Clinical trials: Diabetes Management
Diabetic Macular Edema
Study of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) in Patients With Diabetic Macular Edema
The purpose of this study is to determine the efficacy of Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321) on the best corrected visual acuity (BCVA) assessed by the early treatment diabetic retinopathy study (ETDRS)…
- Trial name
- VISTA DME (NCT01363440)
- Testing
- Intravitreal Aflibercept Injection (IAI; EYLEA®; BAY86-5321), Macular Laser Photocoagulation
- Where
- 51 sites in United States
- Volunteers
- 466 people
- Sponsor
- Regeneron Pharmaceuticals
Blood Loss, Surgical
Vasopressin Administration During Laparoscopic Myomectomy: a Randomized Controlled Trial
The main purpose of this study is to compare blood loss at the time of laparoscopic or robotically-assisted laparoscopic myomectomy when using different amounts of dilute vasopressin solution.
- Trial name
- NCT01393704
- Testing
- Vasopressin
- Where
- United States
- Volunteers
- 152 people
- Sponsor
- Brigham and Women's Hospital
Diabetes Mellitus, Type 2
Managing Diabetes to Gain Opportunities for a More Active Life
The purpose of this novel patient-facing disease management intervention is to develop and test a system embedded within the electronic medical record to engage patients in personalized goal setting and chronic disease management.
- Trial name
- NCT03692208
- Testing
- My Diabetes Goal Survey and Optional Care Management
- Where
- United States
- Volunteers
- 110 people
- Sponsor
- University of Chicago
Subclinical Hypercortisolism, Cushing Syndrome
Study of Adrenalectomy Versus Observation for Subclinical Hypercortisolism
Background: Adrenal tumors are a common kind of tumor. Some of these secrete extra cortisol into the body, which can lead to diabetes, obesity, and other diseases.
- Conditions
- Subclinical Hypercortisolism, Cushing Syndrome, Adrenal Neoplasm
- Trial name
- NCT02001051
- Testing
- Adrenalectomy, Observation
- Where
- United States
- Volunteers
- 4 people
- Sponsor
- National Cancer Institute (NCI)
Chronic Kidney Diseases, Type 2 Diabetes
Continuous Glucose Monitoring to Assess Glycemia in Chronic Kidney Disease - Changing Glucose Management
The goal of this study is to test whether a dipeptidyl peptidase-4 inhibitor, compared with a sulfonylurea, improves time in normal blood glucose range and reduces blood glucose variability.
- Trial name
- CANDY-CANE (NCT02608177)
- Testing
- Linagliptin, Glipizide
- Where
- United States
- Volunteers
- 3 people
- Sponsor
- University of Washington
Diabetes Mellitus, Type 2
FAMS Mobile Health Intervention for Diabetes Self-care Support
This study evaluates a family-focused mobile phone-delivered intervention, called FAMS (Family-focused Add-on for Motivating Self-care), in supporting adults with type 2 diabetes in their self-management relative to a control…
- Trial name
- NCT02481596
- Testing
- REACH + FAMS, REACH, Helpline & A1c results
- Where
- United States
- Volunteers
- 512 people, healthy volunteers welcome
- Sponsor
- Vanderbilt University Medical Center
Type 2 Diabetes Mellitus
A Study to Evaluate the Safety, Tolerability, Pharmacokinetics and Pharmacodynamics of PF-06882961 in Japanese Adults With Type 2 Diabetes Mellitus
This is a Phase 1, randomized, double blind (sponsor open), parallel, placebo controlled, twice daily oral dosing study of PF 06882961 in adult Japanese participants with T2DM inadequately controlled on diet and exercise alone.
- Trial name
- NCT04552470
- Testing
- PF-06882961
- Where
- Japan
- Volunteers
- 37 people
- Sponsor
- Pfizer
Type1diabetes
A Cognitive Behavioral Intervention to Reduce Fear of Hypoglycemia in Young Adults With Type 1 Diabetes
This study is being conducted to determine the feasibility of a cognitive behavioral therapy intervention to reduce fear of hypoglycemia and improve glucose levels in young adults with type 1 diabetes.
- Trial name
- FREE (NCT03165786)
- Testing
- FREE
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University of Illinois Chicago
Diabetes Mellitus
Evaluation of GLUCOFACTS® Deluxe Diabetes Management System
The purpose of this study is to evaluate a Diabetes management program in the hands of potential users, both health care professionals and lay persons.
- Trial name
- NCT00892151
- Testing
- GLUCOFACTS® Deluxe
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- Ascensia Diabetes Care
Diabetes Mellitus, Type 2
Diabetes Disparities: Texting to Extend Treatment (DD-TXT)
One way to help Veterans improve their diabetes control is through the use of technology to help provide information, motivation, and reminders necessary to support diabetes self-management.
- Trial name
- DD-TXT (NCT04227379)
- Testing
- Intervention 1- DSMS+, Comparison - DSMS
- Where
- 3 sites in United States
- Volunteers
- 366 people
- Sponsor
- VA Office of Research and Development
Type 2 Diabetes, Obesity
EMI-EHP Weight Management and Type 2 Diabetes Pragmatic Trial
This is a pragmatic, 24 month, single-center, randomized, open-label, parallel-group trial comparing an obesity-centric approach with a medically-supervised and comprehensive weight loss program (Cleveland Clinic's Endocrinology…
- Trial name
- EMPOWER-T2D (NCT04531176)
- Testing
- Weight Management Program (WMP), Traditional care, Phentermine / Topiramate Extended Release Oral Capsule
- Where
- United States
- Volunteers
- 74 people
- Sponsor
- The Cleveland Clinic
Diabetes Mellitus, Type 2
Use of iPro™2 in Real Life Diabetes Management of Type 2 Patients in India
The purpose of the India iPro2 study is to demonstrate that iPro2 Continuous Glucose Monitoring System (CGMS) evaluation enables Health Care Professional (HCP)s treating patients in India with type 2 diabetes to get a better…
- Trial name
- NCT01995539
- Testing
- therapy regimen
- Where
- 11 sites in India
- Volunteers
- 181 people
- Sponsor
- Medtronic MiniMed, Inc.
Chronic Renal Impairment, Diabetes Mellitus
Renal Safety of Iopamidol Versus Iodixanol During Coronary Angiography in Diabetic Patients
The purpose of this study is to compare the incidence of contrast-induced nephropathy (CIN) following the administration of iopamidol-370 (Iopamiro-370) and iodixanol-320 (Visipaque 320) in patients with moderate-to-severe…
- Trial name
- RECARE (NCT00782639)
- Testing
- Iopamidol injection 76%, iodixanol
- Where
- United States
- Volunteers
- 23 people
- Sponsor
- Bracco Diagnostics, Inc
Diabetes Mellitus, Type II, Type 2 Diabetes
TARDIS - Photo Elicitation and Intervention
Veterans with type 2 diabetes (T2D) may become overwhelmed with the self-management behaviors needed to maintain optimal health.
- Conditions
- Diabetes Mellitus, Type II, Type 2 Diabetes, Diabetes Distress, Self Management
- Trial name
- TARDIS (NCT06972251)
- Testing
- TARDIS Photo Elicitation, TARDIS Intervention
- Where
- United States
- Volunteers
- 34 people
- Sponsor
- VA Office of Research and Development
Obesity, PreDiabetes
Reducing Cardiometabolic Risk and Promoting Functional Health in Older Adults With Obesity and Prediabetes
Obesity and pre-diabetes threatens the overall health and functional independence of older adults but lifestyle weight management for diabetes prevention, soon to be reimbursed by Medicare, can reduce this burden.
- Conditions
- Obesity, PreDiabetes, Aging
- Trial name
- Sustain-DPP (NCT03500640)
- Testing
- DPP Intensive: 30-minute calls, DPP Support: 15-minute calls
- Where
- United States
- Volunteers
- 314 people, healthy volunteers welcome
- Sponsor
- University of Pittsburgh
Type 1 Diabetes Mellitus
A Cognitive Behavioral Therapy (CBT) Intervention to Reduce Fear of Hypoglycemia in Type 1 Diabetes
All persons with type 1 diabetes are at risk for developing hypoglycemia (low blood sugar). This is a life-threatening condition that leads to profound fear of hypoglycemia and reduced quality of life.
- Trial name
- CBT (NCT03549104)
- Testing
- Fear Reduction Intervention, Attention Control
- Where
- United States
- Volunteers
- 51 people
- Sponsor
- University of Illinois Chicago
Diabetic Neuropathy, Painful
An Open-Label Comparison of Duloxetine to Other Alternatives for the Management of Diabetic Peripheral Neuropathic Pain
To test the non-inferiority of duloxetine monotherapy as a treatment for the management of diabetic peripheral neuropathic pain as compared to pregabalin treatment among patients who have not had an adequate response to…
- Trial name
- NCT00385671
- Testing
- duloxetine hydrochloride, pregabalin, gabapentin
- Where
- 9 sites in United States, Germany
- Volunteers
- 407 people
- Sponsor
- Eli Lilly and Company
Diabetic Ketoacidosis, Type 1 Diabetes Mellitus
Early Glargine (Lantus) in DKA Management in Children With Type 1 Diabetes
A frequent complication in the management of diabetic ketoacidosis (DKA) in children with type 1 diabetes is rebound hyperglycemia (blood glucose over 180 mg/dL) which increases the risk of re-developing DKA and can lengthen the…
- Trial name
- NCT03107208
- Testing
- Glargine, Continuous Glucose Monitor (Abbott FreeStyle Libre Pro)
- Where
- United States
- Volunteers
- 61 people, healthy volunteers welcome
- Sponsor
- University of Colorado, Denver
Diabetes Mellitus
Improving Diabetes Care:Effectiveness of Physician Profiling and Care Coordination by a Diabetes Resource Nurse
The purpose of this study is to test the effectiveness of physician profiling and care coordination by a diabetes resource nurse in improving the quality of diabetes care.
- Trial name
- NCT00258674
- Testing
- Medicare Claims Feedback, Medical Record Review, Diabetes Resource Nurse
- Where
- United States
- Volunteers
- 1,891 people
- Sponsor
- Baylor Research Institute
Heart Diseases, Stroke
The HARMONY Study: A Intervention to Reduce Cardiometabolic Risk in African American Women
This study will test whether a culturally-tailored nutrition and exercise intervention designed for African-American women will lead to sustained improvements in exercise and healthy eating through improvements in self-management…
- Conditions
- Heart Diseases, Stroke, Pre-diabetes, Hypertension
- Trial name
- NCT04705779
- Testing
- HARMONY, Nutrition and Exercise Education (NEEW)
- Where
- United States
- Volunteers
- 175 people
- Sponsor
- University of North Carolina, Chapel Hill