Clinical trials: Diabete Type 1
Diabetes Type 1, Diabetic Retinopathy
Assessment of Retinal Microcirculation in Patients With Type 1 Diabetes Mellitus
Type 1 diabetes mellitus (T1DM) is associated with an increased lifetime risk of developing diabetic retinopathy, a leading cause of visual impairment among working-age adults worldwide.
- Conditions
- Diabetes Type 1, Diabetic Retinopathy, Microvascular Circulation, Retinal Microvascular Disease
- Trial name
- NCT07705321
- Testing
- Optical Coherence Tomography Angiography (OCTA)
- Where
- Greece
- Volunteers
- 100 people
- Sponsor
- University of Athens
Diabetes, Type I
Prevention of Clinical Onset of Type 1 Diabetes in High Risk First Degree Relatives
Prophylactic administration of metabolically active insulin can prevent or delay clinical onset of diabetes in a high risk group of nondiabetic siblings as defined by positivity for autoantibodies against IA-2 (IA-2-A).
- Trial name
- NCT00654121
- Testing
- Actrapid HM
- Where
- 3 sites in Belgium
- Volunteers
- 112 people, healthy volunteers welcome
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetes type1
Protocol for Self-Compassion Intervention for Teens With Diabetes Type 1 and Their Caregivers
The goal of this study is to examine the feasibility and potential effectiveness of a short (4 sessions) self-compassion intervention for adolescents with T1D and their caregivers on psychological, metabolic, and behavioral…
- Trial name
- SWEET (NCT05437913)
- Testing
- Psychological intervention (self-compassion based)
- Where
- Spain
- Volunteers
- 8 people
- Sponsor
- University of Valencia
Diabetes, Diabetes (DM)
Time in rANge vs. Time in nOrmal Glycemia for Better Glycemic Control
The TANGO study is a 12-month study involving 120 children and adolescents with Type 1 Diabetes (T1D) across the Czech Republic, Israel, and Poland who use automated insulin delivery (AID) systems.
- Conditions
- Diabetes, Diabetes (DM), Diabetes Type 1
- Trial name
- TANGO (NCT07376850)
- Testing
- Structured Diabetes Education, Automated Insulin Delivery (AID) System Adjustment
- Where
- 3 sites in Czechia, Israel and 1 more
- Volunteers
- 120 people
- Sponsor
- University Hospital, Motol
Type 1 Diabetes
Bet Cell Therapy in Diabetes Type 1
Primary outcome measurement is a parameter of functional beta cell mass at 6 months PT. Functional beta-cell mass will be calculated using the AUC/min between 150 and 160 min during hyperglycemic clamp at 180 mg/dl.
- Trial name
- NCT01379729
- Testing
- Transplantation of encapsulated beta cells.
- Where
- 2 sites in Belgium
- Volunteers
- 10 people
- Sponsor
- Universitair Ziekenhuis Brussel
Diabetes, Type 1
Reimbursement Study of Continuous Glucose Monitoring in Belgium
Type 1 diabetes mellitus (T1DM) is an autoimmune disease caused by an immune mediated destruction of the pancreatic β-cells. Once the pancreas has been depleted of a critical mass of β-cells the need for exogenous insulin therapy…
- Trial name
- RESCUE (NCT02601729)
- Volunteers
- 589 people
- Sponsor
- KU Leuven
Diabetes Mellitus, Type 1
PK/PD Biosimilarity Study of Gan & Lee Insulin Glargine Injection vs.US & EU Lantus® in Type 1 Diabetes Mellitus Patients
Primary objectives: To demonstrate biosimilarity with regard to the total and maximum pharmacokinetic exposure during one dosing interval (AUC ins. 0-24h, Cins.
- Trial name
- NCT04236895
- Testing
- Gan & Lee Insulin Glargine Injection
- Where
- 2 sites in Germany
- Volunteers
- 114 people
- Sponsor
- Gan and Lee Pharmaceuticals, USA
Diabete Mellitus, Diabetes Mellitus, Type 1
The Efficacy of MDI Treatment With an Optimization Algorithm Adjusting Basal-Bolus Parameters in Children and Adolescents With Type 1 Diabetes at a Diabetes Camp
Our lab at McGill University has developed an optimization algorithm for T1D MDI patients that estimates optimal basal-bolus parameters (basal injections and insulin-to-carbohydrate ratios) using glucose sensor data and insulin…
- Trial name
- NCT03764280
- Testing
- Multiple Daily Injections: Slow acting insulin and Rapid acting insulin
- Where
- Canada
- Volunteers
- 21 people
- Sponsor
- McGill University
Diabetes Type 1
Food Collection From Type 1 Diabetic Patients Practicing Insulin Functional Therapy
a food collection will be performed in this study with type 1 diabetic patients trained to carbohydrate counting, to collect data on the meals consumed daily and their quantities for a period of 1 month.
- Trial name
- GLUCAL2 (NCT04587297)
- Where
- France
- Volunteers
- 30 people
- Sponsor
- University Hospital, Montpellier
Maturity-onset Diabetes of the Young, Monogenic Diabetes
Identifying Maturity-onset Diabetes of the Young in Emirati Patients
Diabetes Mellitus is a disease that affects nearly 1 in 5 people in United Arab Emirates and is one of leading causes of death and disability.
- Conditions
- Maturity-onset Diabetes of the Young, Monogenic Diabetes, MODY
- Trial name
- NCT05586594
- Testing
- Genetic testing for 4 MODY genes (GCK, HNF1A, HNF4A, HNF1B)
- Volunteers
- 150 people
- Sponsor
- United Arab Emirates University
Diabetes, Type 1
Edmonton Automated Sugar Intelligence - Intelligent Diabetes Management, EASI-IDM, App Program to Assist Diabetes Care
A closed loop system for diabetes care utilizing an insulin pump, continuous glucose sensing and appropriate mathematical modelling to guide insulin dosing is a goal for those with Type 1 diabetes.
- Trial name
- EASI-IDM (NCT02214719)
- Testing
- EASI-IDM use
- Where
- Canada
- Volunteers
- 31 people
- Sponsor
- University of Alberta
Diabetes Mellitus Type 1
Assessment of the Neurovascular Microcirculatory Response in Diabetes Type 1 Patients
This study aims to see whether or not the diabetes 1 patients have a neurovascular microcirculatory dysfunction using various microvascular tests which have been previously validated.
- Trial name
- NEURODIAB1 (NCT02538120)
- Testing
- Microvascular assessment
- Where
- France
- Volunteers
- 40 people, healthy volunteers welcome
- Sponsor
- University Hospital, Angers
Diabete Type 1
Eating Disturbances in Patients With Type 1 Diabetes Initiating Insulin Therapy
The prevalence of eating disorders is particularly high among people with type 1 diabetes (T1D). These abnormalities, such as "diabulimia," are frequently responsible for poor insulin therapy management and, consequently, chronic…
- Trial name
- CALI-BF (NCT07151924)
- Testing
- Questionnaires answers, Biological assessment
- Where
- France
- Volunteers
- 100 people
- Sponsor
- University Hospital, Toulouse