Clinical trials: Diabetes Care
Diabetes, Diabetic Foot
Diabetic Foot Ulcer Study Comparing Cytal Wound Matrix 1-Layer to Standard of Care
This is a two-armed randomized controlled trial (RCT) primarily aimed at determining if application of Cytal Wound Matrix 1-Layer intervention to diabetic foot ulcers shows improved wound closure rates when compared to standard…
- Conditions
- Diabetes, Diabetic Foot, Diabetes Mellitus, Type 2, Diabetes Mellitus, Type 1
- Trial name
- NCT03626623
- Testing
- Cytal Wound Matrix 1-Layer, Standard of Care (SOC)
- Where
- 3 sites in United States
- Volunteers
- 15 people
- Sponsor
- Integra LifeSciences Corporation
Diabetes Mellitus, Type 2
Long Term Comparative Effectiveness of Once Weekly Semaglutide Versus Standard of Care in a Real World Adult US Population With Type 2 Diabetes - a Randomized Pragmatic Trial
The main purpose of this study is to compare the effects of semaglutide (Ozempic®) with the effects of other treatments for type 2 diabetes in a normal practice setting.
- Trial name
- NCT03596450
- Testing
- Semaglutide, Standard of care
- Where
- 181 sites in United States, Canada
- Volunteers
- 1,278 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus, Type 2
A Research Study Comparing RYBELSUS® to Other Blood Sugar Lowering Tablets in People Living in America With Type 2 Diabetes (REALYSE)
This study is comparing the medicine RYBELSUS® to other medicines in people with type 2 diabetes who need extra treatment. All medicines used in this study are tablets which lower blood sugar in people with type 2 diabetes.
- Trial name
- REALYSE (NCT05035082)
- Testing
- semaglutide, oral glucose-lowering medications (commercially available)
- Where
- 25 sites in United States
- Volunteers
- 1,018 people
- Sponsor
- Novo Nordisk A/S
Diabetes Mellitus
Effects of a Patient Portal Intervention to Address Diabetes Care Gaps
The purpose of this study is to evaluate the effect of a novel patient portal intervention on the number of patients with diabetes care gaps (e.g., no diabetes eye exam i the last 12 months).
- Trial name
- NCT04894903
- Testing
- Diabetes Care Gaps Patient Portal Intervention
- Where
- United States
- Volunteers
- 440 people
- Sponsor
- Vanderbilt University Medical Center
T2DM (Type 2 Diabetes Mellitus), Continuous Glucose Monitoring
Comparison of 3 Versus 6-Month Use of CGMS in Non-Insulin Using T2DM Patients
To determine whether 3-month versus 6-month professional CGM utilization improves time spent in target range of 70-140mg/dl in patients with poorly controlled T2DM not treated with insulin.
- Trial name
- NCT03067480
- Testing
- iPro2 Professional CGM
- Where
- United States
- Volunteers
- 12 people
- Sponsor
- East Tennessee State University
Type 2 Diabetes
Feasibility and Clinical Utility of the Dexcom G6 Continuous Glucose Monitoring Device for Type 2 Diabetes
The objective of this study is to evaluate the feasibility and clinical utility of a continuous glucose monitoring device (CGM, Dexcom G6) for the care of patients with type 2 diabetes who are on non-insulin therapies.
- Trial name
- NCT05523362
- Testing
- Dexcom continuous glucose monitor
- Where
- United States
- Volunteers
- 56 people
- Sponsor
- Ian J. Neeland, MD
Foot Ulcer
A Personalized Self-care Support Program for Primary Care Patients With Diabetic Foot Ulcer
This clinical trial aims to learn if a personalized self-care program supporting self-care and Healing through Empowerment and Active Listening (HEALing), is acceptable to patients with diabetic foot ulcer (DFU) and wound care…
- Trial name
- NCT06540170
- Testing
- A personalised self-care support program
- Where
- Singapore
- Volunteers
- 29 people
- Sponsor
- National Healthcare Group Polyclinics
Gestational Diabetes Mellitus
Randomized Translational Study to Examine the Effects of Shared Care in Management of Gestational Diabetes
Research question (s)/hypothesis: 1. . The effectiveness of the shared care management of gestational diabetes mellitus; 2. . The cost-effectiveness of the shared care management; 3. . Its sustainability
- Trial name
- NCT01565564
- Testing
- Shared glycaemic control care within the local three-tier's antenatal care network
- Where
- China
- Volunteers
- 948 people
- Sponsor
- Tianjin Women and Children's Health Center
Type 2 Diabetes, Obesity
EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial
This is a pragmatic, 24 month, single-center, randomized, open-label, parallel-group trial comparing an obesity-centric approach with a medically-supervised and comprehensive weight loss program (Cleveland Clinic's Endocrinology…
- Trial name
- EMPOWER-T2D (NCT04531176)
- Testing
- Weight Management Program (WMP), Traditional care, Phentermine / Topiramate Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- The Cleveland Clinic
PreDiabetes, Prediabetic State
Implementation and Evaluation of a Diabetes Prevention Clinical Pathway in Primary Care
Prediabetes is a significant public health problem affecting 88 million U.S. adults. Evidence suggest that the vast majority of people with prediabetes are unaware of having this condition and many are not receiving appropriate…
- Trial name
- NCT05265312
- Testing
- START diabetes prevention clinical pathway
- Where
- United States
- Volunteers
- 1,910 people
- Sponsor
- Johns Hopkins University
Diabetes Mellitus, Type 2, Patient Education as Topic
Differing Completion Rates of DIABETES Education on Patient Reported Outcomes
The goal of this clinical feasibility trial is to test the impact of differing completion rates of a face-to-face diabetes self-management education programme on patient-reported outcomes measuring self-care, diabetes distress…
- Trial name
- DIABETES-PRO (NCT06419907)
- Testing
- Type 2 Live Well (structured diabetes self management education programme)
- Where
- United Kingdom
- Volunteers
- 120 people
- Sponsor
- University of Liverpool
Neuropathic Diabetic Ulcer - Foot
Safety Trial of the RedDress Wound Care System (RD1) in Management of Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
The purpose of this study is to assess the safety of the RedDress Wound Care System (RD1) in patients Texas 1a or 2a Neuropathic Diabetic Foot Ulcers.
- Trial name
- NCT01396837
- Testing
- RedDress Wound Care System (RD1)
- Where
- 4 sites in United States
- Volunteers
- 20 people
- Sponsor
- RedDress Ltd.
Diabetes, Hypertension
Adherence and Intensification of Medications (AIM) Implementation Study
Background: Good blood pressure (BP) control among patients with diabetes is essential in preventing diabetes complications and has been found to be not only cost-effective but cost-saving.
- Trial name
- NCT00495794
- Testing
- Clinical pharmacist-based intervention
- Where
- United States
- Volunteers
- 4,622 people
- Sponsor
- US Department of Veterans Affairs
Diabetic Foot Ulcer
Clinical Study to Compare Two Skin Substitute Categories for Their Effectiveness to Treat Diabetic Foot Ulcers
The purpose of this clinical evaluation is to collect patient outcome data on a commercially available 510K FDA cleared advanced skin substitute. The commercially available product is Helicoll® Advanced Skin Substitute.
- Trial name
- NCT06557122
- Testing
- SOC and Advanced Bioengineered Skin Substitute, SOC and Active Comparator
- Where
- 3 sites in United States
- Volunteers
- 24 people
- Sponsor
- Encoll Corp
Diabetes, Cardiovascular Disease
Reverse Innovation and Patient Engagement to Improve Quality of Care and Patient Outcomes
Project CONNECT ("Community-based Organizations Neighborhood Network: Enhancing Capacity Together") is a randomized controlled trial that involves 22 community-based organizations (CBOs) located in Baltimore, MD.
- Conditions
- Diabetes, Cardiovascular Disease, Substance Abuse Disorder, Mental Health Disorder
- Trial name
- CONNECT (NCT02222909)
- Testing
- Co-developed IT intervention
- Where
- United States
- Volunteers
- 6,767 people
- Sponsor
- Johns Hopkins Bloomberg School of Public Health
Diabetic Foot Ulcer, Ulcer Foot
Bioresorbable Glass Fiber Matrix in the Treatment of Diabetic Foot Ulcers
This study is a prospective, multi-center, randomized controlled trial designed to collect patient outcome data on 2 commercially available treatments for diabetic foot wounds.
- Conditions
- Diabetic Foot Ulcer, Ulcer Foot, Diabetic Foot
- Trial name
- NCT06403605
- Testing
- Mirragen Advanced Wound Matrix, Fibracol
- Where
- 15 sites in United States
- Volunteers
- 148 people, healthy volunteers welcome
- Sponsor
- ETS Wound Care, LLC
Diabetes
Multi-arm Intervention Diabetes Adherence Study
The purpose of this study is to compare the effectiveness of two different interventions to improve adherence to diabetes medications among patients with diabetes and poor metabolic control.
- Trial name
- MIDAS (NCT00754741)
- Testing
- Adherence information, Adherence information plus motivational interviewing
- Where
- United States
- Volunteers
- 1,692 people
- Sponsor
- Henry Ford Health System
Chronic Kidney Disease
Home-base Kidney Care in Zuni Indians
People reach End Stage Renal Disease (ESRD) due to progressive chronic kidney disease (CKD). CKD is associated with increased risks for heart disease and death.
- Trial name
- HBKC (NCT02915029)
- Testing
- Educational and lifestyle coaching
- Volunteers
- 125 people
- Sponsor
- University of New Mexico
Chromium Deficiency, Diabetes Mellitus
Examination of the Effects of Chromium Levels on Glucose Metabolism, Lipid Metabolism, Morbidity and Mortality Rates in Patients Followed in Intensive Care Unit
The goal of this observational study is to determine the effects of chromium serum levels on glucose metabolism, lipid metabolism, morbidity and mortality rates in critically ill intensive care patients.
- Conditions
- Chromium Deficiency, Diabetes Mellitus, Hyperlipidemias, Hypercholesterolemia
- Trial name
- NCT06334042
- Testing
- Serum Chromium Level
- Where
- Turkey (Türkiye)
- Volunteers
- 309 people, healthy volunteers welcome
- Sponsor
- Oguzhan Kahveci
Diabetes, Hyperglycemia
Diabetes in the Elderly: Prospective Study
Diabetes is highly prevalent in the elderly, afflicting about 20% of older adults aged 65-75 years and 40% of adults >80years of age.
- Trial name
- DMElderly (NCT01131052)
- Testing
- Insulin Glargine, Insulin, Insulin glulisine
- Where
- United States
- Volunteers
- 150 people
- Sponsor
- Guillermo Umpierrez