Clinical trials: Diabetes Complication
Proteinuria
Safety and Pharmacokinetic Study of Subcutaneous ALXN1720 in Participants With Proteinuria
The primary objective of this study is to assess the impact of proteinuria on the pharmacokinetic (PK) of a single dose of ALXN1720 in participants with proteinuria.
- Trial name
- NCT05314231
- Testing
- ALXN1720
- Where
- 2 sites in South Korea
- Volunteers
- 13 people
- Sponsor
- Alexion Pharmaceuticals, Inc.
Foot Ulcer, Diabetic
Health Economic Assessment of Lower Extremity Diabetic (HEALED) Ulcers With PriMatrix
The objective of this study is to compare the effectiveness of PriMatrix Moist Wound Therapy (MWT) with Standard of Care MWT for the treatment of chronic diabetic foot ulcers in subjects with diabetes mellitus and without…
- Trial name
- HEALED (NCT01729286)
- Testing
- PriMatrix Moist Wound Therapy, Standard of Care Moist Wound Therapy
- Where
- 18 sites in United States, Puerto Rico
- Volunteers
- 92 people
- Sponsor
- Integra LifeSciences Corporation
Diabetic Foot
Phase 2b Study of GAM501 in the Treatment of Diabetic Ulcers of the Lower Extremities
This is a Phase 2b, double-blind, randomized, placebo-controlled study to evaluate the safety and efficacy of one or two applications of topically applied GAM501 (Ad5PDGF-B/Bovine Type I Collagen Gel) in subjects ≥ 18 years old…
- Trial name
- MATRIX (NCT00493051)
- Testing
- GAM501, Standard of care
- Where
- 29 sites in United States
- Volunteers
- 124 people
- Sponsor
- Tissue Repair Company
Chronic Kidney Diseases, Diabetes Mellitus
Automated Insulin Delivery in Adults With Advanced Kidney Disease
Diabetes is the leading cause of kidney failure in the UK. Many people with diabetes and advanced kidney failure inject themselves with insulin and do finger-prick blood glucose tests.
- Trial name
- AIDkidney (NCT06463483)
- Testing
- Medtronic 780G System, Continuous Glucose Monitoring
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- Imperial College London
Type 1 Diabetes, End Stage Renal Disease
Intraportal or Intramuscular Site for Islets in Simultaneous Islet and Kidney Transplantation
Islet transplantation is a promising treatment of type 1 diabetes in selected cases. Results are however hampered by a relatively low number of islets surviving the transplantation into the liver, which currently is the site for…
- Trial name
- NCT01967186
- Testing
- Intraportal islet transplantation, Intramuscular islet transplantation, Intramuscular transpl with stemcells
- Volunteers
- 36 people
- Sponsor
- The Nordic Network For Clinical Islet Transplantation
Diabetic Kidney Disease
Role of Finerenone in African American Veterans With Diabetic Kidney Disease
Primary Objectives: To study podocyte specific injury markers (podocyte specific proteins, PSP) nephrin, podocalyxin and Wilms'Tumor (WT-1) protein in exosomes urine from African American Veterans with albuminuric stage 2 and 3…
- Trial name
- NCT07155694
- Testing
- Finerenone 10 MG, Empagliflozin 10 MG
- Where
- United States
- Volunteers
- 30 people
- Sponsor
- Washington D.C. Veterans Affairs Medical Center
Diabetes and Risk of Diabetic Foot Ulcer, Diabetes Mellitus
An Analysis of Plantar Pressure Distribution and Postural Balance Parameters in Individuals With Diabetic Foot Diagnosis
This study aims to investigate the relationship between plantar pressure distribution and postural balance in individuals diagnosed with diabetic foot.
- Conditions
- Diabetes and Risk of Diabetic Foot Ulcer, Diabetes Mellitus, Postural Control, Plantar Pressure Distrubution
- Trial name
- NCT07084922
- Testing
- No interventions. This is an observational study where participants undergo assessments of plantar pressure and postural balance without any treatment or intervention.
- Where
- Turkey (Türkiye)
- Volunteers
- 32 people, healthy volunteers welcome
- Sponsor
- Medipol University
Diabetic Foot Ulcers, Diabetes
A Comparison of TCC-EZ Using Human Amnion Allograft vs TCC-EZ and Standard Wound Care in Treating Diabetic Foot Ulcers.
A Comparison of AmnioExcel® and Total Contact Casting (TCC-EZ) Versus Standard Wound Care and TCC-EZ in Treating Diabetic Foot Ulcers Best practice is to treat DFUs with standardized care and, if unsuccessful, use advanced…
- Trial name
- TAD (NCT02344329)
- Testing
- Topical wound dressing, Human Amnion Allograft, usual wound care
- Where
- United States
- Volunteers
- 12 people, healthy volunteers welcome
- Sponsor
- University of North Dakota
Septic Shock, Renal Function Replacement
Renal Outcomes in the Early Use of Vasopressin in the Treatment of Septic Shock
The aim of the present study is to verify whether the earlier association of vasopressin and norepinephrine, in patients in septic shock, determines variations in terms of use of renal function replacement techniques in the first…
- Trial name
- EVSS (NCT06471231)
- Testing
- vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.25 mcg/kg/min, vasopressin infusion when the norepinephrine dosage is equal to or greater than 0.5 mcg/kg/min
- Where
- Italy
- Volunteers
- 264 people
- Sponsor
- Azienda Usl di Bologna
Diabetic Foot Ulcer, Offloading
Novel Offloading for Diabetic Foot Ulcers With PulseFlow: A Prospective Study
Diabetic foot ulceration (DFU) is a common and largely preventable complication of diabetes. While most of these ulcers can be treated successfully, some will persist and become infected.
- Trial name
- NCT02783066
- Testing
- Offloading boot: PulseFlow
- Where
- United States
- Volunteers
- 16 people
- Sponsor
- Baylor College of Medicine
Gestational Diabetes
Early Screen and Treatment for Gestational Diabetes
In the current study we aim to determine if early glucose screening and treatment among women at high risk for GDM improves perinatal outcome and decreases gestational weight gain.
- Trial name
- NCT02377531
- Testing
- Early glucose screen group, Standard glucose screen group
- Where
- 2 sites in United States
- Volunteers
- 1,020 people, healthy volunteers welcome
- Sponsor
- University of South Florida
Kidney Disease, Glomerular Disease
Kidney Disease Biomarkers
Kidney Disease Biomarkers Summary: This study will identify biomarkers (proteins and other molecules in the blood or urine) that may help scientists predict what kidney disease a patient has and whether a given patient would…
- Conditions
- Kidney Disease, Glomerular Disease, Idiopathic Nephrotic Syndrome, Focal Segmental Glomerulosclerosis
- Trial name
- NCT00255398
- Where
- United States
- Volunteers
- 25 people
- Sponsor
- National Institute of Diabetes and Digestive and Kidney Diseases (NIDDK)
Pancreatitis, Pancreatic Neoplasms
Follow-up Study of Complications of Acute Pancreatitis
This is a follow-up study focusing on long-term complications of acute pancreatitis. The primary purposes include: 1. To assess the incidence of type 2 diabetes mellitus（2-DM）,impaired glucose tolerance, metabolic abnormalities…
- Conditions
- Pancreatitis, Pancreatic Neoplasms, Metabolic Diseases, Hypertension, Portal
- Trial name
- FSCAP (NCT02305914)
- Where
- China
- Volunteers
- 1,300 people
- Sponsor
- The First Affiliated Hospital of Nanchang University
Diabetic Nephropathy, Type 2 Diabetes
Safety and Efficacy of Mesenchymal Precursor Cells in Diabetic Nephropathy
The study investigates the safety, tolerability and efficacy of a single intravenous infusion of two doses of mesenchymal precursor cells versus placebo in subjects with diabetic nephropathy and type 2 diabetes.
- Trial name
- NCT01843387
- Testing
- Mesenchymal Precursor Cells (MPCs)
- Where
- 2 sites in Australia
- Volunteers
- 30 people
- Sponsor
- Mesoblast, Ltd.
Diabetes Mellitus, Type 2, Renal Insufficiency, Chronic
Self-Management and Resourceful Transition of Type 2 Diabetes With Stage 3 Kidney Disease
The purpose of this study is to establish the usefulness and the impact of a tailored behavioral-education and counseling intervention titled Self-Management and Resourceful Transition (S.M.a.R.T) among patients with type 2…
- Trial name
- SMaRT (NCT01067963)
- Testing
- Computer assisted education and motivational interviewing., Group talks/social chat
- Where
- 2 sites in United States
- Volunteers
- 80 people
- Sponsor
- University of Colorado, Denver
Surgical Site Infection, Obesity
SUpPress SSI - Single Use Negative Pressure Wound Therapy (NPWT) to Reduce Surgical Site Infections
Our goal is to provide data that will give surgeons and hospitals clear recommendations on the use of NPWT for Cesarean section, abdominal hysterectomy and colon surgeries in patients with diabetes and/or obesity.
- Conditions
- Surgical Site Infection, Obesity, Diabetes, Cesarean Section Complications
- Trial name
- SUpPressSSI (NCT03816293)
- Testing
- Negative Pressure Wound Therapy
- Where
- 5 sites in United States
- Volunteers
- 3,680 people
- Sponsor
- University of Illinois at Chicago
Diabetes Mellitus, Diabetes, Gestational
Recent GDM Lifestyle Intervention
Women with a history of gestational diabetes (GDM) have a substantially increased risk of developing type 2 diabetes. In fact, 50-70% of these women will go on to develop type 2 diabetes within the 20 years following their…
- Trial name
- LIFe (NCT01910805)
- Testing
- Lifestyle and Risk Assessment class
- Where
- United States
- Volunteers
- 15 people, healthy volunteers welcome
- Sponsor
- Brigham and Women's Hospital
Gestational Diabetes Mellitus
SPARK- a Digital Platform to Improve Self-management of Gestational Diabetes
Gestational diabetes mellitus (GDM) is an increasing public health challenge. Innovative, effective and scalable lifestyle interventions to support women with GDM to manage their disease and to prevent adverse obstetric and…
- Trial name
- SPARK (NCT05348863)
- Testing
- SPARK
- Where
- Sweden
- Volunteers
- 360 people, healthy volunteers welcome
- Sponsor
- Karolinska Institutet
ADHD, ADD
ADHD Electrophysiological Subtypes and Implications in Transcranial Direct-current Stimulation
In the present study the aim is to examine whether transcranial direct-current stimulation (tDCS) generated excitability changes and induce modifications of functional cortical architecture in Attention Deficit Hyperactivity…
- Trial name
- tdcs&adhd (NCT01649232)
- Testing
- Active tDCS
- Where
- United Kingdom
- Volunteers
- 60 people, healthy volunteers welcome
- Sponsor
- Spanish Foundation for Neurometrics Development
T2DM (Type 2 Diabetes Mellitus)
PRKAA2 Genetic Polymorphisms and Its Susceptibility to Chinese Type 2 Diabetes Mellitus and Diabetic Nephropathy
Metformin is a classical oral antidiabetic drug, often recommended to be the first-choice treatment of type 2 diabetes mellitus (T2DM).
- Trial name
- NCT03155087
- Testing
- Metformin
- Volunteers
- 750 people, healthy volunteers welcome
- Sponsor
- People's Hospital of Zhengzhou University