Clinical trials: Diabetes Mellitus, Type I
Type 1 Diabetes
Effect of Vitamin D on the Honeymoon Period in Children and Adolescents With Type 1 Diabetes
The purpose of this study is to determine if supplementation with Vitamin D in children and adolescents with newly diagnosed type 1 diabetes increases the number of patients who enter the honeymoon period.
- Trial name
- NCT01724190
- Testing
- Vitamin D
- Where
- United States
- Volunteers
- 38 people
- Sponsor
- Nationwide Children's Hospital
Diabetes Mellitus, Type 1
Test of the Efficacy and Safety of Insulin Glulisine Injected Subcutaneously in Patients With Type 1 Diabetes Mellitus
Primary Objective: To evaluate the efficacy and the safety of insulin glulisine in type I Diabetes Melittus (DM) patients Secondary Objective: To evaluate the insulin glulisine doses To assess the patient satisfaction
- Trial name
- PORTAL 1 (NCT00964574)
- Testing
- INSULIN GLULISINE (HMR1964), INSULIN GLARGINE
- Where
- Belarus
- Volunteers
- 68 people
- Sponsor
- Sanofi
Insulin-Dependent Diabetes Mellitus
Interferon-Alpha for Diabetes Mellitus Type 1
This study will see if interferon-alpha given early in the disease can stop or slow the immune attack on insulin-producing cells.
- Trial name
- NCT00024518
- Testing
- 30,000 units hrINF-alpha, 5,000 hrINF-alpha
- Where
- 5 sites in United States
- Volunteers
- 57 people
- Sponsor
- The University of Texas Health Science Center, Houston
Type 1 Diabetes, Type 2 Diabetes
Understanding and Optimizing Care for Young Adults With Type 1 and Type 2 Diabetes Mellitus Transitioning to Adult Care
In this study, we will determine the feasibility of an innovative care model for young adults with diabetes and compare the primary and secondary outcomes in the innovative model to those in the usual care model for adult…
- Trial name
- NCT05229718
- Testing
- Diabetes Collaborative Care Model for Young Adults, Usual Care Model
- Where
- United States
- Volunteers
- 45 people
- Sponsor
- Massachusetts General Hospital
Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus
Evaluation of a Novel Insulin Sensitizer in People With Type 1 Diabetes
The purpose of this study is to see if the study drug CIR-0602K will improve glucose time-in-range and/or lower total daily insulin dose in people with type 1 diabetes who are using closed-loop automated insulin delivery.
- Conditions
- Type 1 Diabetes (T1D), Glycemic Control for Diabetes Mellitus, Insulin, Ketones
- Trial name
- WBH003 (NCT07186660)
- Testing
- CIR-0602K
- Where
- United States
- Volunteers
- 40 people
- Sponsor
- University of Virginia
Type 1 Diabetes
Do Advanced Hybrid Closed Loop Systems Effect Nutrient Intake?: Real Life Data
This 6-month follow-up study was conducted to investigate the effect of AHCLS on the energy and macronutrient intake of children, adolescents, and young adults with Type 1 diabetes (T1D).
- Trial name
- NCT05666596
- Where
- 2 sites in Turkey (Türkiye)
- Volunteers
- 29 people
- Sponsor
- Ege University
Diabetes Mellitus
Compare Blood Sugar Level Between Lantus in the Morning and Other Insulins in Type 1 Diabetes Adolescents
The purpose of the study is to compare the effect in blood sugar control between Lantus and twice daily intermediate acting insulins (NPH or Lente) when used as the basal insulin in a multiple daily injection setting with fast…
- Trial name
- NCT00046501
- Testing
- Lantus (insulin glargine [rDNA origin] injection), Humulin N, Humulin L
- Where
- United States
- Volunteers
- 250 people, healthy volunteers welcome
- Sponsor
- Sanofi
Diabetes Mellitus, Type 1, Cardiovascular Diseases
Activation Innate Immune System in Type 1 Diabetes
Hyperglycemia is a well-known cardiovascular risk factor. It has also been shown that episodes of hyperglycemia increase the risk for cardiovascular diseases despite return to normoglycemia, a phenomenon termed 'glycemic or…
- Conditions
- Diabetes Mellitus, Type 1, Cardiovascular Diseases, Innate Immune System, Inflammation
- Trial name
- NCT03441919
- Testing
- PET-CT (positron emission tomography - computer tomography), Blood drawn
- Where
- Netherlands
- Volunteers
- 66 people, healthy volunteers welcome
- Sponsor
- Radboud University Medical Center
Type 1 Diabetes
Resilience Promotion in Teens With Type 1 Diabetes: Preventing Negative Outcomes
Adolescents with type 1 diabetes are at increased risk for depressive symptoms, poor coping and problem-solving skills, poor regimen adherence, and negative diabetes-specific health outcomes.
- Trial name
- NCT01490619
- Testing
- Healthy Thinking In Teens, Advanced Diabetes Education.
- Where
- United States
- Volunteers
- 280 people
- Sponsor
- Ann & Robert H Lurie Children's Hospital of Chicago
Diabetes Mellitus, Type 1
A Study of Technology to Improve Glucose Control in Participants With Type 1 Diabetes
The main purpose of this study is to determine whether combining meal, glucose, and insulin data in a web-based system will improve management of type 1 diabetes (T1D). No study drug will be given.
- Trial name
- NCT03758430
- Testing
- Meal-Tagging App, Fitness Tracker
- Where
- United States
- Volunteers
- 28 people
- Sponsor
- Eli Lilly and Company
Type 1 Diabetes, Diabetes Mellitus, Type 1
Weekly Subcutaneous Semaglutide as Adjunct to Closed-loop Therapy in Type 1 Diabetes Care
A closed-loop insulin system, also referred to as the "artificial pancreas" (AP), is made up of an insulin pump, a continuous glucose monitor, and an application communicating between the two to adjust insulin administration…
- Trial name
- SEMA-AP (NCT05205928)
- Testing
- Outpatient therapy: 11 weeks of drug therapy with usual treatment + 4 weeks of closed-loop therapy
- Where
- Canada
- Volunteers
- 28 people
- Sponsor
- McGill University Health Centre/Research Institute of the McGill University Health Centre
Type 1 Diabetes (T1D)
The T1D Talks Pilot Study
Despite recent technological advances in type 1 diabetes (T1D) treatment, adolescents are the only age group for which glycemic levels have not improved.
- Trial name
- NCT07109128
- Testing
- The T1D Talks: A Virtual Group for Teens and Tweens with T1D
- Where
- United States
- Volunteers
- 18 people
- Sponsor
- Western Michigan University School of Medicine
Type 1 Diabetes (T1D), Registry
UK Islet Autoantibody Registry
Type 1 diabetes (T1D) is a life-long condition where the immune system destroys part of the body (the pancreas) which makes the chemical, insulin. Insulin is needed to control blood sugar levels.
- Conditions
- Type 1 Diabetes (T1D), Registry, Pre-diabetes, Screening
- Trial name
- UKIAb Registry (NCT07125365)
- Where
- United Kingdom
- Volunteers
- 350 people
- Sponsor
- University of Oxford
Type 1 Diabetes, Closed Loop
Semi-closed Loop Automated Insulin Therapy in the Pediatric Population Aged 2-6 Years With Type 1 Diabetes: Impact on Quality of Life and Glycemic Control
The incidence of type 1 diabetes is increasing, with an incidence of +4% per year in France today. The treatment for type 1 diabetes is insulin therapy.
- Conditions
- Type 1 Diabetes, Closed Loop, Insulin, Quality of Life
- Trial name
- Diablife (NCT06875167)
- Where
- France
- Volunteers
- 20 people
- Sponsor
- Fondation Lenval
Diabetes Mellitus, Type 1
Acceptability of Virtual Educational Intervention for Adolescents and Young Adults With Type 1 Diabetes Mellitus
In this pilot study, study investigators aim to evaluate the acceptability and feasibility of a 3-month interactive virtual educational program, designed on principles of self-efficacy, reviewing aspects of Diabetes Mellitus care…
- Trial name
- NCT04878419
- Testing
- Virtual Educational Program
- Where
- United States
- Volunteers
- 10 people
- Sponsor
- University Hospitals Cleveland Medical Center
Type 1 Diabetes Mellitus
5-MTHF Supplementation for Treatment of Type 1 Diabetes Patients
This study aims to evaluate the improvement of autoimmune status in patients with Type 1 Diabetes (T1D) through supplementation with 5-Methyltetrahydrofolate, and to explore the safety and efficacy of this treatment.
- Trial name
- NCT06930144
- Testing
- active folate
- Volunteers
- 34 people
- Sponsor
- Shanghai Changzheng Hospital
Alopecia Areata, Alopecia Totalis
The Epidemiology, Management and Comorbidities in Alopecia Areata in Czech Republic
The study series consists of three studies with the aim to assess the incidence, prevalence, risk factors, comorbidities and management of patients with alopecia areata in Czech Republic based on the patients and registry of a…
- Conditions
- Alopecia Areata, Alopecia Totalis, Alopecia Universalis, Alopecia Areata (& Ophiasis)
- Trial name
- NCT05098600
- Testing
- Exposure of interest
- Where
- Czechia
- Volunteers
- 123 people
- Sponsor
- Faculty Hospital Kralovske Vinohrady
Diabetes Mellitus, Type 1
Patient and Parent Preferences for an On-Body Automated Insulin Delivery System
The goal of this study is to learn more about patient and family preferences regarding use of advanced diabetes technologies. Young persons with type 1 diabetes (ages 8-25) and parents of young persons with type 1 diabetes will…
- Trial name
- NCT03534544
- Where
- 2 sites in United States
- Volunteers
- 362 people
- Sponsor
- Joslin Diabetes Center
Type 1 Diabetes
Closing the Loop in Adults With Type 1 Diabetes
The main objective of this study is to evaluate the feasibility of closed loop insulin pump therapy to improve overnight glucose control in adults with type 1 diabetes.
- Trial name
- ANGELA01 (NCT00910767)
- Testing
- Conventional insulin pump delivery, Closed loop
- Where
- United Kingdom
- Volunteers
- 12 people
- Sponsor
- University of Cambridge
Type1diabetes, Childhood ALL
Hb A1C Pre and Post Confinement in Latin American Children With Type 1 Diabetes: Dulce Study Group
A multicenter retrospective observational study among children with type 1 diabetes will be performed. The Objective of this study will be to determine a) the association between the increase in Hba1c in children with type 1…
- Trial name
- NCT04640064
- Where
- Argentina
- Volunteers
- 500 people
- Sponsor
- Hospital General Puyo
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