Clinical trials: Dextrose Concentration
Type 2 Diabetes Mellitus
Metformin and Pioglitazone Effects on Fetuin-A and Osteoprotegrin Concentrations in Type 2 Diabetes Patients
Oral hypoglycemic agents, along with dietary modification and exercise encompass the mainstay of treatment in early stages of T2DM.
- Trial name
- NCT02027103
- Testing
- Metformin, Pioglitazone
- Where
- Iran
- Volunteers
- 102 people
- Sponsor
- Tehran University of Medical Sciences
Diabetes Mellitus, Type 2
Serum METRNL Concentration in Type 2 Diabetes
The investigators measured serum METRNL levels in newly diagnosed patients with type 2 diabetes (T2DM) compared with normal glucose tolerance or prediabetes and explored the correlations between its serum levels and various…
- Trial name
- NCT03194100
- Volunteers
- 125 people, healthy volunteers welcome
- Sponsor
- Chungnam National University Hospital
PreDiabetes, Impaired Fasting Glucose (IFG)
Metformin and Its Impact on the Substances Associated With NO Production in Prediabetes Patients.
This study evaluates the effect of different doses of metformin on the function of endothelium in people with pre-diabetes. One group of the patients will receive metformin in dose: 1500 mg, the second one will receive 3000…
- Conditions
- PreDiabetes, Impaired Fasting Glucose (IFG), Impaired Glucose Tolerance (IGT)
- Trial name
- NCT03398356
- Testing
- Metformin
- Where
- Poland
- Volunteers
- 47 people, healthy volunteers welcome
- Sponsor
- Wroclaw Medical University
Hypoxia, Oxygen Deficiency
Investigation of Hemoglobin Oxygenation With Third Harmonic Generation Microscopy
The specific aims of the project are performing a pre-clinical study on a human model and evaluating the oxygenation and other status of human erythrocytes by spectrally-resolved third harmonic generation (srTHG) microscopy .
- Conditions
- Hypoxia, Oxygen Deficiency, Tumor, Diabetes
- Trial name
- NCT03619356
- Where
- Taiwan
- Volunteers
- 100 people, healthy volunteers welcome
- Sponsor
- National Taiwan University Hospital
Hypertension, Diabetes
The Effect of Calcium Supplementation on Insulin Resistance and 24h Blood Pressure
Increased levels of intracellular calcium are thought to diminish maximal cellular response to insulin and induce insulin resistance.
- Conditions
- Hypertension, Diabetes, Insulin Resistance
- Trial name
- NCT00549536
- Testing
- tablets each containing of 1000mg elemental calcium (Mega-Calcium Sandoz)
- Where
- Greece
- Volunteers
- 31 people
- Sponsor
- Aristotle University Of Thessaloniki
Type 2 Diabetes Mellitus
A Study of the Effects of Co-Administration of Sitagliptin (MK-0431) and Metformin on Incretin Hormone Concentrations (MK-0431-110)
This study will assess the effects of sitagliptin and metformin alone and after co-administration on incretin hormone concentrations in patients with Type 2 diabetes.
- Trial name
- NCT00830076
- Testing
- sitagliptin phosphate, metformin hydrochloride
- Volunteers
- 18 people
- Sponsor
- Merck Sharp & Dohme LLC
Diabetes Mellitus
Effects of Linagliptin on Active GLP-1 Concentrations in Subjects With Renal Impairment
This is a bi-centric, prospective, open study comparing the effects of linagliptin on active GLP-1 concentrations in subjects with renal impairment compared to subjects with normal renal function.
- Trial name
- NCT01903070
- Testing
- Linagliptin
- Where
- Germany
- Volunteers
- 99 people
- Sponsor
- Profil Institut für Stoffwechselforschung GmbH
Change in Fasting Plasma LDL-cholesterol Concentration After the Consumption of Quinoa
Effects of Quinoa Consumption on Markers of Cardiovascular Risk and Gastrointestinal Health
Quinoa is possible alternative to wheat, corn and rice due to its high nutritional value and possible properties against cardiovascular diseases and for improving gut health.
- Trial name
- NCT03036618
- Testing
- Quinoa, Wheat
- Where
- United Kingdom
- Volunteers
- 30 people, healthy volunteers welcome
- Sponsor
- Newcastle University
Polycystic Ovary Syndrome
Effects of Flutamide on Insulin and Glucose Metabolism in Women With Polycystic Ovary Syndrome
Polycystic Ovary Syndrome (PCOS) is the major cause of infertility in the United States. Many women with PCOS demonstrate insulin resistance and a compensatory hyperinsulinemia.This is due to both an intrinsic form of insulin…
- Trial name
- PCOS (NCT00729560)
- Testing
- Flutamide
- Where
- United States
- Volunteers
- 8 people
- Sponsor
- Virginia Commonwealth University
Type II Diabetes Mellitus
SGLT2 Inhibition and Stimulation of Endogenous Glucose Production: Protocol 2
In Protocol 2, the investigators will determine the role of pancreatic hormones (increase in plasma glucagon and decrease in plasma insulin concentration) in the stimulation of EGP following SGLT2 inhibition.
- Trial name
- NCT02592421
- Testing
- Dapagliflozin
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- The University of Texas Health Science Center at San Antonio
Type 1 Diabetes Mellitus
Single Dose Clamp Study To Compare Concentration/Time Profile And Metabolic Activity Profile Of 2 New Formulations Of Insulin Glargine With Lantus
Primary Objective: To compare the pharmacokinetic (PK) characteristics of single doses of insulin glargine given as U200 and U500 with those of a single dose (SD) of Lantus® U100 in a euglycemic clamp setting in subjects with…
- Trial name
- NCT02201199
- Testing
- insulin glargine U200 HOE901, insulin glargine U500 HOE901, insulin glargine U100 HOE901
- Where
- Germany
- Volunteers
- 36 people
- Sponsor
- Sanofi
Type II Diabetes Mellitus, Renal Insufficiency
A Study to Look at the Effect MEDI0382 Has on Blood Sugar in People With Type 2 Diabetes and Kidney Problems and Also to Check That MEDI0382 is Well Tolerated
A study to look at the effect MEDI0382 has on blood sugar in people with type 2 diabetes and kidney problems and also to check that MEDI0382 is well tolerated.
- Trial name
- NCT03550378
- Testing
- MEDI0382
- Where
- 7 sites in Germany, United Kingdom
- Volunteers
- 41 people
- Sponsor
- MedImmune LLC
Sex Hormones, Microbial Colonization
The Relationship of the Intestinal Microbiome and the Menstrual Cycle
In the present study the dynamic changes of the intestinal microbiome are observed over a 4-week period in the different stages of the menstrual cycle in women at childbearing age.
- Trial name
- NCT03581201
- Testing
- Laboratory measurements, Stool samples, Bioimpedance analysis
- Where
- Austria
- Volunteers
- 20 people, healthy volunteers welcome
- Sponsor
- Medical University of Vienna
Type 1 Diabetes Mellitus
Single Dose Clamp Study to Evaluate Concentration-time Profile and Metabolic Activity of 3 Dose Levels of Afrezza and 3 Dose Levels of Insulin Lispro in Patients With Type 1 Diabetes Mellitus
Primary Objective: To assess the dose-response pattern of the glucose consumption (GIR-AUC0-end) of 3 different single doses of Afrezza inhaled Technosphere insulin and of 3 single doses of subcutaneous (SC) insulin lispro in a…
- Trial name
- NCT02470637
- Testing
- SAR439065, Insulin lispro
- Where
- Germany
- Volunteers
- 30 people
- Sponsor
- Mannkind Corporation
Appetitive Behavior, Glucose Metabolism Disorders
Splenda: Effects on Blood Glucose Concentration, Appetite Scores and Subsequent Energy Intake
This study investigates the effects of Splenda, an artificial sweetener powder containing sucralose, on post-prandial blood glucose levels, appetite scores and subsequent energy intake.
- Trial name
- NCT05810337
- Testing
- Splenda drink, Maltodextrin drink, High carbohydrate breakfast
- Where
- United Kingdom
- Volunteers
- 51 people, healthy volunteers welcome
- Sponsor
- King's College London
Type 2 Diabetes Mellitus
An Investigational Drug Study in Adults With Type 2 Diabetes on Basal Insulin (MK-0941-006)
A study to assess safety, pharmacokinetics (PK), and pharmacodynamics (PD) of MK-0941 in Type 2 diabetics being treated with basal insulin.
- Trial name
- NCT00511472
- Testing
- MK-0941, LANTUS insulin
- Volunteers
- 70 people
- Sponsor
- Merck Sharp & Dohme LLC
Pre-surgical Anxiety, Blood Glucose Concentration
Vis Pre Surgery Medical Food Validation Study
A pre-market, confirmatory, prospective, interventional, clinical investigation to confirm the clinical safety and performance profile of Vis Pre-surgeryTM that the medical food will reduce pre and post-surgical complications…
- Conditions
- Pre-surgical Anxiety, Blood Glucose Concentration, Blood Cortisol Levels, Electrolyte Levels
- Trial name
- NCT07359222
- Testing
- Pre-surgical medical food
- Where
- India
- Volunteers
- 67 people
- Sponsor
- TM Nutrition LLC
Type 1 Diabetes
Investigation of Correlation Between Concentrations of Glucose in Blood and Interstitial Fluid in Type 1 Diabetics
This is a mono-centre trial performed at the Center for Clinical Research at the Medical University Graz. There will be a screening information and a study visit.In the study visit arterialized venous blood glucose values will be…
- Trial name
- NCT00499954
- Testing
- Microdialysis, Guardian RT, Glucoday S
- Where
- Austria
- Volunteers
- 16 people
- Sponsor
- Medical University of Graz
Craniotomy
Blood Glucose Concentration & Craniotomy
Intraoperative blood glucose concentration abnormalities are associated with increased perioperative morbidity and mortality (1-4).
- Trial name
- NCT01923571
- Testing
- intraoperative BGC measure
- Where
- 2 sites in Italy
- Volunteers
- 53 people
- Sponsor
- University of Roma La Sapienza
Type 2 Diabetes Mellitus, Cardiovascular Disease
The Impact of Reformulated Foods on Cardiovascular Risk Factors
Specific policies on obesity reduction often include a recommendation to reduce sugar consumption as a means of lowering overall caloric intake. Reformulating processed foods (e.g.
- Conditions
- Type 2 Diabetes Mellitus, Cardiovascular Disease, Obesity
- Trial name
- REFORM (NCT01645995)
- Testing
- Reformulated products, Conventional products
- Where
- United Kingdom
- Volunteers
- 50 people, healthy volunteers welcome
- Sponsor
- University of Reading