Clinical trials: Diabetes During Pregnancy
Gestational Diabetes Mellitus
The Effect of Oral Probiotics on Glycemic Control of Women With Gestational Diabetes Mellitus
Scientific background: Uncontrolled gestational diabetes mellitus (GDM) is associated with severe maternal and neonatal morbidities. Treatment of GDM is multidisciplinary and includes lifestyle changes and medications.
- Trial name
- NCT03864549
- Testing
- Femina II
- Where
- 4 sites in Israel
- Volunteers
- 93 people
- Sponsor
- HaEmek Medical Center, Israel
Gestational Weight Gain
Gestational Weight Gain Criteria for Pregnant Women With Gestational Diabetes Mellitus in China
Appropriate gestational weight gain (GWG) is a key factor in balancing maternal and neonatal needs of nourishment and health, which is especially important in women with gestational diabetes mellitus (GDM).
- Trial name
- NCT04744714
- Where
- China
- Volunteers
- 10,000 people, healthy volunteers welcome
- Sponsor
- Women's Hospital School Of Medicine Zhejiang University
Misoprostol Allergy, Oxytocin Allergy
Methods Decreasing Bleeding in Open Myomectomy
Uterine leiomyomas (fibroids or myomas) are benign, smooth muscle tumors of the human uterus. Most myomas are asymptomatic (symptomless) and are discovered incidentally during a routine pelvic examination or imaging studies and…
- Conditions
- Misoprostol Allergy, Oxytocin Allergy, Tranexamic Acid Allergy, Ethamsylate Allergy
- Trial name
- NCT05806307
- Testing
- Misoprostol, Tourniquet, Carbetocin
- Where
- Egypt
- Volunteers
- 105 people
- Sponsor
- Cairo University
Weight Loss, Gestational Diabetes
Pragmatic Lifestyle Pregnancy and Post Pregnancy Intervention for Overweight Women With Gestational Diabetes Mellitus
This study is designed to determine if a postnatal lifestyle intervention will lead to weight reduction over a 12 month period post-delivery in women who have been diagnosed with gestational diabetes mellitus and who have a BMI…
- Trial name
- PAIGE2 (NCT04579016)
- Testing
- PAIGE2 lifestyle intervention, Standard care
- Where
- United Kingdom
- Volunteers
- 200 people, healthy volunteers welcome
- Sponsor
- Belfast Health and Social Care Trust
Overweight or Obesity
NDPP-NextGen: A Clinical Trial to Reduce Intergenerational Obesity and Diabetes Risks
The goal of this clinical trial is to test an enhanced version of the National Diabetes Prevention Program (NDPP-NextGen) that is tailored to young women in childbearing years.
- Trial name
- NCT05674799
- Testing
- NDPP-NextGen
- Where
- United States
- Volunteers
- 403 people, healthy volunteers welcome
- Sponsor
- Wake Forest University Health Sciences
Gestational Diabetes Mellitus (GDM)
Implementation and Evaluation of Bump2Baby and Me+ Programme for Gestational Diabetes Mellitus in Routine Maternity Care Setting.
Gestational diabetes mellitus (GDM) affects approximately 1 in 7 pregnancies globally and is associated with significant short and long-term health consequences for both mothers and infants.
- Trial name
- B2B&ME+ (NCT07189221)
- Testing
- Life Style Intervention
- Volunteers
- 3,600 people
- Sponsor
- University College Dublin
Gestational Diabetes, Type 2 Diabetes
Abnormal Post-partum Glucose Metabolism After Gestational Diabetes Diagnosed Before or After 24 Weeks of Gestation
The main objective of the study is to estimate and compare the percentage of patients with abnormal glucose metabolism at 4-12 weeks postpartum between two groups: patients diagnosed with gestational diabetes before or after 24…
- Conditions
- Gestational Diabetes, Type 2 Diabetes, Glucose Intolerance
- Trial name
- DG Post-Partum (NCT01839448)
- Testing
- Post-partum oral glucose tolerance test
- Where
- 4 sites in France
- Volunteers
- 500 people
- Sponsor
- Centre Hospitalier Universitaire de Nīmes
Gestational Diabetes Mellitus
FGF19 and the Expression of IRS-1 and GLUT-1 in Gestational Diabetes Mellitus
Insulin resistance plays a key role in the development of gestational diabetes mellitus(GDM). As the largest endocrine organ and the transport intermediary of maternal-fetal nutrient and a large of hormone and enzymes, placenta…
- Trial name
- NCT03816605
- Where
- China
- Volunteers
- 36 people, healthy volunteers welcome
- Sponsor
- First Affiliated Hospital, Sun Yat-Sen University
Gestational Diabetes
Continuous Glucose Monitoring to Detect Postpartum Dysglycemia in Patients With Gestational Diabetes
The aim of this study is to determine the ability of postpartum continuous glucose monitoring (CGM) for subjects with gestational diabetes (GDM) to predict dysglycemia on 4-12 week postpartum oral glucose tolerance test (OGTT).
- Trial name
- NCT07034261
- Testing
- Blinded Continuous Glucose Monitoring Device
- Volunteers
- 50 people
- Sponsor
- University of Chicago
Diabetes, Gestational Diabetes
GDM Post Partum Screening
Immediate postpartum screening for diabetes mellitus in women with gestational diabetes The objective of this study is to determine if screening for type 2 diabetes can be done 24 hours after delivery, versus 6-12 weeks…
- Conditions
- Diabetes, Gestational Diabetes, Diabetes Mellitus, Type 2
- Trial name
- NCT03946631
- Testing
- 2 hour glucose tolerance test using 75g glucose drink
- Where
- United States
- Volunteers
- 21 people
- Sponsor
- Pediatrix
Diabetic Nephropathies
This Study Tests a New Medicine Called BI 685509 in Patients That Have Kidney Problems Because of Diabetes. The Study Tests How BI 685509 is Taken up in the Body and How Well it is Tolerated (Multiple Rising Doses)
The main objective of this trial is the safety and tolerability of 3 multiple rising oral doses of BI 685509 over 28 days in male and female patients with Diabetic Nephropathy (DN) as adjunctive to Angiotensin Converting Enzyme…
- Trial name
- NCT03165227
- Testing
- BI 685509
- Where
- 35 sites in United States, Belgium and 3 more
- Volunteers
- 75 people
- Sponsor
- Boehringer Ingelheim
Gestational Diabetes
To Identify Urinary Biomarkers Associated With Gestational Diabetes Mellitus [GDM]
Gestational diabetes mellitus(GDM) is one of the most common complications of pregnancy. The incidence of GDM is higher in Asian than in other regions, and GDM can increase the risk of a series of perinatal complications.
- Trial name
- NCT05992974
- Where
- 2 sites in China
- Volunteers
- 1,000 people
- Sponsor
- Peking Union Medical College Hospital
Hypertensive Disorder of Pregnancy, Preeclampsia
MumCare: Mum's Cardiovascular Health for Life
The goal of this randomized clinical trial study is to test the potential benefits of eHealth-assisted follow-up after pregnancy complications that confer and increased risk for premature cardiovascular (CV) disease.
- Conditions
- Hypertensive Disorder of Pregnancy, Preeclampsia, Gestational Hypertension, Gestational Diabetes
- Trial name
- MumCare (NCT05835596)
- Testing
- Access to MumCare app
- Where
- Norway
- Volunteers
- 400 people
- Sponsor
- Oslo University Hospital
Gestational Diabetes Mellitus With Baby Delivered
Time-restricted Eating and High-intensity Interval Training After Gestational Diabetes
This trial will recruit participants who had gestational diabetes in their most previous pregnancy. Participants will be randomly allocated into two groups: one intervention group and one control group 6-12 weeks after giving…
- Trial name
- TRE-HIITmoms (NCT07776886)
- Testing
- Time-restricted eating and exercise
- Where
- Norway
- Volunteers
- 56 people
- Sponsor
- Norwegian University of Science and Technology
Diabetes Mellitus, Kidney Transplantation
Influence of Pioglitazone for Renal Transplant Function in Diabetics
The purpose of this study is to test whether pioglitazone is able to prevent the progression of diabetic nephropathy in kidney transplant recipients with diabetes mellitus.
- Conditions
- Diabetes Mellitus, Kidney Transplantation, Proteinuria
- Trial name
- NCT00507494
- Testing
- pioglitazone
- Where
- Germany
- Sponsor
- Technische Universität Dresden
Hypertension, Hypertension, Systolic
Treatment of Hypertension During Sleep
On the basis of new evidence on the relationship between achieved office blood pressure (BP) measurements (OBPM) and the risk of cardiovascular disease (CVD) morbidity and mortality documented in the SPRINT trial, the recent 2017…
- Trial name
- THADEUS (NCT03457168)
- Testing
- Treatment of elevated asleep SBP mean
- Where
- 9 sites in Spain
- Volunteers
- 5,320 people
- Sponsor
- University of Vigo
Gestational Diabetes Mellitus
Diet, Exercise, and Breastfeeding Intervention Program for Women With Gestational Diabetes (DEBI Trial)
The primary aim of this study is to evaluate whether a lifestyle intervention of diet, exercise, and breastfeeding is associated with decreased postpartum weight retention and reduced plasma glucose levels, measured at 6-weeks…
- Trial name
- DEBI (NCT00460018)
- Testing
- Diet, Exercise, and Breastfeeding Intervention
- Where
- 5 sites in United States
- Volunteers
- 180 people
- Sponsor
- Kaiser Permanente
Medical Nutrition Therapy, Gestational Diabetes Mellitus
Medical Nutrition Therapy Combined With TPF-DM in Pregnant Women With Gestational Diabetes Mellitus
Background: Gestational diabetes mellitus (GDM), GDM is the first time of gestational impaired glucose tolerance in pregnant women. It is the most common complication disease in women of childbearing age.
- Conditions
- Medical Nutrition Therapy, Gestational Diabetes Mellitus, Adverse Pregnancy Outcomes, Fasting Plasma Glucose
- Trial name
- NCT03957603
- Testing
- Enteral Nutrition Suspension (TFP-DM), Medical Nutrition Therpay
- Where
- China
- Volunteers
- 100 people
- Sponsor
- Capital Medical University
Pregestational Obesity (BMI > 27kg/m2), History of Polycystic Ovary Syndrome
Medical Nutrition Therapy Plus Transgestational Metformin For Preventing Gestational Diabetes In High Risk Mexican Women
Gestational diabetes mellitus is one of the most frequent complications of pregnancy, that affect between 1 to 14% of population around the world.
- Trial name
- NCT01675310
- Testing
- medical nutrition therapy + metformin, Medical nutrition therapy
- Where
- Mexico
- Volunteers
- 90 people
- Sponsor
- Instituto Nacional de Perinatologia Isidro Espinosa de los Reyes
Gestational Diabetes
Gestational Diabetes - PrEvention of PostPartum Diabetes Study
Gestational diabetes is the most common metabolic abnormality during pregnancy. In a Swedish population 2-10% of all pregnant women are diagnosed with gestational diabetes mellitus (GDM).
- Trial name
- PEPP (NCT05112588)
- Testing
- Intervention
- Where
- Sweden
- Volunteers
- 600 people, healthy volunteers welcome
- Sponsor
- Vastra Gotaland Region