Clinical trials: Dexmedetomidine Infusion
Dexmedetomidine, Postoperative Delirium
Intraoperative Infusion of Dexmedetomidine for Prevention of Postoperative Delirium in Elderly Patients
Postoperative delirium (POD) is a common surgical complication. The incidence is 10% to 22% in neurological procedures, and advanced age is a risk factor for neurological procedures.
- Trial name
- NCT05168280
- Testing
- Dexmedetomidine, 0.9% saline
- Where
- 2 sites in China
- Volunteers
- 420 people
- Sponsor
- Beijing Tiantan Hospital
Analgesic, Sedative
Analgesic and Sedative Effect of Fentanyl Versus Dexmedetomidine Infusion in Post-Operative Mechanically Ventilated Children After Open Abdominal Surgeries
This study aimed to compare the efficacy and safety of fentanyl versus dexmedetomidine infusion in this population.
- Conditions
- Analgesic, Sedative, Fentanyl, Dexmedetomidine
- Trial name
- NCT06994273
- Testing
- Fentanyl, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 54 people
- Sponsor
- Tanta University
Bladder Tumors, Spinal Anesthesia
Magnesium vs. Dexmedetomidine in TURBT Under Spinal Anesthesia
This randomized controlled trial evaluated the effects of intraoperative intravenous magnesium sulfate versus dexmedetomidine on postoperative pain, analgesic consumption, hemodynamic stability, and respiratory function in…
- Conditions
- Bladder Tumors, Spinal Anesthesia, Postoperative Pain, Magnesium Sulfate
- Trial name
- TURBT (NCT07445451)
- Testing
- magnesium sulfate, Dexmedetomidine, Normal Saline
- Where
- Turkey (Türkiye)
- Volunteers
- 93 people
- Sponsor
- Dr. Lutfi Kirdar Kartal Training and Research Hospital
Major Abdominal Surgery
Immunomodulatory Effects of Dexmedetomidine Infusion
Anesthetic management may affect both immunostimulatory and immunosuppressive mechanisms directly by modulating immune cell function or indirectly by attenuating the stress response, Thus, the choice of anesthetic technique may…
- Trial name
- NCT04923737
- Testing
- Dexmedetomidine, 0.9% sodium chloride
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Alexandria University
Epidural Analgesics for Comparison
A Comparative Study Between Lumbar Epidural Analgesia Versus Local Infiltration Anesthesia Combined With Dexmedetomidine Intravenous Infusion in Endoscopic Lumbar Discectomy Surgeries: A Retrospective Study
The goal of this observational study is to compare the effectiveness and patient satisfaction of local anesthesia combined with intravenous Dexmedetomidine versus epidural anesthesia in endoscopic lumbar discectomy surgeries
- Trial name
- NCT07088016
- Where
- Egypt
- Volunteers
- 100 people
- Sponsor
- Ain Shams University
Lidocaine, Dexmedetomidine
Dexmedetomidine Combined With Lidocaine Infusion Affect PONV
BACKGROUND: Few researches have manifested that intravenous (IV) lidocaine or dexmedetomidine decreased the incidence of postoperative nausea and vomiting (PONV).
- Conditions
- Lidocaine, Dexmedetomidine, Nausea and Vomiting, Postoperative
- Trial name
- NCT03809923
- Testing
- lidocaine and dexmedetomidine infusion, Saline infusion, Lidocaine infusion
- Where
- China
- Volunteers
- 240 people, healthy volunteers welcome
- Sponsor
- Anqing Municipal Hospital
Pain
Placebo Controlled Clinical Trial of the Postoperative Opioid Sparing Effects of Intraoperative Dexmedetomidine Infusion for Thoracic Surgery
The purpose of this study is to see if the drug, Dexmedetomidine (also known as Precedex), can reduce pain for patients having Thoracic Surgery and therefore reduce the amount of opioid drug needed after surgery.
- Trial name
- NCT01973452
- Testing
- Dexmedetomidine
- Where
- 4 sites in United States
- Volunteers
- 333 people
- Sponsor
- Memorial Sloan Kettering Cancer Center
Acute Kidney Injury
To Evaluate if Dexmedetomidine Infusion Provides Renal Protection in Patients Undergoing Coronary Artery Bypass Graft
OBJECTIVE: Aim of this study is to follow and compare the changes in serum creatinine and urine output up to 48 hours of surgery in patients receiving dexmedetomidine infusion in addition to standard protocol (Experimental Group)…
- Trial name
- NCT05375188
- Testing
- Dexmedetomidine, Normal Saline
- Where
- Pakistan
- Volunteers
- 60 people
- Sponsor
- National Institute of Cardiovascular Diseases, Pakistan
Anxiety and Fear
A Comparison Between Dexmedetomidine and Propofol-fentanyl Infusions for Sedation for Colonoscopy Procedures
Background: Different intravenous sedative drugs have been utilized for colonoscopy, with many anesthetists for painless sedation or monitored anesthesia care.
- Trial name
- NCT06148103
- Testing
- Patients who received Dexmedetomodine, patients who received propofol-fentanyl
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Zulekha Hospitals
Sublingual Microcirculation
Effect Of Dexmedetomidine On Sublingual Microcirculation In Patients Undergoing On Pump CABG Surgery
This study is designed to explore the possible effects of dexmedetomidine infusion on sublingual microcirculation in patients undergoing on-pump coronary artery bypass graft surgery
- Trial name
- NCT02714725
- Testing
- Dexmedetomidine, Propofol infusion
- Where
- Egypt
- Volunteers
- 70 people
- Sponsor
- Cairo University
Intensive Care Unit, Mechanical Ventilation
Night-time Dexmedetomidine-esketamine Infusion and Sleep Quality in ICU Patients
Dexmedetomidine and ketamine are both suggested for sedation and analgesia in ICU patients. Recent studies suggest that low-dose dexmedetomidine or ketamine/esketamine may improve sleep quality of ICU patients.
- Conditions
- Intensive Care Unit, Mechanical Ventilation, Dexmedetomidine, Esketamine
- Trial name
- NCT05718024
- Testing
- Dexmedetomidine-esketamine, Routine sedation and analgesia
- Where
- China
- Volunteers
- 174 people
- Sponsor
- Peking University First Hospital
Analgesia
Opioid Sparing Analgesia Continuous Intraoperative Infusion of Dexmedetomidine Versus Lidocaine for Laparoscopic Cholecystectomy
Opioid sparing analgesia: Continuous intraoperative infusion of dexmedetomidine versus lidocaine for laparoscopic cholecystectomy, a randomized double-blind clinical trial.
- Trial name
- NCT05788393
- Testing
- Dexmedetomidine Injection [Precedex], Lidocaine IV
- Where
- Egypt
- Volunteers
- 64 people
- Sponsor
- Assiut University
Anesthesia
Dexmedetomidine and Desflurane Consumption
The aim of this study is to calculate desflurane consumption when combined with intraoperative dexmedetomidine infusion guided by bispectral index (BIS)
- Trial name
- NCT02652312
- Testing
- Dexmedetomidine, Ondansetron, fentanyl
- Where
- Egypt
- Volunteers
- 40 people
- Sponsor
- Theodor Bilharz Research Institute
Abdominal Cancer Surgeries
Hemodynamic and Cardiac Effects of Dexmedetomidine Versus Fentanyl by Intravenous Infusion as Adjuncts to General Anesthesia in Patients Undergoing Major Abdominal Cancer Surgeries.
________________________________________ Background : Major abdominal cancer surgery is among the most invasive procedures, often associated with extensive tissue damage, severe postoperative pain, and delayed recovery.
- Trial name
- NCT07214714
- Testing
- Fentanyl (IV), Dexmedetomidine
- Volunteers
- 70 people
- Sponsor
- Assiut University
Lumbar Disc Herniation
Lumbar Epidural Analgesia Versus Local Anesthesia With Dexmedetomidine Infusion in Endoscopic Lumbar Discectomy
To compare between local anesthesia combined with intravenous Dexmedetomidine and epidural analgesia as regard the effectiveness and patient satisfaction during percutaneous transforaminal endoscopic discectomy.
- Trial name
- NCT05850455
- Testing
- Dexmedetomidine Hydrochloride 'Precedex' combined with, Lumbar epidural analgesia with Bupivacaine 0.25% 'Sunnypivacaine', General anesthesia
- Where
- Egypt
- Volunteers
- 78 people
- Sponsor
- Ain Shams University
Labor Pain
Dexmedetomidine for Intermittent Epidural Boluses Versus Continuous Epidural Infusion for Labour Epidural Analgesia
The aim of this study is to compare two modes of labour epidural analgesia: programmed intermittent epidural boluses (PIEB) versus continuous epidural infusion (CEI), with patient controlled epidural analgesia (PCEA), using…
- Trial name
- NCT05781854
- Testing
- Epidural analgesia with bupivacaine and dexmedetomidine
- Where
- Egypt
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Assiut University
Superior Laryngeal Nerve Block, Sedation
Nerve Block Vs Sedation Infusion for Awake Fiberoptic Intubation.
This study compares the efficacy and safety of dexmedetomidine infusion versus superior laryngeal nerve block during awake fiberoptic intubation in hemimandibulectomy patients.
- Conditions
- Superior Laryngeal Nerve Block, Sedation, Dexmedetomidine, Awake Fiberoptic Intubation
- Trial name
- NCT06651905
- Testing
- Dexmedetomidine, Superior laryngeal nerve block
- Where
- Egypt
- Volunteers
- 80 people
- Sponsor
- Cairo University
Total Intravenous Anesthesia
Dexmedetomidine-Ketamine Infusion in Breast Surgeries
This is a prospective randomized double blind controlled study. Female patients undergoing radical mastectomy will be included in this study where they will be randomly allocated into; - Control group in which patients will…
- Trial name
- NCT04048226
- Testing
- Dexmedetomidine +Ketamine
- Where
- Egypt
- Volunteers
- 103 people
- Sponsor
- Tanta University
Hypertension
Nitroglycerine Versus Dexmedetomidine Infusion in Intraoperative Management of Uncontrolled Hypertension
This study aim to compare the efficacy of intraoperative dexmedetomidine infusion versus Nitroglycerin infusion in cancer patients with accidental uncontrolled intraoperative elevation of blood pressure.
- Trial name
- NCT04953156
- Testing
- Nitroglycerin, Dexmedetomidine
- Where
- Egypt
- Volunteers
- 77 people
- Sponsor
- National Cancer Institute, Egypt
Analgesia, Anesthesia
Analgesic Depth Evaluation During General Anesthesia With Dexmedetomidine-remifentanil Infusion. A Pilot Study
The aim of this study is to verify the feasibility of an evaluation of the depth of analgesia during an opioid sparing anesthesia (OSA) carried out with continuous infusion of dexmedetomidine in addition to general multimodal…
- Trial name
- NCT05785273
- Testing
- Pupillometer
- Where
- Italy
- Volunteers
- 45 people
- Sponsor
- Università degli Studi di Brescia