Clinical trials: Dexmedetomidine Infusion
Sedation
Use of Clonidine to Prevent Withdrawal Following Prolonged Dexmedetomidine Infusions
The investigators' clinical practice makes use of oral clonidine as a means of transitioning from intravenous dexmedetomidine following prolonged infusions (more than 3-5 days).
- Trial name
- NCT02404077
- Testing
- Clonidine
- Volunteers
- 712 people
- Sponsor
- Joseph D. Tobias
Postoperative Pain
Dexmedetomidine Versus Magnesium Sulfate Infusion During Spinal Anesthesia
The aim of this work is to compare the hemodynamic and analgesic properties of Dexmedetomidine and Magnesium sulphate infusion in lower abdominal surgery.
- Trial name
- NCT03640390
- Testing
- Dexmedetomidine, Magnesium Sulphate, Normal saline
- Where
- Egypt
- Volunteers
- 60 people
- Sponsor
- Cairo University
Unstable Angina, Coronary Artery Bypass Graft
Comparison Between Lidocaine, Dexmedetomidine, and Their Combined Infusion in Subjects Undergoing Coronary Artery Bypass Graft
The aim of the present study is to compare the antiarrhythmic and myocardial protective effect between lidocaine, dexmedetomidine, and their combined infusion in subjects undergoing coronary artery bypass graft.
- Conditions
- Unstable Angina, Coronary Artery Bypass Graft, Dexmedetomidine, Lidocaine
- Trial name
- NCT01688648
- Testing
- Lidocaine infusion, Dexmedetomidine infusion
- Where
- South Korea
- Volunteers
- 160 people
- Sponsor
- Samsung Medical Center
Obstructive Sleep Apnea
Decrease Emergence Agitation and Provide Pain Relief for Children Undergoing Tonsillectomy & Adenoidectomy
Pediatric tonsillectomy (with or without adenoidectomy) is a brief but painful surgery carried out in children who very often also present with obstructive sleep apnea. To provide pain relief, i.e.
- Trial name
- NCT00468052
- Testing
- dexmedetomidine, fentanyl
- Where
- United States
- Volunteers
- 122 people
- Sponsor
- University of Medicine and Dentistry of New Jersey
Craniotomy Surgery
Dexmedetomidine Versus Magnesium Sulfate Infusion in Craniotomy
To compare the intraoperative effects of Dexmedetomidine and Magnesium Sulfate infusion on intracranial pressure and cerebral perfusion pressure in adult patients undergoing craniotomy
- Trial name
- NCT07199595
- Testing
- Dexamedomedine, MgSO4
- Volunteers
- 60 people
- Sponsor
- Assiut University
Geriatrics, Outpatients
Dexmedetomidine vs. Remifentanil Undergoing Cataract Surgery in Geriatrics
Dexmedetomidine is an α2-adrenergic receptor agonist used for its sympatholytic effect, providing sedation, analgesia, and cardiovascular stabilization in the perioperative period.
- Conditions
- Geriatrics, Outpatients, Personal Satisfaction
- Trial name
- NCT04935541
- Testing
- Dexmedetomidine infusion, Remifentanil infusion
- Where
- Turkey (Türkiye)
- Volunteers
- 80 people
- Sponsor
- Selcuk University
Thyroidectomy
Antitussive Effect of Single-dose Dexmedetomidine With Low-dose Remifentanil Infusion
After thyroid surgery, the incidence and severity of coughing is important because it may cause serious complications, such as bleeding in the surgical field, laryngospasm, and cardiovascular disturbance.
- Trial name
- NCT02208505
- Testing
- Dexmedetomidine + Remifentanil-low dose, Remifentanil-high dose
- Where
- South Korea
- Volunteers
- 168 people
- Sponsor
- Yonsei University
Pain
Safety and Efficacy of Intravenous (IV) Dexmedetomidine During Flexible Bronchoscopy and Endobronchial Ultrasound
To achieve safe,consistent, continuous sedation using Dexmedetomidine in advaced bronchoscopy procedures that may reduce the need for rapid pain sedative infusion.
- Trial name
- NCT00691886
- Testing
- dexmedetomidine hydrochloride
- Where
- United States
- Sponsor
- Lahey Clinic
Gonarthrosis
Dexmedetomidine Infusion and Iscemia and Reperfusion Injury
The effect of deksmedetomidine infusion on ischemia-reperfusion injury related to tourniquet application during total knee replacement will be evaluated by malondialdehyde and total antioksidant status.
- Trial name
- NCT07875231
- Testing
- Dexmedetomidine, saline
- Volunteers
- 60 people
- Sponsor
- Diskapi Yildirim Beyazit Education and Research Hospital
Sphenopalatine Ganglion Nerve Block, Transnasal Endoscopic Pitutary Surgery
Sphenopalatine Block vs Dexmedetomidine Infusion in Trans Nasal Endoscopic Pituitary Surgery
Improving pain and surgical field by using sphenopalatine ganglion block and dexmedetomidine in trans-nasal endoscopic pituitary surgery.
- Trial name
- NCT06639659
- Testing
- Sphenopalatine Ganglion Block, Dexmedetomidine, General Anesthesia (control group)
- Where
- Egypt
- Volunteers
- 69 people
- Sponsor
- Zagazig University
Adjuvants, Anesthesia
Effects of Dexmedetomidine Target Controlled Infusion on Patient State Index Values and Electroencephalographic Spectrum During Total Intravenous Anesthesia With Propofol
Dexmedetomidine Target Controlled infusion (TCI, Dyck model) effects on Neuromonitoring during Total Intravenous Anesthesia (TIVA) with Propofol and Remifentanil TCI (Eleveld model) has not been investigate yet.
- Trial name
- NCT07259460
- Where
- Italy
- Volunteers
- 60 people
- Sponsor
- University of Padova
The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index., Effect of Dexmedetomidine on Sufentanil Consumption.
Study of Cisatracurium and Sufentanil Consumption Using a Closed Loop Computer Control Infusion System
The purpose of this study is to: determine the effect of dexmedetomidine on cisatracurium infusion requirements and sufentanil consumption.
- Conditions
- The Intraoperative Effect of Dexmedetomidine on Cisatracurium Infusion Consumption and Its Recovery Index., Effect of Dexmedetomidine on Sufentanil Consumption., Quantitative Analysis of Cisatracurium Infusion Requirements, Sufentanil Consumption and Recovery Index in Different Age Groups.
- Trial name
- NCT01785446
- Testing
- Effect of dexmedetomidine on cisatracurium and sufentanil consumption, Consumption of cisatracurium and sufentanil in different age groups.
- Where
- China
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Tianjin Medical University General Hospital
Coronary Artery Disease
Dexmedetomidine in Off Pump Coronary Artery Bypass Grafting
the study will assess the impact of intraoperative dexmedetomidine infusion on myocardial performance by investigating the left ventricular (LV) systolic and diastolic function and right ventricular (RV) fraction area change…
- Trial name
- NCT05577871
- Testing
- Dexmedetomidine, normal saline
- Where
- Egypt
- Volunteers
- 36 people
- Sponsor
- Suez Canal University
Hysterectomy, Myomectomy
Effect of Perioperative iv Dexmedetomidine vs. Lidocaine on Postoperative Pain, Analgesic Consumption and Recovery After Abdominal Gynaecological Surgery
Postoperative pain continues to be inadequately managed and is the most common reason for the delay in discharge and unplanned hospital admission after surgery. Opioids remain the mainstay for postoperative analgesia.
- Trial name
- NCT03363425
- Testing
- Lidocaine Iv, Dexmedetomidine, Normal saline
- Where
- Greece
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Athens
Post Anesthesia Discharge Time in Patients of Breast Cancer Surgery
Effect of Dexmedetomidine Infusion on Post Anesthesia Discharge Time
A randomised control trial evaluating the effect of low dose dexmedetomidine infusion on post anesthesia discharge time in patients of day case breast cancer surgery compared with placebo infusion.
- Trial name
- NCT07180810
- Testing
- Dexmedetomidine infusion low dose, Group B receiving normal saline
- Where
- Pakistan
- Volunteers
- 82 people
- Sponsor
- Shaukat Khanum Memorial Cancer Hospital & Research Centre
Anesthesia, Obesity, Morbid
Effect of Two Different Doses of Dexmedetomidine Infusion in Morbidly Obese Patients
Compare the effects of two different doses of dexmedetomidine infusion on oxygenation as a primary outcome and on lung mechanics, quality of recovery and perioperative analgesia as secondary outcomes in morbidly obese patients…
- Conditions
- Anesthesia, Obesity, Morbid, Dexmedetomidine
- Trial name
- NCT06018948
- Testing
- Dexmedetomidine 0.6, Dexmedetomidine 0.3, Saline
- Where
- Egypt
- Volunteers
- 90 people
- Sponsor
- Tanta University