Clinical trials: Diabete Type 1
Diabetes Mellitus Type 1, Diabetes Mellitus Type 2
Natural History of Autoimmune Diabetes and Its Complications
Background: Diabetes is a disease defined by abnormally high blood sugar (glucose) levels. Glucose is an essential source of energy for the body s cells, but insulin is required to move the glucose into the cells.
- Trial name
- NCT00896610
- Where
- United States
- Volunteers
- 356 people, healthy volunteers welcome
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Diabetes, Type 1
Hybrid Closed-Loop Insulin Delivery System in Type 1 Diabetes Candidates for a Living Donor Kidney Transplant
The investigators' primary aim is to determine the impact of using hybrid closed-loop (HCL) system in patients with type 1 diabetes (T1D) and end stage renal disease (ESRD) prior to kidney transplantation.
- Trial name
- NCT03494010
- Testing
- Observation
- Where
- United States
- Sponsor
- Yale University
Diabetes Type 1
Multicenter Study Evaluating the Relationship Between Perceived Daily Stress Level and Glycemic Level in Subjects With Type 1 Diabetes
Type 1 diabetes (T1D) affects around 200,000 people in France. The only treatment is insulin, administered either by multiple injections, by pump alone or, more recently, by automated insulin delivery systems (AIDs), which have…
- Trial name
- EVASTRESS (NCT06896045)
- Testing
- Assess stress levels 4 times a day before meals (morning, noon and evening and at bedtime) using a visual analogue scale
- Where
- 14 sites in France
- Volunteers
- 125 people
- Sponsor
- Centre d'Etudes et de Recherche pour l'Intensification du Traitement du Diabète
Diabetes type1
Insulin Requirement for Pure-protein Meal in Children With Type 1 Diabetes on Insulin Pumps.
This is a randomized, cross-over study. The aim of this study is to compare the post-prandial glycaemic variability after pure protein meal following with an administration of square-wave bolus of meal-insulin or without any…
- Trial name
- NCT02685449
- Testing
- Insulin glulisine, Insulin aspart, Insulin lispro
- Where
- Poland
- Volunteers
- 70 people
- Sponsor
- Medical University of Warsaw
Diabetes Mellitus Type 1
A Prospective, Randomized, Double-blind, Placebo Controlled Study to Assess the Impact of ORMD-0801 (Insulin Capsules) on the Exogenous Insulin Requirements of Type 1 Diabetics
This will be a prospective, randomized, double-blind, placebo controlled study. Patients with established Type 1 diabetes will be eligible for entry into the study.
- Trial name
- NCT02094534
- Testing
- ORMD-0801 Capsules
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- Oramed, Ltd.
Type 1 Diabetes
Incretin-based Therapy in Early Diagnosed Type 1 Diabetes
The main objective of the trial is to study whether daily treatment with liraglutide improves insulin secretion and reduces the requirement of exogenous insulin, and whether liraglutide treatment is tolerable and safe in subjects…
- Trial name
- NCT02908087
- Testing
- Victoza® (liraglutide)
- Where
- 4 sites in Finland, Sweden
- Volunteers
- 13 people
- Sponsor
- University of Oulu
Type 1 Diabetes Mellitus
A Phase III Study to Investigate the Impact of Diamyd in Patients Newly Diagnosed With Type 1 Diabetes (EU)
The purpose of this study is to determine whether Diamyd (rhGAD65 formulated in alum) is effective in preserving the body's own insulin producing capacity in patients recently diagnosed with type 1 diabetes.
- Trial name
- NCT00723411
- Testing
- rhGAD65
- Where
- 70 sites in Finland, France and 7 more
- Volunteers
- 334 people
- Sponsor
- Diamyd Therapeutics AB
Addison's Disease, Adrenal Insufficiency
Counterregulatory Hormone Production in Adrenal Insufficiency and Diabetes Type I
Patients with adrenal insufficiency also exhibit an adrenomedullary dysfunction. Furthermore, patients who suffer from both, adrenal insufficiency and type I diabetes more frequently report hypoglycemia, particularly after…
- Conditions
- Addison's Disease, Adrenal Insufficiency, Diabetes Mellitus Type I
- Trial name
- CANDI (NCT01452893)
- Testing
- Spiroergometry
- Where
- Germany
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University of Wuerzburg
Diabetes, Type I
Childhood Diabetes
Purpose of the study: To compare three different regimes for children newly diagnosed with type 1 diabetes: (1) traditional hospital based care, (2) intensive psychological support to the family, and (3) home based family…
- Trial name
- NCT00804232
- Testing
- childhood diabetes
- Where
- 2 sites in Sweden
- Volunteers
- 210 people
- Sponsor
- Vardalinstitutet The Swedish Institute for Health Sciences
Diabetes Type 1
Optimising the Delivery of Diabetes Distress Informed Care for Its Prevention, Detection, and Management in Adults With Type 1 Diabetes: a Feasibility Study (D-stress Study)
Up to one in two adults with type 1 diabetes find living with and managing diabetes to be emotionally challenging. This 'emotional side' of diabetes - feeling worried, frustrated, overwhelmed, sad, burnt-out - is called diabetes…
- Trial name
- NCT07193446
- Testing
- D-stress study: The detection, prevention and management of diabetes distress for adults living with type 1 diabetes.
- Where
- 3 sites in United Kingdom
- Volunteers
- 110 people
- Sponsor
- Guy's and St Thomas' NHS Foundation Trust
Diabetic Foot Ulcer
Treating Diabetic Foot Ulcers, Comparing Two Topical Antimicrobial Agents, Dakin´s and Prontosan
202 Diabetic foot ulcers will be cleaned with either Hypochlorous Acid, HClO or Polyhexamethylene biguanide, PHMB twice a week until healed or 24 weeks.
- Trial name
- NCT05132179
- Testing
- Dakins Full Strength Solution, 0.5% Topical Solution, HOCl solution
- Where
- Sweden
- Volunteers
- 202 people
- Sponsor
- Vastra Gotaland Region
Glucose Metabolism Disorders (Including Diabetes Mellitus), Diabetes Mellitus, Type 1
Flash Glucose Measure System and Continuous Subcutaneous Insulin Infusion Therapy in Poorly Controlled Diabetes Type 1 Patients
Patients with diabetes type 1 with poor glycemic control will be switched to insulin pump and FGM system (Flash Glucose Monitoring) during 6 months, correlated to the hypothesis that they could benefit from this intervention by…
- Trial name
- FREESTYLE (NCT03671161)
- Testing
- Insulin Pump and flash glucose monitoring
- Where
- France
- Volunteers
- 19 people
- Sponsor
- Groupe Hospitalier Pitie-Salpetriere
TYPE 1 DIABETES
β-cell Function in Type 1 Diabetes May Not Be As Low As Presumed
Enhancing endogenous insulin production in type 1 diabetic patients (T1DP) can improve glycemic control and decrease complications and rates of mortality.
- Trial name
- NCT02199470
- Where
- Turkey (Türkiye)
- Volunteers
- 135 people
- Sponsor
- Gonca Incemehmet Tamer
Diabetes Type 1, Endothelial Dysfunction
Cardiovascular Risk Factors After Single Pancreas Transplantation
Patients accepted for the waiting list for single pancreas transplantation suffer from severe glucose instability with hyperglycemia due to diabetes type 1, but do not have significant diabetes-related complications.
- Trial name
- Diamant (NCT02066350)
- Testing
- Single pancreas transplantation
- Where
- Norway
- Volunteers
- 35 people, healthy volunteers welcome
- Sponsor
- Oslo University Hospital
Diabetes, Type I
12 Week,Comparing Safety of HMR1964 & Insulin Aspart Used in Continuous Subcutaneous Infusion in Type 1 Diabetes.
The purpose of this study is to compare the safety of HMR 1964 and insulin aspart when used in external pumps with respect to catheter occlusions, GHb assessment, insulin doses, blood glucose parameters, hypoglycemic episodes…
- Trial name
- NCT00046150
- Testing
- Insulin glulisine (HMR1964)
- Where
- 3 sites in France, Germany and 1 more
- Volunteers
- 59 people
- Sponsor
- Sanofi
Diabetes, Type 1, Diabetes, Type 2
Breakfast Nutrition and Inpatient Glycemia
A standard hospital meal often contains a high percentage of carbohydrates (CHO), which may not be ideal for patients with diabetes. This concern is particularly pertinent to the breakfast meal, which often contains mainly CHO.
- Conditions
- Diabetes, Type 1, Diabetes, Type 2, Cardiovascular Disease, Hyperglycemia
- Trial name
- NCT01805414
- Testing
- Modified Carbohydrate Breakfast, Control Breakfast
- Where
- United States
- Volunteers
- 237 people
- Sponsor
- Duke University
Pregnant Women, Diabetes Type 1
Factors Associated With Cesarean Delivery in Women With Type 1 Diabetes
Introduction : Cesarean rate varies from 45% to 73% in the literature in patient with diabetes type 1. Having a prior C-section is the most important risk factor.
- Conditions
- Pregnant Women, Diabetes Type 1, Cesrean Delivery
- Trial name
- NCT03538106
- Where
- France
- Volunteers
- 153 people, healthy volunteers welcome
- Sponsor
- University Hospital, Montpellier
Diabetes Type 1
The Effect of Type 1 Diabetes on Pan-Arterial Vascular Function and Insulin Sensitivity in Humans
Arterial vascular disease is the major cause of morbidity and mortality for Type 1 diabetic patients (DM1). Metabolic insulin resistance (metIR), even in the absence of hyperglycemia, conveys a 1.5 to 3-fold increased CVD risk in…
- Trial name
- EJB046 (NCT02490124)
- Where
- United States
- Volunteers
- 7 people, healthy volunteers welcome
- Sponsor
- University of Virginia
Diabetes Type 2, Diabetes Type 1
Disentangling the Effect of Brain Insulin Resistance on Brain Health
People with diabetes are at increased risk of developing dementia, including Alzheimer's disease and vascular dementia. In addition, persons with diabetes have more pronounced age-related brain atrophy and cognitive difficulties…
- Trial name
- BIR 1 (NCT07374705)
- Where
- 3 sites in Denmark, Germany
- Volunteers
- 150 people, healthy volunteers welcome
- Sponsor
- Henrik Bo Wiberg Larsson
Diabetes Mellitus
Role of TMEM219 Marker in Type 1 Diabetes
Type 1 diabetes (T1D) is a chronic metabolic disease characterized by autoimmune destruction of β cells of the insulin producing pancreatic islets.
- Trial name
- NPOD (NCT03794739)
- Where
- Italy
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- University of Milan