as adjuvants to bupivacaine in ultrasound-guided ACB for postoperative analgesia after knee surgeries
- Trial name
- NCT07240402
- Testing
- Adductor Canal Block (ACB) Only
- Volunteers
- 15 people
- Sponsor
- Kafrelsheikh University
Scoliosis Correction, Postoperative Analgesia
Different Dose Esketamine and Dexmedetomidine for Supplemental Analgesia and Longterm Outcomes
Chronic postsurgical pain (CPSP) refers to pain that occurs or increases after surgery and lasts longer than 3 months. Severe acute postoperative pain is one of the major risk factors of CPSP.
- Conditions
- Scoliosis Correction, Postoperative Analgesia, Esketamine, Dexmedetomidine
- Trial name
- NCT06087510
- Testing
- Esketamine
- Where
- China
- Volunteers
- 312 people
- Sponsor
- Peking University First Hospital
Intrathecal Dexmedetomidine, Adductor Canal Block
Combined Intrathecal Dexmedetomidine and Adductor Canal Block for Analgesia After Total Knee Arthroplasty
The aim of this work is to evaluate the effect of combined intrathecal dexmedetomidine and adductor canal block for analgesia after total knee arthroplasty (TKA).
- Conditions
- Intrathecal Dexmedetomidine, Adductor Canal Block, Analgesia, Total Knee Arthroplasty
- Trial name
- NCT06837844
- Testing
- Intrathecal Dexmedetomidine, Adductor Canal Block, Intrathecal Dexmedetomidine + Adductor Canal Block
- Where
- Egypt
- Volunteers
- 75 people
- Sponsor
- Kafrelsheikh University
Analgesia, Patient-Controlled, Dexmedetomidine
Two-channel IV-PCA With Dexmedetomidine
Dexmedetomidine was administered in the 'selector' channel and fentanyl in the 'basic \& bolus' channel of dual channel intravenous patient-controlled analgesia (IV-PCA) and the amount of opioid consumption was compared.
- Trial name
- NCT05672225
- Testing
- Dexmedetomidine, Control
- Where
- South Korea
- Volunteers
- 110 people
- Sponsor
- Korea University Guro Hospital